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Entry version 103 (13 Nov 2019)
Sequence version 2 (16 Jun 2009)
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Protein

Methylcytosine dioxygenase TET1

Gene

Tet1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an essential role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).By similarity8 Publications

Caution

Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system (PubMed:21496894). According to another model, cytosine demethylation is rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi574ZincBy similarity1
Metal bindingi577ZincBy similarity1
Metal bindingi580ZincBy similarity1
Metal bindingi586ZincBy similarity1
Metal bindingi589ZincBy similarity1
Metal bindingi592ZincBy similarity1
Metal bindingi602ZincBy similarity1
Metal bindingi607ZincBy similarity1
Metal bindingi1371Zinc 1By similarity1
Metal bindingi1373Zinc 1By similarity1
Metal bindingi1430Zinc 2By similarity1
Metal bindingi1456Zinc 1; via pros nitrogenBy similarity1
Metal bindingi1458Zinc 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei14992-oxoglutarateBy similarity1
Metal bindingi1509Zinc 2By similarity1
Metal bindingi1511Zinc 2By similarity1
Metal bindingi1527Zinc 3By similarity1
Metal bindingi1536Zinc 3By similarity1
Metal bindingi1596Zinc 3By similarity1
Binding sitei16122-oxoglutarateBy similarity1
Metal bindingi1618Zinc 2; via tele nitrogenBy similarity1
Metal bindingi1620Iron; catalyticBy similarity1
Metal bindingi1622Iron; catalyticBy similarity1
Binding sitei1625SubstrateBy similarity1
Binding sitei16532-oxoglutarateBy similarity1
Metal bindingi1907Iron; catalyticBy similarity1
Metal bindingi1938Zinc 3; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri567 – 608CXXC-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Dioxygenase, DNA-binding, Oxidoreductase, Repressor
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylcytosine dioxygenase TET1 (EC:1.14.11.n22 Publications)
Alternative name(s):
CXXC-type zinc finger protein 6
Ten-eleven translocation 1 gene protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tet1
Synonyms:Cxxc6, Kiaa1676
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098693 Tet1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype; mice are viable, fertile and grossly normal, although some mice have a slightly smaller body size at birth. Embryonic stem cells (ESCs) have reduced levels of 5-hydroxymethylcytosine (5hmC) and slight changes in global gene expression, but are pluripotent and support development. Mice lacking both Tet1 and Tet2 are fertile, with females having smaller ovaries and reduced fertility. They display decreased 5hmC and abnormal methylation at various imprinted loci. ESCs lacking both Tet1 and Tet2 remain pluripotent but lack 5hmC, leading to developmental defects in chimeric embryos.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1620H → Y: Loss of enzyme activity; when associated with A-1622. 2 Publications1
Mutagenesisi1622D → A: Loss of enzyme activity; when associated with Y-1620. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003775491 – 2007Methylcytosine dioxygenase TET1Add BLAST2007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei854PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated. Interaction with OGT leads to GlcNAcylation.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3URK3

PeptideAtlas

More...
PeptideAtlasi
Q3URK3

PRoteomics IDEntifications database

More...
PRIDEi
Q3URK3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3URK3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3URK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in embryonic stem cells (ES cells).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000047146 Expressed in 201 organ(s), highest expression level in embryonic stem cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q3URK3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q3URK3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIN3A; recruits the transcriptional co-repressor SIN3A to gene promoters (PubMed:21490601).

Interacts with HCFC1 and OGT (PubMed:23352454).

Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q605202EBI-4291699,EBI-349034

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
206599, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant

Protein interaction database and analysis system

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IntActi
Q3URK3, 9 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000133279

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3URK3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni512 – 657Sufficient for binding to genomic CpG islandsBy similarityAdd BLAST146
Regioni1528 – 1541Interaction with DNABy similarityAdd BLAST14
Regioni1922 – 19242-oxoglutarate bindingBy similarity3
Regioni1928 – 1930Substrate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CXXC zinc finger mediates binding to CpG-DNA.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri567 – 608CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE22 Eukaryota
ENOG410XPWW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158935

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3URK3

Identification of Orthologs from Complete Genome Data

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OMAi
FHLKTES

Database of Orthologous Groups

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OrthoDBi
29059at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q3URK3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3
IPR002857 Znf_CXXC

