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Entry version 124 (13 Nov 2019)
Sequence version 1 (01 Nov 1996)
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Protein

WD repeat-containing protein wdr-5.1

Gene

wdr-5.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to histone modification (PubMed:16710447, PubMed:17967446, PubMed:20188723, PubMed:20555324, PubMed:21455483, PubMed:22012258). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:21455483). Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3 (PubMed:20555324, PubMed:21455483, PubMed:24682813, PubMed:21527717). Not required for demethylation of histone H3 'Lys-27' (PubMed:21455483). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function (PubMed:21455483). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:17967446, PubMed:20555324, PubMed:28379943). Required for RNA interference with probable antagonistic role against hpl-2 function (PubMed:17967446). Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2 (PubMed:17967446). Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development (PubMed:24682813). Acts with the sex determining factor tra-1, and redundantly with wdr-5.2, to regulate fog-3 expression, which in turn determines germ cell fate (PubMed:24682813). Cooperates with jmjd-3.1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).10 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei149Important for interaction with histone H3By similarity1
Sitei175Important for interaction with histone H3By similarity1
Sitei305Important for interaction with histone H3By similarity1
Sitei364Important for interaction with histone H3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3214841 PKMTs methylate histone lysines
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-CEL-8951664 Neddylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q17963

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein wdr-5.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wdr-5.1
Synonyms:swd-3.1, tag-125
ORF Names:C14B1.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
C14B1.4 ; CE00901 ; WBGene00006474 ; wdr-5.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increase in life span (PubMed:17967446). Longer time span to reach adulthood and reduced brood size resulting in sterility between generations F3 and F4 (PubMed:17967446). Associated embryonic lethality and additional somatic defects at elevated temperatures (PubMed:17967446). Defects in germ cells including defective sperm development and endomitotic oocytes (PubMed:17967446, PubMed:24682813). Significantly reduced H3 'Lys-4' trimethylation in both embryonic and adult germ cells in a sex-independent manner (PubMed:17967446). Increased fog-3 expression at 20 degrees Celsius (PubMed:24682813). At 20 and 25 degrees Celsius, double knockdown mutants with wdr-5.2 have increased fog-3 expression (PubMed:24682813). At 25 degrees Celsius, these mutants have increased wdr-5.2 and fog-1 expression, reduced brood size accompanied by 42% embryonic lethality with 100% of the surviving progeny being sterile (PubMed:24682813). Surviving progeny display enhanced defects in the spermatogenesis to oogenesis transition compared to the single wdr-5.1 knockout with 88% of the gonads only containing sperm (PubMed:24682813). The remaining germ cells in the gonads switch to oogenesis, but the oocytes display either an endoreplication or endomitotic phenotype (PubMed:24682813). Germ cells also have increased expression of the sex determining factor tra-1 in the cytoplasm and as a result there is reduced binding of tra-1 to the fog-3 promoter (PubMed:24682813). RNAi-mediated knockdown leads to an enrichment of mono-unsaturated fatty acids (PubMed:28379943).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515031 – 376WD repeat-containing protein wdr-5.1Add BLAST376

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q17963

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17963

PeptideAtlas

More...
PeptideAtlasi
Q17963

PRoteomics IDEntifications database

More...
PRIDEi
Q17963

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Enriched in the germline (PubMed:17967446, PubMed:24682813). Detected in all nuclei of the embryo (PubMed:17967446). In larvae, expression is detected in the nuclei of seam cells, somatic gonad precursor cells Z1 and Z4, vulval precursor cells, distal tip cells, hypodermal cells, intestinal and muscle cells (PubMed:17967446). Also detected in the neurons from the ventral nerve cord, head and tail region (PubMed:17967446). Expressed in the head and tail region, intestinal cells, muscle cells, cells of the vulva, spermatheca and sheath cells in adults (PubMed:17967446).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected from the 20 cell embryo stage and continues through to adult, although in a restricted manner.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006474 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with histone H3 both unmethylated and methylated at 'Lys-4' (PubMed:21455483).

