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Entry version 135 (16 Oct 2019)
Sequence version 1 (01 Feb 2005)
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Protein

Histone-lysine N-methyltransferase SETD1

Gene

Set1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1By similarity (EC:2.1.1.43By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Set1Imported
ORF Names:CG40351
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0040022 Set1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1613E → K in G5; predominantly lethal at the pupal stage with low levels of late L3 larval lethality. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004293781 – 1641Histone-lysine N-methyltransferase SETD1Add BLAST1641

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5LJZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q5LJZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0040022 Expressed in 4 organ(s), highest expression level in head

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5LJZ2 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1.

Interacts with ash2 and wds.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9V4C83EBI-3405171,EBI-2912878

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
78096, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q5LJZ2, 27 interactors

Molecular INTeraction database

More...
MINTi
Q5LJZ2

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0291454

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5LJZ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 179RRMPROSITE-ProRule annotationAdd BLAST79
Domaini1502 – 1619SETPROSITE-ProRule annotationAdd BLAST118
Domaini1625 – 1641Post-SETPROSITE-ProRule annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1091 – 1132Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi247 – 386Arg-richSequence analysisAdd BLAST140
Compositional biasi460 – 465Poly-ProSequence analysis6
Compositional biasi888 – 918Ser-richSequence analysisAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1080 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169211

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5LJZ2

KEGG Orthology (KO)

More...
KOi
K11422

Identification of Orthologs from Complete Genome Data

More...
OMAi
DAEDINF

Database of Orthologous Groups

More...
OrthoDBi
1234689at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5LJZ2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR001214 SET_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00360 RRM, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5LJZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDVRNINLV NNSSNSHDSS LANSKMPRNF KLLSDPQLVK CGTRLYRYDG
60 70 80 90 100
LMPGDPSYPT ITPRDPRNPL IRIRARAVEP LMLLIPRFVI DSDYVGQPPA
110 120 130 140 150
VEVTIVNLND NIDKQFLASM LDKCGTSDEI NIYHHPITNK HLGIARIVFD
160 170 180 190 200
STKGARQFVE KYNQKSVMGK ILDVFCDPFG ATLKKSLESL TNSVAGKQLI
210 220 230 240 250
GPKVTPQWTF QQAALEDTEF IHGYPEKNGE HIKDIYTTQT NHEIPNRSRD
260 270 280 290 300
RNWNRDKERE RDRHFKERSR HSSERSYDRD RGMRENVGTS IRRRRTFYRR
310 320 330 340 350
RSSDISPEDS RDILIMTRER SRDSDSRPRD YCRSRERESF RDRKRSHEKG
360 370 380 390 400
RDQPREKREH YYNSSKDREY RGRDRDRSAE IDQRDRGSLK YCSRYSLHEY
410 420 430 440 450
IETDVRRSSN TISSYYSASS LPIASHGFNS CSFPSIENIK TWSDRRAWTA
460 470 480 490 500
FQPDFHPVQP PPPPPEEIDN WDEEEHDKNS IVPTHYGCMA KLQPPVPSNV
510 520 530 540 550
NFATKLQSVT QPNSDPGTVD LDTRIALIFK GKTFGNAPPF LQMDSSDSET
560 570 580 590 600
DQGKPEVFSD VNSDSNNSEN KKRSCEKNNK VLHQPNEASD ISSDEELIGK
610 620 630 640 650
KDKSKLSLIC EKEVNDDNMS LSSLSSQEDP IQTKEGAEYK SIMSSYMYSH
660 670 680 690 700
SNQNPFYYHA SGYGHYLSGI PSESASRLFS NGAYVHSEYL KAVASFNFDS
710 720 730 740 750
FSKPYDYNKG ALSDQNDGIR QKVKQVIGYI VEELKQILKR DVNKRMIEIT
760 770 780 790 800
AFKHFETWWD EHTSKARSKP LFEKADSTVN TPLNCIKDTS YNEKNPDINL
810 820 830 840 850
LINAHREVAD FQSYSSIGLR AAMPKLPSFR RIRKHPSPIP TKRNFLERDL
860 870 880 890 900
SDQEEMVQRS DSDKEDSNVE ISDTARSKIK GPVPIQESDS KSHTSGLNSK
910 920 930 940 950
RKGSASSFFS SSSSSTSSEA EYEAIDCVEK ARTSEEDSPR GYGQRNLNQR
960 970 980 990 1000
TTTIRNRNLV GTMDVINVRN LCSGSNEFKK ENVTKRTKKN IYSDTDEDND
1010 1020 1030 1040 1050
RTLFPALKEK NISTILSDLE EISKDSCIGL DENGIEPTIL RKIPNTPKLN
1060 1070 1080 1090 1100
EECRRSLTPV PPPGYNEEEI KKKVDCKQKP SFEYDRIYSD SEEEKEYQER
1110 1120 1130 1140 1150
RKRNTEYMAQ MEREFLEEQE KRIEKSLDKN LQSPNNIVKN NNSPRNKNDE
1160 1170 1180 1190 1200
TRKTAISQTR SCFESASKVD TTLVNIISVE NDINEFGPHE EGDVLTNGCN
1210 1220 1230 1240 1250
KMYTNSKGKT KRTQSPVYSE GGSSQASQAS QVALEHCYSL PPHSVSLGDY
1260 1270 1280 1290 1300
PSGKVNETKN ILKREAENIA IVSQMTRTGP GRPRKDPICI QKKKRDLAPR
1310 1320 1330 1340 1350
MSNVKSKMTP NGDEWPDLAH KNVHFVPCDM YKTRDQNEEM VILYTFLTKG
1360 1370 1380 1390 1400
IDAEDINFIK MSYLDHLHKE PYAMFLNNTH WVDHCTTDRA FWPPPSKKRR
1410 1420 1430 1440 1450
KDDELIRHKT GCARTEGFYK LDVREKAKHK YHYAKANTED SFNEDRSDEP
1460 1470 1480 1490 1500
TALTNHHHNK LISKMQGISR EARSNQRRLL TAFGSMGESE LLKFNQLKFR
1510 1520 1530 1540 1550
KKQLKFAKSA IHDWGLFAME PIAADEMVIE YVGQMIRPVV ADLRETKYEA
1560 1570 1580 1590 1600
IGIGSSYLFR IDMETIIDAT KCGNLARFIN HSCNPNCYAK VITIESEKKI
1610 1620 1630 1640
VIYSKQPIGI NEEITYDYKF PLEDEKIPCL CGAQGCRGTL N
Length:1,641
Mass (Da):188,383
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89877A04B630D954
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL89913 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAL89913 differs from that shown. Reason: Frameshift.Curated
The sequence AAY51545 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: EAL24598.1
AE014296 Genomic DNA Translation: EAL24599.1
AE014296 Genomic DNA Translation: EDP28071.1
AE014296 Genomic DNA Translation: EFA98694.1
AE014296 Genomic DNA Translation: EFA98695.1
AE014296 Genomic DNA Translation: EFA98696.1
AE014296 Genomic DNA Translation: EFA98697.1
AE014296 Genomic DNA Translation: EFA98698.1
AE014296 Genomic DNA Translation: EFA98699.1
AY084175 mRNA Translation: AAL89913.1 Sequence problems.
BT022150 mRNA Translation: AAY51545.1 Sequence problems.
BT150052 mRNA Translation: AGJ89714.1

