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Entry version 123 (16 Oct 2019)
Sequence version 2 (01 Sep 2009)
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Protein

LON peptidase N-terminal domain and RING finger protein 1

Gene

LONRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri123 – 159RING-type 1PROSITE-ProRule annotationAdd BLAST37
Zinc fingeri479 – 517RING-type 2PROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LON peptidase N-terminal domain and RING finger protein 1
Alternative name(s):
RING finger protein 191
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LONRF1
Synonyms:RNF191
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26302 LONRF1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q17RB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
91694

Open Targets

More...
OpenTargetsi
ENSG00000154359

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394743

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q17RB8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LONRF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
257051033

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002776691 – 773LON peptidase N-terminal domain and RING finger protein 1Add BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei431PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q17RB8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q17RB8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q17RB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q17RB8

PeptideAtlas

More...
PeptideAtlasi
Q17RB8

PRoteomics IDEntifications database

More...
PRIDEi
Q17RB8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61144 [Q17RB8-1]
61145 [Q17RB8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q17RB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q17RB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154359 Expressed in 202 organ(s), highest expression level in upper arm skin

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q17RB8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q17RB8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023584
HPA024814

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124867, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q17RB8, 97 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381298

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q17RB8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 81TPR 1Add BLAST34
Repeati212 – 244TPR 2Add BLAST33
Repeati246 – 278TPR 3Add BLAST33
Repeati279 – 312TPR 4Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini565 – 766Lon N-terminalPROSITE-ProRule annotationAdd BLAST202

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri123 – 159RING-type 1PROSITE-ProRule annotationAdd BLAST37
Zinc fingeri479 – 517RING-type 2PROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4159 Eukaryota
COG2802 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000033329

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060199

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q17RB8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMFSLAY

Database of Orthologous Groups

More...
OrthoDBi
458276at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q17RB8

TreeFam database of animal gene trees

More...
TreeFami
TF327043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003111 Lon_substr-bd
IPR015947 PUA-like_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02190 LON_substr_bdg, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00464 LON, 1 hit
SM00184 RING, 2 hits
SM00028 TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF88697 SSF88697, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51787 LON_N, 1 hit
PS50293 TPR_REGION, 1 hit
PS00518 ZF_RING_1, 2 hits
PS50089 ZF_RING_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q17RB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL
60 70 80 90 100
LLRRGELLAL GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR
110 120 130 140 150
HGLGWSAAPV AGADGGAGGL LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE
160 170 180 190 200
LRARCRLCRD RLPPATASAT DAEGTAPRPP PLAAAIAASD FRTSVVLNHL
210 220 230 240 250
AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA EPSDLIVKIY
260 270 280 290 300
RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ
310 320 330 340 350
LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR
360 370 380 390 400
PFDFHSVMEE SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE
410 420 430 440 450
MPAREDCLKR VSSEPVLSVQ EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ
460 470 480 490 500
GETPNEVCMF SLAYGDIPEE LIDVSDFECS LCMRLFFEPV TTPCGHSFCK
510 520 530 540 550
NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV KYLPDELSER
560 570 580 590 600
KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ
610 620 630 640 650
TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL
660 670 680 690 700
KRGMKDGYCT ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD
710 720 730 740 750
RFRSQILQHF GSMPEREENL QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM
760 770
KSLKERLTKI QHILTYFSRD QSK
Length:773
Mass (Da):86,725
Last modified:September 1, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB151BEB07CF3638B
GO
Isoform 2 (identifier: Q17RB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-462: Missing.

