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Entry version 149 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

snRNA-activating protein complex subunit 1

Gene

SNAPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
snRNA-activating protein complex subunit 1
Short name:
SNAPc subunit 1
Alternative name(s):
Proximal sequence element-binding transcription factor subunit gamma
Short name:
PSE-binding factor subunit gamma
Short name:
PTF subunit gamma
Small nuclear RNA-activating complex polypeptide 1
snRNA-activating protein complex 43 kDa subunit
Short name:
SNAPc 43 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNAPC1
Synonyms:SNAP43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11134 SNAPC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600591 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16533

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6617

Open Targets

More...
OpenTargetsi
ENSG00000023608

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35982

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNAPC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
8134716

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720171 – 368snRNA-activating protein complex subunit 1Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei289PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q16533

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16533

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16533

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16533

PeptideAtlas

More...
PeptideAtlasi
Q16533

PRoteomics IDEntifications database

More...
PRIDEi
Q16533

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60896

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16533

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16533

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000023608 Expressed in 218 organ(s), highest expression level in cartilage tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16533 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067076
HPA072276

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112501, 93 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q16533

Database of interacting proteins

More...
DIPi
DIP-504N

Protein interaction database and analysis system

More...
IntActi
Q16533, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216294

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 168SNAPC3-bindingAdd BLAST168
Regioni164 – 268SNAPC4-bindingAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi347 – 352Poly-Glu6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4746 Eukaryota
ENOG410Z6WG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018691

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294209

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16533

KEGG Orthology (KO)

More...
KOi
K15208

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGKMRNL

Database of Orthologous Groups

More...
OrthoDBi
1269640at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16533

TreeFam database of animal gene trees

More...
TreeFami
TF324445

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019188 SNAPc_SNAP43

The PANTHER Classification System

More...
PANTHERi
PTHR15131 PTHR15131, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09808 SNAPc_SNAP43, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q16533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE
60 70 80 90 100
KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA
110 120 130 140 150
LKDWDEVLKF QQDLVNAQHF DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK
160 170 180 190 200
KIHRAEVTEE FKDPSDRVMK LITSDVLEEM LNVHDHYQNM KHVISVDKSK
210 220 230 240 250
PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN DGEEKMEGNS
260 270 280 290 300
QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ
310 320 330 340 350
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE
360
NESLSGTEFT ASKKRRKH
Length:368
Mass (Da):42,994
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i324E89CF8B540C32
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z47542 mRNA Translation: CAA87590.1
U44754 mRNA Translation: AAC50358.1
BC014984 mRNA Translation: AAH14984.1
BC019038 mRNA Translation: AAH19038.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9755.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC6081

NCBI Reference Sequences

More...
RefSeqi
NP_003073.1, NM_003082.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216294; ENSP00000216294; ENSG00000023608

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6617

UCSC genome browser

More...
UCSCi
uc001xft.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47542 mRNA Translation: CAA87590.1
U44754 mRNA Translation: AAC50358.1
BC014984 mRNA Translation: AAH14984.1
BC019038 mRNA Translation: AAH19038.1
CCDSiCCDS9755.1
PIRiJC6081
RefSeqiNP_003073.1, NM_003082.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112501, 93 interactors
CORUMiQ16533
DIPiDIP-504N
IntActiQ16533, 5 interactors
STRINGi9606.ENSP00000216294

PTM databases

iPTMnetiQ16533
PhosphoSitePlusiQ16533

Polymorphism and mutation databases

BioMutaiSNAPC1
DMDMi8134716

Proteomic databases

EPDiQ16533
jPOSTiQ16533
MaxQBiQ16533
PaxDbiQ16533
PeptideAtlasiQ16533
PRIDEiQ16533
ProteomicsDBi60896

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6617
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216294; ENSP00000216294; ENSG00000023608
GeneIDi6617
KEGGihsa:6617
UCSCiuc001xft.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6617
DisGeNETi6617

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SNAPC1
HGNCiHGNC:11134 SNAPC1
HPAiHPA067076
HPA072276
MIMi600591 gene
neXtProtiNX_Q16533
OpenTargetsiENSG00000023608
PharmGKBiPA35982

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4746 Eukaryota
ENOG410Z6WG LUCA
GeneTreeiENSGT00390000018691
HOGENOMiHOG000294209
InParanoidiQ16533
KOiK15208
OMAiCGKMRNL
OrthoDBi1269640at2759
PhylomeDBiQ16533
TreeFamiTF324445

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SNAPC1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SNAPC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6617

Protein Ontology

More...
PROi
PR:Q16533

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000023608 Expressed in 218 organ(s), highest expression level in cartilage tissue
GenevisibleiQ16533 HS

Family and domain databases

InterProiView protein in InterPro
IPR019188 SNAPc_SNAP43
PANTHERiPTHR15131 PTHR15131, 1 hit
PfamiView protein in Pfam
PF09808 SNAPc_SNAP43, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNPC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16533
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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