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Entry version 175 (08 May 2019)
Sequence version 2 (27 May 2002)
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Protein

Transcriptional enhancer factor TEF-4

Gene

TEAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi38 – 114TEAPROSITE-ProRule annotationAdd BLAST77

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15562

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-4
Alternative name(s):
TEA domain family member 2
Short name:
TEAD-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEAD2
Synonyms:TEF4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11715 TEAD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601729 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15562

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8463

Open Targets

More...
OpenTargetsi
ENSG00000074219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36433

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TEAD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21264529

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002059321 – 447Transcriptional enhancer factor TEF-4Add BLAST447

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15562

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15562

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15562

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15562

PeptideAtlas

More...
PeptideAtlasi
Q15562

PRoteomics IDEntifications database

More...
PRIDEi
Q15562

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60636

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15562

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15562

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15562

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074219 Expressed in 179 organ(s), highest expression level in islet of Langerhans

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15562 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15562 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066292
HPA069963

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114041, 115 interactors

Database of interacting proteins

More...
DIPi
DIP-59318N

Protein interaction database and analysis system

More...
IntActi
Q15562, 79 interactors

Molecular INTeraction database

More...
MINTi
Q15562

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000472109

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15562

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15562

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni172 – 447Transcriptional activationSequence analysisAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi152 – 216Pro-richAdd BLAST65

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3841 Eukaryota
ENOG410XQMP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182956

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000253933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15562

KEGG Orthology (KO)

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KOi
K09448

Identification of Orthologs from Complete Genome Data

More...
OMAi
WQTRALG

Database of Orthologous Groups

More...
OrthoDBi
823827at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15562

TreeFam database of animal gene trees

More...
TreeFami
TF313443

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1610, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000818 TEA/ATTS_dom
IPR038096 TEA/ATTS_sf
IPR016361 TEF_metazoa
IPR041086 YBD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01285 TEA, 1 hit
PF17725 YBD, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF002603 TEF, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00065 TEADOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00426 TEA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00554 TEA_1, 1 hit
PS51088 TEA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15562-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEPRAGAAL DDGSGWTGSE EGSEEGTGGS EGAGGDGGPD AEGVWSPDIE
60 70 80 90 100
QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV
110 120 130 140 150
SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL
160 170 180 190 200
GPTGPQASEL FQFWSGGSGP PWNVPDVKPF SQTPFTLSLT PPSTDLPGYE
210 220 230 240 250
PPQALSPLPP PTPSPPAWQA RGLGTARLQL VEFSAFVEPP DAVDSYQRHL
260 270 280 290 300
FVHISQHCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV
310 320 330 340 350
KFWADLNWGP SGEEAGAGGS ISSGGFYGVS SQYESLEHMT LTCSSKVCSF
360 370 380 390 400
GKQVVEKVET ERAQLEDGRF VYRLLRSPMC EYLVNFLHKL RQLPERYMMN
410 420 430 440
SVLENFTILQ VVTNRDTQEL LLCTAYVFEV STSERGAQHH IYRLVRD
Length:447
Mass (Da):49,243
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9077F55638A3AC7
GO
Isoform 2 (identifier: Q15562-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-155: P → PQVV

Show »
Length:450
Mass (Da):49,569
Checksum:iF90CF8D5E42E20E6
GO
Isoform 3 (identifier: Q15562-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     155-155: P → PQVV

Show »
Length:319
Mass (Da):35,403
Checksum:i91BCE65CE4E8A7D1
GO
Isoform 4 (identifier: Q15562-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: K → KALNV

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,640
Checksum:i8DB857BAE7F47CF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R290M0R290_HUMAN
Transcriptional enhancer factor TEF...
TEAD2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1A5M0R1A5_HUMAN
Transcriptional enhancer factor TEF...
TEAD2
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144P → L in CAA64214 (PubMed:8702974).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451261 – 131Missing in isoform 3. 2 PublicationsAdd BLAST131
Alternative sequenceiVSP_055673120K → KALNV in isoform 4. Curated1
Alternative sequenceiVSP_045127155P → PQVV in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093236 mRNA Translation: BAC04104.1
AK290736 mRNA Translation: BAF83425.1
AK300241 mRNA Translation: BAG62008.1
AC010524 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52469.1
BC051301 mRNA Translation: AAH51301.1
BC007556 mRNA Translation: AAH07556.1
BC018803 mRNA No translation available.
X94440 mRNA Translation: CAA64214.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12761.1 [Q15562-1]
CCDS58670.1 [Q15562-3]
CCDS58671.1 [Q15562-2]
CCDS59406.1 [Q15562-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
G01116