The PANTHER Classification System

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PANTHERi
PTHR23358 PTHR23358, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF12851 Tet_JBP, 1 hit
PF02008 zf-CXXC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01333 Tet_JBP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058 ZF_CXXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q3URK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSRPAKPS KSVKTKLQKK KDIQMKTKTS KQAVRHGASA KAVNPGKPKQ
60 70 80 90 100
LIKRRDGKKE TEDKTPTPAP SFLTRAGAAR MNRDRNQVLF QNPDSLTCNG
110 120 130 140 150
FTMALRRTSL SWRLSQRPVV TPKPKKVPPS KKQCTHNIQD EPGVKHSEND
160 170 180 190 200
SVPSQHATVS PGTENGEQNR CLVEGESQEI TQSCPVFEER IEDTQSCISA
210 220 230 240 250
SGNLEAEISW PLEGTHCEEL LSHQTSDNEC TSPQECAPLP QRSTSEVTSQ
260 270 280 290 300
KNTSNQLADL SSQVESIKLS DPSPNPTGSD HNGFPDSSFR IVPELDLKTC
310 320 330 340 350
MPLDESVYPT ALIRFILAGS QPDVFDTKPQ EKTLITTPEQ VGSHPNQVLD
360 370 380 390 400
ATSVLGQAFS TLPLQWGFSG ANLVQVEALG KGSDSPEDLG AITMLNQQET
410 420 430 440 450
VAMDMDRNAT PDLPIFLPKP PNTVATYSSP LLGPEPHSST SCGLEVQGAT
460 470 480 490 500
PILTLDSGHT PQLPPNPESS SVPLVIAANG TRAEKQFGTS LFPAVPQGFT
510 520 530 540 550
VAAENEVQHA PLDLTQGSQA APSKLEGEIS RVSITGSADV KATAMSMPVT
560 570 580 590 600
QASTSSPPCN STPPMVERRK RKACGVCEPC QQKANCGECT YCKNRKNSHQ
610 620 630 640 650
ICKKRKCEVL KKKPEATSQA QVTKENKRPQ REKKPKVLKT DFNNKPVNGP
660 670 680 690 700
KSESMDCSRR GHGEEEQRLD LITHPLENVR KNAGGMTGIE VEKWAPNKKS
710 720 730 740 750
HLAEGQVKGS CDANLTGVEN PQPSEDDKQQ TNPSPTFAQT IRNGMKNVHC
760 770 780 790 800
LPTDTHLPLN KLNHEEFSKA LGNNSSKLLT DPSNCKDAMS VTTSGGECDH
810 820 830 840 850
LKGPRNTLLF QKPGLNCRSG AEPTIFNNHP NTHSAGSRPH PPEKVPNKEP
860 870 880 890 900
KDGSPVQPSL LSLMKDRRLT LEQVVAIEAL TQLSEAPSES SSPSKPEKDE
910 920 930 940 950
EAHQKTASLL NSCKAILHSV RKDLQDPNVQ GKGLHHDTVV FNGQNRTFKS
960 970 980 990 1000
PDSFATNQAL IKSQGYPSSP TAEKKGAAGG RAPFDGFENS HPLPIESHNL
1010 1020 1030 1040 1050
ENCSQVLSCD QNLSSHDPSC QDAPYSQIEE DVAAQLTQLA STINHINAEV
1060 1070 1080 1090 1100
RNAESTPESL VAKNTKQKHS QEKRMVHQKP PSSTQTKPSV PSAKPKKAQK
1110 1120 1130 1140 1150
KARATPHANK RKKKPPARSS QENDQKKQEQ LAIEYSKMHD IWMSSKFQRF
1160 1170 1180 1190 1200
GQSSPRSFPV LLRNIPVFNQ ILKPVTQSKT PSQHNELFPP INQIKFTRNP
1210 1220 1230 1240 1250
ELAKEKVKVE PSDSLPTCQF KTESGGQTFA EPADNSQGQP MVSVNQEAHP
1260 1270 1280 1290 1300
LPQSPPSNQC ANIMAGAAQT QFHLGAQENL VHQIPPPTLP GTSPDTLLPD
1310 1320 1330 1340 1350
PASILRKGKV LHFDGITVVT EKREAQTSSN GPLGPTTDSA QSEFKESIMD
1360 1370 1380 1390 1400
LLSKPAKNLI AGLKEQEAAP CDCDGGTQKE KGPYYTHLGA GPSVAAVREL
1410 1420 1430 1440 1450
METRFGQKGK AIRIEKIVFT GKEGKSSQGC PVAKWVIRRS GPEEKLICLV
1460 1470 1480 1490 1500
RERVDHHCST AVIVVLILLW EGIPRLMADR LYKELTENLR SYSGHPTDRR
1510 1520 1530 1540 1550
CTLNKKRTCT CQGIDPKTCG ASFSFGCSWS MYFNGCKFGR SENPRKFRLA
1560 1570 1580 1590 1600
PNYPLHEKQL EKNLQELATV LAPLYKQMAP VAYQNQVEYE EVAGDCRLGN
1610 1620 1630 1640 1650
EEGRPFSGVT CCMDFCAHSH KDIHNMHNGS TVVCTLIRAD GRDTNCPEDE
1660 1670 1680 1690 1700
QLHVLPLYRL ADTDEFGSVE GMKAKIKSGA IQVNGPTRKR RLRFTEPVPR
1710 1720 1730 1740 1750
CGKRAKMKQN HNKSGSHNTK SFSSASSTSH LVKDESTDFC PLQASSAETS
1760 1770 1780 1790 1800
TCTYSKTASG GFAETSSILH CTMPSGAHSG ANAAAGECTG TVQPAEVAAH
1810 1820 1830 1840 1850
PHQSLPTADS PVHAEPLTSP SEQLTSNQSN QQLPLLSNSQ KLASCQVEDE
1860 1870 1880 1890 1900
RHPEADEPQH PEDDNLPQLD EFWSDSEEIY ADPSFGGVAI APIHGSVLIE
1910 1920 1930 1940 1950
CARKELHATT SLRSPKRGVP FRVSLVFYQH KSLNKPNHGF DINKIKCKCK
1960 1970 1980 1990 2000
KVTKKKPADR ECPDVSPEAN LSHQIPSRVA STLTRDNVVT VSPYSLTHVA

