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Entry version 119 (13 Feb 2019)
Sequence version 2 (24 Jul 2007)
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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc2-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.131 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-4551295 Defective ALG11 causes ALG11-CDG (CDG-1p)

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT4 Glycosyltransferase Family 4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALG11
Synonyms:GT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000253710.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32456 ALG11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613666 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2TAA5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 1P (CDG1P)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:613661
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06490886L → S in CDG1P; does not affect subcellular localization; results in the accumulation of under-glycosylated proteins. 1 PublicationCorresponds to variant dbSNP:rs267606652EnsemblClinVar.1
Natural variantiVAR_068070279Y → S in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907181EnsemblClinVar.1
Natural variantiVAR_068071318Q → P in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907184EnsemblClinVar.1
Natural variantiVAR_068072381L → S in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907182EnsemblClinVar.1
Natural variantiVAR_068073398E → K in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907183EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86L → A: Does not affect function. 1 Publication1
Mutagenesisi86L → P: Loss of function. 1 Publication1

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
440138

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ALG11

MalaCards human disease database

More...
MalaCardsi
ALG11
MIMi613661 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000253710

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
280071 ALG11-CDG

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ALG11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156631015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002956161 – 492GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferaseAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2TAA5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2TAA5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2TAA5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2TAA5

PeptideAtlas

More...
PeptideAtlasi
Q2TAA5

PRoteomics IDEntifications database

More...
PRIDEi
Q2TAA5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61454

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2TAA5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2TAA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000253710 Expressed in 95 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2TAA5 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047214

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
136328, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000430236

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q2TAA5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1387 Eukaryota
COG0438 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000075118

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000209670

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057178

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q2TAA5

KEGG Orthology (KO)

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KOi
K03844

Identification of Orthologs from Complete Genome Data

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OMAi
PPDIFID

Database of Orthologous Groups

More...
OrthoDBi
1051021at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2TAA5

TreeFam database of animal gene trees

More...
TreeFami
TF313056

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03806 GT1_ALG11_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038013 ALG11
IPR031814 ALG11_N
IPR001296 Glyco_trans_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15924 ALG11_N, 1 hit
PF00534 Glycos_transf_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q2TAA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGERSWCL CKLLRFFYSL FFPGLIVCGT LCVCLVIVLW GIRLLLQRKK
60 70 80 90 100
KLVSTSKNGK NQMVIAFFHP YCNAGGGGER VLWCALRALQ KKYPEAVYVV
110 120 130 140 150
YTGDVNVNGQ QILEGAFRRF NIRLIHPVQF VFLRKRYLVE DSLYPHFTLL
160 170 180 190 200
GQSLGSIFLG WEALMQCVPD VYIDSMGYAF TLPLFKYIGG CQVGSYVHYP
210 220 230 240 250
TISTDMLSVV KNQNIGFNNA AFITRNPFLS KVKLIYYYLF AFIYGLVGSC
260 270 280 290 300
SDVVMVNSSW TLNHILSLWK VGNCTNIVYP PCDVQTFLDI PLHEKKMTPG
310 320 330 340 350
HLLVSVGQFR PEKNHPLQIR AFAKLLNKKM VESPPSLKLV LIGGCRNKDD
360 370 380 390 400
ELRVNQLRRL SEDLGVQEYV EFKINIPFDE LKNYLSEATI GLHTMWNEHF
410 420 430 440 450
GIGVVECMAA GTIILAHNSG GPKLDIVVPH EGDITGFLAE SEEDYAETIA
460 470 480 490
HILSMSAEKR LQIRKSARAS VSRFSDQEFE VTFLSSVEKL FK
Length:492
Mass (Da):55,651
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B3B0789030777FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISU2A0A3B3ISU2_HUMAN
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alph...
ALG11
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS90A0A3B3IS90_HUMAN
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alph...
ALG11
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYL8A0A087WYL8_HUMAN
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alph...
ALG11
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TAP0Q5TAP0_HUMAN
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alph...
ALG11
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISP7A0A3B3ISP7_HUMAN
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alph...
ALG11
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI11023 differs from that shown. Reason: Frameshift at position 16.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96A → V in AAI42999 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06490886L → S in CDG1P; does not affect subcellular localization; results in the accumulation of under-glycosylated proteins. 1 PublicationCorresponds to variant dbSNP:rs267606652EnsemblClinVar.1
Natural variantiVAR_055902108N → S. Corresponds to variant dbSNP:rs17480245EnsemblClinVar.1
Natural variantiVAR_068070279Y → S in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907181EnsemblClinVar.1
Natural variantiVAR_068071318Q → P in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907184EnsemblClinVar.1
Natural variantiVAR_068072381L → S in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907182EnsemblClinVar.1
Natural variantiVAR_068073398E → K in CDG1P. 1 PublicationCorresponds to variant dbSNP:rs387907183EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK296747 mRNA Translation: BAG59331.1
AL139082 Genomic DNA No translation available.
BC073862 mRNA Translation: AAH73862.1
BC010857 mRNA Translation: AAH10857.3
BC111022 mRNA Translation: AAI11023.1 Sequence problems.
BC142998 mRNA Translation: AAI42999.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31977.1

