Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q14749 (GNMT_HUMAN)

Entry version 179 (18 Sep 2019)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Glycine N-methyltransferase

Gene

GNMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei22S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei31S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei34SubstratePROSITE-ProRule annotation1
Binding sitei41S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei65S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei86S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei139S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei141SubstratePROSITE-ProRule annotation1
Binding sitei178SubstratePROSITE-ProRule annotation1
Binding sitei223SubstratePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandFolate-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.20 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se
R-HSA-389661 Glyoxylate metabolism and glycine degradation

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q14749

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycine N-methyltransferase (EC:2.1.1.20)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4415 GNMT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606628 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glycine N-methyltransferase deficiency (GNMT deficiency)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThe only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01276650L → P in GNMT deficiency; 10% wild-type activity. 2 PublicationsCorresponds to variant dbSNP:rs121907888EnsemblClinVar.1
Natural variantiVAR_019840141N → S in GNMT deficiency; 0.5% wild-type activity. 2 PublicationsCorresponds to variant dbSNP:rs864321678EnsemblClinVar.1
Natural variantiVAR_012767177H → N in GNMT deficiency; 75% wild-type activity, decreases stability of the tetramer. 3 PublicationsCorresponds to variant dbSNP:rs121907889EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		27232

MalaCards human disease database

More...MalaCardsi		GNMT
MIMi606664 phenotype

Open Targets

More...OpenTargetsi		ENSG00000124713

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		289891 Hypermethioninemia due to glycine N-methyltransferase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28794

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14749

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00118 Ademetionine
DB04272 Citric acid
DB00145 Glycine
DB01752 S-adenosyl-L-homocysteine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GNMT

Domain mapping of disease mutations (DMDM)

More...DMDMi		12644416

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875242 – 295Glycine N-methyltransferaseAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylvalineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei34PhosphotyrosineBy similarity1
Modified residuei46N6-succinyllysineBy similarity1
Modified residuei193N6-succinyllysineBy similarity1
Modified residuei198N6-succinyllysineBy similarity1
Modified residuei203N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14749

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14749

PeptideAtlas

More...PeptideAtlasi		Q14749

PRoteomics IDEntifications database

More...PRIDEi		Q14749

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60155

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14749

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14749

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124713 Expressed in 95 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14749 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14749 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA027501

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		118081, 23 interactors

Protein interaction database and analysis system

More...IntActi		Q14749, 26 interactors

Molecular INTeraction database

More...MINTi		Q14749

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361894

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14749

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14749

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni117 – 118S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IF1C Eukaryota
ENOG410ZWXN LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006845

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000276537

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14749

KEGG Orthology (KO)

More...KOi		K00552

Identification of Orthologs from Complete Genome Data

More...OMAi		MITLDYT

Database of Orthologous Groups

More...OrthoDBi		1049906at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14749

TreeFam database of animal gene trees

More...TreeFami		TF324814

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014369 Gly/Sar_N_MeTrfase
IPR041698 Methyltransf_25
IPR029063 SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR16458 PTHR16458, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13649 Methyltransf_25, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000385 Gly_N-mtase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51600 SAM_GNMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q14749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL 
        60         70         80         90        100
GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW 
       110        120        130        140        150
NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK 
       160        170        180        190        200
GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD 
       210        220        230        240        250
LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL 
       260        270        280        290 
ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD
Length:295
Mass (Da):32,742
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34F4546136FD27ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119Missing in CAA44164 (PubMed:8281755).Curated1
Sequence conflicti129 – 130AE → PK in AAF78289 (PubMed:10843803).Curated2
Sequence conflicti175I → S in CAA44164 (PubMed:8281755).Curated1
Sequence conflicti256 – 260LLQAA → SPSS in CAA44164 (PubMed:8281755).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01276650L → P in GNMT deficiency; 10% wild-type activity. 2 PublicationsCorresponds to variant dbSNP:rs121907888EnsemblClinVar.1
Natural variantiVAR_019840141N → S in GNMT deficiency; 0.5% wild-type activity. 2 PublicationsCorresponds to variant dbSNP:rs864321678EnsemblClinVar.1
Natural variantiVAR_012767177H → N in GNMT deficiency; 75% wild-type activity, decreases stability of the tetramer. 3 PublicationsCorresponds to variant dbSNP:rs121907889EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF101477 mRNA Translation: AAF78290.1
AF101475 Genomic DNA Translation: AAF78289.1
AL158815 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04124.1
BC032627 mRNA Translation: AAH32627.1
X62250 mRNA Translation: CAA44164.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4876.1

