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UniProtKB - Q5LJZ2 (SET1_DROME)

Entry version 135 (16 Oct 2019)
Sequence version 1 (01 Feb 2005)
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Protein

Histone-lysine N-methyltransferase SETD1

Gene

Set1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1By similarity (EC:2.1.1.43By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Set1Imported
ORF Names:CG40351
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0040022 Set1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1613E → K in G5; predominantly lethal at the pupal stage with low levels of late L3 larval lethality. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004293781 – 1641Histone-lysine N-methyltransferase SETD1Add BLAST1641

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5LJZ2

PRoteomics IDEntifications database

More...PRIDEi		Q5LJZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0040022 Expressed in 4 organ(s), highest expression level in head

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5LJZ2 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1.

Interacts with ash2 and wds.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9V4C83EBI-3405171,EBI-2912878

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		78096, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q5LJZ2, 27 interactors

Molecular INTeraction database

More...MINTi		Q5LJZ2

STRING: functional protein association networks

More...STRINGi		7227.FBpp0291454

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5LJZ2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 179RRMPROSITE-ProRule annotationAdd BLAST79
Domaini1502 – 1619SETPROSITE-ProRule annotationAdd BLAST118
Domaini1625 – 1641Post-SETPROSITE-ProRule annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1091 – 1132Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi247 – 386Arg-richSequence analysisAdd BLAST140
Compositional biasi460 – 465Poly-ProSequence analysis6
Compositional biasi888 – 918Ser-richSequence analysisAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1080 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000169211

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5LJZ2

KEGG Orthology (KO)