NCBI Reference Sequences

More...
RefSeqi
NP_001015221.1, NM_001015221.3
NP_001015222.1, NM_001015222.3
NP_001104406.1, NM_001110936.3
NP_001163846.1, NM_001170375.2
NP_001163847.1, NM_001170376.2
NP_001163848.1, NM_001170377.1
NP_001163849.1, NM_001170378.1
NP_001163850.1, NM_001170379.1
NP_001163851.1, NM_001170380.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0113869; FBpp0112592; FBgn0040022
FBtr0113870; FBpp0112593; FBgn0040022
FBtr0113871; FBpp0112594; FBgn0040022
FBtr0302243; FBpp0291452; FBgn0040022
FBtr0302244; FBpp0291453; FBgn0040022
FBtr0302245; FBpp0291454; FBgn0040022
FBtr0302246; FBpp0291455; FBgn0040022
FBtr0302247; FBpp0291456; FBgn0040022
FBtr0302248; FBpp0291457; FBgn0040022

Database of genes from NCBI RefSeq genomes

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GeneIDi
3354971

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG40351

UCSC genome browser

More...
UCSCi
CG40351-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: EAL24598.1
AE014296 Genomic DNA Translation: EAL24599.1
AE014296 Genomic DNA Translation: EDP28071.1
AE014296 Genomic DNA Translation: EFA98694.1
AE014296 Genomic DNA Translation: EFA98695.1
AE014296 Genomic DNA Translation: EFA98696.1
AE014296 Genomic DNA Translation: EFA98697.1
AE014296 Genomic DNA Translation: EFA98698.1
AE014296 Genomic DNA Translation: EFA98699.1
AY084175 mRNA Translation: AAL89913.1 Sequence problems.
BT022150 mRNA Translation: AAY51545.1 Sequence problems.
BT150052 mRNA Translation: AGJ89714.1
RefSeqiNP_001015221.1, NM_001015221.3
NP_001015222.1, NM_001015222.3
NP_001104406.1, NM_001110936.3
NP_001163846.1, NM_001170375.2
NP_001163847.1, NM_001170376.2
NP_001163848.1, NM_001170377.1
NP_001163849.1, NM_001170378.1
NP_001163850.1, NM_001170379.1
NP_001163851.1, NM_001170380.2

3D structure databases

SMRiQ5LJZ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi78096, 6 interactors
IntActiQ5LJZ2, 27 interactors
MINTiQ5LJZ2
STRINGi7227.FBpp0291454

Proteomic databases

PaxDbiQ5LJZ2
PRIDEiQ5LJZ2

Genome annotation databases

EnsemblMetazoaiFBtr0113869; FBpp0112592; FBgn0040022
FBtr0113870; FBpp0112593; FBgn0040022
FBtr0113871; FBpp0112594; FBgn0040022
FBtr0302243; FBpp0291452; FBgn0040022
FBtr0302244; FBpp0291453; FBgn0040022
FBtr0302245; FBpp0291454; FBgn0040022
FBtr0302246; FBpp0291455; FBgn0040022
FBtr0302247; FBpp0291456; FBgn0040022
FBtr0302248; FBpp0291457; FBgn0040022
GeneIDi3354971
KEGGidme:Dmel_CG40351
UCSCiCG40351-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3354971
FlyBaseiFBgn0040022 Set1

Phylogenomic databases

eggNOGiKOG1080 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000169211
InParanoidiQ5LJZ2
KOiK11422
OMAiDAEDINF
OrthoDBi1234689at2759
PhylomeDBiQ5LJZ2

Enzyme and pathway databases

ReactomeiR-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3354971

Protein Ontology

More...
PROi
PR:Q5LJZ2

Gene expression databases

BgeeiFBgn0040022 Expressed in 4 organ(s), highest expression level in head
GenevisibleiQ5LJZ2 DM

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR001214 SET_dom
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00360 RRM, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5LJZ2
Secondary accession number(s): M9WDY6, Q4V706, Q8SXR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 11, 2014
Last sequence update: February 1, 2005
Last modified: October 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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