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Entry version 105 (16 Oct 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Transforming growth factor-beta receptor-associated protein 1

Gene

Tgfbrap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity).By similarity
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transforming growth factor-beta receptor-associated protein 1
Short name:
TGF-beta receptor-associated protein 1
Short name:
TRAP-1
Short name:
TRAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2447427 Tgfbrap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal, both before blastula stage or during gastrulation.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003454061 – 860Transforming growth factor-beta receptor-associated protein 1Add BLAST860

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3UR70

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UR70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UR70

PeptideAtlas

More...
PeptideAtlasi
Q3UR70

PRoteomics IDEntifications database

More...
PRIDEi
Q3UR70

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UR70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UR70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000070939 Expressed in 246 organ(s), highest expression level in ear

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UR70 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UR70 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFBR2 and ACVR2B; in the absence of ligand stimulation.

Interacts with TGFBR1, ACVRL1, BMPR1A and ACVR1B; in the absence of ligand stimulation and to a less extent.

Interacts with SMAD4; the interaction seems to be mutually exclusive with the interaction of SMAD4 and phosphorylated SMAD2. May interact with ALOX5 (By similarity).

Interacts with RAB5C.

Interacts with VPS8, VPS11 and VPS16.

Component of the putative class C core vacuole/endosome tethering (CORVET) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS8 and TGFBRAP1 (PubMed:25266290).

By similarity1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
215781, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q3UR70, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000092624

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 297CNHPROSITE-ProRule annotationAdd BLAST274
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati564 – 732CHCRAdd BLAST169

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2063 Eukaryota
ENOG410XNSX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007291

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UR70

KEGG Orthology (KO)

More...
KOi
K20177

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLLPDTW

Database of Orthologous Groups

More...
OrthoDBi
682722at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UR70

TreeFam database of animal gene trees

More...
TreeFami
TF328650

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000547 Clathrin_H-chain/VPS_repeat
IPR001180 CNH_dom
IPR032914 Vam6/VPS39/TRAP1
IPR019452 VPS39/TGF_beta_rcpt-assoc_1
IPR019453 VPS39/TGF_beta_rcpt-assoc_2

The PANTHER Classification System

More...
PANTHERi
PTHR12894 PTHR12894, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637 Clathrin, 1 hit
PF00780 CNH, 1 hit
PF10366 Vps39_1, 1 hit
PF10367 Vps39_2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236 CHCR, 1 hit
PS50219 CNH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UR70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNIKAFTLV SAVERELLMG DRDHISIECV ECCGRNLYVG TNDCFIYHFL
60 70 80 90 100
LEEKAMPTGT ATFVATKQLH RHLGFKKPVN ELCAASALNR LLVLCDNSIT
110 120 130 140 150
LVNMLNLEPV PSGARIKGAT TFAVNESPVN GDPFCVEVCI ISVKRRTVQM
160 170 180 190 200
FLVYEDRVQI VKEVSTPEQP LAVAVDGYFL CLALTTQYII LNYSTGLSQD
210 220 230 240 250
LFPYCSEEKP PIVKRIGRQE FLLAGPGGLG MFATVAGISQ RAPVHWSENV
260 270 280 290 300
IGAAVCFPYV IALDDEFITV HSMLDQQQKQ TLPFKEGHIL QDFEGRVIVA
310 320 330 340 350
TSKGVYILVP LPLEKQIQDL LANRRVEEAL VLAKGARRNI PKEKFQVMYR
360 370 380 390 400
RILQQAGFIQ FAQLQFLEAK ELFRSSQLDV RELISLYPFL LPTSSSFTRS
410 420 430 440 450
HPPLHEYADL NQLTQGDQEK MAKCKRFLMS YLNEIRSTEV ANGYKEDIDT
460 470 480 490 500
ALLKLYAEAD HDSLLDLLVT ENFCLLTDSA AWLEKHKKYF ALGLLYHYNK
510 520 530 540 550
QDASAVQLWV NIVNGDIQDS TRSDLYEYIV DFLTYCLDQE LVWTHADWLL
560 570 580 590 600
QKSEEIGVQI FTKRPLDEQQ QTSFNPDNII SSLKKYPKAL VKYLEHLVID
610 620 630 640 650
RRLQKEEYHT HLAILYLEEV LRQRVSTGGK DVEATETQAK LRRLLQKSDL
660 670 680 690 700
YRVHLLKEKV QGAGLPMESA ILHGKLGEHE KALHILVHEM GDFSAAEDYC
710 720 730 740 750
LWSSEGQGAA CRQRLFHTLL AMYLRAGPSA QDLTVAAVDL LNHHAREFDV
760 770 780 790 800
TQVLQLLPDT WSVQLLCPFL MGAMRDSIHA RRTTQVALGL AKSENLIYMY
810 820 830 840 850
DKMKLKGNAV RLSERELCQL CQNPFGEPVF VRYPNGGLVH THCAASRHTA
860
PSSPSPGTRT
Length:860
Mass (Da):97,303
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB86BD77735D04C7B
GO
Isoform 2 (identifier: Q3UR70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-247: MFATVAGISQRAPVHWS → EEGWGSLLMAPASCLLS
     248-860: Missing.

