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UniProtKB - Q58WW2 (DCAF6_HUMAN)

Entry version 149 (13 Nov 2019)
Sequence version 1 (26 Apr 2005)
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Protein

DDB1- and CUL4-associated factor 6

Gene

DCAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8951664 Neddylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q58WW2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 6
Alternative name(s):
Androgen receptor complex-associated protein
Short name:
ARCAP
IQ motif and WD repeat-containing protein 1
Nuclear receptor interaction protein
Short name:
NRIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCAF6
Synonyms:IQWD1
ORF Names:MSTP055
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30002 DCAF6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610494 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q58WW2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55827

Open Targets

More...OpenTargetsi		ENSG00000143164

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165751150

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q58WW2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DCAF6

Domain mapping of disease mutations (DMDM)

More...DMDMi		74755134

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003044011 – 860DDB1- and CUL4-associated factor 6Add BLAST860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei336PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei654PhosphothreonineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei847PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q58WW2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q58WW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q58WW2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q58WW2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q58WW2

PeptideAtlas

More...PeptideAtlasi		Q58WW2

PRoteomics IDEntifications database

More...PRIDEi		Q58WW2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62628 [Q58WW2-1]
62629 [Q58WW2-2]
62630 [Q58WW2-3]
62631 [Q58WW2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q58WW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q58WW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143164 Expressed in 226 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q58WW2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q58WW2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA054305

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand.

Interacts with DDB1, CUL4A and CUL4B.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9UHL92EBI-2559044,EBI-372530

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120933, 54 interactors

Database of interacting proteins

More...DIPi		DIP-44678N

Protein interaction database and analysis system

More...IntActi		Q58WW2, 31 interactors

Molecular INTeraction database

More...MINTi		Q58WW2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356814

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1860
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q58WW2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q58WW2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati49 – 88WD 1Add BLAST40
Repeati92 – 133WD 2Add BLAST42
Repeati139 – 179WD 3Add BLAST41
Repeati189 – 229WD 4Add BLAST41
Repeati251 – 290WD 5Add BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini676 – 705IQPROSITE-ProRule annotationAdd BLAST30
Repeati718 – 756WD 6Add BLAST39
Repeati759 – 798WD 7Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XQZP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000038027

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q58WW2

KEGG Orthology (KO)

More...KOi		K11795

Identification of Orthologs from Complete Genome Data

More...OMAi		RDNGHIT

Database of Orthologous Groups

More...OrthoDBi		1270484at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q58WW2

TreeFam database of animal gene trees

More...TreeFami		TF326071

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50096 IQ, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q58WW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH 
        60         70         80         90        100
DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA 
       110        120        130        140        150
KFLPCTNDKQ IVSCSGDGVI FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV 
       160        170        180        190        200
PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC 
       210        220        230        240        250
PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLN 
       260        270        280        290        300
NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE 
       310        320        330        340        350
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS 
       360        370        380        390        400
RWFEEASEVA QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME 
       410        420        430        440        450
VDTPAEQFLQ PSTSSTMSAQ AHSTSSPTES PHSTPLLSSP DSEQRQSVEA 
       460        470        480        490        500
SGHHTHHQSD NNNEKLSPKP GTGEPVLSLH YSTEGTTTST IKLNFTDEWS 
       510        520        530        540        550
SIASSSRGIG SHCKSEGQEE SFVPQSSVQP PEGDSETKAP EESSEDVTKY 
       560        570        580        590        600
QEGVSAENPV ENHINITQSD KFTAKPLDSN SGERNDLNLD RSCGVPEESA 
       610        620        630        640        650
SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA HEETSTRDSA 
       660        670        680        690        700
LQDTDDSDDD PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD 
       710        720        730        740        750
TLNIRRPLVK MVYKGHRNSR TMIKEANFWG ANFVMSGSDC GHIFIWDRHT 
       760        770        780        790        800
AEHLMLLEAD NHVVNCLQPH PFDPILASSG IDYDIKIWSP LEESRIFNRK 
       810        820        830        840        850
LADEVITRNE LMLEETRNTI TVPASFMLRM LASLNHIRAD RLEGDRSEGS 
       860
GQENENEDEE
Length:860
Mass (Da):96,292
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C7602D635DAF124
GO
Isoform 2 (identifier: Q58WW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SDSPSSVVNKQLGSMSLDEQQ

