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Entry version 129 (31 Jul 2019)
Sequence version 1 (12 Apr 2005)
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Protein

E3 ubiquitin-protein ligase MARCH8

Gene

MARCH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri72 – 133RING-CH-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processAdaptive immunity, Immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MARCH8 (EC:2.3.2.27)
Alternative name(s):
Cellular modulator of immune recognition
Short name:
c-MIR
Membrane-associated RING finger protein 8
Membrane-associated RING-CH protein VIII
Short name:
MARCH-VIII
RING finger protein 178
RING-type E3 ubiquitin transferase MARCH8Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARCH8
Synonyms:MIR, RNF178
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:23356 MARCH8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613335 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T0T0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
220972

Open Targets

More...
OpenTargetsi
ENSG00000165406

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37370

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MARCH8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74744352

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002743701 – 291E3 ubiquitin-protein ligase MARCH8Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5T0T0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5T0T0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T0T0

PeptideAtlas

More...
PeptideAtlasi
Q5T0T0

PRoteomics IDEntifications database

More...
PRIDEi
Q5T0T0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
35410
64200 [Q5T0T0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q5T0T0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T0T0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed. Present in immature dendritic cells (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165406 Expressed in 223 organ(s), highest expression level in trabecular bone tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5T0T0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5T0T0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014597

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD86.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128666, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T0T0, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000411848

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1291
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T0T0

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q5T0T0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-CH-type zinc finger domain is required for E3 ligase activity.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 133RING-CH-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1609 Eukaryota
COG5183 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113483

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T0T0

KEGG Orthology (KO)

More...
KOi
K10656

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCRICHC

Database of Orthologous Groups

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OrthoDBi
1222747at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T0T0

TreeFam database of animal gene trees

More...
TreeFami
TF319557

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011016 Znf_RING-CH
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12906 RINGv, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00744 RINGv, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51292 ZF_RING_CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T0T0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMPLHQISA IPSQDAISAR VYRSKTKEKE REEQNEKTLG HFMSHSSNIS
60 70 80 90 100
KAGSPPSASA PAPVSSFSRT SITPSSQDIC RICHCEGDDE SPLITPCHCT
110 120 130 140 150
GSLHFVHQAC LQQWIKSSDT RCCELCKYEF IMETKLKPLR KWEKLQMTSS
160 170 180 190 200
ERRKIMCSVT FHVIAITCVV WSLYVLIDRT AEEIKQGQAT GILEWPFWTK
210 220 230 240 250
LVVVAIGFTG GLLFMYVQCK VYVQLWKRLK AYNRVIYVQN CPETSKKNIF
260 270 280 290
EKSPLTEPNF ENKHGYGICH SDTNSSCCTE PEDTGAEIIH V
Length:291
Mass (Da):32,965
Last modified:April 12, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF45D9BFAA3889BB3
GO
Isoform 2 (identifier: Q5T0T0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-79: I → ICSSSAVFSE...ISPVSTSGDV

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:573
Mass (Da):63,319
Checksum:i8B7E5DF14206565E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSM7A0A0A0MSM7_HUMAN
E3 ubiquitin-protein ligase MARCH8
MARCH8
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNS9A0A0G2JNS9_HUMAN
E3 ubiquitin-protein ligase MARCH8
MARCH8
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03026692P → S. Corresponds to variant dbSNP:rs3764990Ensembl.1
Natural variantiVAR_030267266Y → H1 PublicationCorresponds to variant dbSNP:rs7908745Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05569779I → ICSSSAVFSECCHHSSVQSA VVSKAPHCQSSLTQGLTVTV ICKDTLQASKRNSFGSEWAQ ALKPAKNTKARRTLKFSRSL NDVGEKAQDTSESFAYVERT CSEGKLILPQDTCLRTNRFH HKEKRTLNHKPLGNSKHSCV SCLSAGRSTASEVEAGKGGR PGLLLEEKADGEATSRSRQL LQYLFSLSHGLSASSLHRFH ELESCAARLHTAKSSSGLAG SMGFCSDEMGDDDVFEDSTS AKLKSRVLRAPLCSTEKDSD LDCPSPFSEKLPPISPVSTS GDV in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK313340 mRNA Translation: BAG36144.1
AL445201 Genomic DNA No translation available.
AL512595 Genomic DNA No translation available.
AL731567 Genomic DNA No translation available.
CH471160 Genomic DNA Translation: EAW86647.1
CH471160 Genomic DNA Translation: EAW86648.1
BC025394 mRNA Translation: AAH25394.1
BC066988 mRNA Translation: AAH66988.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS60519.1 [Q5T0T0-2]
CCDS7213.1 [Q5T0T0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001002266.1, NM_001002266.2 [Q5T0T0-1]
NP_001269795.1, NM_001282866.1 [Q5T0T0-2]
NP_659458.2, NM_145021.5 [Q5T0T0-1]
XP_005271861.1, XM_005271804.2 [Q5T0T0-2]
XP_006717767.1, XM_006717704.2 [Q5T0T0-2]
XP_011537794.1, XM_011539492.2 [Q5T0T0-2]
XP_011537795.1, XM_011539493.2
XP_011537796.1, XM_011539494.2
XP_011537797.1, XM_011539495.1 [Q5T0T0-1]
XP_016871383.1, XM_017015894.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319836; ENSP00000317087; ENSG00000165406 [Q5T0T0-1]
ENST00000395769; ENSP00000379116; ENSG00000165406 [Q5T0T0-1]
ENST00000395771; ENSP00000379118; ENSG00000278545
ENST00000453424; ENSP00000411848; ENSG00000165406 [Q5T0T0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
220972

