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Entry version 79 (13 Nov 2019)
Sequence version 1 (15 Mar 2005)
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Protein

Inhibitor of nuclear factor kappa-B kinase-interacting protein

Gene

Ikbip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Target of p53/TP53 with pro-apoptotic function.By similarity

Miscellaneous

Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inhibitor of nuclear factor kappa-B kinase-interacting protein
Short name:
I kappa-B kinase-interacting protein
Short name:
IKBKB-interacting protein
Short name:
IKK-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ikbip
Synonyms:Ikip
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
1305457 Ikbip

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 59HelicalSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003422631 – 373Inhibitor of nuclear factor kappa-B kinase-interacting proteinAdd BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated at Asn-151.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5EAJ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5EAJ6

PRoteomics IDEntifications database

More...
PRIDEi
Q5EAJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000008247 Expressed in 9 organ(s), highest expression level in lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5EAJ6 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
260816, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000010913

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5EAJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili64 – 257Sequence analysisAdd BLAST194
Coiled coili290 – 325Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJN2 Eukaryota
ENOG410YFQ8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000045001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113024

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5EAJ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
MHDIQNS

Database of Orthologous Groups

More...
OrthoDBi
1191353at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5EAJ6

TreeFam database of animal gene trees

More...
TreeFami
TF331715

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024152 Inh_kappa-B_kinase-int

The PANTHER Classification System

More...
PANTHERi
PTHR21734 PTHR21734, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5EAJ6-1) [UniParc]FASTAAdd to basket
Also known as: Ikip1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEVKSRKKP GPKVAAPEPE KRSDGRKNPE ARGGAGWADP RTGLSLLSLA
60 70 80 90 100
TSLGLAWLVF QQSEKFAKVE NQYRLLQTES SEFQGLQSKI SLISNKLEST
110 120 130 140 150
ENTLQEATSS MSLMTQFEQE VAGLQRSIHD IENSEEMLTQ KLQNLNEKFQ
160 170 180 190 200
NITDLWKRTL VEMSDNTAVF KSEAKSTHSE VTLKINSAEQ EIKLLTERLK
210 220 230 240 250
DLEDSTLRNI RTVSRQEEED LLRVEAQLSS DTKAVEKLEE EQRTLLARDE
260 270 280 290 300
DLTDKLSSYE PKVEECKAHL PTIENAVHSV LRVSQDLIGT ERKMEELTVQ
310 320 330 340 350
MFNMEDDMLK AVSEIMEMQN TLEGIQYDNS LLKMQNELVV LKGKVHDFMA
360 370
YSSAGEKGTL EEYNLENKGT DDY
Length:373
Mass (Da):42,361
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6BA554B510E4E38
GO
Isoform 2 (identifier: Q5EAJ6-2) [UniParc]FASTAAdd to basket
Also known as: Ikip2

The sequence of this isoform differs from the canonical sequence as follows:
     97-373: LESTENTLQE...NLENKGTDDY → YQKCEALLEQ...MKDEITHISG

Show »
Length:345
Mass (Da):38,346
Checksum:iD6AABDBBB84834CD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03441297 – 373LESTE…GTDDY → YQKCEALLEQLKAFQIVAHL KLLQEEIHGMKTWSIGITEK QKILNNTLTSLSEDIIKVDQ GTASVAKDMGLKITSVKTDV RRISGLVTEVESLTDAVQAL ENKVKKVETATVESIGDLLS SSIDRTTALRKTASENSRRI DSVTKRLAELQGDFDEHTDR FLSLESERAKVLKAVSFAND LKPKVYNLKKDFSRLEPLVN DLTLRIGRLGSDLMQREKEI ASLKEKISNLTIVQAAIKDM KDEITHISG in isoform 2. 2 PublicationsAdd BLAST277

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BN000112 mRNA Translation: CAD62384.1
BN000113 mRNA Translation: CAD62385.1
BC088210 mRNA Translation: AAH88210.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009430.2, NM_001009430.2 [Q5EAJ6-1]
XP_006241312.1, XM_006241250.3 [Q5EAJ6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000010914; ENSRNOP00000010913; ENSRNOG00000008247 [Q5EAJ6-1]
ENSRNOT00000010929; ENSRNOP00000010929; ENSRNOG00000008247 [Q5EAJ6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
314730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:314730

UCSC genome browser

More...
UCSCi
RGD:1305457 rat [Q5EAJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN000112 mRNA Translation: CAD62384.1
BN000113 mRNA Translation: CAD62385.1
BC088210 mRNA Translation: AAH88210.1
RefSeqiNP_001009430.2, NM_001009430.2 [Q5EAJ6-1]
XP_006241312.1, XM_006241250.3 [Q5EAJ6-2]

3D structure databases

SMRiQ5EAJ6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi260816, 1 interactor
STRINGi10116.ENSRNOP00000010913

Proteomic databases

jPOSTiQ5EAJ6
PaxDbiQ5EAJ6
PRIDEiQ5EAJ6

Genome annotation databases

EnsembliENSRNOT00000010914; ENSRNOP00000010913; ENSRNOG00000008247 [Q5EAJ6-1]
ENSRNOT00000010929; ENSRNOP00000010929; ENSRNOG00000008247 [Q5EAJ6-2]
GeneIDi314730
KEGGirno:314730
UCSCiRGD:1305457 rat [Q5EAJ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
121457
RGDi1305457 Ikbip

Phylogenomic databases

eggNOGiENOG410IJN2 Eukaryota
ENOG410YFQ8 LUCA
GeneTreeiENSGT00500000045001
HOGENOMiHOG000113024
InParanoidiQ5EAJ6
OMAiMHDIQNS
OrthoDBi1191353at2759
PhylomeDBiQ5EAJ6
TreeFamiTF331715

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5EAJ6

Gene expression databases

BgeeiENSRNOG00000008247 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiQ5EAJ6 RN

Family and domain databases

InterProiView protein in InterPro
IPR024152 Inh_kappa-B_kinase-int
PANTHERiPTHR21734 PTHR21734, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKIP_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5EAJ6
Secondary accession number(s): Q5M859
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 15, 2005
Last modified: November 13, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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