GPYNRWV
Length:2,007
Mass (Da):219,261
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC563672511ACFFC6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9Y4E9Q9Y4_MOUSE
Methylcytosine dioxygenase TET1
Tet1
2,039Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UXI7G3UXI7_MOUSE
Methylcytosine dioxygenase TET1
Tet1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZ35G3UZ35_MOUSE
Methylcytosine dioxygenase TET1
Tet1
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZN8G3UZN8_MOUSE
Methylcytosine dioxygenase TET1
Tet1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P7E3A0A1W2P7E3_MOUSE
Methylcytosine dioxygenase TET1
Tet1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB27288 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC98231 differs from that shown. Partially unspliced pre-RNA.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC166359 Genomic DNA No translation available.
AK010953 mRNA Translation: BAB27288.1 Different initiation.
AK141438 mRNA Translation: BAE24685.1
AK129421 Transcribed RNA Translation: BAC98231.1 Sequence problems.

NCBI Reference Sequences

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RefSeqi
NP_081660.1, NM_027384.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000050826; ENSMUSP00000059527; ENSMUSG00000047146

UCSC genome browser

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UCSCi
uc007fje.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166359 Genomic DNA No translation available.
AK010953 mRNA Translation: BAB27288.1 Different initiation.
AK141438 mRNA Translation: BAE24685.1
AK129421 Transcribed RNA Translation: BAC98231.1 Sequence problems.
RefSeqiNP_081660.1, NM_027384.1

3D structure databases

SMRiQ3URK3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi206599, 11 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
IntActiQ3URK3, 9 interactors
STRINGi10090.ENSMUSP00000133279

PTM databases

iPTMnetiQ3URK3
PhosphoSitePlusiQ3URK3

Proteomic databases

PaxDbiQ3URK3
PeptideAtlasiQ3URK3
PRIDEiQ3URK3

Genome annotation databases

EnsembliENSMUST00000050826; ENSMUSP00000059527; ENSMUSG00000047146
UCSCiuc007fje.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80312
MGIiMGI:1098693 Tet1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IE22 Eukaryota
ENOG410XPWW LUCA
GeneTreeiENSGT00940000158935
InParanoidiQ3URK3
OMAiFHLKTES
OrthoDBi29059at2759
PhylomeDBiQ3URK3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tet1 mouse

Protein Ontology

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PROi
PR:Q3URK3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000047146 Expressed in 201 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ3URK3 baseline and differential
GenevisibleiQ3URK3 MM

Family and domain databases

InterProiView protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3
IPR002857 Znf_CXXC
PANTHERiPTHR23358 PTHR23358, 2 hits
PfamiView protein in Pfam
PF12851 Tet_JBP, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM01333 Tet_JBP, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3URK3
Secondary accession number(s): Q6ZPK2, Q9CY36
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 13, 2019
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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