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Entry version 168 (31 Jul 2019)
Sequence version 2 (07 Jun 2004)
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Protein

Extracellular matrix protein 1

Gene

ECM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Biomineralization, Mineral balance, Osteogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114608 Platelet degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16610

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extracellular matrix protein 1
Alternative name(s):
Secretory component p85
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ECM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:3153 ECM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602201 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q16610

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lipoid proteinosis (LiP)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018691167F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1893

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ECM1

MalaCards human disease database

More...
MalaCardsi
ECM1
MIMi247100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000143369

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
530 Lipoid proteinosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27598

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ECM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48429255

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002114620 – 540Extracellular matrix protein 1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q16610

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16610

MaxQB - The MaxQuant DataBase

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MaxQBi
Q16610

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q16610

PeptideAtlas

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PeptideAtlasi
Q16610

PRoteomics IDEntifications database

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PRIDEi
Q16610

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60944 [Q16610-1]
60945 [Q16610-2]
60946 [Q16610-3]
60947 [Q16610-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1228

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q16610

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q16610

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143369 Expressed in 213 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16610 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16610 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027241

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with HSPG2 (via C-terminus).

Interacts with EFEMP1/FBLN3 and LAMB3.

Interacts with MMP9.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108222, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q16610, 39 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358045

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati150 – 2791Add BLAST130
Repeati283 – 4052Add BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 4052 X approximate repeatsAdd BLAST256

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVN8 Eukaryota
ENOG4111TGN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006215

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16610

Identification of Orthologs from Complete Genome Data

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OMAi
QTNCFNI

Database of Orthologous Groups

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OrthoDBi
509393at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16610

TreeFam database of animal gene trees

More...
TreeFami
TF330786

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008605 ECM1
IPR020858 Serum_albumin-like

The PANTHER Classification System

More...
PANTHERi
PTHR16776 PTHR16776, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05782 ECM1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48552 SSF48552, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16610-1) [UniParc]FASTAAdd to basket
Also known as: 1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP
60 70 80 90 100
LSRSLPMDHP DSSQHGPPFE GQSQVQPPPS QEATPLQQEK LLPAQLPAEK
110 120 130 140 150
EVGPPLPQEA VPLQKELPSL QHPNEQKEGT PAPFGDQSHP EPESWNAAQH
160 170 180 190 200
CQQDRSQGGW GHRLDGFPPG RPSPDNLNQI CLPNRQHVVY GPWNLPQSSY
210 220 230 240 250
SHLTRQGETL NFLEIGYSRC CHCRSHTNRL ECAKLVWEEA MSRFCEAEFS
260 270 280 290 300
VKTRPHWCCT RQGEARFSCF QEEAPQPHYQ LRACPSHQPD ISSGLELPFP
310 320 330 340 350
PGVPTLDNIK NICHLRRFRS VPRNLPATDP LQRELLALIQ LEREFQRCCR
360 370 380 390 400
QGNNHTCTWK AWEDTLDKYC DREYAVKTHH HLCCRHPPSP TRDECFARRA
410 420 430 440 450
PYPNYDRDIL TIDIGRVTPN LMGHLCGNQR VLTKHKHIPG LIHNMTARCC
460 470 480 490 500
DLPFPEQACC AEEEKLTFIN DLCGPRRNIW RDPALCCYLS PGDEQVNCFN
510 520 530 540
INYLRNVALV SGDTENAKGQ GEQGSTGGTN ISSTSEPKEE
Length:540
Mass (Da):60,674
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA575895CDE068BE
GO
Isoform 2 (identifier: Q16610-2) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     237-361: Missing.

Show »
Length:415
Mass (Da):46,099
Checksum:iE6878AE9DEF1D5AC
GO
Isoform 3 (identifier: Q16610-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     72-81: QSQVQPPPSQ → MALPLRDRVK
     237-241: WEEAM → VRLGS
     242-540: Missing.

Show »
Length:170
Mass (Da):19,069
Checksum:i4C3B05692F1D1C8C
GO
Isoform 4 (identifier: Q16610-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-74: Q → GKEGRGPRPHSQPWLGERVGCSHIPPSI

Note: May be due to intron retention.
Show »
Length:567
Mass (Da):63,563
Checksum:iFBCFB0E51CE13735
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78 – 84Missing in BAG63622 (PubMed:14702039).Curated7
Sequence conflicti520Q → R in BAF85124 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018690130T → M3 PublicationsCorresponds to variant dbSNP:rs3737240Ensembl.1
Natural variantiVAR_018691167F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar.1
Natural variantiVAR_014761415G → S4 PublicationsCorresponds to variant dbSNP:rs13294Ensembl.1
Natural variantiVAR_014762528G → R. Corresponds to variant dbSNP:rs1050901Ensembl.1
Natural variantiVAR_014763535S → F. Corresponds to variant dbSNP:rs1050904Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0364111 – 71Missing in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_03641272 – 81QSQVQPPPSQ → MALPLRDRVK in isoform 3. 1 Publication10
Alternative sequenceiVSP_03641374Q → GKEGRGPRPHSQPWLGERVG CSHIPPSI in isoform 4. 1 Publication1
Alternative sequenceiVSP_036414237 – 361Missing in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_036415237 – 241WEEAM → VRLGS in isoform 3. 1 Publication5
Alternative sequenceiVSP_036416242 – 540Missing in isoform 3. 1 PublicationAdd BLAST299

