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Entry version 92 (03 Jul 2019)
Sequence version 2 (18 Mar 2008)
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Protein

Exportin-1

Gene

xpo1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-5687128 MAPK6/MAPK4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-1
Short name:
Exp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xpo1
Synonyms:crm1
ORF Names:DDB_G0291306
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0291306 xpo1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003284791 – 1057Exportin-1Add BLAST1057

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q54EV7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a nuclear export receptor complex.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0234066

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q54EV7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 102Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati239 – 275HEAT 1Add BLAST37
Repeati281 – 321HEAT 2Add BLAST41
Repeati462 – 501HEAT 3Add BLAST40
Repeati506 – 544HEAT 4Add BLAST39
Repeati551 – 588HEAT 5Add BLAST38
Repeati596 – 633HEAT 6Add BLAST38
Repeati739 – 776HEAT 7Add BLAST38
Repeati781 – 818HEAT 8Add BLAST38
Repeati855 – 892HEAT 9Add BLAST38
Repeati902 – 925HEAT 10Add BLAST24
Repeati926 – 965HEAT 11Add BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2020 Eukaryota
COG5101 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q54EV7

KEGG Orthology (KO)

More...
KOi
K14290

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEYPEHR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q54EV7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR041123 CRM1_repeat
IPR041235 Exp1_repeat_2
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
IPR040485 XPO1_repeat_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08767 CRM1_C, 1 hit
PF18777 CRM1_repeat, 1 hit
PF18784 CRM1_repeat_2, 1 hit
PF18787 CRM1_repeat_3, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q54EV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENILNFNEP LDINLLDQIV SVLYNPLSNK NDIKAAQMVL GKFQEHPDAW
60 70 80 90 100
SKVDTILETS KIVQTKFIAL VIMDSLIKYR WKSLPREQCE GIKNYIVSLI
110 120 130 140 150
IRLSSDPQTS SREKLLVNKL NLVFVQILKQ EWTTNWSTFI PEIISSSKTN
160 170 180 190 200
ESLCENNMVI LRLLSEEIFN FSEEQMTQTK IQTLKITFEK EFSLINDLCF
210 220 230 240 250
YILENATRAS LIKATLETLQ RFLNWVPLHY IIEVNGGIAE PSKLVKLLLH
260 270 280 290 300
KYFPEPLFRN STLKCLTEIG NLNLGNQQYD AVFIAIIDKF MNQIKFIKPD
310 320 330 340 350
PSKIPQDYED GDQGERSFIH TVSLFLTGFF KSHLKIMENS LNIPYLTLAH
360 370 380 390 400
EILVNISNID ELELFKICLE YWNFLSSNLY SDIATFTTTL LSTPPRLQLY
410 420 430 440 450
KSVLSKVRVV LIDHMAKPEE VIVVEDENGN IVRETTKDTD SLTLYESMRE
460 470 480 490 500
TLIFLTHLDS ENTQHIMLEK LQTLISGREF TFQRLNTLCW AIGSISGAQN
510 520 530 540 550
KEQEKRFLVT VIKDLLELCQ NKKGKDNKAV IASDIMYIVG QYPRFLKDHW
560 570 580 590 600
KFLKTVVNKL FEFMHESHPG VQDMACDTFL KISKQCKRKF VVLQVEESQP
610 620 630 640 650
FINELLNQLS TTIAHLEQSQ IHTFYEAVGY MIASSSDAAF REKLVNKFME
660 670 680 690 700
LPNHSWLQIM GAASVKVESL LTVEVARDIL NLIKTNNRAA MSLENCYITQ
710 720 730 740 750
ISKIYLDLLN VYRTYSDHIS RNPNIYRETL GQAMRSVKKE TLKLLETFIE
760 770 780 790 800
KSSDKQVIYS NFLQPLLEAV LGDYRTNIPE TRDPEVLSLM TAIITSLKQL
810 820 830 840 850
VHPEVPKILE AVFETTLSMI TKNFEDYPYH RINFFNLIRA INSNAFTVFH
860 870 880 890 900
NLHPQQFKLL IDCVVWAFKH TERNISETGL HILKELIENV SKNSDVANVF
910 920 930 940 950
FKTYLVSLLN DILYILTDSF HKSGFALECD ILRMMFQVVE NGVVKIPLFD
960 970 980 990 1000
PQQANFPSNS EYVKEIVVTF LSASPNVSRP QIQAFVTRLF NLANINNNDF
1010 1020 1030 1040 1050
KSATRDFLIT LKEWKSHENA DLYSDEKNIE KALALKKQSM IPGMVRPNDV

NLEMNDL
Length:1,057
Mass (Da):122,014
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B9B86C8BDF82C69
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000177 Genomic DNA Translation: EAL61637.2

NCBI Reference Sequences

More...
RefSeqi
XP_635133.2, XM_630041.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL61637; EAL61637; DDB_G0291306

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8628079

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0291306

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA Translation: EAL61637.2
RefSeqiXP_635133.2, XM_630041.2

3D structure databases

SMRiQ54EV7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234066

Proteomic databases

PaxDbiQ54EV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL61637; EAL61637; DDB_G0291306
GeneIDi8628079
KEGGiddi:DDB_G0291306

Organism-specific databases

dictyBaseiDDB_G0291306 xpo1

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
InParanoidiQ54EV7
KOiK14290
OMAiSEYPEHR
PhylomeDBiQ54EV7

Enzyme and pathway databases

ReactomeiR-DDI-5687128 MAPK6/MAPK4 signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q54EV7

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR041123 CRM1_repeat
IPR041235 Exp1_repeat_2
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
IPR040485 XPO1_repeat_3
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF18777 CRM1_repeat, 1 hit
PF18784 CRM1_repeat_2, 1 hit
PF18787 CRM1_repeat_3, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO1_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q54EV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 18, 2008
Last modified: July 3, 2019
This is version 92 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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