Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 113 (31 Jul 2019)
Sequence version 1 (21 Feb 2006)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

A-kinase anchor protein SPHKAP

Gene

SPHKAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein SPHKAP
Alternative name(s):
SPHK1-interactor and AKAP domain-containing protein
Sphingosine kinase type 1-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPHKAP
Synonyms:KIAA1678, SKIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30619 SPHKAP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611646 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2M3C7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80309

Open Targets

More...
OpenTargetsi
ENSG00000153820

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162404477

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPHKAP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121941477

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206661 – 1700A-kinase anchor protein SPHKAPAdd BLAST1700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1025PhosphoserineBy similarity1
Modified residuei1085PhosphoserineBy similarity1
Modified residuei1107PhosphoserineBy similarity1
Modified residuei1120PhosphoserineBy similarity1
Modified residuei1121PhosphoserineBy similarity1
Modified residuei1124PhosphoserineBy similarity1
Modified residuei1259PhosphoserineBy similarity1
Modified residuei1288PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2M3C7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2M3C7

PeptideAtlas

More...
PeptideAtlasi
Q2M3C7

PRoteomics IDEntifications database

More...
PRIDEi
Q2M3C7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61371 [Q2M3C7-1]
61372 [Q2M3C7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2M3C7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2M3C7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153820 Expressed in 87 organ(s), highest expression level in left ventricle myocardium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2M3C7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042499
HPA048168

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA.

Interacts with SPHK1; the interaction greatly reduces SPHK1 activity.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SPHK1Q9NYA14EBI-1803914,EBI-985303

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123222, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q2M3C7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375909

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni929 – 946PKA-RII subunit binding domainBy similarityAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHCW Eukaryota
ENOG41113DA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154389

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2M3C7

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTNCSVS

Database of Orthologous Groups

More...
OrthoDBi
33853at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2M3C7