More...KOi		K11422

Identification of Orthologs from Complete Genome Data

More...OMAi		DAEDINF

Database of Orthologous Groups

More...OrthoDBi		1234689at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5LJZ2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR001214 SET_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00360 RRM, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5LJZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDVRNINLV NNSSNSHDSS LANSKMPRNF KLLSDPQLVK CGTRLYRYDG 
        60         70         80         90        100
LMPGDPSYPT ITPRDPRNPL IRIRARAVEP LMLLIPRFVI DSDYVGQPPA 
       110        120        130        140        150
VEVTIVNLND NIDKQFLASM LDKCGTSDEI NIYHHPITNK HLGIARIVFD 
       160        170        180        190        200
STKGARQFVE KYNQKSVMGK ILDVFCDPFG ATLKKSLESL TNSVAGKQLI 
       210        220        230        240        250
GPKVTPQWTF QQAALEDTEF IHGYPEKNGE HIKDIYTTQT NHEIPNRSRD 
       260        270        280        290        300
RNWNRDKERE RDRHFKERSR HSSERSYDRD RGMRENVGTS IRRRRTFYRR 
       310        320        330        340        350
RSSDISPEDS RDILIMTRER SRDSDSRPRD YCRSRERESF RDRKRSHEKG 
       360        370        380        390        400
RDQPREKREH YYNSSKDREY RGRDRDRSAE IDQRDRGSLK YCSRYSLHEY 
       410        420        430        440        450
IETDVRRSSN TISSYYSASS LPIASHGFNS CSFPSIENIK TWSDRRAWTA 
       460        470        480        490        500
FQPDFHPVQP PPPPPEEIDN WDEEEHDKNS IVPTHYGCMA KLQPPVPSNV 
       510        520        530        540        550
NFATKLQSVT QPNSDPGTVD LDTRIALIFK GKTFGNAPPF LQMDSSDSET 
       560        570        580        590        600
DQGKPEVFSD VNSDSNNSEN KKRSCEKNNK VLHQPNEASD ISSDEELIGK 
       610        620        630        640        650
KDKSKLSLIC EKEVNDDNMS LSSLSSQEDP IQTKEGAEYK SIMSSYMYSH 
       660        670        680        690        700
SNQNPFYYHA SGYGHYLSGI PSESASRLFS NGAYVHSEYL KAVASFNFDS 
       710        720        730        740        750
FSKPYDYNKG ALSDQNDGIR QKVKQVIGYI VEELKQILKR DVNKRMIEIT 
       760        770        780        790        800
AFKHFETWWD EHTSKARSKP LFEKADSTVN TPLNCIKDTS YNEKNPDINL 
       810        820        830        840        850
LINAHREVAD FQSYSSIGLR AAMPKLPSFR RIRKHPSPIP TKRNFLERDL 
       860        870        880        890        900
SDQEEMVQRS DSDKEDSNVE ISDTARSKIK GPVPIQESDS KSHTSGLNSK 
       910        920        930        940        950
RKGSASSFFS SSSSSTSSEA EYEAIDCVEK ARTSEEDSPR GYGQRNLNQR 
       960        970        980        990       1000
TTTIRNRNLV GTMDVINVRN LCSGSNEFKK ENVTKRTKKN IYSDTDEDND 
      1010       1020       1030       1040       1050
RTLFPALKEK NISTILSDLE EISKDSCIGL DENGIEPTIL RKIPNTPKLN 
      1060       1070       1080       1090       1100
EECRRSLTPV PPPGYNEEEI KKKVDCKQKP SFEYDRIYSD SEEEKEYQER 
      1110       1120       1130       1140       1150
RKRNTEYMAQ MEREFLEEQE KRIEKSLDKN LQSPNNIVKN NNSPRNKNDE 
      1160       1170       1180       1190       1200
TRKTAISQTR SCFESASKVD TTLVNIISVE NDINEFGPHE EGDVLTNGCN 
      1210       1220       1230       1240       1250
KMYTNSKGKT KRTQSPVYSE GGSSQASQAS QVALEHCYSL PPHSVSLGDY 
      1260       1270       1280       1290       1300
PSGKVNETKN ILKREAENIA IVSQMTRTGP GRPRKDPICI QKKKRDLAPR 
      1310       1320       1330       1340       1350
MSNVKSKMTP NGDEWPDLAH KNVHFVPCDM YKTRDQNEEM VILYTFLTKG 
      1360       1370       1380       1390       1400
IDAEDINFIK MSYLDHLHKE PYAMFLNNTH WVDHCTTDRA FWPPPSKKRR 
      1410       1420       1430       1440       1450
KDDELIRHKT GCARTEGFYK LDVREKAKHK YHYAKANTED SFNEDRSDEP 
      1460       1470       1480       1490       1500
TALTNHHHNK LISKMQGISR EARSNQRRLL TAFGSMGESE LLKFNQLKFR 
      1510       1520       1530       1540       1550
KKQLKFAKSA IHDWGLFAME PIAADEMVIE YVGQMIRPVV ADLRETKYEA 
      1560       1570       1580       1590       1600
IGIGSSYLFR IDMETIIDAT KCGNLARFIN HSCNPNCYAK VITIESEKKI 
      1610       1620       1630       1640 
VIYSKQPIGI NEEITYDYKF PLEDEKIPCL CGAQGCRGTL N
Length:1,641
Mass (Da):188,383
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89877A04B630D954
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL89913 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAL89913 differs from that shown. Reason: Frameshift.Curated
The sequence AAY51545 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: EAL24598.1
AE014296 Genomic DNA Translation: EAL24599.1
AE014296 Genomic DNA Translation: EDP28071.1
AE014296 Genomic DNA Translation: EFA98694.1
AE014296 Genomic DNA Translation: EFA98695.1
AE014296 Genomic DNA Translation: EFA98696.1
AE014296 Genomic DNA Translation: EFA98697.1
AE014296 Genomic DNA Translation: EFA98698.1
AE014296 Genomic DNA Translation: EFA98699.1
AY084175 mRNA Translation: AAL89913.1 Sequence problems.
BT022150 mRNA Translation: AAY51545.1 Sequence problems.
BT150052 mRNA Translation: AGJ89714.1

