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UniProtKB - Q45135 (Q45135_9MICO)

Entry version 89 (13 Nov 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Homoprotocatechuate 2,3-dioxygenase

Gene
N/A
Organism
Brevibacterium fuscum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi155Iron 1; via tele nitrogenCombined sources1
Metal bindingi155Iron 2; via tele nitrogenCombined sources1
Metal bindingi155Manganese; via tele nitrogenCombined sources1
Metal bindingi157Iron 1Combined sources1
Metal bindingi184CalciumCombined sources1
Metal bindingi185CalciumCombined sources1
Metal bindingi200Iron 1; via tele nitrogenCombined sources1
Metal bindingi214Iron 1; via tele nitrogenCombined sources1
Metal bindingi214Iron 2; via tele nitrogenCombined sources1
Metal bindingi214Manganese; via tele nitrogenCombined sources1
Metal bindingi257Iron 1Combined sources1
Metal bindingi267Iron 1Combined sources1
Metal bindingi267Iron 2Combined sources1
Metal bindingi267ManganeseCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenaseImported, Oxidoreductase
LigandCalciumCombined sources, IronCombined sources, ManganeseCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.13.11.15 962

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q45135

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Homoprotocatechuate 2,3-dioxygenaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacterium fuscumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri47914 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Micrococcales › Brevibacteriaceae › Brevibacterium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q45135

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q45135

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 131VOCInterPro annotationAdd BLAST115
Domaini152 – 271VOCInterPro annotationAdd BLAST120

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni345 – 365DisorderedSequence analysisAdd BLAST21

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.180.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011981 DHPA_dOase_Mn/Fe
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00903 Glyoxalase, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54593 SSF54593, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02295 HpaD, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51819 VOC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q45135-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNEIPKPVA PAPDILRCAY AELVVTDLAK SRNFYVDVLG LHVSYEDENQ 
        60         70         80         90        100
IYLRSFEEFI HHNLVLTKGP VAALKAMAFR VRTPEDVDKA EAYYQELGCR 
       110        120        130        140        150
TERRKDGFVK GIGDALRVED PLGFPYEFFF ETTHVERLHM RYDLYSAGEL 
       160        170        180        190        200
VRLDHFNQVT PDVPRGRKYL EDLGFRVTED IQDDEGTTYA AWMHRKGTVH 
       210        220        230        240        250
DTALTGGNGP RLHHVAFSTH EKHNIIQICD KMGALRISDR IERGPGRHGV 
       260        270        280        290        300
SNAFYLYILD PDNHRIEIYT QDYYTGDPDN PTITWNVHDN QRRDWWGNPV 
       310        320        330        340        350
VPSWYTEASK VLDLDGNVQE IIERTDDSEL EVTIGADGFS FTRAGDEDGS 
       360 
YHGQASKGFK LGNQL
Length:365
Mass (Da):41,699
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B589C989665BAC1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U58132 Genomic DNA Translation: AAB66502.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58132 Genomic DNA Translation: AAB66502.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F1XX-ray1.60A/B/C/D1-322[»]
1Q0CX-ray2.10A/B/C/D1-365[»]
1Q0OX-ray2.30A/B1-365[»]
2IG9X-ray1.90A/B/C/D1-365[»]
2IGAX-ray1.95A/B/C/D1-365[»]
3BZAX-ray1.70A/B/C/D1-365[»]
3ECJX-ray1.65A/B/C/D1-365[»]
3ECKX-ray1.60A/B/C/D1-365[»]
3OJJX-ray1.72A/B/C/D1-365[»]
3OJKX-ray1.68A/B/C/D1-365[»]
3OJNX-ray1.65A/B/C/D1-365[»]
3OJTX-ray1.70A/B/C/D1-365[»]
4GHCX-ray1.55A/B/C/D1-365[»]
4GHDX-ray1.85A/B/C/D1-365[»]
4GHEX-ray1.60A/B/C/D1-365[»]
4GHFX-ray1.67A/B/C/D1-365[»]
4GHGX-ray1.50A/B/C/D1-365[»]
4GHHX-ray1.55A/B/C/D1-365[»]
4Z6LX-ray1.65A/B/C/D1-365[»]
4Z6MX-ray1.35A/B/C/D1-365[»]
4Z6NX-ray1.52A/B/C/D1-365[»]
4Z6OX-ray1.63A/B/C/D1-365[»]
4Z6PX-ray1.75A/B/C/D1-365[»]
4Z6QX-ray1.57A/B/C/D1-365[»]
4Z6RX-ray1.70A/B/C/D1-365[»]
4Z6SX-ray1.42A/B/C/D1-365[»]
4Z6TX-ray1.50A/B/C/D1-365[»]
4Z6UX-ray1.48A/B/C/D1-365[»]
4Z6VX-ray1.37A/B/C/D1-365[»]
4Z6WX-ray1.57A/B/C/D1-365[»]
4Z6ZX-ray1.52A/B/C/D1-365[»]
5BWGX-ray1.75A/B/C/D1-365[»]
5BWHX-ray1.46A/B/C/D1-365[»]
5TRXX-ray2.38A/B/C/D1-365[»]
SMRiQ45135
ModBaseiSearch...
PDBe-KBiSearch...

Chemistry databases

DrugBankiDB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid

Enzyme and pathway databases

BRENDAi1.13.11.15 962
SABIO-RKiQ45135

Miscellaneous databases

EvolutionaryTraceiQ45135

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR011981 DHPA_dOase_Mn/Fe
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 2 hits
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR02295 HpaD, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ45135_9MICO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q45135
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 13, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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