Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 141 (13 Nov 2019)
Sequence version 3 (19 Feb 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

SH3 and multiple ankyrin repeat domains protein 3

Gene

Shank3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6794361 Neurexins and neuroligins
R-MMU-8853659 RET signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 3
Short name:
Shank3
Alternative name(s):
Proline-rich synapse-associated protein 2
Short name:
ProSAP2
SPANK-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shank3
Synonyms:Kiaa1650, Prosap2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1930016 Shank3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Animals deficient for isoforms 1-7 exhibit self-injourious repetitive grooming and deficits in social interaction. They show defects at striatal synapses and cortico-striatal circuits with an increase in striatal volume, dendritic length, and surface area and a decrease of spine density, length and thickness of PSD. They seem to have an altered molecular composition of postsynaptic machinery in the striatum (PubMed:21423165). In contrast, animals deficient for isoforms 1 and 2 exhibit a normal initiation of social interaction with a perturbed recognition of social novelty (PubMed:21423165). In PubMed:21558424, animals deficient for isoforms 1 and 2 show abnormal social behaviors, communication patterns, repetitive behaviors, learning and memory. In CA1 hippocampus, the synaptic plasticity is impaired with longer dendritic spines, decreased spine density and deficient long-term potentiation. The expression of specific synaptic scaffolding proteins and receptor subunits are altered. Animals deficient for isoforms 1-5 exhibit self-injourious repetitive grooming, brain-region-specific up-regulation of ionotropic glutamate receptors and increased levels of SHANK2 (PubMed:22699619). Animals deficient for predominant isoforms containing exon 21 exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty and minimal social abnormalities. They show a decrease in NMDA-AMPA excitatory postsynaptic current ratio in hippocampal CA1, reduced long-term potentiation and deficits in hippocampus-dependent spatial learning and memory (PubMed:24259569).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002912571 – 1730SH3 and multiple ankyrin repeat domains protein 3Add BLAST1730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei122PhosphotyrosineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei394PhosphoserineBy similarity1
Modified residuei482PhosphoserineCombined sources1
Modified residuei555PhosphotyrosineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei781PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Modified residuei801PhosphoserineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1
Modified residuei912PhosphothreonineBy similarity1
Modified residuei930PhosphotyrosineBy similarity1
Modified residuei965Asymmetric dimethylarginineCombined sources1
Modified residuei995PhosphoserineCombined sources1
Modified residuei1130PhosphothreonineCombined sources1
Modified residuei1134PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1163PhosphoserineBy similarity1
Modified residuei1166PhosphoserineCombined sources1
Modified residuei1234PhosphothreonineCombined sources1
Modified residuei1253PhosphoserineBy similarity1
Modified residuei1420PhosphoserineBy similarity1
Modified residuei1510PhosphoserineCombined sources1
Modified residuei1521PhosphoserineCombined sources1
Modified residuei1529PhosphoserineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1634PhosphoserineCombined sources1
Modified residuei1636PhosphoserineCombined sources1
Modified residuei1638PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4ACU6

PeptideAtlas

More...
PeptideAtlasi
Q4ACU6

PRoteomics IDEntifications database

More...
PRIDEi
Q4ACU6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4ACU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4ACU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 3 is weakly expressed at 17 dpc but its expression increases after birth.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022623 Expressed in 214 organ(s), highest expression level in medial dorsal nucleus of thalamus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4ACU6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4ACU6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May homomultimerize via its SAM domain.

Interacts with BAIAP2, DBNL and SLC17A7/VGLUT1.

Interacts with DLGAP1/GKAP, GRM1/MGLUR1, GRM5/MGLUR5 and LZTS3 C-termini via its PDZ domain.

Interacts with ABI1, HOMER1, HOMER2, HOMER3 and CTTN/cortactin SH3 domain. Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP.

Interacts (via PDZ domain) with the GRIA1 subunit of the AMPA receptor (via PDZ-binding motif).

Interacts with WASF1 and CYFIP2; the interactions mediate the association of SHANK3 with the WAVE1 complex.

Interacts with ARPC2; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.

Interacts (via ANK repeats) with SHARPIN and SPTAN1.

Interacts (via PDZ domain) with ARHGAP44 (probably via PDZ-binding motif); the interaction takes place in dendritic spines and promotes GRIA1 exocytosis.