Note: No experimental confirmation available.
Show »
Length:247
Mass (Da):27,199
Checksum:i829B1480CAF29146
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQF3A0A087WQF3_MOUSE
Transforming growth factor-beta rec...
Tgfbrap1
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQX7A0A087WQX7_MOUSE
Transforming growth factor-beta rec...
Tgfbrap1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR01A0A087WR01_MOUSE
Transforming growth factor-beta rec...
Tgfbrap1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034944231 – 247MFATV…PVHWS → EEGWGSLLMAPASCLLS in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_034945248 – 860Missing in isoform 2. 1 PublicationAdd BLAST613

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK051333 mRNA Translation: BAC34606.1
AK141742 mRNA Translation: BAE24818.1
AK159332 mRNA Translation: BAE34997.1
CH466589 Genomic DNA Translation: EDK96916.1
BC138866 mRNA Translation: AAI38867.1
BC138867 mRNA Translation: AAI38868.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14920.1 [Q3UR70-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001013043.1, NM_001013025.2 [Q3UR70-1]
XP_006496364.1, XM_006496301.3
XP_006496365.1, XM_006496302.3 [Q3UR70-1]
XP_006496366.1, XM_006496303.2 [Q3UR70-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000095014; ENSMUSP00000092624; ENSMUSG00000070939 [Q3UR70-1]
ENSMUST00000186694; ENSMUSP00000140132; ENSMUSG00000070939 [Q3UR70-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
73122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:73122

UCSC genome browser

More...
UCSCi
uc007ave.1 mouse [Q3UR70-1]
uc007avh.1 mouse [Q3UR70-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051333 mRNA Translation: BAC34606.1
AK141742 mRNA Translation: BAE24818.1
AK159332 mRNA Translation: BAE34997.1
CH466589 Genomic DNA Translation: EDK96916.1
BC138866 mRNA Translation: AAI38867.1
BC138867 mRNA Translation: AAI38868.1
CCDSiCCDS14920.1 [Q3UR70-1]
RefSeqiNP_001013043.1, NM_001013025.2 [Q3UR70-1]
XP_006496364.1, XM_006496301.3
XP_006496365.1, XM_006496302.3 [Q3UR70-1]
XP_006496366.1, XM_006496303.2 [Q3UR70-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi215781, 1 interactor
IntActiQ3UR70, 1 interactor
STRINGi10090.ENSMUSP00000092624

PTM databases

iPTMnetiQ3UR70
PhosphoSitePlusiQ3UR70

Proteomic databases

EPDiQ3UR70
MaxQBiQ3UR70
PaxDbiQ3UR70
PeptideAtlasiQ3UR70
PRIDEiQ3UR70

Genome annotation databases

EnsembliENSMUST00000095014; ENSMUSP00000092624; ENSMUSG00000070939 [Q3UR70-1]
ENSMUST00000186694; ENSMUSP00000140132; ENSMUSG00000070939 [Q3UR70-1]
GeneIDi73122
KEGGimmu:73122
UCSCiuc007ave.1 mouse [Q3UR70-1]
uc007avh.1 mouse [Q3UR70-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9392
MGIiMGI:2447427 Tgfbrap1

Phylogenomic databases

eggNOGiKOG2063 Eukaryota
ENOG410XNSX LUCA
GeneTreeiENSGT00530000063596
HOGENOMiHOG000007291
InParanoidiQ3UR70
KOiK20177
OMAiQLLPDTW
OrthoDBi682722at2759
PhylomeDBiQ3UR70
TreeFamiTF328650

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tgfbrap1 mouse

Protein Ontology

More...
PROi
PR:Q3UR70

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000070939 Expressed in 246 organ(s), highest expression level in ear
ExpressionAtlasiQ3UR70 baseline and differential
GenevisibleiQ3UR70 MM

Family and domain databases

InterProiView protein in InterPro
IPR000547 Clathrin_H-chain/VPS_repeat
IPR001180 CNH_dom
IPR032914 Vam6/VPS39/TRAP1
IPR019452 VPS39/TGF_beta_rcpt-assoc_1
IPR019453 VPS39/TGF_beta_rcpt-assoc_2
PANTHERiPTHR12894 PTHR12894, 1 hit
PfamiView protein in Pfam
PF00637 Clathrin, 1 hit
PF00780 CNH, 1 hit
PF10366 Vps39_1, 1 hit
PF10367 Vps39_2, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 1 hit
PS50219 CNH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGFA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UR70
Secondary accession number(s): Q8BKN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 11, 2005
Last modified: October 16, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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