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Entry version 141 (16 Oct 2019)
Sequence version 2 (05 Jul 2004)
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Protein

Lysine-specific demethylase rbr-2

Gene

rbr-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:17320161). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20' (PubMed:17320161). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4' (PubMed:17320161). Required for normal longevity of the soma in a germline-dependent manner (PubMed:20555324, PubMed:22212395). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Involved in larval development and vulva formation (PubMed:17320161).4 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi514Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi517Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi602Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri319 – 371PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri1203 – 1257PHD-type 2PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri1411 – 1466PHD-type 3PROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3214842 HDMs demethylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-specific demethylase rbr-2
Alternative name(s):
Histone demethylase rbr-2 (EC:1.14.11.-)
Jumonji/ARID domain-containing protein rbr-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rbr-2
ORF Names:ZK593.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
ZK593.4a ; CE35704 ; WBGene00004319 ; rbr-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown decreases lifespan in wild type worms with an intact germline (PubMed:20555324). Results in extended lifespan when egg production is inhibited by the addition of floxuridine (FUDR) or in a glp-1 mutant background which lacks a germline (PubMed:22212395, PubMed:20555324).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002924201 – 1477Lysine-specific demethylase rbr-2Add BLAST1477

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q23541

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23541

PeptideAtlas

More...
PeptideAtlasi
Q23541

PRoteomics IDEntifications database

More...
PRIDEi
Q23541

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004319 Expressed in 3 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q23541 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
43086, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q23541, 26 interactors

STRING: functional protein association networks

More...
STRINGi
6239.ZK593.4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 97JmjNPROSITE-ProRule annotationAdd BLAST42
Domaini121 – 218ARIDPROSITE-ProRule annotationAdd BLAST98
Domaini468 – 634JmjCPROSITE-ProRule annotationAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili874 – 926Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi309 – 315Poly-Asp7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JARID1 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri319 – 371PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri1203 – 1257PHD-type 2PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri1411 – 1466PHD-type 3PROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1246 Eukaryota
ENOG410XR9J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113216

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23541

KEGG Orthology (KO)

More...
KOi
K11446

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKTTLFM

Database of Orthologous Groups

More...
OrthoDBi
664180at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23541