Interacts with CAMK2A (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
208407, 163 interactors

Database of interacting proteins

More...
DIPi
DIP-32262N

Protein interaction database and analysis system

More...
IntActi
Q4ACU6, 164 interactors

Molecular INTeraction database

More...
MINTi
Q4ACU6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104932

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11730
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4ACU6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q4ACU6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati148 – 178ANK 1Add BLAST31
Repeati182 – 211ANK 2Add BLAST30
Repeati215 – 245ANK 3Add BLAST31
Repeati249 – 278ANK 4Add BLAST30
Repeati282 – 311ANK 5Add BLAST30
Repeati315 – 345ANK 6Add BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini470 – 529SH3PROSITE-ProRule annotationAdd BLAST60
Domaini570 – 664PDZPROSITE-ProRule annotationAdd BLAST95
Domaini1667 – 1730SAMPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75Intramolecular interaction with the ANK repeatsBy similarityAdd BLAST75
Regioni677 – 684Required for interaction with ABI1By similarity8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1494 – 1514Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1410 – 1416SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi435 – 462Pro-richAdd BLAST28
Compositional biasi677 – 680Poly-Pro4
Compositional biasi813 – 1349Pro-richAdd BLAST537

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In isoform 1, the N-terminal region preceding the ANK repeats interacts with the 6 ANK repeats in an intramolecular manner, thereby restricting access to ligands, such as SHARPIN and SPTAN1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SHANK family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000198621

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4ACU6

KEGG Orthology (KO)

More...
KOi
K15009

Database of Orthologous Groups

More...
OrthoDBi
98033at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4ACU6

TreeFam database of animal gene trees

More...
TreeFami
TF324593

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF17820 PDZ_6, 1 hit
PF00536 SAM_1, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 5 hits
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Additional isoform seem to exist. These isoforms may be the product of multiple intragenic promoter and/or alternative splicing.2 Publications

