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Entry version 167 (08 May 2019)
Sequence version 2 (08 Feb 2011)
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Protein

Interleukin-10 receptor subunit alpha

Gene

IL10RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6783783 Interleukin-10 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13651

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13651

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL10RA
Synonyms:IL10R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5964 IL10RA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
146933 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13651

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 578CytoplasmicSequence analysisAdd BLAST322

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Inflammatory bowel disease 28 (IBD28)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07166369W → R in IBD28. 1 PublicationCorresponds to variant dbSNP:rs1343534194Ensembl.1
Natural variantiVAR_06354284T → I in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853580EnsemblClinVar.1
Natural variantiVAR_07166491Y → C in IBD28. 2 Publications1
Natural variantiVAR_071665101R → W in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs368287711EnsemblClinVar.1
Natural variantiVAR_071666117R → H in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs199989396Ensembl.1
Natural variantiVAR_063543141G → R in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853579EnsemblClinVar.1
Natural variantiVAR_071667262R → C in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs149491038EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3587

MalaCards human disease database

More...
MalaCardsi
IL10RA
MIMi613148 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000110324

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
238569 Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29779

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1727

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL10RA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510034

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001101222 – 578Interleukin-10 receptor subunit alphaAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 751 Publication
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi202 ↔ 2231 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation.By similarity
Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13651

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13651

PeptideAtlas

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PeptideAtlasi
Q13651

PRoteomics IDEntifications database

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PRIDEi
Q13651

ProteomicsDB human proteome resource

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ProteomicsDBi
59648

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13651

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13651

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Primarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expresssed in non-hematopoetic cells such as fibroblasts or endothelial cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000110324 Expressed in 176 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13651 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13651 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IL10 (PubMed:16982608, PubMed:15837194).

Interacts with IL10RB (PubMed:16982608).

Interacts (via its cytoplasmic domain) with JAK1 (via N-terminus) (PubMed:12133952).

Interacts with BTRC; this interaction leads to IL10RA ubiquitination and subsequent degradation (PubMed:22087322).

Interacts with STAT3 (By similarity).

By similarity4 Publications

(Microbial infection)

Interacts with human cytomegalovirus protein IL10.

1 Publication

(Microbial infection)

Interacts with Epstein-Barr virus protein IL10.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109801, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13651

Database of interacting proteins

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DIPi
DIP-3512N

Protein interaction database and analysis system

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IntActi
Q13651, 23 interactors

Molecular INTeraction database

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MINTi
Q13651

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000227752

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1578
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13651

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13651

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi318 – 323BTRC recognition motif1 Publication6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGAG Eukaryota
ENOG410YMSK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000048847

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112980

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13651

KEGG Orthology (KO)

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KOi
K05134

Identification of Orthologs from Complete Genome Data

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OMAi
TEEPQFL

Database of Orthologous Groups

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OrthoDBi
1311668at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13651

TreeFam database of animal gene trees

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TreeFami
TF334107

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01108 Tissue_fac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13651-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN
60 70 80 90 100
QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV
110 120 130 140 150
RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM
160 170 180 190 200
APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE
210 220 230 240 250
FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF AFVLLLSGAL
260 270 280 290 300
AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA
310 320 330 340 350
FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN
360 370 380 390 400
REPPVLGDSC SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD
410 420 430 440 450
SGIDLVQNSE GRAGDTQGGS ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT
460 470 480 490 500
RCAEEKATKT GCLEEESPLT DGLGPKFGRC LVDEAGLHPP ALAKGYLKQD
510 520 530 540 550
PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS FAHDLAPLGC
560 570
VAAPGGLLGS FNSDLVTLPL ISSLQSSE
Length:578
Mass (Da):63,003
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54B183ABE84808DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPU4E9PPU4_HUMAN
Interleukin-10 receptor subunit alp...
IL10RA
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKU2E9PKU2_HUMAN
Interleukin-10 receptor subunit alp...
IL10RA
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01629461L → V1 PublicationCorresponds to variant dbSNP:rs4252250EnsemblClinVar.1
Natural variantiVAR_07166369W → R in IBD28. 1 PublicationCorresponds to variant dbSNP:rs1343534194Ensembl.1
Natural variantiVAR_06354284T → I in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853580EnsemblClinVar.1
Natural variantiVAR_07166491Y → C in IBD28. 2 Publications1
Natural variantiVAR_071665101R → W in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs368287711EnsemblClinVar.1
Natural variantiVAR_016295113V → I1 PublicationCorresponds to variant dbSNP:rs4252303EnsemblClinVar.1
Natural variantiVAR_071666117R → H in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs199989396Ensembl.1
Natural variantiVAR_063543141G → R in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853579EnsemblClinVar.1
Natural variantiVAR_016296159S → G1 PublicationCorresponds to variant dbSNP:rs3135932EnsemblClinVar.1
Natural variantiVAR_016297212R → Q1 PublicationCorresponds to variant dbSNP:rs4252273Ensembl.1
Natural variantiVAR_020004224I → V. Corresponds to variant dbSNP:rs2228055EnsemblClinVar.1
Natural variantiVAR_071667262R → C in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs149491038EnsemblClinVar.1
Natural variantiVAR_016298351R → G5 PublicationsCorresponds to variant dbSNP:rs2229113EnsemblClinVar.1
Natural variantiVAR_049175353P → S. Corresponds to variant dbSNP:rs35235073Ensembl.1
Natural variantiVAR_016299420S → L1 PublicationCorresponds to variant dbSNP:rs2229114EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U00672 mRNA Translation: AAA17896.1
AY195619 Genomic DNA Translation: AAN86349.1
EF444988 Genomic DNA Translation: ACA06005.1
AK291645 mRNA Translation: BAF84334.1
AP002962 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67343.1
BC028082 mRNA Translation: AAH28082.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8388.1

