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Entry version 167 (08 May 2019)
Sequence version 3 (08 Nov 2005)
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Protein

Pumilio homolog 3

Gene

PUM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • regulation of protein ADP-ribosylation Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pumilio homolog 3Curated
Alternative name(s):
HBV X-transactivated gene 5 protein
HBV XAg-transactivated protein 5
Minor histocompatibility antigen HA-8
Short name:
HLA-HA8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PUM3Imported
Synonyms:cPERP-C1 Publication, KIAA0020Imported, PUF-A1 Publication, XTP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29676 PUM3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609960 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15397

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9933

Open Targets

More...
OpenTargetsi
ENSG00000080608

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134895115

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PUM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
81175177

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759291 – 648Pumilio homolog 3Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15397

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15397

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15397

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15397

PeptideAtlas

More...
PeptideAtlasi
Q15397

PRoteomics IDEntifications database

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PRIDEi
Q15397

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60566

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q15397

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15397

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15397

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15397

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000080608 Expressed in 211 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15397 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15397 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002353

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PARP1 (via catalytic domain).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115259, 141 interactors

Protein interaction database and analysis system

More...
IntActi
Q15397, 21 interactors

Molecular INTeraction database

More...
MINTi
Q15397

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1648
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WZRX-ray2.15A/B123-648[»]
4WZWX-ray2.95A129-648[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15397

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini143 – 510PUM-HDPROSITE-ProRule annotationAdd BLAST368
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati177 – 212Pumilio 11 PublicationAdd BLAST36
Repeati213 – 248Pumilio 21 PublicationAdd BLAST36
Repeati249 – 277Pumilio 31 PublicationAdd BLAST29
Repeati289 – 325Pumilio 41 PublicationAdd BLAST37
Repeati326 – 361Pumilio 51 PublicationAdd BLAST36
Repeati362 – 397Pumilio 61 PublicationAdd BLAST36
Repeati398 – 435Pumilio 71 PublicationAdd BLAST38
Repeati436 – 504Pumilio 81 PublicationAdd BLAST69
Repeati505 – 551Pumilio 91 PublicationAdd BLAST47
Repeati552 – 596Pumilio 101 PublicationAdd BLAST45
Repeati597 – 636Pumilio 111 PublicationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni289 – 297HA-89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi106 – 118Nuclear localization signal1 PublicationAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen.
A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2050 Eukaryota
ENOG410XSHY LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000015757

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15397

KEGG Orthology (KO)

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KOi
K14844

Identification of Orthologs from Complete Genome Data

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OMAi
YLQEHAQ

Database of Orthologous Groups

More...
OrthoDBi
845051at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15397

TreeFam database of animal gene trees

More...
TreeFami
TF312954

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012959 CPL_dom
IPR033133 PUM-HD
IPR040059 PUM3
IPR001313 Pumilio_RNA-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR13389 PTHR13389, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08144 CPL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00025 Pumilio, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50302 PUM, 5 hits
PS50303 PUM_HD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15397-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKGKKQFT GKSTKTAQEK NRFHKNSDSG SSKTFPTRKV AKEGGPKVTS
60 70 80 90 100
RNFEKSITKL GKKGVKQFKN KQQGDKSPKN KFQPANKFNK KRKFQPDGRS
110 120 130 140 150
DESAAKKPKW DDFKKKKKEL KQSRQLSDKT NYDIVVRAKQ MWEILRRKDC
160 170 180 190 200
DKEKRVKLMS DLQKLIQGKI KTIAFAHDST RVIQCYIQYG NEEQRKQAFE
210 220 230 240 250
ELRDDLVELS KAKYSRNIVK KFLMYGSKPQ IAEIIRSFKG HVRKMLRHAE
260 270 280 290 300
ASAIVEYAYN DKAILEQRNM LTEELYGNTF QLYKSADHRT LDKVLEVQPE
310 320 330 340 350
KLELIMDEMK QILTPMAQKE AVIKHSLVHK VFLDFFTYAP PKLRSEMIEA
360 370 380 390 400
IREAVVYLAH THDGARVAMH CLWHGTPKDR KVIVKTMKTY VEKVANGQYS
410 420 430 440 450
HLVLLAAFDC IDDTKLVKQI IISEIISSLP SIVNDKYGRK VLLYLLSPRD
460 470 480 490 500
PAHTVREIIE VLQKGDGNAH SKKDTEVRRR ELLESISPAL LSYLQEHAQE
510 520 530 540 550
VVLDKSACVL VSDILGSATG DVQPTMNAIA SLAATGLHPG GKDGELHIAE
560 570 580 590 600
HPAGHLVLKW LIEQDKKMKE NGREGCFAKT LVEHVGMKNL KSWASVNRGA
610 620 630 640
IILSSLLQSC DLEVANKVKA ALKSLIPTLE KTKSTSKGIE ILLEKLST
Length:648
Mass (Da):73,584
Last modified:November 8, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i449BFBF22F1BBA86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3K8S4R3K8_HUMAN
Pumilio homolog 3
PUM3
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA02808 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti625L → S in CAG33238 (Ref. 8) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing. The sequence shown is that of HA-8R.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05161313S → N1 PublicationCorresponds to variant dbSNP:rs10968457Ensembl.1
Natural variantiVAR_051614264I → V. Corresponds to variant dbSNP:rs35869387Ensembl.1
Natural variantiVAR_023772289R → P in allele HA-8P and allele HA-8PL. 2 PublicationsCorresponds to variant dbSNP:rs2173904Ensembl.1
Natural variantiVAR_023773297V → L in allele HA-8PL. 2 PublicationsCorresponds to variant dbSNP:rs2270891Ensembl.1
Natural variantiVAR_051615414T → S. Corresponds to variant dbSNP:rs3736390Ensembl.1
Natural variantiVAR_051616480R → Q. Corresponds to variant dbSNP:rs2270889Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK292169 mRNA Translation: BAF84858.1
AL354723 Genomic DNA No translation available.
AL589675 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58802.1
BC016137 mRNA Translation: AAH16137.2
D13645 mRNA Translation: BAA02808.1 Different initiation.
AF490254 mRNA Translation: AAO85462.1
CR456957 mRNA Translation: CAG33238.1
AY047588 mRNA Translation: AAL06072.1
AY047589 mRNA Translation: AAL06073.1
AY047590 mRNA Translation: AAL06074.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6448.2

