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Entry version 130 (16 Oct 2019)
Sequence version 3 (20 Feb 2007)
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Protein

Genetic suppressor element 1

Gene

GSE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genetic suppressor element 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSE1
Synonyms:KIAA0182
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28979 GSE1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616886 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14687

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23199

Open Targets

More...
OpenTargetsi
ENSG00000131149

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485512

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q14687

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507301 – 1217Genetic suppressor element 1Add BLAST1217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei95PhosphoserineBy similarity1
Modified residuei305Asymmetric dimethylarginineCombined sources1
Modified residuei433PhosphothreonineCombined sources1
Modified residuei496N6-acetyllysineCombined sources1
Modified residuei739N6-acetyllysineCombined sources1
Modified residuei766PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei907PhosphothreonineCombined sources1
Modified residuei909PhosphoserineCombined sources1
Modified residuei1101PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14687

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14687

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q14687

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14687

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14687

PeptideAtlas

More...
PeptideAtlasi
Q14687

PRoteomics IDEntifications database

More...
PRIDEi
Q14687

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60121 [Q14687-1]
60122 [Q14687-2]
60123 [Q14687-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14687

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14687

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Negatively regulated by miR-489-5p.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131149 Expressed in 232 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14687 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14687 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036365

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116808, 51 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q14687

Protein interaction database and analysis system

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IntActi
Q14687, 41 interactors

Molecular INTeraction database

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MINTi
Q14687

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253458

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili321 – 403Sequence analysisAdd BLAST83
Coiled coili1127 – 1201Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi532 – 722Pro-richAdd BLAST191
Compositional biasi745 – 748Poly-Arg4
Compositional biasi1102 – 1107Poly-Glu6

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGKK Eukaryota
ENOG410Z7HR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00700000104539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112825

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14687

Identification of Orthologs from Complete Genome Data

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OMAi
PNHHEPG

Database of Orthologous Groups

More...
OrthoDBi
207938at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14687

TreeFam database of animal gene trees

More...
TreeFami
TF332496

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022207 GSE-like
IPR042337 GSE1

The PANTHER Classification System

More...
PANTHERi
PTHR17608 PTHR17608, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12540 DUF3736, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGMSHEPKS PSLGMLSTAT RTTATVNPLT PSPLNGALVP SGSPATSSAL
60 70 80 90 100
SAQAAPSSSF AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP
110 120 130 140 150
KRVPMGPIIV PPGGHSVPST PPVVTIAPTK TVNGVWRSES RQDAGSRSSS
160 170 180 190 200
GGRERLIVEP PLPQEKAGGP AIPSHLLSTP YPFGLSPSSV VQDSRFPPLN
210 220 230 240 250
LQRPVHHVVP PSTVTEDYLR SFRPYHTTDD LRMSSLPPLG LDPATAAAYY
260 270 280 290 300
HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH
310 320 330 340 350
LSGVRYPPEL SHSSLAALHS ERMSGLSAER LQMDEELRRE RERERERERE
360 370 380 390 400
READREREKE REREREKERE QEKEREREKE RERELERQRE QRAREKELLA
410 420 430 440 450
AKALEPSFLP VAELHGLRGH ATEERGKPSE QLTPTRAEKL KDAGLQAPKP
460 470 480 490 500
VQHPLHPVPT PHHTVPSLIS NHGIFSLPSS SAATALLIQR TNEEEKWLAR
510 520 530 540 550
QRRLRQEKED RQSQVSEFRQ QVLEQHLDMG RPPVPAEAEH RPESTTRPGP
560 570 580 590 600
NRHEPGGRDP PQHFGGPPPL ISPKPQLHAA PTALWNPVSL MDNTLETRRA
610 620 630 640 650
ESHSLHSHPA AFEPSRQAAV PLVKVERVFC PEKAEEGPRK REPAPLDKYQ
660 670 680 690 700
PPPPPPREGG SLEHQPFLPG PGPFLAELEK STQTILGQQR ASLPQAATFG
710 720 730 740 750
ELSGPLKPGS PYRPPVPRAP DPAYIYDEFL QQRRRLVSKL DLEERRRREA
760 770 780 790 800
QEKGYYYDLD DSYDESDEEE VRAHLRCVAE QPPLKLDTSS EKLEFLQLFG
810 820 830 840 850
LTTQQQKEEL VAQKRRKRRR MLRERSPSPP TIQSKRQTPS PRLALSTRYS
860 870 880 890 900
PDEMNNSPNF EEKKKFLTIF NLTHISAEKR KDKERLVEML RAMKQKALSA
910 920 930 940 950
AVADSLTNSP RDSPAVSLSE PATQQASLDV EKPVGVAASL SDIPKAAEPG
960 970 980 990 1000
KLEQVRPQEL SRVQELAPAS GEKARLSEAP GGKKSLSMLH YIRGAAPKDI
1010 1020 1030 1040 1050
PVPLSHSTNG KSKPWEPFVA EEFAHQFHES VLQSTQKALQ KHKGSVAVLS
1060 1070 1080 1090 1100
AEQNHKVDTS VHYNIPELQS SSRAPPPQHN GQQEPPTARK GPPTQELDRD
1110 1120 1130 1140 1150
SEEEEEEDDE DGEDEEEVPK RKWQGIEAVF EAYQEHIEEQ NLERQVLQTQ
1160 1170 1180 1190 1200
CRRLEARHYS LSLTAEQLSH SVAELRSQKQ KMVSERERLQ AELDHLRKCL
1210
ALPAMHWPRG YLKGYPR
Length:1,217
Mass (Da):136,164
Last modified:February 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4291FBE301B70F36
GO
Isoform 2 (identifier: Q14687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:1,113
Mass (Da):125,842
Checksum:i5AB78CBD09B3216F
GO
Isoform 3 (identifier: Q14687-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-75: Missing.