Show »
Length:762
Mass (Da):85,473
Checksum:iA9A06A836F433EE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGE8A0A0C4DGE8_HUMAN
LON peptidase N-terminal domain and...
LONRF1
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5V9H7C5V9_HUMAN
LON peptidase N-terminal domain and...
LONRF1
376Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQH4E9PQH4_HUMAN
LON peptidase N-terminal domain and...
LONRF1
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRX6E9PRX6_HUMAN
LON peptidase N-terminal domain and...
LONRF1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI17382 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI17386 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB85052 differs from that shown. Reason: Frameshift.Curated
The sequence BAG59741 differs from that shown. Reason: Frameshift.Curated
The sequence BAG62246 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti663I → V in BAG62246 (PubMed:14702039).Curated1
Sequence conflicti773K → E in BAG59741 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058706265I → L. Corresponds to variant dbSNP:rs1139354Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037971452 – 462Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC123777 Genomic DNA No translation available.
AK074329 mRNA Translation: BAB85052.1 Frameshift.
AK297266 mRNA Translation: BAG59741.1 Frameshift.
AK300538 mRNA Translation: BAG62246.1 Different initiation.
BC004538 mRNA Translation: AAH04538.2
BC117381 mRNA Translation: AAI17382.1 Different initiation.
BC117385 mRNA Translation: AAI17386.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5987.2 [Q17RB8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001316905.1, NM_001329976.1 [Q17RB8-2]
NP_689484.3, NM_152271.4 [Q17RB8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398246; ENSP00000381298; ENSG00000154359 [Q17RB8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
91694

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91694

UCSC genome browser

More...
UCSCi
uc003wwd.2 human [Q17RB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123777 Genomic DNA No translation available.
AK074329 mRNA Translation: BAB85052.1 Frameshift.
AK297266 mRNA Translation: BAG59741.1 Frameshift.
AK300538 mRNA Translation: BAG62246.1 Different initiation.
BC004538 mRNA Translation: AAH04538.2
BC117381 mRNA Translation: AAI17382.1 Different initiation.
BC117385 mRNA Translation: AAI17386.1 Different initiation.
CCDSiCCDS5987.2 [Q17RB8-1]
RefSeqiNP_001316905.1, NM_001329976.1 [Q17RB8-2]
NP_689484.3, NM_152271.4 [Q17RB8-1]

3D structure databases

SMRiQ17RB8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124867, 39 interactors
IntActiQ17RB8, 97 interactors
STRINGi9606.ENSP00000381298

PTM databases

iPTMnetiQ17RB8
PhosphoSitePlusiQ17RB8

Polymorphism and mutation databases

BioMutaiLONRF1
DMDMi257051033

Proteomic databases

jPOSTiQ17RB8
MassIVEiQ17RB8
MaxQBiQ17RB8
PaxDbiQ17RB8
PeptideAtlasiQ17RB8
PRIDEiQ17RB8
ProteomicsDBi61144 [Q17RB8-1]
61145 [Q17RB8-2]

Genome annotation databases

EnsembliENST00000398246; ENSP00000381298; ENSG00000154359 [Q17RB8-1]
GeneIDi91694
KEGGihsa:91694
UCSCiuc003wwd.2 human [Q17RB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91694
DisGeNETi91694

GeneCards: human genes, protein and diseases

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GeneCardsi
LONRF1
HGNCiHGNC:26302 LONRF1
HPAiHPA023584
HPA024814
neXtProtiNX_Q17RB8
OpenTargetsiENSG00000154359
PharmGKBiPA128394743

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4159 Eukaryota
COG2802 LUCA
GeneTreeiENSGT00440000033329
HOGENOMiHOG000060199
InParanoidiQ17RB8
OMAiCMFSLAY
OrthoDBi458276at2759
PhylomeDBiQ17RB8
TreeFamiTF327043

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LONRF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91694
PharosiQ17RB8

Protein Ontology

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PROi
PR:Q17RB8

Gene expression databases

BgeeiENSG00000154359 Expressed in 202 organ(s), highest expression level in upper arm skin
ExpressionAtlasiQ17RB8 baseline and differential
GenevisibleiQ17RB8 HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR003111 Lon_substr-bd
IPR015947 PUA-like_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF02190 LON_substr_bdg, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00464 LON, 1 hit
SM00184 RING, 2 hits
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS50293 TPR_REGION, 1 hit
PS00518 ZF_RING_1, 2 hits
PS50089 ZF_RING_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLONF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q17RB8
Secondary accession number(s): B4DM29
, B4DU84, Q8TEA0, Q9BSV1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 1, 2009
Last modified: October 16, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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