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Entry version 36 (31 Jul 2019)
Sequence version 2 (15 May 2007)
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Protein
Submitted name:

1,3-beta-D-glucan synthase subunit

Gene

FKS1

Organism
Pichia kudriavzevii (Yeast) (Issatchenkia orientalis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT48 Glycosyltransferase Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
1,3-beta-D-glucan synthase subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKS1Imported
ORF Names:C5L36_0E04550Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPichia kudriavzevii (Yeast) (Issatchenkia orientalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4909 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaePichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000249293 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei509 – 528HelicalSequence analysisAdd BLAST20
Transmembranei548 – 571HelicalSequence analysisAdd BLAST24
Transmembranei577 – 605HelicalSequence analysisAdd BLAST29
Transmembranei693 – 714HelicalSequence analysisAdd BLAST22
Transmembranei1369 – 1390HelicalSequence analysisAdd BLAST22
Transmembranei1456 – 1476HelicalSequence analysisAdd BLAST21
Transmembranei1482 – 1500HelicalSequence analysisAdd BLAST19
Transmembranei1577 – 1595HelicalSequence analysisAdd BLAST19
Transmembranei1607 – 1628HelicalSequence analysisAdd BLAST22
Transmembranei1649 – 1672HelicalSequence analysisAdd BLAST24
Transmembranei1678 – 1703HelicalSequence analysisAdd BLAST26
Transmembranei1811 – 1833HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075260

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini316 – 426FKS1_dom1InterPro annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 118DisorderedSequence analysisAdd BLAST118
Regioni267 – 289DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 37PolarSequence analysisAdd BLAST37
Compositional biasi46 – 82PolarSequence analysisAdd BLAST37

