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Entry version 101 (18 Sep 2019)
Sequence version 2 (20 Feb 2007)
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Protein

Uncharacterized protein KIAA1755

Gene

KIAA1755

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein KIAA1755
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29372 KIAA1755

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JYT7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85449

Open Targets

More...
OpenTargetsi
ENSG00000149633

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393181

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIAA1755

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166977309

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172841 – 1200Uncharacterized protein KIAA1755Add BLAST1200

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5JYT7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5JYT7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JYT7

PeptideAtlas

More...
PeptideAtlasi
Q5JYT7

PRoteomics IDEntifications database

More...
PRIDEi
Q5JYT7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63515

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JYT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JYT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149633 Expressed in 148 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JYT7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JYT7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q5JYT7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000279024

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPNG Eukaryota
ENOG41114VC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161174

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231247

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JYT7

Identification of Orthologs from Complete Genome Data

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OMAi
EGSRCLQ

Database of Orthologous Groups

More...
OrthoDBi
112611at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JYT7

TreeFam database of animal gene trees

More...
TreeFami
TF334329

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5JYT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPPSLDTAI QHALAGLYPP FEATAPTVLG QVFRLLDSGF QGDGLSFLLD
60 70 80 90 100
FLIPAKRLCE QVREAACAPY SHCLFLHEGW PLCLRDEVVV HLAPLNPLLL
110 120 130 140 150
RQGDFYLQVE PQEEQSVCIM IKCLSLDLCT VDKKPVPEPA YPILFTQEWL
160 170 180 190 200
EAINSDFEGN PLHNCLVASE NGIAPVPWTK ITSPEFVDDR PQVVNALCQA
210 220 230 240 250
WGPLPLEALD LSSPQELHQA SSPDNQVLPA QSLAKGKGRT YGSKYPGLIK
260 270 280 290 300
VEQARCGEVA FRMDEVVSQD FEGDYVALLG FSQESRGESP SREAGTSSGC
310 320 330 340 350
TSGALEEIAG TKETPLFQKI LPLSEANEGP SLGNRACTKP ESSEERPYNL
360 370 380 390 400
GFRRKVNLKA PTHNSERPPQ GSYMNVLEDA LDCASGLRAG VSQEPAASKM
410 420 430 440 450
QGPLGNPENM VQLRPGPRQA SSPRLSPASP AAAASETKIE VKTKERNGRL
460 470 480 490 500
PKPMPCPSRN TSSPEPPTPG LKFSFLRGQR QPSVTPEKAS LQHNGPWKVL
510 520 530 540 550
CSLYSPKPNR AKSLGKAGTT QTKTSGPATA PSPLTEEKAA LPEASAGSPE
560 570 580 590 600
RGPTLEEEPP GPEPRIGALG VKVFRSRIAC LPGGRDRAGR PLLLVSTTEG
610 620 630 640 650
AWEAPWCTVS EVTKLLSYLC TIPRPEDKAK GLAVLIDARR QPPQPGLVSA
660 670 680 690 700
LQATQAQVPA SIRAILFLGE KEAALQLQTL PDVQVEVLTS LKALSHHVDP
710 720 730 740 750
SQLPAVLEGP FPYCHTEWVH FFQKLDPFLA DLHQASSLLQ ASIEEFEKAD
760 770 780 790 800
PPGGMQEATR CLSKSKELME AVLRDPGLLG LQREGGATLA RLQHDASRLD
810 820 830 840 850
FSPDVRSHLA AATALYSLVD EQLHVLVTAS NSLLGKLELR VRLGRLEAAI
860 870 880 890 900
HQVSDWMEQE GRRCLQSLTP KDGSLETVEK AHAEFENFFL QAAAQYRRGL
910 920 930 940 950
ELSKQAAQLG ATARGAGEAE RAEFPELAAF ASTQRAFQAE LTHFYMAAER
960 970 980 990 1000
QRTDLETLLH LHRFCKRMTW FHMDCQDLMA QLRLDKTSRV SPGDQRRLHR
1010 1020 1030 1040 1050
YLQRLASEFP AEKLAAVGLQ VASLSRAGLG QELWEEARIR HEEIRMLLEK
1060 1070 1080 1090 1100
ALTHSSCPEA PAAHSARPER RGVAAKGQGV SVEVTSKGRW DQPPLDSLGM
1110 1120 1130 1140 1150
DHLPKSYWPP GPPRGEQNRT FQAGSPPQEA GQAAEAEDGK GSHKLPDPAR
1160 1170 1180 1190 1200
EHLLATTFFR QQPPRQSQVP RLTGGSFSSE GTDSQTSLED SPQTSPLASL
Length:1,200
Mass (Da):130,846
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC43B5ABAFD00CFA1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0C1A0A087X0C1_HUMAN
Uncharacterized protein KIAA1755
KIAA1755
732Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWV7A0A087WWV7_HUMAN
Uncharacterized protein KIAA1755
KIAA1755
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JYT8Q5JYT8_HUMAN
Uncharacterized protein KIAA1755
KIAA1755
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038501339K → N1 PublicationCorresponds to variant dbSNP:rs1205434Ensembl.1
Natural variantiVAR_038502415P → L. Corresponds to variant dbSNP:rs6024235Ensembl.1
Natural variantiVAR_038503633A → V. Corresponds to variant dbSNP:rs16987188Ensembl.1
Natural variantiVAR_038504940E → K1 PublicationCorresponds to variant dbSNP:rs760998Ensembl.1
Natural variantiVAR_0385051045R → W1 PublicationCorresponds to variant dbSNP:rs3746471Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL031651 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76038.1
AB051542 mRNA Translation: BAB21846.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33467.1

NCBI Reference Sequences

More...
RefSeqi
NP_001025035.1, NM_001029864.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000279024; ENSP00000279024; ENSG00000149633

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85449

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85449

UCSC genome browser

More...
UCSCi
uc002xhy.2 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031651 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76038.1
AB051542 mRNA Translation: BAB21846.1
CCDSiCCDS33467.1
RefSeqiNP_001025035.1, NM_001029864.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ5JYT7, 1 interactor
STRINGi9606.ENSP00000279024

PTM databases

iPTMnetiQ5JYT7
PhosphoSitePlusiQ5JYT7

Polymorphism and mutation databases

BioMutaiKIAA1755
DMDMi166977309

Proteomic databases

jPOSTiQ5JYT7
MassIVEiQ5JYT7
PaxDbiQ5JYT7
PeptideAtlasiQ5JYT7
PRIDEiQ5JYT7
ProteomicsDBi63515

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279024; ENSP00000279024; ENSG00000149633
GeneIDi85449
KEGGihsa:85449
UCSCiuc002xhy.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85449
DisGeNETi85449

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIAA1755
HGNCiHGNC:29372 KIAA1755
HPAiHPA051064
neXtProtiNX_Q5JYT7
OpenTargetsiENSG00000149633
PharmGKBiPA162393181

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPNG Eukaryota
ENOG41114VC LUCA
GeneTreeiENSGT00940000161174
HOGENOMiHOG000231247
InParanoidiQ5JYT7
OMAiEGSRCLQ
OrthoDBi112611at2759
PhylomeDBiQ5JYT7
TreeFamiTF334329

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85449

Pharos

More...
Pharosi
Q5JYT7

Protein Ontology

More...
PROi
PR:Q5JYT7

Gene expression databases

BgeeiENSG00000149633 Expressed in 148 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ5JYT7 baseline and differential
GenevisibleiQ5JYT7 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1755_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JYT7
Secondary accession number(s): Q9C0A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: September 18, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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