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:220972

UCSC genome browser

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UCSCi
uc001jcf.5 human [Q5T0T0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313340 mRNA Translation: BAG36144.1
AL445201 Genomic DNA No translation available.
AL512595 Genomic DNA No translation available.
AL731567 Genomic DNA No translation available.
CH471160 Genomic DNA Translation: EAW86647.1
CH471160 Genomic DNA Translation: EAW86648.1
BC025394 mRNA Translation: AAH25394.1
BC066988 mRNA Translation: AAH66988.1
CCDSiCCDS60519.1 [Q5T0T0-2]
CCDS7213.1 [Q5T0T0-1]
RefSeqiNP_001002266.1, NM_001002266.2 [Q5T0T0-1]
NP_001269795.1, NM_001282866.1 [Q5T0T0-2]
NP_659458.2, NM_145021.5 [Q5T0T0-1]
XP_005271861.1, XM_005271804.2 [Q5T0T0-2]
XP_006717767.1, XM_006717704.2 [Q5T0T0-2]
XP_011537794.1, XM_011539492.2 [Q5T0T0-2]
XP_011537795.1, XM_011539493.2
XP_011537796.1, XM_011539494.2
XP_011537797.1, XM_011539495.1 [Q5T0T0-1]
XP_016871383.1, XM_017015894.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8SNMR-A70-136[»]
SMRiQ5T0T0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128666, 10 interactors
IntActiQ5T0T0, 6 interactors
STRINGi9606.ENSP00000411848

PTM databases

iPTMnetiQ5T0T0
PhosphoSitePlusiQ5T0T0

Polymorphism and mutation databases

BioMutaiMARCH8
DMDMi74744352

Proteomic databases

jPOSTiQ5T0T0
MaxQBiQ5T0T0
PaxDbiQ5T0T0
PeptideAtlasiQ5T0T0
PRIDEiQ5T0T0
ProteomicsDBi35410
64200 [Q5T0T0-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319836; ENSP00000317087; ENSG00000165406 [Q5T0T0-1]
ENST00000395769; ENSP00000379116; ENSG00000165406 [Q5T0T0-1]
ENST00000395771; ENSP00000379118; ENSG00000278545
ENST00000453424; ENSP00000411848; ENSG00000165406 [Q5T0T0-2]
GeneIDi220972
KEGGihsa:220972
UCSCiuc001jcf.5 human [Q5T0T0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
220972
DisGeNETi220972

GeneCards: human genes, protein and diseases

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GeneCardsi
MARCH8
HGNCiHGNC:23356 MARCH8
HPAiHPA014597
MIMi613335 gene
neXtProtiNX_Q5T0T0
OpenTargetsiENSG00000165406
PharmGKBiPA37370

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1609 Eukaryota
COG5183 LUCA
GeneTreeiENSGT00940000158282
HOGENOMiHOG000113483
InParanoidiQ5T0T0
KOiK10656
OMAiTCRICHC
OrthoDBi1222747at2759
PhylomeDBiQ5T0T0
TreeFamiTF319557

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MARCH8 human
EvolutionaryTraceiQ5T0T0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
220972

Protein Ontology

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PROi
PR:Q5T0T0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165406 Expressed in 223 organ(s), highest expression level in trabecular bone tissue
ExpressionAtlasiQ5T0T0 baseline and differential
GenevisibleiQ5T0T0 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011016 Znf_RING-CH
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12906 RINGv, 1 hit
SMARTiView protein in SMART
SM00744 RINGv, 1 hit
PROSITEiView protein in PROSITE
PS51292 ZF_RING_CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARH8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T0T0
Secondary accession number(s): B2R8E7
, H0Y7C6, Q5T0S8, Q8TC72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 12, 2005
Last modified: July 31, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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