NCBI Reference Sequences

More...
RefSeqi
NP_001243587.1, NM_001256658.1 [Q15562-2]
NP_001243588.1, NM_001256659.1 [Q15562-2]
NP_001243589.1, NM_001256660.1 [Q15562-4]
NP_001243590.1, NM_001256661.1 [Q15562-4]
NP_001243591.1, NM_001256662.1 [Q15562-3]
NP_003589.1, NM_003598.1 [Q15562-1]
XP_006723487.1, XM_006723424.1
XP_011525705.1, XM_011527403.1 [Q15562-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311227; ENSP00000310701; ENSG00000074219 [Q15562-1]
ENST00000377214; ENSP00000366419; ENSG00000074219 [Q15562-2]
ENST00000539846; ENSP00000437928; ENSG00000074219 [Q15562-3]
ENST00000593945; ENSP00000469640; ENSG00000074219 [Q15562-4]
ENST00000598810; ENSP00000472109; ENSG00000074219 [Q15562-4]
ENST00000601519; ENSP00000469672; ENSG00000074219 [Q15562-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8463

UCSC genome browser

More...
UCSCi
uc002png.5 human [Q15562-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093236 mRNA Translation: BAC04104.1
AK290736 mRNA Translation: BAF83425.1
AK300241 mRNA Translation: BAG62008.1
AC010524 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52469.1
BC051301 mRNA Translation: AAH51301.1
BC007556 mRNA Translation: AAH07556.1
BC018803 mRNA No translation available.
X94440 mRNA Translation: CAA64214.1
CCDSiCCDS12761.1 [Q15562-1]
CCDS58670.1 [Q15562-3]
CCDS58671.1 [Q15562-2]
CCDS59406.1 [Q15562-4]
PIRiG01116
RefSeqiNP_001243587.1, NM_001256658.1 [Q15562-2]
NP_001243588.1, NM_001256659.1 [Q15562-2]
NP_001243589.1, NM_001256660.1 [Q15562-4]
NP_001243590.1, NM_001256661.1 [Q15562-4]
NP_001243591.1, NM_001256662.1 [Q15562-3]
NP_003589.1, NM_003598.1 [Q15562-1]
XP_006723487.1, XM_006723424.1
XP_011525705.1, XM_011527403.1 [Q15562-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L15X-ray2.00A/B217-447[»]
5DQ8X-ray2.31A/B217-447[»]
5DQEX-ray2.18A/B217-447[»]
5EMVX-ray2.00A/B218-446[»]
5HGUX-ray2.05A/B217-447[»]
6E5GX-ray2.43A/B217-447[»]
SMRiQ15562
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114041, 115 interactors
DIPiDIP-59318N
IntActiQ15562, 79 interactors
MINTiQ15562
STRINGi9606.ENSP00000472109

PTM databases

iPTMnetiQ15562
PhosphoSitePlusiQ15562
SwissPalmiQ15562

Polymorphism and mutation databases

BioMutaiTEAD2
DMDMi21264529

Proteomic databases

EPDiQ15562
jPOSTiQ15562
MaxQBiQ15562
PaxDbiQ15562
PeptideAtlasiQ15562
PRIDEiQ15562
ProteomicsDBi60636

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8463
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311227; ENSP00000310701; ENSG00000074219 [Q15562-1]
ENST00000377214; ENSP00000366419; ENSG00000074219 [Q15562-2]
ENST00000539846; ENSP00000437928; ENSG00000074219 [Q15562-3]
ENST00000593945; ENSP00000469640; ENSG00000074219 [Q15562-4]
ENST00000598810; ENSP00000472109; ENSG00000074219 [Q15562-4]
ENST00000601519; ENSP00000469672; ENSG00000074219 [Q15562-2]
GeneIDi8463
KEGGihsa:8463
UCSCiuc002png.5 human [Q15562-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8463
DisGeNETi8463

GeneCards: human genes, protein and diseases

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GeneCardsi
TEAD2
HGNCiHGNC:11715 TEAD2
HPAiHPA066292
HPA069963
MIMi601729 gene
neXtProtiNX_Q15562
OpenTargetsiENSG00000074219
PharmGKBiPA36433

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3841 Eukaryota
ENOG410XQMP LUCA
GeneTreeiENSGT00950000182956
HOGENOMiHOG000253933
InParanoidiQ15562
KOiK09448
OMAiWQTRALG
OrthoDBi823827at2759
PhylomeDBiQ15562
TreeFamiTF313443

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SIGNORiQ15562

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TEAD2 human
EvolutionaryTraceiQ15562

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TEAD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8463

Protein Ontology

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PROi
PR:Q15562

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074219 Expressed in 179 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ15562 baseline and differential
GenevisibleiQ15562 HS

Family and domain databases

Gene3Di1.10.10.1610, 1 hit
InterProiView protein in InterPro
IPR000818 TEA/ATTS_dom
IPR038096 TEA/ATTS_sf
IPR016361 TEF_metazoa
IPR041086 YBD
PfamiView protein in Pfam
PF01285 TEA, 1 hit
PF17725 YBD, 1 hit
PIRSFiPIRSF002603 TEF, 1 hit
PRINTSiPR00065 TEADOMAIN
SMARTiView protein in SMART
SM00426 TEA, 1 hit
PROSITEiView protein in PROSITE
PS00554 TEA_1, 1 hit
PS51088 TEA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEAD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15562
Secondary accession number(s): B4DTJ6
, M0R1T9, Q8NA25, Q96IG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: May 8, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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