This entry has 10 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4ACU6-1) [UniParc]FASTAAdd to basket
Also known as: A, Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGPGASAVV VRVGIPDLQQ TKCLRLDPTA PVWAAKQRVL CALNHSLQDA
60 70 80 90 100
LNYGLFQPPS RGRAGKFLDE ERLLQDYPPN LDTPLPYLEF RYKRRVYAQN
110 120 130 140 150
LIDDKQFAKL HTKANLKKFM DYVQLHSTDK VARLLDKGLD PNFHDPDSGE
160 170 180 190 200
CPLSLAAQLD NATDLLKVLR NGGAHLDFRT RDGLTAVHCA TRQRNAGALT
210 220 230 240 250
TLLDLGASPD YKDSRGLTPL YHSALGGGDA LCCELLLHDH AQLGTTDENG
260 270 280 290 300
WQEIHQACRF GHVQHLEHLL FYGANMGAQN ASGNTALHIC ALYNQESCAR
310 320 330 340 350
VLLFRGANKD VRNYNSQTAF QVAIIAGNFE LAEVIKTHKD SDVVPFRETP
360 370 380 390 400
SYAKRRRLAG PSGLASPRPL QRSASDINLK GDQPAASPGP TLRSLPHQLL
410 420 430 440 450
LQRLQEEKDR DRDGELENDI SGPSAGRGGH NKISPSGPGG SGPAPGPGPA
460 470 480 490 500
SPAPPAPPPR GPKRKLYSAV PGRKFIAVKA HSPQGEGEIP LHRGEAVKVL
510 520 530 540 550
SIGEGGFWEG TVKGRTGWFP ADCVEEVQMR QYDTRHETRE DRTKRLFRHY
560 570 580 590 600
TVGSYDSLTS HSDYVIDDKV AILQKRDHEG FGFVLRGAKA ETPIEEFTPT
610 620 630 640 650
PAFPALQYLE SVDVEGVAWR AGLRTGDFLI EVNGVNVVKV GHKQVVGLIR
660 670 680 690 700
QGGNRLVMKV VSVTRKPEED GARRRAPPPP KRAPSTTLTL RSKSMTAELE
710 720 730 740 750
ELASIRRRKG EKLDEILAVA AEPTLRPDIA DADSRAATVK QRPTSRRITP
760 770 780 790 800
AEISSLFERQ GLPGPEKLPG SLRKGIPRTK SVGEDEKLAS LLEGRFPRST
810 820 830 840 850
SMQDTVREGR GIPPPPQTAP PPPPAPYYFD SGPPPTFSPP PPPGRAYDTV
860 870 880 890 900
RSSFKPGLEA RLGAGAAGLY DPSTPLGPLP YPERQKRARS MIILQDSAPE
910 920 930 940 950
VGDVPRPAPA ATPPERPKRR PRPSGPDSPY ANLGAFSASL FAPSKPQRRK
960 970 980 990 1000
SPLVKQLQVE DAQERAALAV GSPGPVGGSF AREPSPTHRG PRPGSLDYSS
1010 1020 1030 1040 1050
GEGLGLTFGG PSPGPVKERR LEERRRSTVF LSVGAIEGSP PSADLPSLQP
1060 1070 1080 1090 1100
SRSIDERLLG TGATTGRDLL LPSPVSALKP LVGGPSLGPS GSTFIHPLTG
1110 1120 1130 1140 1150
KPLDPSSPLA LALAARERAL ASQTPSRSPT PVHSPDADRP GPLFVDVQTR
1160 1170 1180 1190 1200
DSERGPLASP AFSPRSPAWI PVPARREAEK PPREERKSPE DKKSMILSVL
1210 1220 1230 1240 1250
DTSLQRPAGL IVVHATSNGQ EPSRLGAEEE RPGTPELAPA PMQAAAVAEP
1260 1270 1280 1290 1300
MPSPRAQPPG SIPADPGPGQ GSSEEEPELV FAVNLPPAQL SSSDEETREE
1310 1320 1330 1340 1350
LARIGLVPPP EEFANGILLT TPPPGPGPLP TTVPSPASGK PSSELPPAPE
1360 1370 1380 1390 1400
SAADSGVEEA DTRSSSDPHL ETTSTISTVS SMSTLSSESG ELTDTHTSFA
1410 1420 1430 1440 1450
DGHTFLLEKP PVPPKPKLKS PLGKGPVTFR DPLLKQSSDS ELMAQQHHAA
1460 1470 1480 1490 1500
STGLASAAGP ARPRYLFQRR SKLWGDPVES RGLPGPEDDK PTVISELSSR
1510 1520 1530 1540 1550
LQQLNKDTRS LGEEPVGGLG SLLDPAKKSP IAAARLFSSL GELSTISAQR
1560 1570 1580 1590 1600
SPGGPGGGAS YSVRPSGRYP VARRAPSPVK PASLERVEGL GAGVGGAGRP
1610 1620 1630 1640 1650
FGLTPPTILK SSSLSIPHEP KEVRFVVRSV SARSRSPSPS PLPSPSPGSG
1660 1670 1680 1690 1700
PSAGPRRPFQ QKPLQLWSKF DVGDWLESIH LGEHRDRFED HEIEGAHLPA
1710 1720 1730
LTKEDFVELG VTRVGHRMNI ERALRQLDGS
Length:1,730
Mass (Da):185,397
Last modified:February 19, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1343F857BE3EECD8
GO
Isoform 2 (identifier: Q4ACU6-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MDGPGASAVV...NLDTPLPYLE → MGLCGSLLPTFSLSEQ
     703-710: Missing.
     784-790: EDEKLAS → SSAASVS
     791-1730: Missing.

Note: Produced by alternative promoter usage and alternative splicing.
Show »
Length:709
Mass (Da):77,277
Checksum:i5CF7C46C7DC4B486
GO
Isoform 4 (identifier: Q4ACU6-3) [UniParc]FASTAAdd to basket
Also known as: C3, Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: MDGPGASAVV...SAGRGGHNKI → MEAPGAGFACPLPPGIASVTYVFVY

Note: Produced by alternative splicing of isoform 3.
Show »
Length:1,322
Mass (Da):140,218
Checksum:i4F90D15CB93B334C
GO
Isoform 5 (identifier: Q4ACU6-6) [UniParc]FASTAAdd to basket
Also known as: C4

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: MDGPGASAVV...SAGRGGHNKI → MEAPGAGFACPLPPGIASVTYVFVY
     784-790: EDEKLAS → SSAASVS
     791-1730: Missing.