Note: No experimental confirmation available.
Show »
Length:1,144
Mass (Da):128,923
Checksum:iEFEA707A543C49D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3B5H7C3B5_HUMAN
Genetic suppressor element 1
GSE1
419Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y613H0Y613_HUMAN
Genetic suppressor element 1
GSE1
986Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLW9C9JLW9_HUMAN
Genetic suppressor element 1
GSE1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUX8A0A1B0GUX8_HUMAN
Genetic suppressor element 1
GSE1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUL3A0A1B0GUL3_HUMAN
Genetic suppressor element 1
GSE1
894Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11499 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti444G → S in BAA11499 (PubMed:8724849).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035926627R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs757859891Ensembl.1
Natural variantiVAR_029546936V → A1 PublicationCorresponds to variant dbSNP:rs17853763Ensembl.1
Natural variantiVAR_0295471153R → Q. Corresponds to variant dbSNP:rs2303203Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0218201 – 104Missing in isoform 2. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_0218213 – 75Missing in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D80004 mRNA Translation: BAA11499.2 Different initiation.
CH471114 Genomic DNA Translation: EAW95445.1
CH471114 Genomic DNA Translation: EAW95447.1
BC000753 mRNA Translation: AAH00753.2
BC009854 mRNA Translation: AAH09854.2
BC037556 mRNA Translation: AAH37556.1
BQ214916 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10952.1 [Q14687-1]
CCDS45539.1 [Q14687-2]
CCDS62007.1 [Q14687-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001127945.1, NM_001134473.2 [Q14687-2]
NP_001265113.1, NM_001278184.1 [Q14687-3]
NP_055430.1, NM_014615.3 [Q14687-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253458; ENSP00000253458; ENSG00000131149 [Q14687-1]
ENST00000393243; ENSP00000376934; ENSG00000131149 [Q14687-3]
ENST00000405402; ENSP00000384839; ENSG00000131149 [Q14687-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23199

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23199

UCSC genome browser

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UCSCi
uc002fiw.4 human [Q14687-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80004 mRNA Translation: BAA11499.2 Different initiation.
CH471114 Genomic DNA Translation: EAW95445.1
CH471114 Genomic DNA Translation: EAW95447.1
BC000753 mRNA Translation: AAH00753.2
BC009854 mRNA Translation: AAH09854.2
BC037556 mRNA Translation: AAH37556.1
BQ214916 mRNA No translation available.
CCDSiCCDS10952.1 [Q14687-1]
CCDS45539.1 [Q14687-2]
CCDS62007.1 [Q14687-3]
RefSeqiNP_001127945.1, NM_001134473.2 [Q14687-2]
NP_001265113.1, NM_001278184.1 [Q14687-3]
NP_055430.1, NM_014615.3 [Q14687-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116808, 51 interactors
CORUMiQ14687
IntActiQ14687, 41 interactors
MINTiQ14687
STRINGi9606.ENSP00000253458

PTM databases

iPTMnetiQ14687
PhosphoSitePlusiQ14687

Polymorphism and mutation databases

BioMutaiGSE1
DMDMi126302550

Proteomic databases

EPDiQ14687
jPOSTiQ14687
MassIVEiQ14687
MaxQBiQ14687
PaxDbiQ14687
PeptideAtlasiQ14687
PRIDEiQ14687
ProteomicsDBi60121 [Q14687-1]
60122 [Q14687-2]
60123 [Q14687-3]

Genome annotation databases

EnsembliENST00000253458; ENSP00000253458; ENSG00000131149 [Q14687-1]
ENST00000393243; ENSP00000376934; ENSG00000131149 [Q14687-3]
ENST00000405402; ENSP00000384839; ENSG00000131149 [Q14687-2]
GeneIDi23199
KEGGihsa:23199
UCSCiuc002fiw.4 human [Q14687-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23199
DisGeNETi23199

GeneCards: human genes, protein and diseases

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GeneCardsi
GSE1
HGNCiHGNC:28979 GSE1
HPAiHPA036365
MIMi616886 gene
neXtProtiNX_Q14687
OpenTargetsiENSG00000131149
PharmGKBiPA143485512

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGKK Eukaryota
ENOG410Z7HR LUCA
GeneTreeiENSGT00700000104539
HOGENOMiHOG000112825
InParanoidiQ14687
OMAiPNHHEPG
OrthoDBi207938at2759
PhylomeDBiQ14687
TreeFamiTF332496

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GSE1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA0182

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23199
PharosiQ14687

Protein Ontology

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PROi
PR:Q14687

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000131149 Expressed in 232 organ(s), highest expression level in thymus
ExpressionAtlasiQ14687 baseline and differential
GenevisibleiQ14687 HS

Family and domain databases

InterProiView protein in InterPro
IPR022207 GSE-like
IPR042337 GSE1
PANTHERiPTHR17608 PTHR17608, 1 hit
PfamiView protein in Pfam
PF12540 DUF3736, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14687
Secondary accession number(s): D3DUM4
, Q8IY61, Q96GA4, Q9BW09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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