NCBI Reference Sequences

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RefSeqi
NP_001004127.2, NM_001004127.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.512963
Hs.732220

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000521508; ENSP00000430236; ENSG00000253710

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
440138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:440138

UCSC genome browser

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UCSCi
uc001vga.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296747 mRNA Translation: BAG59331.1
AL139082 Genomic DNA No translation available.
BC073862 mRNA Translation: AAH73862.1
BC010857 mRNA Translation: AAH10857.3
BC111022 mRNA Translation: AAI11023.1 Sequence problems.
BC142998 mRNA Translation: AAI42999.1
CCDSiCCDS31977.1
RefSeqiNP_001004127.2, NM_001004127.2
UniGeneiHs.512963
Hs.732220

3D structure databases

ProteinModelPortaliQ2TAA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136328, 12 interactors
STRINGi9606.ENSP00000430236

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

PTM databases

iPTMnetiQ2TAA5
PhosphoSitePlusiQ2TAA5

Polymorphism and mutation databases

BioMutaiALG11
DMDMi156631015

Proteomic databases

EPDiQ2TAA5
jPOSTiQ2TAA5
MaxQBiQ2TAA5
PaxDbiQ2TAA5
PeptideAtlasiQ2TAA5
PRIDEiQ2TAA5
ProteomicsDBi61454

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
440138
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521508; ENSP00000430236; ENSG00000253710
GeneIDi440138
KEGGihsa:440138
UCSCiuc001vga.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
440138
DisGeNETi440138
EuPathDBiHostDB:ENSG00000253710.2

GeneCards: human genes, protein and diseases

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GeneCardsi
ALG11
GeneReviewsiALG11

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0011337
HGNCiHGNC:32456 ALG11
HPAiHPA047214
MalaCardsiALG11
MIMi613661 phenotype
613666 gene
neXtProtiNX_Q2TAA5
OpenTargetsiENSG00000253710
Orphaneti280071 ALG11-CDG

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1387 Eukaryota
COG0438 LUCA
GeneTreeiENSGT00550000075118
HOGENOMiHOG000209670
HOVERGENiHBG057178
InParanoidiQ2TAA5
KOiK03844
OMAiPPDIFID
OrthoDBi1051021at2759
PhylomeDBiQ2TAA5
TreeFamiTF313056

Enzyme and pathway databases

BRENDAi2.4.1.131 2681
ReactomeiR-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-4551295 Defective ALG11 causes ALG11-CDG (CDG-1p)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ALG11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ALG11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
440138

Protein Ontology

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PROi
PR:Q2TAA5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000253710 Expressed in 95 organ(s), highest expression level in lung
ExpressionAtlasiQ2TAA5 baseline and differential

Family and domain databases

CDDicd03806 GT1_ALG11_like, 1 hit
InterProiView protein in InterPro
IPR038013 ALG11
IPR031814 ALG11_N
IPR001296 Glyco_trans_1
PfamiView protein in Pfam
PF15924 ALG11_N, 1 hit
PF00534 Glycos_transf_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALG11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2TAA5
Secondary accession number(s): A5PLP3
, B4DKW9, Q5TAN9, Q6DKI6, Q96FI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 13, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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