NCBI Reference Sequences

More...RefSeqi		NP_001015221.1, NM_001015221.3
NP_001015222.1, NM_001015222.3
NP_001104406.1, NM_001110936.3
NP_001163846.1, NM_001170375.2
NP_001163847.1, NM_001170376.2
NP_001163848.1, NM_001170377.1
NP_001163849.1, NM_001170378.1
NP_001163850.1, NM_001170379.1
NP_001163851.1, NM_001170380.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0113869; FBpp0112592; FBgn0040022
FBtr0113870; FBpp0112593; FBgn0040022
FBtr0113871; FBpp0112594; FBgn0040022
FBtr0302243; FBpp0291452; FBgn0040022
FBtr0302244; FBpp0291453; FBgn0040022
FBtr0302245; FBpp0291454; FBgn0040022
FBtr0302246; FBpp0291455; FBgn0040022
FBtr0302247; FBpp0291456; FBgn0040022
FBtr0302248; FBpp0291457; FBgn0040022

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3354971

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG40351

UCSC genome browser

More...UCSCi		CG40351-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: EAL24598.1
AE014296 Genomic DNA Translation: EAL24599.1
AE014296 Genomic DNA Translation: EDP28071.1
AE014296 Genomic DNA Translation: EFA98694.1
AE014296 Genomic DNA Translation: EFA98695.1
AE014296 Genomic DNA Translation: EFA98696.1
AE014296 Genomic DNA Translation: EFA98697.1
AE014296 Genomic DNA Translation: EFA98698.1
AE014296 Genomic DNA Translation: EFA98699.1
AY084175 mRNA Translation: AAL89913.1 Sequence problems.
BT022150 mRNA Translation: AAY51545.1 Sequence problems.
BT150052 mRNA Translation: AGJ89714.1
RefSeqiNP_001015221.1, NM_001015221.3
NP_001015222.1, NM_001015222.3
NP_001104406.1, NM_001110936.3
NP_001163846.1, NM_001170375.2
NP_001163847.1, NM_001170376.2
NP_001163848.1, NM_001170377.1
NP_001163849.1, NM_001170378.1
NP_001163850.1, NM_001170379.1
NP_001163851.1, NM_001170380.2

3D structure databases

SMRiQ5LJZ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi78096, 6 interactors
IntActiQ5LJZ2, 27 interactors
MINTiQ5LJZ2
STRINGi7227.FBpp0291454

Proteomic databases

PaxDbiQ5LJZ2
PRIDEiQ5LJZ2

Genome annotation databases

EnsemblMetazoaiFBtr0113869; FBpp0112592; FBgn0040022
FBtr0113870; FBpp0112593; FBgn0040022
FBtr0113871; FBpp0112594; FBgn0040022
FBtr0302243; FBpp0291452; FBgn0040022
FBtr0302244; FBpp0291453; FBgn0040022
FBtr0302245; FBpp0291454; FBgn0040022
FBtr0302246; FBpp0291455; FBgn0040022
FBtr0302247; FBpp0291456; FBgn0040022
FBtr0302248; FBpp0291457; FBgn0040022
GeneIDi3354971
KEGGidme:Dmel_CG40351
UCSCiCG40351-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3354971
FlyBaseiFBgn0040022 Set1

Phylogenomic databases

eggNOGiKOG1080 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000169211
InParanoidiQ5LJZ2
KOiK11422
OMAiDAEDINF
OrthoDBi1234689at2759
PhylomeDBiQ5LJZ2

Enzyme and pathway databases

ReactomeiR-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3354971

Protein Ontology

More...PROi		PR:Q5LJZ2

Gene expression databases

BgeeiFBgn0040022 Expressed in 4 organ(s), highest expression level in head
GenevisibleiQ5LJZ2 DM

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR001214 SET_dom
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00360 RRM, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5LJZ2
Secondary accession number(s): M9WDY6, Q4V706, Q8SXR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 11, 2014
Last sequence update: February 1, 2005
Last modified: October 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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