Note: Produced by alternative splicing of isoform 3.
Show »
Length:382
Mass (Da):41,168
Checksum:i27B9B22AB57A32EE
GO
Isoform 6 (identifier: Q4ACU6-7) [UniParc]FASTAAdd to basket
Also known as: D1

The sequence of this isoform differs from the canonical sequence as follows:
     1-536: MDGPGASAVV...VQMRQYDTRH → MLPA

Note: Produced by alternative promoter usage.
Show »
Length:1,198
Mass (Da):127,378
Checksum:iFBDB744E8EC00FB4
GO
Isoform 7 (identifier: Q4ACU6-8) [UniParc]FASTAAdd to basket
Also known as: D2

The sequence of this isoform differs from the canonical sequence as follows:
     1-589: MDGPGASAVV...GFGFVLRGAK → MLVNAFYLALPA

Note: Produced by alternative splicing of isoform 6.
Show »
Length:1,153
Mass (Da):122,073
Checksum:iC61D0CF8C4EE18F1
GO
Isoform 8 (identifier: Q4ACU6-9) [UniParc]FASTAAdd to basket
Also known as: E1

The sequence of this isoform differs from the canonical sequence as follows:
     1-675: MDGPGASAVV...KPEEDGARRR → MKKFASSRSL...RRAKASLFFA

Note: Produced by alternative promoter usage.
Show »
Length:1,112
Mass (Da):118,003
Checksum:i749558749E5CCD1D
GO
Isoform 9 (identifier: Q4ACU6-10) [UniParc]FASTAAdd to basket
Also known as: E2

The sequence of this isoform differs from the canonical sequence as follows:
     1-675: MDGPGASAVV...KPEEDGARRR → MKKFASSRSL...RRAKASLFFA
     703-710: Missing.

Note: Produced by alternative splicing of isoform 8.
Show »
Length:1,104
Mass (Da):117,078
Checksum:i1133661F14C1619A
GO
Isoform 3 (identifier: Q4ACU6-11) [UniParc]FASTAAdd to basket
Also known as: C1

The sequence of this isoform differs from the canonical sequence as follows:
     1-528: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:1,202
Mass (Da):128,053
Checksum:iD2247B82002EFA7E
GO
Isoform 10 (identifier: Q4ACU6-12) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-890: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:840
Mass (Da):88,196
Checksum:iFD0680BF85041222
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A571BEU3A0A571BEU3_MOUSE
SH3 and multiple ankyrin repeat dom...
Shank3
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VH81A0A2R8VH81_MOUSE
SH3 and multiple ankyrin repeat dom...
Shank3
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q1P5E9Q1P5_MOUSE
SH3 and multiple ankyrin repeat dom...
Shank3
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A589M675A0A589M675_MOUSE
SH3 and multiple ankyrin repeat dom...
Shank3
768Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0536061 – 890Missing in isoform 10. CuratedAdd BLAST890
Alternative sequenceiVSP_0536071 – 675MDGPG…GARRR → MKKFASSRSLNKILAQCDSS SREYEEVQAVERKWHLHLAT PRRLLLDRRAKASLFFA in isoform 8 and isoform 9. CuratedAdd BLAST675
Alternative sequenceiVSP_0536081 – 589MDGPG…LRGAK → MLVNAFYLALPA in isoform 7. CuratedAdd BLAST589
Alternative sequenceiVSP_0536091 – 536MDGPG…YDTRH → MLPA in isoform 6. CuratedAdd BLAST536
Alternative sequenceiVSP_0536101 – 528Missing in isoform 3. 1 PublicationAdd BLAST528
Alternative sequenceiVSP_0536111 – 433MDGPG…GHNKI → MEAPGAGFACPLPPGIASVT YVFVY in isoform 4 and isoform 5. 1 PublicationAdd BLAST433
Alternative sequenceiVSP_0536121 – 89MDGPG…LPYLE → MGLCGSLLPTFSLSEQ in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_053613703 – 710Missing in isoform 2 and isoform 9. 1 Publication8
Alternative sequenceiVSP_053614784 – 790EDEKLAS → SSAASVS in isoform 2 and isoform 5. 1 Publication7
Alternative sequenceiVSP_053615791 – 1730Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST940

