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Entry version 107 (08 May 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Protein mono-ADP-ribosyltransferase PARP3

Gene

Parp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:21270334, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (PubMed:26000965).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processDNA damage, DNA repair
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mono-ADP-ribosyltransferase PARP3Curated (EC:2.4.2.-By similarity)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 3By similarity
Short name:
ARTD3By similarity
DNA ADP-ribosyltransferase PARP3Curated (EC:2.4.2.-By similarity)
NAD(+) ADP-ribosyltransferase 31 Publication
Short name:
ADPRT-31 Publication
Poly [ADP-ribose] polymerase 31 Publication
Short name:
PARP-31 Publication
Poly[ADP-ribose] synthase 31 Publication
Short name:
pADPRT-3By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Parp31 PublicationImported
Synonyms:Adprt31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891258 Parp3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype in normal conditions, but mutant mice are sensitive to ionizing radiation (PubMed:21270334). In B-cells, class switch recombination is increased, while somatic hypermutation is unaffected, due to increased occupancy of Aicda/Aid at the donor switch region (PubMed:26000965).2 Publications

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004461701 – 533Protein mono-ADP-ribosyltransferase PARP3Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6N6-(ADP-ribosyl)lysineBy similarity1
Modified residuei12ADP-ribosyl glutamic acidBy similarity1
Modified residuei24ADP-ribosyl glutamic acidBy similarity1
Modified residuei32ADP-ribosyl glutamic acidBy similarity1
Modified residuei138ADP-ribosyl aspartic acidBy similarity1
Modified residuei160ADP-ribosyl glutamic acidBy similarity1
Modified residuei230ADP-ribosyl glutamic acidBy similarity1
Modified residuei309ADP-ribosyl glutamic acidBy similarity1
Modified residuei310ADP-ribosyl glutamic acidBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ADP-ribosylated.By similarity

Keywords - PTMi

ADP-ribosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q3ULW8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q3ULW8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q3ULW8

PRoteomics IDEntifications database

More...
PRIDEi
Q3ULW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023249 Expressed in 222 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q3ULW8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PARP1; leading to activate PARP1 in absence of DNA. Interacts with PRKDC. Interacts with XRCC5/Ku80; the interaction is dependent on nucleic acids. Interacts with XRCC6/Ku70; the interaction is dependent on nucleic acids. Interacts with EZH2, HDAC1, HDAC2, SUZ12, YY1, LRIG3 and LIG4.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000064513

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q3ULW8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3ULW8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 299PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST119
Domaini313 – 533PARP catalyticPROSITE-ProRule annotationAdd BLAST221

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi14 – 18Nuclear localization signalSequence analysis5

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1037 Eukaryota
ENOG410XP18 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158855

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000173055

KEGG Orthology (KO)

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KOi
K10798

Identification of Orthologs from Complete Genome Data

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OMAi
NSKSACY

Database of Orthologous Groups

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OrthoDBi
909382at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315407

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.142.10, 1 hit
2.20.140.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031275 PARP3
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10459:SF66 PTHR10459:SF66, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF05406 WGR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00773 WGR, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3ULW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKRKASVQ TEGSKKRRQG TEEEDSFRST AEALRAAPAD NRVIRVDPSC
60 70 80 90 100
PFSRNPGIQV HEDYDCTLNQ TNIGNNNNKF YIIQLLEEGS RFFCWNRWGR
110 120 130 140 150
VGEVGQSKMN HFTCLEDAKK DFKKKFWEKT KNKWEERDRF VAQPNKYTLI
160 170 180 190 200
EVQGEAESQE AVVKALSPQV YSGPVRTVVK PCSLDPATQN LITNIFSKEM
210 220 230 240 250
FKNAMTLMNL DVKKMPLGKL TKQQIARGFE ALEALEEAMK NPTGDGQSLE
260 270 280 290 300
ELSSCFYTVI PHNFGRSRPP PINSPDVLQA KKDMLLVLAD IELAQTLQAA
310 320 330 340 350
PGEEEEKVEE VPHPLDRDYQ LLRCQLQLLD SGESEYKAIQ TYLKQTGNSY
360 370 380 390 400
RCPDLRHVWK VNREGEGDRF QAHSKLGNRR LLWHGTNVAV VAAILTSGLR
410 420 430 440 450
IMPHSGGRVG KGIYFASENS KSAGYVTTMH CGGHQVGYMF LGEVALGKEH
460 470 480 490 500
HITIDDPSLK SPPSGFDSVI ARGQTEPDPA QDIELELDGQ PVVVPQGPPV
510 520 530
QCPSFKSSSF SQSEYLIYKE SQCRLRYLLE IHL
Length:533
Mass (Da):59,949
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC6EB55D4985766F
GO
Isoform 2 (identifier: Q3ULW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-169: Missing.