Protein sequence database of the Protein Information Resource

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PIRi
I56215

NCBI Reference Sequences

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RefSeqi
NP_001549.2, NM_001558.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000227752; ENSP00000227752; ENSG00000110324

Database of genes from NCBI RefSeq genomes

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GeneIDi
3587

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3587

UCSC genome browser

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UCSCi
uc001prv.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00672 mRNA Translation: AAA17896.1
AY195619 Genomic DNA Translation: AAN86349.1
EF444988 Genomic DNA Translation: ACA06005.1
AK291645 mRNA Translation: BAF84334.1
AP002962 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67343.1
BC028082 mRNA Translation: AAH28082.1
CCDSiCCDS8388.1
PIRiI56215
RefSeqiNP_001549.2, NM_001558.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J7VX-ray2.90R22-235[»]
1LQSX-ray2.70R/S22-235[»]
1Y6KX-ray2.52R22-235[»]
1Y6MX-ray2.80R22-235[»]
1Y6NX-ray2.70R22-235[»]
5IXIX-ray2.57B263-303[»]
SMRiQ13651
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109801, 4 interactors
CORUMiQ13651
DIPiDIP-3512N
IntActiQ13651, 23 interactors
MINTiQ13651
STRINGi9606.ENSP00000227752

Chemistry databases

GuidetoPHARMACOLOGYi1727

PTM databases

iPTMnetiQ13651
PhosphoSitePlusiQ13651

Polymorphism and mutation databases

BioMutaiIL10RA
DMDMi322510034

Proteomic databases

jPOSTiQ13651
PaxDbiQ13651
PeptideAtlasiQ13651
PRIDEiQ13651
ProteomicsDBi59648

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3587
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227752; ENSP00000227752; ENSG00000110324
GeneIDi3587
KEGGihsa:3587
UCSCiuc001prv.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3587
DisGeNETi3587

GeneCards: human genes, protein and diseases

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GeneCardsi
IL10RA

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0010172
HGNCiHGNC:5964 IL10RA
MalaCardsiIL10RA
MIMi146933 gene
613148 phenotype
neXtProtiNX_Q13651
OpenTargetsiENSG00000110324
Orphaneti238569 Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome
PharmGKBiPA29779

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGAG Eukaryota
ENOG410YMSK LUCA
GeneTreeiENSGT00510000048847
HOGENOMiHOG000112980
InParanoidiQ13651
KOiK05134
OMAiTEEPQFL
OrthoDBi1311668at2759
PhylomeDBiQ13651
TreeFamiTF334107

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
SignaLinkiQ13651
SIGNORiQ13651

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IL10RA human
EvolutionaryTraceiQ13651

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_10_receptor,_alpha_subunit

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3587

Protein Ontology

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PROi
PR:Q13651

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110324 Expressed in 176 organ(s), highest expression level in leukocyte
ExpressionAtlasiQ13651 baseline and differential
GenevisibleiQ13651 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI10R1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13651
Secondary accession number(s): A8K6I0, B0YJ27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 8, 2011
Last modified: May 8, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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