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ245904 mRNA Translation: CAB89816.1
AB841411 mRNA Translation: BAN67189.1
AB841412 mRNA Translation: BAN67190.1
AC122401 Genomic DNA No translation available.
AC137513 Genomic DNA No translation available.
AB231013 mRNA Translation: BAE16756.1
AK173228 mRNA Translation: BAD32506.1
HQ405757 mRNA Translation: AEB77764.1
HQ405758 mRNA Translation: AEB77765.1
HQ405759 mRNA Translation: AEB77766.1
HQ405760 mRNA Translation: AEB77767.1
HQ405761 mRNA Translation: AEB77768.1
HQ405762 mRNA Translation: AEB77769.1
HQ405763 mRNA Translation: AEB77770.1

NCBI Reference Sequences

More...
RefSeqi
NP_067398.2, NM_021423.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000109309; ENSMUSP00000104932; ENSMUSG00000022623 [Q4ACU6-1]
ENSMUST00000230807; ENSMUSP00000155608; ENSMUSG00000022623 [Q4ACU6-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:58234

UCSC genome browser

More...
UCSCi
uc007xha.2 mouse [Q4ACU6-1]
uc007xhb.2 mouse [Q4ACU6-2]
uc033gwe.1 mouse [Q4ACU6-3]
uc033gwf.1 mouse [Q4ACU6-6]
uc056zac.1 mouse [Q4ACU6-10]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245904 mRNA Translation: CAB89816.1
AB841411 mRNA Translation: BAN67189.1
AB841412 mRNA Translation: BAN67190.1
AC122401 Genomic DNA No translation available.
AC137513 Genomic DNA No translation available.
AB231013 mRNA Translation: BAE16756.1
AK173228 mRNA Translation: BAD32506.1
HQ405757 mRNA Translation: AEB77764.1
HQ405758 mRNA Translation: AEB77765.1
HQ405759 mRNA Translation: AEB77766.1
HQ405760 mRNA Translation: AEB77767.1
HQ405761 mRNA Translation: AEB77768.1
HQ405762 mRNA Translation: AEB77769.1
HQ405763 mRNA Translation: AEB77770.1
RefSeqiNP_067398.2, NM_021423.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O5NX-ray1.83A/B/C/D/E/F/G/H562-669[»]
5IZUX-ray2.49A/C533-665[»]
SMRiQ4ACU6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi208407, 163 interactors
DIPiDIP-32262N
IntActiQ4ACU6, 164 interactors
MINTiQ4ACU6
STRINGi10090.ENSMUSP00000104932

PTM databases

iPTMnetiQ4ACU6
PhosphoSitePlusiQ4ACU6

Proteomic databases

PaxDbiQ4ACU6
PeptideAtlasiQ4ACU6
PRIDEiQ4ACU6

Genome annotation databases

EnsembliENSMUST00000109309; ENSMUSP00000104932; ENSMUSG00000022623 [Q4ACU6-1]
ENSMUST00000230807; ENSMUSP00000155608; ENSMUSG00000022623 [Q4ACU6-6]
GeneIDi58234
KEGGimmu:58234
UCSCiuc007xha.2 mouse [Q4ACU6-1]
uc007xhb.2 mouse [Q4ACU6-2]
uc033gwe.1 mouse [Q4ACU6-3]
uc033gwf.1 mouse [Q4ACU6-6]
uc056zac.1 mouse [Q4ACU6-10]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85358
MGIiMGI:1930016 Shank3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000153561
HOGENOMiHOG000198621
InParanoidiQ4ACU6
KOiK15009
OrthoDBi98033at2759
PhylomeDBiQ4ACU6
TreeFamiTF324593

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins
R-MMU-8853659 RET signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Shank3 mouse
EvolutionaryTraceiQ4ACU6

Protein Ontology

More...
PROi
PR:Q4ACU6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022623 Expressed in 214 organ(s), highest expression level in medial dorsal nucleus of thalamus
ExpressionAtlasiQ4ACU6 baseline and differential
GenevisibleiQ4ACU6 MM

Family and domain databases

Gene3Di1.10.150.50, 1 hit
1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF17820 PDZ_6, 1 hit
PF00536 SAM_1, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHAN3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4ACU6
Secondary accession number(s): F8S0X0
, F8S0X2, F8S0X3, F8S0X5, F8S0X6, Q69ZD8, Q9JJZ3, S6BMD3, S6CCV8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 19, 2014
Last modified: November 13, 2019
This is version 141 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again