Note: No experimental confirmation available.
Show »
Length:880
Mass (Da):98,423
Checksum:i3CB84C1FBB647E0D
GO
Isoform 3 (identifier: Q58WW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Show »
Length:951
Mass (Da):106,542
Checksum:iA60EC942B9C5035A
GO
Isoform 4 (identifier: Q58WW2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-84: Missing.
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Note: No experimental confirmation available.
Show »
Length:920
Mass (Da):103,070
Checksum:i30564F36EFA28122
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z305F2Z305_HUMAN
DDB1- and CUL4-associated factor 6
DCAF6
472Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035020547V → A1 PublicationCorresponds to variant dbSNP:rs11558511Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04331254 – 84Missing in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_028019459S → SDSPSSVVNKQLGSMSLDEQ Q in isoform 2. 1 Publication1
Alternative sequenceiVSP_028020459S → SEFLRGPEIALLRKRLQQLR LKKAEQQRQQELAAHTQQQP STSDQSSHEGSSQDPHASDS PSSVVNKQLGSMSLDEQQ in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_028021675D → DRFNIRGTTIGDRIM in isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY766164 mRNA Translation: AAX09330.1
DQ768089 mRNA Translation: ABG76793.1
AF116725 mRNA Translation: AAO15301.1
AK297847 mRNA Translation: BAG60180.1
Z97876 Genomic DNA No translation available.
AL033531 Genomic DNA No translation available.
AL031287 Genomic DNA No translation available.
AL033532 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90809.1
BC025262 mRNA Translation: AAH25262.2
AL136738 mRNA Translation: CAB66672.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1267.2 [Q58WW2-2]
CCDS30933.1 [Q58WW2-1]
CCDS55657.1 [Q58WW2-3]
CCDS55658.1 [Q58WW2-4]

NCBI Reference Sequences

More...RefSeqi		NP_001017977.1, NM_001017977.2 [Q58WW2-1]
NP_001185885.1, NM_001198956.1 [Q58WW2-3]
NP_001185886.1, NM_001198957.1 [Q58WW2-4]
NP_060912.2, NM_018442.3 [Q58WW2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000312263; ENSP00000311949; ENSG00000143164 [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164 [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164 [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164 [Q58WW2-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55827

UCSC genome browser

More...UCSCi		uc001gev.5 human [Q58WW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY766164 mRNA Translation: AAX09330.1
DQ768089 mRNA Translation: ABG76793.1
AF116725 mRNA Translation: AAO15301.1
AK297847 mRNA Translation: BAG60180.1
Z97876 Genomic DNA No translation available.
AL033531 Genomic DNA No translation available.
AL031287 Genomic DNA No translation available.
AL033532 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90809.1
BC025262 mRNA Translation: AAH25262.2
AL136738 mRNA Translation: CAB66672.2
CCDSiCCDS1267.2 [Q58WW2-2]
CCDS30933.1 [Q58WW2-1]
CCDS55657.1 [Q58WW2-3]
CCDS55658.1 [Q58WW2-4]
RefSeqiNP_001017977.1, NM_001017977.2 [Q58WW2-1]
NP_001185885.1, NM_001198956.1 [Q58WW2-3]
NP_001185886.1, NM_001198957.1 [Q58WW2-4]
NP_060912.2, NM_018442.3 [Q58WW2-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I7OX-ray2.80B9-21[»]
SMRiQ58WW2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120933, 54 interactors
DIPiDIP-44678N
IntActiQ58WW2, 31 interactors
MINTiQ58WW2
STRINGi9606.ENSP00000356814

PTM databases

iPTMnetiQ58WW2
PhosphoSitePlusiQ58WW2

Polymorphism and mutation databases

BioMutaiDCAF6
DMDMi74755134

Proteomic databases

EPDiQ58WW2
jPOSTiQ58WW2
MassIVEiQ58WW2
MaxQBiQ58WW2
PaxDbiQ58WW2
PeptideAtlasiQ58WW2
PRIDEiQ58WW2
ProteomicsDBi62628 [Q58WW2-1]
62629 [Q58WW2-2]
62630 [Q58WW2-3]
62631 [Q58WW2-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		55827

Genome annotation databases

EnsembliENST00000312263; ENSP00000311949; ENSG00000143164 [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164 [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164 [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164 [Q58WW2-4]
GeneIDi55827
KEGGihsa:55827
UCSCiuc001gev.5 human [Q58WW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55827
DisGeNETi55827

GeneCards: human genes, protein and diseases

More...GeneCardsi		DCAF6
HGNCiHGNC:30002 DCAF6
HPAiHPA054305
MIMi610494 gene
neXtProtiNX_Q58WW2
OpenTargetsiENSG00000143164
PharmGKBiPA165751150

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XQZP LUCA
GeneTreeiENSGT00950000182900
HOGENOMiHOG000038027
InParanoidiQ58WW2
KOiK11795
OMAiRDNGHIT
OrthoDBi1270484at2759
PhylomeDBiQ58WW2
TreeFamiTF326071

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-8951664 Neddylation
SignaLinkiQ58WW2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DCAF6 human
EvolutionaryTraceiQ58WW2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55827
PharosiQ58WW2

Protein Ontology

More...PROi		PR:Q58WW2

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143164 Expressed in 226 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
ExpressionAtlasiQ58WW2 baseline and differential
GenevisibleiQ58WW2 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCAF6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58WW2
Secondary accession number(s): A2A295
, B4DNB8, Q7L8I0, Q8IXH3, Q8TB19
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: November 13, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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