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Entry version 39 (08 May 2019)
Sequence version 1 (02 Aug 2005)
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Protein
Submitted name:

Hsf

Gene
N/A
Organism
Haemophilus influenzae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HsfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaemophilus influenzaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri727 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
VTNP0400412EBI-12501515,EBI-1036653From Homo sapiens.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q4KTX9, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 24ESPRInterPro annotationAdd BLAST24
Domaini254 – 320TAA-Trp-ringInterPro annotationAdd BLAST67
Domaini540 – 591HiaBD2InterPro annotationAdd BLAST52
Domaini603 – 651Trp_ringInterPro annotationAdd BLAST49
Domaini920 – 986TAA-Trp-ringInterPro annotationAdd BLAST67
Domaini1217 – 1261HiaBD2InterPro annotationAdd BLAST45
Domaini1283 – 1337Trp_ringInterPro annotationAdd BLAST55
Domaini1619 – 1686TAA-Trp-ringInterPro annotationAdd BLAST68
Domaini1907 – 1957HiaBD2InterPro annotationAdd BLAST51
Domaini1969 – 2020Trp_ringInterPro annotationAdd BLAST52
Domaini2031 – 2108TAA-Trp-ringInterPro annotationAdd BLAST78
Domaini2353 – 2413YadA_anchorInterPro annotationAdd BLAST61