NCBI Reference Sequences

More...
RefSeqi
NP_055693.4, NM_014878.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397885; ENSP00000380982; ENSG00000080608

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9933

UCSC genome browser

More...
UCSCi
uc003zhp.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292169 mRNA Translation: BAF84858.1
AL354723 Genomic DNA No translation available.
AL589675 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58802.1
BC016137 mRNA Translation: AAH16137.2
D13645 mRNA Translation: BAA02808.1 Different initiation.
AF490254 mRNA Translation: AAO85462.1
CR456957 mRNA Translation: CAG33238.1
AY047588 mRNA Translation: AAL06072.1
AY047589 mRNA Translation: AAL06073.1
AY047590 mRNA Translation: AAL06074.1
CCDSiCCDS6448.2
RefSeqiNP_055693.4, NM_014878.4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WZRX-ray2.15A/B123-648[»]
4WZWX-ray2.95A129-648[»]
SMRiQ15397
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115259, 141 interactors
IntActiQ15397, 21 interactors
MINTiQ15397
STRINGi9606.ENSP00000380982

PTM databases

iPTMnetiQ15397
PhosphoSitePlusiQ15397
SwissPalmiQ15397

Polymorphism and mutation databases

BioMutaiPUM3
DMDMi81175177

2D gel databases

SWISS-2DPAGEiQ15397

Proteomic databases

EPDiQ15397
jPOSTiQ15397
MaxQBiQ15397
PaxDbiQ15397
PeptideAtlasiQ15397
PRIDEiQ15397
ProteomicsDBi60566

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9933
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397885; ENSP00000380982; ENSG00000080608
GeneIDi9933
KEGGihsa:9933
UCSCiuc003zhp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9933
DisGeNETi9933

GeneCards: human genes, protein and diseases

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GeneCardsi
PUM3
HGNCiHGNC:29676 PUM3
HPAiHPA002353
MIMi609960 gene
neXtProtiNX_Q15397
OpenTargetsiENSG00000080608
PharmGKBiPA134895115

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2050 Eukaryota
ENOG410XSHY LUCA
GeneTreeiENSGT00390000015757
InParanoidiQ15397
KOiK14844
OMAiYLQEHAQ
OrthoDBi845051at2759
PhylomeDBiQ15397
TreeFamiTF312954

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PUM3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA0020

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9933

Protein Ontology

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PROi
PR:Q15397

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000080608 Expressed in 211 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiQ15397 baseline and differential
GenevisibleiQ15397 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012959 CPL_dom
IPR033133 PUM-HD
IPR040059 PUM3
IPR001313 Pumilio_RNA-bd_rpt
PANTHERiPTHR13389 PTHR13389, 1 hit
PfamiView protein in Pfam
PF08144 CPL, 1 hit
SMARTiView protein in SMART
SM00025 Pumilio, 6 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50302 PUM, 5 hits
PS50303 PUM_HD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15397
Secondary accession number(s): A8K804
, Q547G7, Q5SZY9, Q6IB47, Q96B27, Q96L78, Q96L79, Q96L80
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 8, 2005
Last modified: May 8, 2019
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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