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Entry version 100 (31 Jul 2019)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

T-cell lymphoma invasion and metastasis 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
T-cell lymphoma invasion and metastasis 2 variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q59EY7

PRoteomics IDEntifications database

More...
PRIDEi
Q59EY7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q59EY7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q59EY7, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini752 – 866PHInterPro annotationAdd BLAST115
Domaini1056 – 1127RBDInterPro annotationAdd BLAST72
Domaini1136 – 1222PDZInterPro annotationAdd BLAST87
Domaini1345 – 1539DHInterPro annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni163 – 233DisorderedSequence analysisAdd BLAST71
Regioni447 – 496DisorderedSequence analysisAdd BLAST50
Regioni511 – 539DisorderedSequence analysisAdd BLAST29
Regioni635 – 663DisorderedSequence analysisAdd BLAST29
Regioni1316 – 1338DisorderedSequence analysisAdd BLAST23
Regioni1746 – 1802DisorderedSequence analysisAdd BLAST57
Regioni1814 – 1874DisorderedSequence analysisAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili916 – 936Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi167 – 181PolarSequence analysisAdd BLAST15
Compositional biasi203 – 218PolyampholyteSequence analysisAdd BLAST16
Compositional biasi447 – 461PolarSequence analysisAdd BLAST15
Compositional biasi468 – 496PolarSequence analysisAdd BLAST29
Compositional biasi635 – 656PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1746 – 1792PolarSequence analysisAdd BLAST47
Compositional biasi1814 – 1828PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1838 – 1853PolyampholyteSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITS1 Eukaryota
ENOG410XPCM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154573

