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Entry version 96 (13 Feb 2019)
Sequence version 1 (13 Jun 2006)
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Protein

Dual oxidase maturation factor 1

Gene

DUOXA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual oxidase maturation factor 1
Alternative name(s):
Dual oxidase activator 1
Numb-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DUOXA1
Synonyms:NIP, NUMBIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140254.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26507 DUOXA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612771 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q1HG43

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 51CytoplasmicSequence analysis6
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 183ExtracellularSequence analysisAdd BLAST111
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 206CytoplasmicSequence analysis2
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 249ExtracellularSequence analysisAdd BLAST22
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 343CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
90527

Open Targets

More...
OpenTargetsi
ENSG00000140254

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145008497

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DUOXA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119368662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002642411 – 343Dual oxidase maturation factor 1Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q1HG43

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q1HG43

PeptideAtlas

More...
PeptideAtlasi
Q1HG43

PRoteomics IDEntifications database

More...
PRIDEi
Q1HG43

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61213
61214 [Q1HG43-2]
61215 [Q1HG43-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q1HG43

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q1HG43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in thyroid gland. Also detected in esophagus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140254 Expressed in 112 organ(s), highest expression level in esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q1HG43 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q1HG43 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041578

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with NUMB.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124731, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267803

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q1HG43

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DUOXA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3921 Eukaryota
ENOG410ZP7G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008240

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231775

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080429

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q1HG43

KEGG Orthology (KO)

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KOi
K17233

Identification of Orthologs from Complete Genome Data

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OMAi
GWCFWLV

Database of Orthologous Groups

More...
OrthoDBi
835845at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1HG43

TreeFam database of animal gene trees

More...
TreeFami
TF312996

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018469 Dual_oxidase_maturation_fac

The PANTHER Classification System

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PANTHERi
PTHR31158 PTHR31158, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10204 DuoxA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q1HG43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR
60 70 80 90 100
LFWLLRVVTS LFIGAAILAV NFSSEWSVGQ VSTNTSYKAF SSEWISADIG
110 120 130 140 150
LQVGLGGVNI TLTGTPVQQL NETINYNEEF TWRLGENYAE EYAKALEKGL
160 170 180 190 200
PDPVLYLAEK FTPRSPCGLY RQYRLAGHYT SAMLWVAFLC WLLANVMLSM
210 220 230 240 250
PVLVYGGYML LATGIFQLLA LLFFSMATSL TSPCPLHLGA SVLHTHHGPA
260 270 280 290 300
FWITLTTGLL CVLLGLAMAV AHRMQPHRLK AFFNQSVDED PMLEWSPEEG
310 320 330 340
GLLSPRYRSM ADSPKSQDIP LSEASSTKAY CKEAHPKDPD CAL
Length:343
Mass (Da):37,815
Last modified:June 13, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38958512200260BE
GO
Isoform 2 (identifier: Q1HG43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-343: CKEAHPKDPDCAL → YRPRRLSLVP...CVTSRHTPLI

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):53,519
Checksum:i54BEF64528B96C18
GO
Isoform 3 (identifier: Q1HG43-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-113: Missing.

Show »
Length:298
Mass (Da):33,111
Checksum:iD9B346C25D142E1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5M0C0B5M0C0_HUMAN
Dual oxidase maturation factor 1 de...
DUOXA1
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMH9H0YMH9_HUMAN
Dual oxidase maturation factor 1
DUOXA1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLQ4H0YLQ4_HUMAN
Dual oxidase maturation factor 1
DUOXA1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKF3H0YKF3_HUMAN
Dual oxidase maturation factor 1
DUOXA1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMZ8H0YMZ8_HUMAN
Dual oxidase maturation factor 1
DUOXA1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNR1H0YNR1_HUMAN
Dual oxidase maturation factor 1
DUOXA1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKG3H0YKG3_HUMAN
Dual oxidase maturation factor 1
DUOXA1
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLI1H0YLI1_HUMAN
Dual oxidase maturation factor 1
DUOXA1
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05775319P → L. Corresponds to variant dbSNP:rs34734975Ensembl.1
Natural variantiVAR_029630313S → G. Corresponds to variant dbSNP:rs16977686Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02189069 – 113Missing in isoform 3. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_021891331 – 343CKEAH…PDCAL → YRPRRLSLVPADVRGLAPAA LSALPGALLAQAWRALLPGL RCPKAGKESRLGPPHSPWRF GPEGCEERWAEHTGDSPRPL RGRGTGRLWRWGSKERRACG VRAMLPRLVSNSGLKRPSCL DLPKCWDYRRDARAFFHLLE PTPCVTSRHTPLI in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ489735 mRNA Translation: ABF48257.1
AK056896 mRNA Translation: BAB71304.1
BC020841 mRNA Translation: AAH20841.1
BC029819 mRNA Translation: AAH29819.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10119.1 [Q1HG43-2]
CCDS61619.1 [Q1HG43-3]
CCDS61621.1 [Q1HG43-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001263193.1, NM_001276264.1 [Q1HG43-2]
NP_001263194.1, NM_001276265.1
NP_001263195.1, NM_001276266.1 [Q1HG43-1]
NP_001263196.1, NM_001276267.1 [Q1HG43-3]
NP_001263197.1, NM_001276268.1 [Q1HG43-3]
NP_653166.2, NM_144565.3 [Q1HG43-2]
XP_006720806.1, XM_006720743.3 [Q1HG43-1]
XP_006720808.1, XM_006720745.1 [Q1HG43-1]
XP_006720809.1, XM_006720746.1 [Q1HG43-1]
XP_006720810.1, XM_006720747.3 [Q1HG43-1]
XP_006720812.1, XM_006720749.1 [Q1HG43-1]
XP_006720814.1, XM_006720751.3 [Q1HG43-1]
XP_006720817.1, XM_006720754.1 [Q1HG43-3]
XP_006720818.1, XM_006720755.1 [Q1HG43-3]
XP_011520483.1, XM_011522181.2 [Q1HG43-1]
XP_011520484.1, XM_011522182.1
XP_011520485.1, XM_011522183.2 [Q1HG43-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.356664