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4U2W2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDDHYDPN RSQQGGQYDP AYQYDQQQYN QQYDPNVAAY GQEGYDPNYQ
60 70 80 90 100
YQQQQPQQGG YYDEQQYGGG QYYQNQQGGG YYDQPGQHDP ESYSDFSYGP
110 120 130 140 150
GGVPGTPYDN GNGNGGYGAN YTPSQMSYGD PRSSGASTPY YGAGANGMYD
160 170 180 190 200
QGMIALPTDP YPAWTADNEA PVTIEQIEDI FIDLTNKFGF QRDSMRNMFD
210 220 230 240 250
YFMVLLDSRS SRMTPAQALL SLHADYIGGD AANYKKWYFA CQMDIDDRVG
260 270 280 290 300
FANIDLGKIK NSKKKSKKSI FKRSKKNKEE QPVENSENVL QEIENDDSLQ
310 320 330 340 350
AADYQWRARM NILSPMERVQ DIALWLLIWG EANQVRFTPE CLCFIYKCAK
360 370 380 390 400
DYLLSDQCQN RLEPIPEGDY LNRVITPIYR FIRDQVYEIV DGRFVKREND
410 420 430 440 450
HNKVVGYDDV NQLFWYPQGL ARMHVGETRL IDLPQEERYF QLGEIDWNQT
460 470 480 490 500
FVKTYKETRS WLHVVTNFNR IWVAHISVYW MYCAYNSPSL YTHNYVQVLN
510 520 530 540 550
NQPLASSRWA SATIGGAVAS GINILATLFE WMYVPRSWAG AQHLTRRLVF
560 570 580 590 600
LIILFAVNLA PVIFVFAYAG LTYKSTAALA VSIVFFFVAV ATIVYLTVMP
610 620 630 640 650
LGGLFSSYMK GNSRRYVAQQ TFTASFAPLH GLDRYLSYLV WVTVFAAKFS
660 670 680 690 700
ESYYFLILSI RDPIRDLSTM TMRCHGEKWW GNKLCKQQAR ITLGLMYATD
710 720 730 740 750
LILFFLDTYM WYIIVNTIFS VGRSFYLGIS ILTPWRNIFS RLPKRIYSKV
760 770 780 790 800
LATTDMEIKY KPKVLISQVW NAIVISMYRE HLLAIDHVQK LLYHQVPSDV
810 820 830 840 850
EGKRTLRAPT FFVSQDDNNF TTEFFPKDSE AERRISFFAQ SLATPIPEPL
860 870 880 890 900
PVDNMPTFTV FTPHYSEKIL LSLKEIIRED DQFSRVTLLE YLKQLHPVEW
910 920 930 940 950
DCFVKDTKIL AEETVAFEDE KEDDVKQEID DLPFYCIGFK SAAPEYTLRT
960 970 980 990 1000
RIWASLRSQT LYRTVSGFMN YARAIKLLYR VENPEIVQMF GGNAEGLERE
1010 1020 1030 1040 1050
LERMARRKFK FVVAMQRLAK FKKEELENAE FLLRAYPDLQ ISYLDEEPPL
1060 1070 1080 1090 1100
EEGGEPRIYS ALIDGHCEIM SNERRRPKFR VQISGNPILG DGKSDNQNHS
1110 1120 1130 1140 1150
IIFTRGEYLQ LIDANQDNYL EECLKIRSVL AEFEELNVEH VNPYAPTLSK
1160 1170 1180 1190 1200
EPVKVTHPVA IVGAREYIFS ENAGVLGDIA AGKEQTFGTL FARTLAQIGG
1210 1220 1230 1240 1250
KLHYGHPDFL NSIYMLTRGG VSKAQKGLHL NEDIYAGMTA MLRGGRIKHC
1260 1270 1280 1290 1300
EYYQCGKGRD LGFGSILNFT TKIGAGMGEQ MLSREYYYLG TQLPLDRFFS
1310 1320 1330 1340 1350
FYYAHLGFHI NNLFISTSLQ MFMLTLVNIN SLAHESIVCI YDKNKPITDV
1360 1370 1380 1390 1400
LYPLGCYNLA PAIDWIRRYT LSIFIVFFIS FVPLVVQELI ERGIWKMCYR
1410 1420 1430 1440 1450
FIRHISSLSP LFEVFVAQVY STALINDVSI GGARYIATGR GFATSRIPFS
1460 1470 1480 1490 1500
VLYSRFAEGT IYVGARCSII LLFGTIAHWQ PALLWFWTII VALMFSPFVF
1510 1520 1530 1540 1550
NPHQFAREDY FIDYRDYIRW LSRGNTKWHR NSWIGYVRLA RSRVTGFKRK
1560 1570 1580 1590 1600
TIGDESEKAA GDAPRAHRTT VLMSDTIPCA IYCAGLFVGY TFINAQTGVR
1610 1620 1630 1640 1650
DAKMVNATLR LIICALGPIV INCGVLFVTL GMSCCSGPLF GMCCKKTGAV
1660 1670 1680 1690 1700
MAGIAHGVAV IVHIVFYIVM WVMEGFHFAR MLLGLITMIY IQRLIFKCIT
1710 1720 1730 1740 1750
LFVLTREFKN DHSNVAFWTG KWYGSGLGLA AWSQPSREFC AKIIELSHFA
1760 1770 1780 1790 1800
GDFVLGHVLL FCQLPLVLIP TIDRWHSMML FWLKPNRQIR PPIYSLKQAR
1810 1820 1830 1840 1850
LRKRMIKKYS VLYYTVLVIF VALIAAPAVV GGLKNVNVTP TDLPEFADGL
1860 1870 1880
FQPRHQNNND TGFGSGSYHP HWTTTTSLVT FSTKK
Length:1,885
Mass (Da):215,927
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i625EE3C65640AC4F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF426563 Genomic DNA Translation: AAY40291.2
CP028777 Genomic DNA Translation: AWU78400.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF426563 Genomic DNA Translation: AAY40291.2
CP028777 Genomic DNA Translation: AWU78400.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

ChEMBLiCHEMBL1075260

Protein family/group databases

CAZyiGT48 Glycosyltransferase Family 48

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4U2W2_PICKU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4U2W2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: May 15, 2007
Last modified: July 31, 2019
This is version 36 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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