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59EY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GRPIDPREGP GRPPLDGRDH FGRPPVDIRE NLVRPGIDHL GRRDHFGFNP
60 70 80 90 100
EKPWGHRGDF DEREHRVLPV YGGPKGLHEE RGRFRSGNYR FDPRSGPWNR
110 120 130 140 150
GFGQEVHRDF DDRRRPWERQ RDRDDRDFDF CREMNGNRLG RDRIQNTWVP
160 170 180 190 200
PPHARVFDYF EGATSQRKGD NVPQVNGENT ERHAQPPPIP VQNDPELYEK
210 220 230 240 250
LTSSNEINKE KSDTVADIES EPVVESTETE GTPLTSLTAE TRRQVKMGNS
260 270 280 290 300
DSQYTLQGSK NHSNTITGAK QIPCSLKIRG IHAKEEKSLH GWGHGSNGAG
310 320 330 340 350
YKSRSLARSC LSHFKSNQPY ASRLGGPTCK VSRGVAYSTH RTNAPGKDFQ
360 370 380 390 400
GISAAFSTEN GFHSVGHELA DNHITSRDCN GHLLNCYGRN ESIASTPPGE
410 420 430 440 450
DRKSPRVLIK TLGKLDGCLR VEFHNGGNPS KVPAEDCSEP VQLLRYSPTL
460 470 480 490 500
ASETSPVPEA RRGSSADSLP SHRPSPTDSR LRSSKGSSLS SESSWYDSPW
510 520 530 540 550
GNAGELSEAE GSFLAPGMPD PSLHASFPPG DAKKPFNQSS SLSSLRELYK
560 570 580 590 600
DANLGSLSPS GIRLSDEYMG THASLSNRVS FASDIDVPSR VAHGDPIQYS
610 620 630 640 650
SFTLPCRKPK AFVEDTAKKD SLKARMRRIS DWTGSLSRKK RKLQEPRSKE
660 670 680 690 700
GSDYFDSRSD GLNTDVQGSS QASAFLWSGG STQILSQRSE STHAIGSDPL
710 720 730 740 750
RQNIYENFMR ELEMSRTNTE NIETSTETAE SSSESLSSLE QLDLLFEKEQ
760 770 780 790 800
GVVRKAGWLF FKPLVTVQKE RKLELVARRK WKQYWVTLKG CTLLFYETYG
810 820 830 840 850
KNSMDQSSAP RCALFAEDSI VQSVPEHPKK ENVFCLSNSF GDVYLFQATS
860 870 880 890 900
QTDLENWVTA VHSACASLFA KKHGKEDTLR LLKNQTKNLL QKIDMDSKMK
910 920 930 940 950
KMAELQLSVV SDPKNRKAIE NQIQQWEQNL EKFHMDLFRM RCYLASLQGG
960 970 980 990 1000
ELPNPKSLLA AASRPSKLAL GRLGILSVSS FHALVCSRDD SALRKRTLSL
1010 1020 1030 1040 1050
TQRGRNKKGI FSSLKGLDTL ARKGKEKRPS ITQVDELLHI YGSTVDGVPR
1060 1070 1080 1090 1100
DNAWEIQTYV HFQDNHGVTV GIKPEHRVED ILTLACKMRQ LEPSHYGLQL
1110 1120 1130 1140 1150
RKLVDDNVEY CIPAPYEYMQ QQVYDEIEVF PLNVYDVQLT KTGSVCDFGF
1160 1170 1180 1190 1200
AVTAQVDERQ HLSRIFISDV LPDGLAYGEG LRKGNEIMTL NGEAVSDLDL
1210 1220 1230 1240 1250
KQMEALFSEK SVGLTLIARP PDTKATLCTS WSDSDLFSRD QKSLLPPPNQ
1260 1270 1280 1290 1300
SQLLEEFLDN FKKNTANDFS NVPDITTGLK RSQTDGTLDQ VSHREKMEQT
1310 1320 1330 1340 1350
FRSAEQITAL CRSFNDSQAN GMEGPRENQD PPPRPLARHL SDADRLRKVI
1360 1370 1380 1390 1400
QELVDTEKSY VKDLSCLFEL YLEPLQNETF LTQDEMESLF GSLPEMLEFQ
1410 1420 1430 1440 1450
KVFLETLEDG ISASSDFNTL ETPSQFRKLL FSLGGSFLYY ADHFKLYSGF
1460 1470 1480 1490 1500
CANHIKVQKV LERAKTDKAF KAFLDARNPT KQHSSTLESY LIKPVQRVLK
1510 1520 1530 1540 1550
YPLLLKELVS LTDQESEEHY HLTEALKAME KVASHINEMQ KIYEDYGTVF
1560 1570 1580 1590 1600
DQLVAEQSGT EKEVTELSMG ELLMHSTVSW LNPFLSLGKA RKDLELTVFV
1610 1620 1630 1640 1650
FKRAVILVYK ENCKLKKKLP SNSRPAHNST DLDPFKFRWL IPISALQVRL
1660 1670 1680 1690 1700
GNPAGTENNS IWELIHTKSE IEGRPETIFQ LCCSDSESKT NIVKVIRSIL
1710 1720 1730 1740 1750
RENFRRHIKC ELPLEKTCKD RLVPLKNRVP VSAKLASSRS LKVLKNSSSN
1760 1770 1780 1790 1800
EWTGETGKGT LLDSDEGSLS SGTQSSGCPT AEGRQDSKST SPGKYPHPGL
1810 1820 1830 1840 1850
ADFADNLIKE SDILSDEDDD HRQTVKQGSP TKDIEIQFQR LRISEDPDVH
1860 1870 1880 1890 1900
PEAEQQPGPE SGEGQKGGEQ PKLVRGHFCP IKRKANSTKR DRGTLLKAQI
1910 1920 1930 1940
RHQSLDSQSE NATIDLNSVL EREFSVQSLT SVVSEECFYE TESHGKS
Length:1,947
Mass (Da):218,691
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3A9BB71D15B5EC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209674 Transcribed RNA Translation: BAD92911.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209674 Transcribed RNA Translation: BAD92911.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ59EY7, 1 interactor

PTM databases

iPTMnetiQ59EY7

Proteomic databases

PeptideAtlasiQ59EY7
PRIDEiQ59EY7

Phylogenomic databases

eggNOGiENOG410ITS1 Eukaryota
ENOG410XPCM LUCA
HOGENOMiHOG000154573

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59EY7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59EY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 31, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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