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Entry version 87 (05 Jun 2019)
Sequence version 1 (24 May 2005)
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Protein
Submitted name:

Uncharacterized protein

Gene

AF310889_1

Organism
Dictyostelium discoideum (Slime mold)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-203641 NOSTRIN mediated eNOS trafficking
R-DDI-432720 Lysosome Vesicle Biogenesis
R-DDI-432722 Golgi Associated Vesicle Biogenesis
R-DDI-437239 Recycling pathway of L1
R-DDI-8856828 Clathrin-mediated endocytosis
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AF310889_1Imported
ORF Names:DDB0201634Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0291984

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54DN5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0201634

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 83CSInterPro annotationAdd BLAST83
Domaini88 – 147SH3InterPro annotationAdd BLAST60
Domaini374 – 435SH3InterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 170DisorderedSequence analysisAdd BLAST29
Regioni204 – 237DisorderedSequence analysisAdd BLAST34
Regioni269 – 339DisorderedSequence analysisAdd BLAST71
Regioni356 – 376DisorderedSequence analysisAdd BLAST21
Regioni435 – 890DisorderedSequence analysisAdd BLAST456

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi447 – 482PolarSequence analysisAdd BLAST36
Compositional biasi505 – 521PolyampholyteSequence analysisAdd BLAST17
Compositional biasi522 – 536PolarSequence analysisAdd BLAST15
Compositional biasi550 – 579PolarSequence analysisAdd BLAST30
Compositional biasi605 – 620Pro-richSequence analysisAdd BLAST16
Compositional biasi629 – 674PolarSequence analysisAdd BLAST46
Compositional biasi689 – 705PolarSequence analysisAdd BLAST17
Compositional biasi721 – 738PolarSequence analysisAdd BLAST18
Compositional biasi739 – 755Pro-richSequence analysisAdd BLAST17
Compositional biasi758 – 782PolarSequence analysisAdd BLAST25
Compositional biasi859 – 874PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0506 Eukaryota
COG2066 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54DN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVTRIYQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR007052 CS_dom
IPR015868 Glutaminase
IPR008978 HSP20-like_chaperone
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04969 CS, 1 hit
PF04960 Glutaminase, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764 SSF49764, 1 hit
SSF50044 SSF50044, 2 hits
SSF56601 SSF56601, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51203 CS, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54DN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKWHQSNNL VYVTFNIPAN VTKQDIHAEI TSSSIGLGVK GFGLNCEGTL
60 70 80 90 100
FSSIKGSKWA IKDDTVQVQM DKQQTGVKWS HLLSEITESN AKAVVLFEYE
110 120 130 140 150
ATSEEELSLI PHQVIDIISK DDSGWWEGSK QQMNGVFPSN FVQEFPTDYQ
160 170 180 190 200
PPEDEDASAE ATKEEEISKP ISQVSRLGIN ISLGSMDELK NKLANRKTAT
210 220 230 240 250
YTSADIEEAH NNNNASNEES NSSSSSSSSS NINSSGGFVA VKPSGAVNTQ
260 270 280 290 300
QRQPGKVLLN NRQSTILSGV PPAIQSIPSS NTNTTTTTNT TPAVQPLIQL
310 320 330 340 350
KPKQTNTEIN TSGNSIPATT SKESQSTKEE SSSGGNKITS LFKKPLKKIT
360 370 380 390 400
AISALTGSHS SNESSSGGDK NNSGSKTKAK VVYDFESKEP NELNLKKGDI
410 420 430 440 450
IVVLAKDSSG WWQGINQSTQ ATGWFSNTFV EEIKEEKLPP PPSSSENKQP
460 470 480 490 500
LKIVKSPPPK SSSSSQPQTV EAKLQSLSDT PKLETARKAG AAKGRKPPSR
510 520 530 540 550
VRASYLLSDD EKAEREKLKQ SFYSHVVSSQ KELSMYDNNE DGGEHLSDDD
560 570 580 590 600
QPSTPPSISR SGGSFTPTQQ QQQQSVDKPI ERPSKPPPPK RTAAMNSSLN
610 620 630 640 650
NINEPPPPSN KPPPPPKSLK PLSTSDGYEP PSPPSSSSTT PITTSGEDTL
660 670 680 690 700
QKSPTLQRKV APPPQQQNEQ DLPSSLVGKP PPLKPTPKPR AIQTNSESTA
710 720 730 740 750
PAPTPSHEVN FKANLKPAKP SSPPIGNSQE IPTDTSSPPN ATTPQPTPPP
760 770 780 790 800
LKRVAKPPVQ QQQPSNENIE NITQFKLKPS PASPTSPSSP TIDPISTTTK
810 820 830 840 850
PPARPPLKKS AAAAAPPSPP NEEATTTSPP TLAAKPKVAL RNGPSSAPTS
860 870 880 890 900
PLSQPQQPLP PSTHKRNLSN PNTTNNEKPP PPTKKPQLIK PLPQFNDICV
910 920 930 940 950
EVSNICNEIQ ERSDNSQETT TTFKHNYPSL IDSFFSVAVC SNDGQFWGND
960 970 980 990 1000
DQLNDHCVPM FQVIYPFLYS ILCEEIGLDE VSKFISDQAR PDSYDNQKPL
1010 1020 1030 1040 1050
NDQKKSHNPF TLAGQLITAN LFTGKYPNAV TRIYQFLNII QELVNCSSVS
1060 1070 1080 1090 1100
CDMVSYLSQK SETSDEILVG HLLKSSGLIK QPDDVLDFFY QINSIQLNSK
1110 1120 1130 1140 1150
QVSVLAATLA NDGVCPFSQD LKLAPKNIIS KTIDLIRICN STPITSSIFD
1160 1170 1180 1190 1200
NNIDNINNSK IIPILSDSGV LMIIIPGLMG VSIISPCNNN NNNNNNNNDN
1210 1220
FNHYPNNNHI EFCKKLCSIL DQ
Length:1,222
Mass (Da):132,532
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE895FBFE4DE74FC4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI01000265 Genomic DNA Translation: EAL61348.1

NCBI Reference Sequences

More...
RefSeqi
XP_629837.1, XM_629835.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8628518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0291984

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI01000265 Genomic DNA Translation: EAL61348.1
RefSeqiXP_629837.1, XM_629835.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0201634

Proteomic databases

PaxDbiQ54DN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8628518
KEGGiddi:DDB_G0291984

Organism-specific databases

dictyBaseiDDB_G0291984

Phylogenomic databases

eggNOGiKOG0506 Eukaryota
COG2066 LUCA
InParanoidiQ54DN5
OMAiAVTRIYQ

Enzyme and pathway databases

ReactomeiR-DDI-203641 NOSTRIN mediated eNOS trafficking
R-DDI-432720 Lysosome Vesicle Biogenesis
R-DDI-432722 Golgi Associated Vesicle Biogenesis
R-DDI-437239 Recycling pathway of L1
R-DDI-8856828 Clathrin-mediated endocytosis
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR007052 CS_dom
IPR015868 Glutaminase
IPR008978 HSP20-like_chaperone
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF04960 Glutaminase, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 2 hits
SUPFAMiSSF49764 SSF49764, 1 hit
SSF50044 SSF50044, 2 hits
SSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ54DN5_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54DN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 5, 2019
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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