Protein sequence database of the Protein Information Resource

More...PIRi		S42627

NCBI Reference Sequences

More...RefSeqi		NP_001305794.1, NM_001318865.1
NP_061833.1, NM_018960.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372808; ENSP00000361894; ENSG00000124713

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27232

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101477 mRNA Translation: AAF78290.1
AF101475 Genomic DNA Translation: AAF78289.1
AL158815 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04124.1
BC032627 mRNA Translation: AAH32627.1
X62250 mRNA Translation: CAA44164.1
CCDSiCCDS4876.1
PIRiS42627
RefSeqiNP_001305794.1, NM_001318865.1
NP_061833.1, NM_018960.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R74X-ray2.55A/B2-295[»]
2AZTX-ray2.70A/B1-295[»]
SMRiQ14749
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi118081, 23 interactors
IntActiQ14749, 26 interactors
MINTiQ14749
STRINGi9606.ENSP00000361894

Chemistry databases

DrugBankiDB00118 Ademetionine
DB04272 Citric acid
DB00145 Glycine
DB01752 S-adenosyl-L-homocysteine

PTM databases

iPTMnetiQ14749
PhosphoSitePlusiQ14749

Polymorphism and mutation databases

BioMutaiGNMT
DMDMi12644416

Proteomic databases

MassIVEiQ14749
PaxDbiQ14749
PeptideAtlasiQ14749
PRIDEiQ14749
ProteomicsDBi60155

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		27232

Genome annotation databases

EnsembliENST00000372808; ENSP00000361894; ENSG00000124713
GeneIDi27232
KEGGihsa:27232

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27232
DisGeNETi27232

GeneCards: human genes, protein and diseases

More...GeneCardsi		GNMT
HGNCiHGNC:4415 GNMT
HPAiHPA027501
MalaCardsiGNMT
MIMi606628 gene
606664 phenotype
neXtProtiNX_Q14749
OpenTargetsiENSG00000124713
Orphaneti289891 Hypermethioninemia due to glycine N-methyltransferase deficiency
PharmGKBiPA28794

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IF1C Eukaryota
ENOG410ZWXN LUCA
GeneTreeiENSGT00390000006845
HOGENOMiHOG000276537
InParanoidiQ14749
KOiK00552
OMAiMITLDYT
OrthoDBi1049906at2759
PhylomeDBiQ14749
TreeFamiTF324814

Enzyme and pathway databases

BRENDAi2.1.1.20 2681
ReactomeiR-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se
R-HSA-389661 Glyoxylate metabolism and glycine degradation
SABIO-RKiQ14749

Miscellaneous databases

EvolutionaryTraceiQ14749

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GNMT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27232
PharosiQ14749

Protein Ontology

More...PROi		PR:Q14749

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124713 Expressed in 95 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ14749 baseline and differential
GenevisibleiQ14749 HS

Family and domain databases

InterProiView protein in InterPro
IPR014369 Gly/Sar_N_MeTrfase
IPR041698 Methyltransf_25
IPR029063 SAM-dependent_MTases
PANTHERiPTHR16458 PTHR16458, 1 hit
PfamiView protein in Pfam
PF13649 Methyltransf_25, 1 hit
PIRSFiPIRSF000385 Gly_N-mtase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51600 SAM_GNMT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNMT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14749
Secondary accession number(s): Q5T8W2, Q9NNZ1, Q9NS24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again