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.150.10.10, 1 hit
3.90.1780.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024973 ESPR
IPR029275 HiaBD2_put_GIN_domain
IPR011049 Serralysin-like_metalloprot_C
IPR028230 TAA-Trp-ring
IPR037174 Trimeric_adhesin
IPR040482 Trp_ring
IPR005594 YadA_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13018 ESPR, 1 hit
PF15403 HiaBD2, 3 hits
PF15401 TAA-Trp-ring, 4 hits
PF18669 Trp_ring, 3 hits
PF03895 YadA_anchor, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4KTX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKIFNVIWN VMTQTWVVVS ELTRTHTKRA SATVETAVLA TLLFATVQAN
60 70 80 90 100
ATDEDEELDP VVRTAPVLSF HSDKEGTGEK EVTENSNWGI YFDNKGVLKA
110 120 130 140 150
GAITLKAGDN LKIKQNTDES TNASSFTYSL KKDLTDLTSV ATEKLSFGAN
160 170 180 190 200
GDKVDITSDA NGLKLAKTGN GNVHLNGLDS TLPDAVTNTG VLSSSSFTPN
210 220 230 240 250
DVEKTRAATV KDVLNAGWNI KGAKTAGGNV ESVDLVSAYN NVEFITGDKN
260 270 280 290 300
TLDVVLTAKE NGKTTEVKFT PKTSVIKEKD GKLFTGKENN DTNKVTSNTA
310 320 330 340 350
TDNTDEGNGL VTAKAVIDAV NKAGWRVKTT TANGQNGDFA TVASGTNVTF
360 370 380 390 400
ESGDGTTASV TKDTNGNGIT VKYDAKVGDG LKFDSDKKIV ADTTALTVTG
410 420 430 440 450
GKVAEIAKED DKKKLVNAGD LVTALGNLSW KAKAEADTDG ALEGISKDQE
460 470 480 490 500
VKAGETVTFK AGKNLKVKQD GANFTYSLQD ALTGLTSITL GGTTNGGNDA
510 520 530 540 550
KTVINKDGLT ITPAGNGGTT GTNTISVTKD GIKAGNKAIT NVASGLRAYD
560 570 580 590 600
DANFDVLNNS ATDLNRHVED AYKGLLNLNE KNANKQPLVT DSTAATVGDL
610 620 630 640 650
RKLGWVVSTK NGTKEESNQV KQADEVLFTG AGAATVTSKS ENGKHTITVS
660 670 680 690 700
VAETKADSGL EKDGDTIKLK VDNQNTDNVL TVGNNGTAVT KGGFETVKTG
710 720 730 740 750
ATDADRGKVT VKDATANDAD KKVATVKDVA TAINSAATFV KTENLTTSID
760 770 780 790 800
EDNPTDNGKD DALKAGDTLT FKAGKNLKVK RDGKNITFDL AKNLEVKTAK
810 820 830 840 850
VSDTLTIGGN TPTGGTTATP KVNITSTADG LNFAKETADA SGSKNVYLKG
860 870 880 890 900
IATTLTEPSA GAKSSHVDLN VDATKKSNAA SIEDVLRAGW NIQGNGNNVD
910 920 930 940 950
YVATYDTVNF TDDSTGTTTV TVTQKADGKG ADVKIGAKTS VIKDHNGKLF
960 970 980 990 1000
TGKGLKDANN GATVSEDDGK DTGTGLVTAK TVIDAVNKSG WRVTGEGATA
1010 1020 1030 1040 1050
ETGATAVNAG NAETVTSGTS VNFKNGNATT ATVSKDNGNI NVKYDVNVGD
1060 1070 1080 1090 1100
GLKIGDDKKI VADTTTLTVT GGKVSVPAGA NSVNNNKKLV NAEGLATALN
1110 1120 1130 1140 1150
NLSWTAKADK YADGESEGET DQEVKAGDKV TFKAGKNLKV KQSEKDFTYS
1160 1170 1180 1190 1200
LQDTLTGLTS ITLGGTANGR NDTGTVINKD GLTITLANGA AAGTDASNGN
1210 1220 1230 1240 1250
TISVTKDGIS AGNKEITNVK SALKTYKDTQ NTAGATQPAA NTAEVAKQDL
1260 1270 1280 1290 1300
VDLTKPATGA AGNGADAKAP DTTAATVGDL RGLGWVLSAK KTADETQDKE
1310 1320 1330 1340 1350
FHAAVKNANE VEFVGKNGAT VSAKTDNNGK HTVTIDVAEA KVGDGLEKDT
1360 1370 1380 1390 1400
DGKIKLKVDN TDGNNLLTVD ATKGASVAKG EFNAVTTDAT TAQGTNANER
1410 1420 1430 1440 1450
GKVVVKGSNG ATATETDKKK VATVGDVAKA INDAATFVKV ENDDSATIDD
1460 1470 1480 1490 1500
SPTDDGANDA LKAGDTLTLK AGKNLKVKRD GKNITFALAN DLSVKSATVS
1510 1520 1530 1540 1550
DKLSLGTNGN KVNITSDTKG LNFAKDSKTG DDANIHLNGI ASTLTDTLLN
1560 1570 1580 1590 1600
SGATTNLGGN GITDNEKKRA ASVKDVLNAG WNVRGVKPAS ANNQVENIDF
1610 1620 1630 1640 1650
VATYDTVDFV SGDKDTTSVT VESKDNGKRT EVKIGAKTSV IKDHNGKLFT
1660 1670 1680 1690 1700
GKELKDANNN GVTVTETDGK DEGNGLVTAK AVIDAVNKAG WRVKTTGANG
1710 1720 1730 1740 1750
QNDDFATVAS GTNVTFADGN GTTAEVTKAN DGSIAVKYNV KVADGLKLDG
1760 1770 1780 1790 1800
DKIVADTTVL TVADGKVTAP NNGDGKKFVD ASGLADALNK LSWTATAGKE
1810 1820 1830 1840 1850
GTGEVDPANS AGQEVKAGDK VTFKAGDNLK IKQSGKDFTY SLKKELKDLT
1860 1870 1880 1890 1900
SVEFKDANGG TGSESTKITK DGLTITPAHG AGAAGANTAN TISVTKDGIS
1910 1920 1930 1940 1950
AGNKAVTNVV SGLKKFGDGH TLANGTVADF EKHYDNAYKD LTNLDEKGAD
1960 1970 1980 1990 2000
NNPTVADNTA ATVGDLRGLG WVISADKTTG EPNQEYNAQV RNANEVKFKS
2010 2020 2030 2040 2050
GNGINVSGKT LNGTRVITFE LAKGEVVKSN EFTVKNADGS ETNLVKVGDM
2060 2070 2080 2090 2100
YYSKEDIDPA TSKPMTGKTE KYKVENGKVV SANGSKTEVT LTNKGSGYVT
2110 2120 2130 2140 2150
GNQVADAIAK SGFELGLADA AEAEKAFAES AKDKQLSKDK AETVNAHDKV
2160 2170 2180 2190 2200
RFANGLNTKV SAATVESTDA NGDKVTTTFV KTDVELPLTQ IYNTDANGNK
2210 2220 2230 2240 2250
IVKKADGKWY ELNADGTASN KEVTLGNVDA NGKKVVKVTE NGADKWYYTS
2260 2270 2280 2290 2300
ADGAADKTKG EVSNDKVSTD EKHVVRLDPN NQSNGKGVVI DNVANGEISA
2310 2320 2330 2340 2350
TSTDAINGSQ LYAVAKGVTN LAGQVNNLEG KVNKVGKRAD AGTASALAAS
2360 2370 2380 2390 2400
QLPQATMPGK SMVAIAGSSY QGQNGLAIGV SRISDNGKVI IRLSGTTNSQ
2410
GKTGVAAGVG YQW
Length:2,413
Mass (Da):249,525
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC383EE95CF46C70C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY823627 Genomic DNA Translation: AAX33325.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823627 Genomic DNA Translation: AAX33325.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ4KTX9, 1 interactor

Family and domain databases

Gene3Di2.150.10.10, 1 hit
3.90.1780.10, 9 hits
InterProiView protein in InterPro
IPR024973 ESPR
IPR029275 HiaBD2_put_GIN_domain
IPR011049 Serralysin-like_metalloprot_C
IPR028230 TAA-Trp-ring
IPR037174 Trimeric_adhesin
IPR040482 Trp_ring
IPR005594 YadA_C
PfamiView protein in Pfam
PF13018 ESPR, 1 hit
PF15403 HiaBD2, 3 hits
PF15401 TAA-Trp-ring, 4 hits
PF18669 Trp_ring, 3 hits
PF03895 YadA_anchor, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4KTX9_HAEIF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4KTX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: May 8, 2019
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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