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Entry version 195 (05 Jun 2019)
Sequence version 2 (03 Oct 2003)
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Protein

S-phase kinase-associated protein 2

Gene

SKP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.14 Publications
Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000145604-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69231 Cyclin D associated events in G1
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13309

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S-phase kinase-associated protein 2
Alternative name(s):
Cyclin-A/CDK2-associated protein p45
F-box protein Skp2
F-box/LRR-repeat protein 1
p45skp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKP2
Synonyms:FBXL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10901 SKP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601436 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13309

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6502

Open Targets

More...
OpenTargetsi
ENSG00000145604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35801

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SKP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37537922

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199541 – 424S-phase kinase-associated protein 2Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineCombined sources1
Modified residuei68N6-acetyllysine; by p300/EP3001 Publication1
Modified residuei71N6-acetyllysine; by p300/EP3001 Publication1
Modified residuei72PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13.1 Publication
Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13309

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13309

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13309

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13309

PeptideAtlas

More...
PeptideAtlasi
Q13309

PRoteomics IDEntifications database

More...
PRIDEi
Q13309

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59298
59299 [Q13309-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q13309-1 [Q13309-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13309

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13309

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145604 Expressed in 229 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13309 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13309 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB013491
CAB013533
HPA051196
HPA054633

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2.

Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2.

Interacts directly with CUL1 and SKP1.

Interacts with CKS1.

Interacts with the cyclin-A-CDK2 complex.

Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1.

Interacts with TRIM21.

Interacts with IFI27; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766).

Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766).

16 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112393, 197 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13309

Database of interacting proteins

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DIPi
DIP-17011N

Protein interaction database and analysis system

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IntActi
Q13309, 57 interactors

Molecular INTeraction database

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MINTi
Q13309

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274255

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13309

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13309

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 140F-boxPROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati151 – 176LRR 11 PublicationAdd BLAST26
Repeati177 – 204LRR 21 PublicationAdd BLAST28
Repeati210 – 234LRR 31 PublicationAdd BLAST25
Repeati235 – 257LRR 41 PublicationAdd BLAST23
Repeati258 – 284LRR 51 PublicationAdd BLAST27
Repeati286 – 308LRR 61 PublicationAdd BLAST23
Repeati309 – 330LRR 71 PublicationAdd BLAST22
Repeati334 – 356LRR 81 PublicationAdd BLAST23
Repeati359 – 378LRR 91 PublicationAdd BLAST20
Repeati380 – 401LRR 101 PublicationAdd BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 220Mediates interaction with hepatitis C virus non-structural protein NS5A1 PublicationAdd BLAST220
Regioni402 – 424Mediates interaction with IFI271 PublicationAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi67 – 73Nuclear localization signal1 Publication7

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2120 Eukaryota
ENOG410Z2W2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007918

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000247037

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13309

KEGG Orthology (KO)

More...
KOi
K03875

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIWGIRC

Database of Orthologous Groups

More...
OrthoDBi
1333044at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13309

TreeFam database of animal gene trees

More...
TreeFami
TF352582

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12937 F-box-like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13309-1) [UniParc]FASTAAdd to basket
Also known as: SKP2-alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN
60 70 80 90 100
IPQELLSNLG HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL
110 120 130 140 150
PDELLLGIFS CLCLPELLKV SGVCKRWYRL ASDESLWQTL DLTGKNLHPD
160 170 180 190 200
VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP FRVQHMDLSN SVIEVSTLHG
210 220 230 240 250
ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC SGFSEFALQT
260 270 280 290 300
LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS
310 320 330 340 350
DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP
360 370 380 390 400
ETLLELGEIP TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT
410 420
IGNKKNQEIW GIKCRLTLQK PSCL
Length:424
Mass (Da):47,761
Last modified:October 3, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF29B7C338A7A37E9
GO
Isoform 2 (identifier: Q13309-2) [UniParc]FASTAAdd to basket
Also known as: SKP2-beta

The sequence of this isoform differs from the canonical sequence as follows:
     355-424: ELGEIPTLKT...RLTLQKPSCL → LVTRAGVRIR...FYFYRLVLKQ

Show »
Length:410
Mass (Da):46,576
Checksum:i8CB41CC9968695E3
GO
Isoform 3 (identifier: Q13309-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.
     180-224: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):23,763
Checksum:i06BF227E9F6974C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTL5A0A0A0MTL5_HUMAN
S-phase kinase-associated protein 2
SKP2
435Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAG5D6RAG5_HUMAN
S-phase kinase-associated protein 2
SKP2
217Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9R7D6R9R7_HUMAN
S-phase kinase-associated protein 2
SKP2
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF40D6RF40_HUMAN
S-phase kinase-associated protein 2
SKP2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9I9H0Y9I9_HUMAN
S-phase kinase-associated protein 2
SKP2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50242 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB87202 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185H → D in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti215Missing in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti238S → P in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti241S → P in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti244 – 247SEFA → PKFP in AAC50242 (PubMed:7553852).Curated4
Sequence conflicti251L → F in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti256S → P in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti268D → N in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti285I → M in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti319D → N in AAC50242 (PubMed:7553852).Curated1
Sequence conflicti332F → S in AAC50242 (PubMed:7553852).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01698485P → L. Corresponds to variant dbSNP:rs3913486Ensembl.1
Natural variantiVAR_01698587L → I. Corresponds to variant dbSNP:rs3913487Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449311 – 169Missing in isoform 3. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_044932180 – 224Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_008432355 – 424ELGEI…KPSCL → LVTRAGVRIRLDSDIGCPQT YRTSKLKSSHKLFCQHVRVI CIFVCDFYFYRLVLKQ in isoform 2. 2 PublicationsAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33761 mRNA Translation: AAC50242.1 Different initiation.
AB050979 mRNA Translation: BAB87200.1
AB050980 mRNA Translation: BAB87201.1
AB050981 mRNA Translation: BAB87202.1 Sequence problems.
AY029177 mRNA Translation: AAK31593.1
AK291255 mRNA Translation: BAF83944.1
AK296223 mRNA Translation: BAG58946.1
AC008942 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55936.1
BC001441 mRNA Translation: AAH01441.1
BC007441 mRNA Translation: AAH07441.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3915.1 [Q13309-2]
CCDS3916.1 [Q13309-1]
CCDS58944.1 [Q13309-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
I39171