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.60, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR003347 JmjC_dom
IPR003349 JmjN
IPR013637 Lys_sp_deMease-like_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR004198 Znf_C5HC2
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF02373 JmjC, 1 hit
PF02375 JmjN, 1 hit
PF00628 PHD, 1 hit
PF08429 PLU-1, 1 hit
PF02928 zf-C5HC2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit
SM00558 JmjC, 1 hit
SM00545 JmjN, 1 hit
SM00249 PHD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774 SSF46774, 1 hit
SSF57903 SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit
PS51184 JMJC, 1 hit
PS51183 JMJN, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q23541-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRARRQENSI STPSAPSTST SPRKKASIGN SRSKNHGSKM EMYDQFYKKF
60 70 80 90 100
VRPPMAPIYY PTEEEFSDPI EYVAKIRHEA EKFGVVKIVP PANFKPPFAI
110 120 130 140 150
DKEAFTFRPR TQKLNEVEAI VKEKHTFIDR LINFNRYSGL TFEFPVDRDG
160 170 180 190 200
NIVDLYRLHR IVQNFGGCEE VNEDEKWRDV AREYLPKEQM ARGVPSAFIN
210 220 230 240 250
LIRSHYNLHI EPFNRNLKEK AMKNDDESDD EMEELKHKYQ HHHGTMRTEI
260 270 280 290 300
EVPNDKTTEG GEDECPVSMQ SGRRRSKNKK ASSSRKTLGT SSKKNSTRGR
310 320 330 340 350
KNKKKAEGDD DDDEDPMDQV FCVACNEGKD EDLLLLCDID GCNNGRHTYC
360 370 380 390 400
CDPVLDEVPE GEWRCPKCIE SEDAKIGLDW GFYDADTEYN LNSFTEFANK
410 420 430 440 450
WKCDYFGVKD VSQVSCDAVE RSFWKNVISH ENPVSVKYGA DLITSRVGSG
460 470 480 490 500
FPRKEDKHTG PDLKLKQQYA SHAWNLNNMP VLRESVLSHF NTGISGMMVP
510 520 530 540 550
WVYVGMCFST FCWHTEDHWT YSVNYNHFGE RKIWYGVGGE DAEKFEDALK
560 570 580 590 600
KIAPGLTGRQ RDLFHHMTTA ANPHLLRSLG VPIHSVHQNA GEFVITFPRA
610 620 630 640 650
YHAGFNEGLN FAEAVNFAPI DWLSKGRECV ESYSNVRRYL VFSHDELLFK
660 670 680 690 700
MVEAMDKLGI SMSLATHEEL IRIYEKQKML RELLARLGVS NRQMQQVMFE
710 720 730 740 750
KIPDEQRSCR FCKTTLFMCA LVCNKHKKMT CVEHHDHLCN SCTTKDYRYQ
760 770 780 790 800
YRFELDQLNN MCDELGKRTV NYNGWKEESD EMLEEEGKPK LERIEEFIDS
810 820 830 840 850
AKQNKYPQTD QVHKLITIRH TAKSAIEKAN QLLFKKVRTR TKTRCQRADT
860 870 880 890 900
RTDTEGVRSL IEQMQAMDCN LTVIIDKLEK WMEQVEMWRN RAKDAIYREQ
910 920 930 940 950
EYSKEEIEKI IEEGDEYDIK LEEIDELRKV IQMKDWSDRA RKVTTWKATP
960 970 980 990 1000
DMEKDIDFEY KLRYASSDIL SLIRDSPRNP TDGTSKLVFE LQQMLRDANT
1010 1020 1030 1040 1050
LEVIANNFCE NPALDQLQSI WQSLRETDWF YEKYINMVRY EIIHVAKIKS
1060 1070 1080 1090 1100
MIDAAIPVLS EFDLKTQLQK IVNVEITLSK AAEISKAFET SKCLNGSEEH
1110 1120 1130 1140 1150
LGILDMISTM NAFTQRIAIL FKPNNAYHNL FEILSERDDL TPLAEGQTIP
1160 1170 1180 1190 1200
LYFQGGAVHP SDEWHQMKEF ESLDQIVHHQ SSLREMQMRI FEKVKQANSA
1210 1220 1230 1240 1250
RGLEACSCLG FNKSDDSEST LTCIMCDSEF HVRCCEWSPF LEKLPEGCFL
1260 1270 1280 1290 1300
CVRCLRGQRP VIDDVTTALN GTPSGCLETH LVRNLIQKTR GITQNLMEAA
1310 1320 1330 1340 1350
NKRKSGESSD DICKIALFDW LSCEILNPNG LPKARELISE FYMEYLQKQS
1360 1370 1380 1390 1400
SAALELKNRP VRSKPSVSLF DPKITAKRKR PSVSHKETSK KSRKRQSQAS
1410 1420 1430 1440 1450
PSEYYEDESE FKSCQARACL KPYGDSVNWV MCEAGCKNWF HVICLGFTLR
1460 1470
EINDMHEYRC SSCLDHADSP TSSVSTD
Length:1,477
Mass (Da):170,791
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2539E727C6E72D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A061ACP3A0A061ACP3_CAEEL
Lysine-specific demethylase rbr-2
rbr-2 CELE_ZK593.4, ZK593.4
1,444Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z69385 Genomic DNA Translation: CAA93426.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T27924

NCBI Reference Sequences

More...
RefSeqi
NP_502032.2, NM_069631.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK593.4a.1; ZK593.4a.1; WBGene00004319

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZK593.4

UCSC genome browser

More...
UCSCi
ZK593.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69385 Genomic DNA Translation: CAA93426.2
PIRiT27924
RefSeqiNP_502032.2, NM_069631.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi43086, 4 interactors
IntActiQ23541, 26 interactors
STRINGi6239.ZK593.4

Proteomic databases

EPDiQ23541
PaxDbiQ23541
PeptideAtlasiQ23541
PRIDEiQ23541

Genome annotation databases

EnsemblMetazoaiZK593.4a.1; ZK593.4a.1; WBGene00004319
GeneIDi177985
KEGGicel:CELE_ZK593.4
UCSCiZK593.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177985
WormBaseiZK593.4a ; CE35704 ; WBGene00004319 ; rbr-2

Phylogenomic databases

eggNOGiKOG1246 Eukaryota
ENOG410XR9J LUCA
GeneTreeiENSGT00940000168915
HOGENOMiHOG000113216
InParanoidiQ23541
KOiK11446
OMAiCKTTLFM
OrthoDBi664180at2759
PhylomeDBiQ23541

Enzyme and pathway databases

ReactomeiR-CEL-3214842 HDMs demethylate histones

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q23541

Gene expression databases

BgeeiWBGene00004319 Expressed in 3 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiQ23541 baseline and differential

Family and domain databases

Gene3Di1.10.150.60, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR003347 JmjC_dom
IPR003349 JmjN
IPR013637 Lys_sp_deMease-like_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR004198 Znf_C5HC2
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF02373 JmjC, 1 hit
PF02375 JmjN, 1 hit
PF00628 PHD, 1 hit
PF08429 PLU-1, 1 hit
PF02928 zf-C5HC2, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00558 JmjC, 1 hit
SM00545 JmjN, 1 hit
SM00249 PHD, 3 hits
SUPFAMiSSF46774 SSF46774, 1 hit
SSF57903 SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51184 JMJC, 1 hit
PS51183 JMJN, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDM5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23541
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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