Interacts with jmjd-3.1, ceh-6, sox-2, sem-4 and egl-27 (PubMed:25124442).

Interacts with set-2 (PubMed:21527717).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
40714, 12 interactors

Database of interacting proteins

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DIPi
DIP-55118N

Protein interaction database and analysis system

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IntActi
Q17963, 6 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C14B1.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q17963

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati85 – 115WD 1Add BLAST31
Repeati127 – 157WD 2Add BLAST31
Repeati169 – 199WD 3Add BLAST31
Repeati211 – 241WD 4Add BLAST31
Repeati254 – 284WD 5Add BLAST31
Repeati296 – 329WD 6Add BLAST34
Repeati341 – 373WD 7Add BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0266 Eukaryota
ENOG410XP3K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000196638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000091642

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17963

KEGG Orthology (KO)

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KOi
K14963

Identification of Orthologs from Complete Genome Data

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OMAi
CTTCHPT

Database of Orthologous Groups

More...
OrthoDBi
957291at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q17963

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037866 Swd3/WDR5
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22847:SF516 PTHR22847:SF516, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 6 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q17963-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSENAASA AEQQPTQQID QLTVPNAPDG GSSAPAPSTS PNSISPSNPT
60 70 80 90 100
GTPAPGASAQ TPNPNAAGAS ASGSANYKLM CTLEGHTKSI SSAKFSPCGK
110 120 130 140 150
YLGTSSADKT VKIWNMDHMI CERTLTGHKL GVNDIAWSSD SRCVVSASDD
160 170 180 190 200
KTLKIFEIVT SRMTKTLKGH NNYVFCCNFN PQSSLVVSGS FDESVRIWDV
210 220 230 240 250
KTGMCIKTLP AHSDPVSAVS FNRDGSLIAS GSYDGLVRIW DTANGQCIKT
260 270 280 290 300
LVDDENPPVA FVKFSPNGKY ILASNLDSTL KLWDFSKGKT LKQYTGHENS
310 320 330 340 350
KYCIFANFSV TGGKWIISGS EDCKIYIWNL QTREIVQCLE GHTQPVLASD
360 370
CHPVQNIIAS GALEPDNKIH IWRSDV
Length:376
Mass (Da):40,393
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3204DC36FE58FC19
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z37139 Genomic DNA Translation: CAA85487.1

Protein sequence database of the Protein Information Resource

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PIRi
T19266

NCBI Reference Sequences

More...
RefSeqi
NP_497749.1, NM_065348.7

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C14B1.4.1; C14B1.4.1; WBGene00006474
C14B1.4.2; C14B1.4.2; WBGene00006474

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C14B1.4

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37139 Genomic DNA Translation: CAA85487.1
PIRiT19266
RefSeqiNP_497749.1, NM_065348.7

3D structure databases

SMRiQ17963
ModBaseiSearch...

Protein-protein interaction databases

BioGridi40714, 12 interactors
DIPiDIP-55118N
IntActiQ17963, 6 interactors
STRINGi6239.C14B1.4

Proteomic databases

EPDiQ17963
PaxDbiQ17963
PeptideAtlasiQ17963
PRIDEiQ17963

Genome annotation databases

EnsemblMetazoaiC14B1.4.1; C14B1.4.1; WBGene00006474
C14B1.4.2; C14B1.4.2; WBGene00006474
GeneIDi175474
KEGGicel:CELE_C14B1.4

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175474
WormBaseiC14B1.4 ; CE00901 ; WBGene00006474 ; wdr-5.1

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00970000196638
HOGENOMiHOG000091642
InParanoidiQ17963
KOiK14963
OMAiCTTCHPT
OrthoDBi957291at2759
PhylomeDBiQ17963

Enzyme and pathway databases

ReactomeiR-CEL-3214841 PKMTs methylate histone lysines
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-CEL-8951664 Neddylation
SignaLinkiQ17963

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q17963

Gene expression databases

BgeeiWBGene00006474 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037866 Swd3/WDR5
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR22847:SF516 PTHR22847:SF516, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR51_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17963
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 13, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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