TreeFam database of animal gene trees

More...
TreeFami
TF105426

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018292 AKAP_110_C
IPR008382 SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...
PANTHERi
PTHR10226 PTHR10226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05716 AKAP_110, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q2M3C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGNSLLSVP SNLESSRMYD VLEPQQGRGC GSSGSGPGNS ITACKKVLRS
60 70 80 90 100
NSLLESTDYW LQNQRMPCQI GFVEDKSENC ASVCFVNLDV NKDECSTEHL
110 120 130 140 150
QQKLVNVSPD LPKLISSMNV QQPKENEIVV LSGLASGNLQ ADFEVSQCPW
160 170 180 190 200
LPDICLVQCA RGNRPNSTNC IIFEINKFLI GLELVQERQL HLETNILKLE
210 220 230 240 250
DDTNCSLSSI EEDFLTASEH LEEESEVDES RNDYENINVS ANVLESKQLK
260 270 280 290 300
GATQVEWNCN KEKWLYALED KYINKYPTPL IKTERSPENL TKNTALQSLD
310 320 330 340 350
PSAKPSQWKR EAVGNGRQAT HYYHSEAFKG QMEKSQALYI PKDAYFSMMD
360 370 380 390 400
KDVPSACAVA EQRSNLNPGD HEDTRNALPP RQDGEVTTGK YATNLAESVL
410 420 430 440 450
QDAFIRLSQS QSTLPQESAV SVSVGSSLLP SCYSTKDTVV SRSWNELPKI
460 470 480 490 500
VVVQSPDGSD AAPQPGISSW PEMEVSVETS SILSGENSSR QPQSALEVAL
510 520 530 540 550
ACAATVIGTI SSPQATERLK MEQVVSNFPP GSSGALQTQA PQGLKEPSIN
560 570 580 590 600
EYSFPSALCG MTQVASAVAV CGLGEREEVT CSVAPSGSLP PAAEASEAMP
610 620 630 640 650
PLCGLASMEL GKEAIAKGLL KEAALVLTRP NTYSSIGDFL DSMNRRIMET
660 670 680 690 700
ASKSQTLCSE NVVRNELAHT LSNVILRHSI DEVHHKNMII DPNDNRHSSE
710 720 730 740 750
ILDTLMESTN QLLLDVICFT FKKMSHIVRL GECPAVLSKE TIRRRETEPS
760 770 780 790 800
CQPSDPGASQ AWTKATESSS SSPLSNSHNT SLVINNLVDG MYSKQDKGGV
810 820 830 840 850
RPGLFKNPTL QSQLSRSHRV PDSSTATTSS KEIYLKGIAG EDTKSPHHSE
860 870 880 890 900
NECRASSEGQ RSPTVSQSRS GSQEAEESIH PNTQEKYNCA TSRINEVQVN
910 920 930 940 950
LSLLGDDLLL PAQSTLQTKH PDIYCITDFA EELADTVVSM ATEIAAICLD
960 970 980 990 1000
NSSGKQPWFC AWKRGSEFLM TPNVPCRSLK RKKESQGSGT AVRKHKPPRL
1010 1020 1030 1040 1050
SEIKRKTDEH PELKEKLMNR VVDESMNLED VPDSVNLFAN EVAAKIMNLT
1060 1070 1080 1090 1100
EFSMVDGMWQ AQGYPRNRLL SGDRWSRLKA SSCESIPEED SEARAYVNSL
1110 1120 1130 1140 1150
GLMSTLSQPV SRASSVSKQS SCESITDEFS RFMVNQMENE GRGFELLLDY
1160 1170 1180 1190 1200
YAGKNASSIL NSAMQQACRK SDHLSVRPSC PSKQSSTESI TEEFYRYMLR
1210 1220 1230 1240 1250
DIERDSRESA SSRRSSQDWT AGLLSPSLRS PVCHRQSSMP DSRSPCSRLT
1260 1270 1280 1290 1300
VNVPIKANSL DGFAQNCPQD FLSVQPVSSA SSSGLCKSDS CLYRRGGTDH
1310 1320 1330 1340 1350
ITNMLIHETW ASSIEALMRK NKIIVDDAEE ADTEPVSGGS PSQAEKCANR
1360 1370 1380 1390 1400
LAASRMCSGP TLLVQESLDC PRKDSVTECK QPPVSSLSKT ASLTNHSPLD
1410 1420 1430 1440 1450
SKKETSSCQD PVPINHKRRS LCSREVPLIQ IETDQREACA GEPEPFLSKS
1460 1470 1480 1490 1500
SLLEEAEGHS NDKNIPDVVR GGDTAVSACQ IHSDSLDTRD VPEAEASTEA
1510 1520 1530 1540 1550
RAPDEAPNPP SSSEESTGSW TQLANEEDNP DDTSSFLQLS ERSMSNGNSS
1560 1570 1580 1590 1600
ATSSLGIMDL DIYQESMPSS PMINELVEEK KILKGQSEST EAPASGPPTG
1610 1620 1630 1640 1650
TASPQRSLLV INFDLEPECP DAELRATLQW IAASELGIPT IYFKKSQENR
1660 1670 1680 1690 1700
IEKFLDVVQL VHRKSWKVGD IFHAVVQYCK MHEEQKDGRL SLFDWLLELG
Length:1,700
Mass (Da):186,456
Last modified:February 21, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D49589CAC5A1BDE
GO
Isoform 2 (identifier: Q2M3C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1546-1574: Missing.