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U68186 mRNA Translation: AAB88081.1
U68187 mRNA Translation: AAB88082.1
U65932 mRNA Translation: AAB05933.1
U65938
, U65933, U65934, U65935, U65936, U65937 Genomic DNA Translation: AAB05934.1
AK097046 mRNA Translation: BAG53412.1
AK292435 mRNA Translation: BAF85124.1
AK301369 mRNA Translation: BAG62911.1
AK302279 mRNA Translation: BAG63622.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53544.1
CH471121 Genomic DNA Translation: EAW53545.1
CH471121 Genomic DNA Translation: EAW53546.1
BC023505 mRNA Translation: AAH23505.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55632.1 [Q16610-4]
CCDS953.1 [Q16610-1]
CCDS954.1 [Q16610-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001189787.1, NM_001202858.1 [Q16610-4]
NP_004416.2, NM_004425.3 [Q16610-1]
NP_073155.2, NM_022664.2 [Q16610-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000346569; ENSP00000271630; ENSG00000143369 [Q16610-2]
ENST00000369047; ENSP00000358043; ENSG00000143369 [Q16610-1]
ENST00000369049; ENSP00000358045; ENSG00000143369 [Q16610-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1893

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1893

UCSC genome browser

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UCSCi
uc001eus.4 human [Q16610-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68186 mRNA Translation: AAB88081.1
U68187 mRNA Translation: AAB88082.1
U65932 mRNA Translation: AAB05933.1
U65938
, U65933, U65934, U65935, U65936, U65937 Genomic DNA Translation: AAB05934.1
AK097046 mRNA Translation: BAG53412.1
AK292435 mRNA Translation: BAF85124.1
AK301369 mRNA Translation: BAG62911.1
AK302279 mRNA Translation: BAG63622.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53544.1
CH471121 Genomic DNA Translation: EAW53545.1
CH471121 Genomic DNA Translation: EAW53546.1
BC023505 mRNA Translation: AAH23505.1
CCDSiCCDS55632.1 [Q16610-4]
CCDS953.1 [Q16610-1]
CCDS954.1 [Q16610-2]
RefSeqiNP_001189787.1, NM_001202858.1 [Q16610-4]
NP_004416.2, NM_004425.3 [Q16610-1]
NP_073155.2, NM_022664.2 [Q16610-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi108222, 33 interactors
IntActiQ16610, 39 interactors
STRINGi9606.ENSP00000358045

PTM databases

GlyConnecti1228
iPTMnetiQ16610
PhosphoSitePlusiQ16610

Polymorphism and mutation databases

BioMutaiECM1
DMDMi48429255

Proteomic databases

EPDiQ16610
jPOSTiQ16610
MaxQBiQ16610
PaxDbiQ16610
PeptideAtlasiQ16610
PRIDEiQ16610
ProteomicsDBi60944 [Q16610-1]
60945 [Q16610-2]
60946 [Q16610-3]
60947 [Q16610-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1893
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346569; ENSP00000271630; ENSG00000143369 [Q16610-2]
ENST00000369047; ENSP00000358043; ENSG00000143369 [Q16610-1]
ENST00000369049; ENSP00000358045; ENSG00000143369 [Q16610-4]
GeneIDi1893
KEGGihsa:1893
UCSCiuc001eus.4 human [Q16610-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1893
DisGeNETi1893

GeneCards: human genes, protein and diseases

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GeneCardsi
ECM1
GeneReviewsiECM1
HGNCiHGNC:3153 ECM1
HPAiHPA027241
MalaCardsiECM1
MIMi247100 phenotype
602201 gene
neXtProtiNX_Q16610
OpenTargetsiENSG00000143369
Orphaneti530 Lipoid proteinosis
PharmGKBiPA27598

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVN8 Eukaryota
ENOG4111TGN LUCA
GeneTreeiENSGT00390000006215
InParanoidiQ16610
OMAiQTNCFNI
OrthoDBi509393at2759
PhylomeDBiQ16610
TreeFamiTF330786

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SIGNORiQ16610

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ECM1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ECM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1893

Protein Ontology

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PROi
PR:Q16610

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143369 Expressed in 213 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ16610 baseline and differential
GenevisibleiQ16610 HS

Family and domain databases

InterProiView protein in InterPro
IPR008605 ECM1
IPR020858 Serum_albumin-like
PANTHERiPTHR16776 PTHR16776, 1 hit
PfamiView protein in Pfam
PF05782 ECM1, 1 hit
SUPFAMiSSF48552 SSF48552, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16610
Secondary accession number(s): A8K8S0
, B4DW49, B4DY60, O43266, Q5T5G4, Q5T5G5, Q5T5G6, Q8IZ60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2004
Last modified: July 31, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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