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267803; ENSP00000267803; ENSG00000140254 [Q1HG43-2]
ENST00000558422; ENSP00000453836; ENSG00000140254 [Q1HG43-3]
ENST00000558996; ENSP00000454019; ENSG00000140254 [Q1HG43-3]
ENST00000559014; ENSP00000453569; ENSG00000140254 [Q1HG43-2]
ENST00000560572; ENSP00000454084; ENSG00000140254 [Q1HG43-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90527

UCSC genome browser

More...
UCSCi
uc001zup.5 human [Q1HG43-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ489735 mRNA Translation: ABF48257.1
AK056896 mRNA Translation: BAB71304.1
BC020841 mRNA Translation: AAH20841.1
BC029819 mRNA Translation: AAH29819.1
CCDSiCCDS10119.1 [Q1HG43-2]
CCDS61619.1 [Q1HG43-3]
CCDS61621.1 [Q1HG43-1]
RefSeqiNP_001263193.1, NM_001276264.1 [Q1HG43-2]
NP_001263194.1, NM_001276265.1
NP_001263195.1, NM_001276266.1 [Q1HG43-1]
NP_001263196.1, NM_001276267.1 [Q1HG43-3]
NP_001263197.1, NM_001276268.1 [Q1HG43-3]
NP_653166.2, NM_144565.3 [Q1HG43-2]
XP_006720806.1, XM_006720743.3 [Q1HG43-1]
XP_006720808.1, XM_006720745.1 [Q1HG43-1]
XP_006720809.1, XM_006720746.1 [Q1HG43-1]
XP_006720810.1, XM_006720747.3 [Q1HG43-1]
XP_006720812.1, XM_006720749.1 [Q1HG43-1]
XP_006720814.1, XM_006720751.3 [Q1HG43-1]
XP_006720817.1, XM_006720754.1 [Q1HG43-3]
XP_006720818.1, XM_006720755.1 [Q1HG43-3]
XP_011520483.1, XM_011522181.2 [Q1HG43-1]
XP_011520484.1, XM_011522182.1
XP_011520485.1, XM_011522183.2 [Q1HG43-1]
UniGeneiHs.356664

3D structure databases

ProteinModelPortaliQ1HG43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124731, 1 interactor
STRINGi9606.ENSP00000267803

PTM databases

iPTMnetiQ1HG43
PhosphoSitePlusiQ1HG43

Polymorphism and mutation databases

BioMutaiDUOXA1
DMDMi119368662

Proteomic databases

jPOSTiQ1HG43
PaxDbiQ1HG43
PeptideAtlasiQ1HG43
PRIDEiQ1HG43
ProteomicsDBi61213
61214 [Q1HG43-2]
61215 [Q1HG43-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
90527
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267803; ENSP00000267803; ENSG00000140254 [Q1HG43-2]
ENST00000558422; ENSP00000453836; ENSG00000140254 [Q1HG43-3]
ENST00000558996; ENSP00000454019; ENSG00000140254 [Q1HG43-3]
ENST00000559014; ENSP00000453569; ENSG00000140254 [Q1HG43-2]
ENST00000560572; ENSP00000454084; ENSG00000140254 [Q1HG43-1]
GeneIDi90527
KEGGihsa:90527
UCSCiuc001zup.5 human [Q1HG43-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90527
DisGeNETi90527
EuPathDBiHostDB:ENSG00000140254.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DUOXA1
HGNCiHGNC:26507 DUOXA1
HPAiHPA041578
MIMi612771 gene
neXtProtiNX_Q1HG43
OpenTargetsiENSG00000140254
PharmGKBiPA145008497

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3921 Eukaryota
ENOG410ZP7G LUCA
GeneTreeiENSGT00390000008240
HOGENOMiHOG000231775
HOVERGENiHBG080429
InParanoidiQ1HG43
KOiK17233
OMAiGWCFWLV
OrthoDBi835845at2759
PhylomeDBiQ1HG43
TreeFamiTF312996

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DUOXA1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90527

Protein Ontology

More...
PROi
PR:Q1HG43

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140254 Expressed in 112 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiQ1HG43 baseline and differential
GenevisibleiQ1HG43 HS

Family and domain databases

InterProiView protein in InterPro
IPR018469 Dual_oxidase_maturation_fac
PANTHERiPTHR31158 PTHR31158, 1 hit
PfamiView protein in Pfam
PF10204 DuoxA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOXA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1HG43
Secondary accession number(s): Q8N6K9, Q96MI4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 13, 2006
Last modified: February 13, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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