Show »
Length:1,671
Mass (Da):183,414
Checksum:iFB6CD08DE8CC4797
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH18152 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89D → G in CAH18317 (PubMed:17974005).Curated1
Sequence conflicti483L → P in CAH18317 (PubMed:17974005).Curated1
Sequence conflicti719F → S in CAH18152 (PubMed:17974005).Curated1
Sequence conflicti921P → L in CAH18152 (PubMed:17974005).Curated1
Sequence conflicti1218D → I in CAH18317 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039263425G → R. Corresponds to variant dbSNP:rs4283414Ensembl.1
Natural variantiVAR_039264617K → E2 PublicationsCorresponds to variant dbSNP:rs3811514Ensembl.1
Natural variantiVAR_039265847H → Q2 PublicationsCorresponds to variant dbSNP:rs3811515Ensembl.1
Natural variantiVAR_039266867Q → R. Corresponds to variant dbSNP:rs3828161Ensembl.1
Natural variantiVAR_0591131603S → R. Corresponds to variant dbSNP:rs16824283Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0317121546 – 1574Missing in isoform 2. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR749297 mRNA Translation: CAH18152.1 Different initiation.
CR749494 mRNA Translation: CAH18317.1
BC104954 mRNA Translation: AAI04955.1
BC104956 mRNA Translation: AAI04957.1
AB051465 mRNA Translation: BAB21769.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33389.1 [Q2M3C7-2]
CCDS46537.1 [Q2M3C7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001136116.1, NM_001142644.1 [Q2M3C7-1]
NP_085126.2, NM_030623.3 [Q2M3C7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344657; ENSP00000339886; ENSG00000153820 [Q2M3C7-2]
ENST00000392056; ENSP00000375909; ENSG00000153820 [Q2M3C7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80309

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80309

UCSC genome browser

More...
UCSCi
uc002vpp.3 human [Q2M3C7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749297 mRNA Translation: CAH18152.1 Different initiation.
CR749494 mRNA Translation: CAH18317.1
BC104954 mRNA Translation: AAI04955.1
BC104956 mRNA Translation: AAI04957.1
AB051465 mRNA Translation: BAB21769.1
CCDSiCCDS33389.1 [Q2M3C7-2]
CCDS46537.1 [Q2M3C7-1]
RefSeqiNP_001136116.1, NM_001142644.1 [Q2M3C7-1]
NP_085126.2, NM_030623.3 [Q2M3C7-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123222, 3 interactors
IntActiQ2M3C7, 3 interactors
STRINGi9606.ENSP00000375909

PTM databases

iPTMnetiQ2M3C7
PhosphoSitePlusiQ2M3C7

Polymorphism and mutation databases

BioMutaiSPHKAP
DMDMi121941477

Proteomic databases

jPOSTiQ2M3C7
PaxDbiQ2M3C7
PeptideAtlasiQ2M3C7
PRIDEiQ2M3C7
ProteomicsDBi61371 [Q2M3C7-1]
61372 [Q2M3C7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80309
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344657; ENSP00000339886; ENSG00000153820 [Q2M3C7-2]
ENST00000392056; ENSP00000375909; ENSG00000153820 [Q2M3C7-1]
GeneIDi80309
KEGGihsa:80309
UCSCiuc002vpp.3 human [Q2M3C7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80309
DisGeNETi80309

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPHKAP
HGNCiHGNC:30619 SPHKAP
HPAiHPA042499
HPA048168
MIMi611646 gene
neXtProtiNX_Q2M3C7
OpenTargetsiENSG00000153820
PharmGKBiPA162404477

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHCW Eukaryota
ENOG41113DA LUCA
GeneTreeiENSGT00940000153313
HOGENOMiHOG000154389
InParanoidiQ2M3C7
OMAiDTNCSVS
OrthoDBi33853at2759
PhylomeDBiQ2M3C7
TreeFamiTF105426

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPHKAP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80309

Protein Ontology

More...
PROi
PR:Q2M3C7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153820 Expressed in 87 organ(s), highest expression level in left ventricle myocardium
GenevisibleiQ2M3C7 HS

Family and domain databases

InterProiView protein in InterPro
IPR018292 AKAP_110_C
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716 AKAP_110, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPKAP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2M3C7
Secondary accession number(s): Q68DA3, Q68DR8, Q9C0I5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 21, 2006
Last modified: July 31, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again