Show »
Length:528
Mass (Da):59,452
Checksum:iBEA210E5959BE0B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17R → Q in BAC31826 (PubMed:16141072).Curated1
Sequence conflicti17R → Q in AAH14870 (PubMed:15489334).Curated1
Sequence conflicti17R → Q in AAH58754 (PubMed:15489334).Curated1
Sequence conflicti171Y → D in BAC31826 (PubMed:16141072).Curated1
Sequence conflicti171Y → D in AAH14870 (PubMed:15489334).Curated1
Sequence conflicti171Y → D in AAH58754 (PubMed:15489334).Curated1
Sequence conflicti294A → V in AAH14870 (PubMed:15489334).Curated1
Sequence conflicti294A → V in AAH58754 (PubMed:15489334).Curated1
Sequence conflicti354D → N in BAC31826 (PubMed:16141072).Curated1
Sequence conflicti354D → N in AAH14870 (PubMed:15489334).Curated1
Sequence conflicti354D → N in AAH58754 (PubMed:15489334).Curated1
Sequence conflicti446L → I in BAE28191 (PubMed:16141072).Curated1
Sequence conflicti464S → P in BAC31826 (PubMed:16141072).Curated1
Sequence conflicti464S → P in AAH14870 (PubMed:15489334).Curated1
Sequence conflicti464S → P in AAH58754 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060032165 – 169Missing in isoform 2. 5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF368233 mRNA Translation: AAN62793.1
AY046316 mRNA Translation: AAL08055.1
AY046317 mRNA Translation: AAL08056.1
AK044223 mRNA Translation: BAC31826.1
AK147868 mRNA Translation: BAE28191.1
AK170541 mRNA Translation: BAE41867.1
AK145259 mRNA Translation: BAE26330.1
AC151729 Genomic DNA No translation available.
BC014870 mRNA Translation: AAH14870.1
BC058754 mRNA Translation: AAH58754.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23480.1 [Q3ULW8-2]
CCDS81066.1 [Q3ULW8-1]

NCBI Reference Sequences

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RefSeqi
NP_001298079.1, NM_001311150.1 [Q3ULW8-1]
NP_663594.2, NM_145619.3 [Q3ULW8-2]
XP_006511781.1, XM_006511718.1 [Q3ULW8-1]
XP_006511782.1, XM_006511719.3 [Q3ULW8-1]
XP_006511783.1, XM_006511720.1 [Q3ULW8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000067218; ENSMUSP00000064513; ENSMUSG00000023249 [Q3ULW8-2]
ENSMUST00000112479; ENSMUSP00000108098; ENSMUSG00000023249 [Q3ULW8-1]
ENSMUST00000123555; ENSMUSP00000123054; ENSMUSG00000023249 [Q3ULW8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
235587

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:235587

UCSC genome browser

More...
UCSCi
uc009rjw.1 mouse
uc009rjz.1 mouse [Q3ULW8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368233 mRNA Translation: AAN62793.1
AY046316 mRNA Translation: AAL08055.1
AY046317 mRNA Translation: AAL08056.1
AK044223 mRNA Translation: BAC31826.1
AK147868 mRNA Translation: BAE28191.1
AK170541 mRNA Translation: BAE41867.1
AK145259 mRNA Translation: BAE26330.1
AC151729 Genomic DNA No translation available.
BC014870 mRNA Translation: AAH14870.1
BC058754 mRNA Translation: AAH58754.1
CCDSiCCDS23480.1 [Q3ULW8-2]
CCDS81066.1 [Q3ULW8-1]
RefSeqiNP_001298079.1, NM_001311150.1 [Q3ULW8-1]
NP_663594.2, NM_145619.3 [Q3ULW8-2]
XP_006511781.1, XM_006511718.1 [Q3ULW8-1]
XP_006511782.1, XM_006511719.3 [Q3ULW8-1]
XP_006511783.1, XM_006511720.1 [Q3ULW8-2]

3D structure databases

SMRiQ3ULW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064513

Chemistry databases

BindingDBiQ3ULW8
ChEMBLiCHEMBL3292

Proteomic databases

EPDiQ3ULW8
jPOSTiQ3ULW8
MaxQBiQ3ULW8
PRIDEiQ3ULW8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067218; ENSMUSP00000064513; ENSMUSG00000023249 [Q3ULW8-2]
ENSMUST00000112479; ENSMUSP00000108098; ENSMUSG00000023249 [Q3ULW8-1]
ENSMUST00000123555; ENSMUSP00000123054; ENSMUSG00000023249 [Q3ULW8-2]
GeneIDi235587
KEGGimmu:235587
UCSCiuc009rjw.1 mouse
uc009rjz.1 mouse [Q3ULW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10039
MGIiMGI:1891258 Parp3

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
GeneTreeiENSGT00940000158855
HOGENOMiHOG000173055
KOiK10798
OMAiNSKSACY
OrthoDBi909382at2759
TreeFamiTF315407

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000023249 Expressed in 222 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ3ULW8 baseline and differential

Family and domain databases

Gene3Di1.20.142.10, 1 hit
2.20.140.10, 1 hit
InterProiView protein in InterPro
IPR031275 PARP3
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain
PANTHERiPTHR10459:SF66 PTHR10459:SF66, 1 hit
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF05406 WGR, 1 hit
SMARTiView protein in SMART
SM00773 WGR, 1 hit
SUPFAMiSSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit
PROSITEiView protein in PROSITE
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARP3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3ULW8
Secondary accession number(s): A0A1L1SRP6
, E9PX17, E9Q992, Q3UGL7, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2019
Last sequence update: October 11, 2005
Last modified: May 8, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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