NCBI Reference Sequences

More...
RefSeqi
NP_001230049.1, NM_001243120.1 [Q13309-4]
NP_005974.2, NM_005983.3 [Q13309-1]
NP_116026.1, NM_032637.3 [Q13309-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274254; ENSP00000274254; ENSG00000145604 [Q13309-2]
ENST00000274255; ENSP00000274255; ENSG00000145604 [Q13309-1]
ENST00000620197; ENSP00000478031; ENSG00000145604 [Q13309-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6502

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6502

UCSC genome browser

More...
UCSCi
uc003jkc.3 human [Q13309-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33761 mRNA Translation: AAC50242.1 Different initiation.
AB050979 mRNA Translation: BAB87200.1
AB050980 mRNA Translation: BAB87201.1
AB050981 mRNA Translation: BAB87202.1 Sequence problems.
AY029177 mRNA Translation: AAK31593.1
AK291255 mRNA Translation: BAF83944.1
AK296223 mRNA Translation: BAG58946.1
AC008942 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55936.1
BC001441 mRNA Translation: AAH01441.1
BC007441 mRNA Translation: AAH07441.1
CCDSiCCDS3915.1 [Q13309-2]
CCDS3916.1 [Q13309-1]
CCDS58944.1 [Q13309-4]
PIRiI39171
RefSeqiNP_001230049.1, NM_001243120.1 [Q13309-4]
NP_005974.2, NM_005983.3 [Q13309-1]
NP_116026.1, NM_032637.3 [Q13309-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQVX-ray2.80A/C/E/G/I/K/M/O89-424[»]
1FS1X-ray1.80A/C89-141[»]
1FS2X-ray2.90A/C89-398[»]
1LDKX-ray3.10E97-137[»]
2ASSX-ray3.00B89-424[»]
2ASTX-ray2.30B89-424[»]
SMRiQ13309
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112393, 197 interactors
CORUMiQ13309
DIPiDIP-17011N
IntActiQ13309, 57 interactors
MINTiQ13309
STRINGi9606.ENSP00000274255

PTM databases

iPTMnetiQ13309
PhosphoSitePlusiQ13309

Polymorphism and mutation databases

BioMutaiSKP2
DMDMi37537922

Proteomic databases

EPDiQ13309
jPOSTiQ13309
MaxQBiQ13309
PaxDbiQ13309
PeptideAtlasiQ13309
PRIDEiQ13309
ProteomicsDBi59298
59299 [Q13309-2]
TopDownProteomicsiQ13309-1 [Q13309-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6502
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274254; ENSP00000274254; ENSG00000145604 [Q13309-2]
ENST00000274255; ENSP00000274255; ENSG00000145604 [Q13309-1]
ENST00000620197; ENSP00000478031; ENSG00000145604 [Q13309-4]
GeneIDi6502
KEGGihsa:6502
UCSCiuc003jkc.3 human [Q13309-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6502
DisGeNETi6502

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SKP2
HGNCiHGNC:10901 SKP2
HPAiCAB013491
CAB013533
HPA051196
HPA054633
MIMi601436 gene
neXtProtiNX_Q13309
OpenTargetsiENSG00000145604
PharmGKBiPA35801

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2120 Eukaryota
ENOG410Z2W2 LUCA
GeneTreeiENSGT00390000007918
HOGENOMiHOG000247037
InParanoidiQ13309
KOiK03875
OMAiEIWGIRC
OrthoDBi1333044at2759
PhylomeDBiQ13309
TreeFamiTF352582

Enzyme and pathway databases

UniPathwayiUPA00143
BioCyciMetaCyc:ENSG00000145604-MONOMER
ReactomeiR-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69231 Cyclin D associated events in G1
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ13309

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SKP2 human
EvolutionaryTraceiQ13309

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SKP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6502

Protein Ontology

More...
PROi
PR:Q13309

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145604 Expressed in 229 organ(s), highest expression level in oocyte
ExpressionAtlasiQ13309 baseline and differential
GenevisibleiQ13309 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 5 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13309
Secondary accession number(s): A8K5E0
, B4DJT4, Q8TDZ0, Q8TDZ1, Q9BV69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: June 5, 2019
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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