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Entry version 126 (16 Oct 2019)
Sequence version 2 (01 May 2007)
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Protein

UBX domain-containing protein 11

Gene

UBXN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UBX domain-containing protein 11
Alternative name(s):
Colorectal tumor-associated antigen COA-1
Socius
UBX domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBXN11
Synonyms:SOC, UBXD5
ORF Names:PP2243
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30600 UBXN11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609151 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T124

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
91544

Open Targets

More...
OpenTargetsi
ENSG00000158062

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162408338

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T124

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBXN11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146325810

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002849211 – 520UBX domain-containing protein 11Add BLAST520

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T124

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T124

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T124

PeptideAtlas

More...
PeptideAtlasi
Q5T124

PRoteomics IDEntifications database

More...
PRIDEi
Q5T124

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64223 [Q5T124-1]
64224 [Q5T124-2]
64225 [Q5T124-3]
64226 [Q5T124-4]
64227 [Q5T124-5]
64228 [Q5T124-6]
64229 [Q5T124-7]
64230 [Q5T124-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T124

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T124

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158062 Expressed in 166 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T124 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T124 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028600
HPA031357

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNA12, GNA13, RND1, RND2 AND RND3.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124844, 44 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T124, 41 interactors

Molecular INTeraction database

More...
MINTi
Q5T124

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T124

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini230 – 294SEPPROSITE-ProRule annotationAdd BLAST65
Domaini392 – 469UBXPROSITE-ProRule annotationAdd BLAST78
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati487 – 49418
Repeati495 – 50228
Repeati503 – 51038

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni487 – 5103 X 8 AA tandem repeats of P-G-P-G-P-G-P-SAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili76 – 149Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi483 – 519Pro-richAdd BLAST37

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2086 Eukaryota
ENOG410YGXU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055567

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T124

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQVHEME

Database of Orthologous Groups

More...
OrthoDBi
690078at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T124

TreeFam database of animal gene trees

More...
TreeFami
TF329799

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T124-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSPLASLSK TRKVPLPSEP MNPGRRGIRI YGDEDEVDML SDGCGSEEKI
60 70 80 90 100
SVPSCYGGIG APVSRQVPAS HDSELMAFMT RKLWDLEQQV KAQTDEILSK
110 120 130 140 150
DQKIAALEDL VQTLRPHPAE ATLQRQEELE TMCVQLQRQV REMERFLSDY
160 170 180 190 200
GLQWVGEPMD QEDSESKTVS EHGERDWMTA KKFWKPGDSL APPEVDFDRL
210 220 230 240 250
LASLQDLSEL VVEGDTQVTP VPGGARLRTL EPIPLKLYRN GIMMFDGPFQ
260 270 280 290 300
PFYDPSTQRC LRDILDGFFP SELQRLYPNG VPFKVSDLRN QVYLEDGLDP
310 320 330 340 350
FPGEGRVVGR QLMHKALDRV EEHPGSRMTA EKFLNRLPKF VIRQGEVIDI
360 370 380 390 400
RGPIRDTLQN CCPLPARIQE IVVETPTLAA ERERSQESPN TPAPPLSMLR
410 420 430 440 450
IKSENGEQAF LLMMQPDNTI GDVRALLAQA RVMDASAFEI FSTFPPTLYQ
460 470 480 490 500
DDTLTLQAAG LVPKAALLLR ARRAPKSSLK FSPGPCPGPG PGPSPGPGPG
510 520
PSPGPGPGPS PCPGPSPSPQ
Length:520
Mass (Da):57,373
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8642DB07C023276E
GO
Isoform 2 (identifier: Q5T124-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-66: Missing.

Show »
Length:487
Mass (Da):53,976
Checksum:i6EC6574FF3D44CE8
GO
Isoform 3 (identifier: Q5T124-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-186: Missing.

Show »
Length:400
Mass (Da):43,272
Checksum:i7E9912421BC64AA9
GO
Isoform 4 (identifier: Q5T124-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Note: No experimental confirmation available.
Show »
Length:482
Mass (Da):53,192
Checksum:i6D512E3805F8F560
GO
Isoform 5 (identifier: Q5T124-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:208
Mass (Da):22,191
Checksum:i17B2577621F2E843
GO
Isoform 6 (identifier: Q5T124-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-324: SDLRNQVYLE...KALDRVEEHP → ISCSSNHTFG...SRCTPWGTPV
     325-520: Missing.

Show »
Length:324
Mass (Da):36,302
Checksum:i992910E8E88948D5
GO
Isoform 7 (identifier: Q5T124-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-66: Missing.
     286-324: SDLRNQVYLE...KALDRVEEHP → ISCSSNHTFG...SRCTPWGTPV
     325-520: Missing.

Show »
Length:291
Mass (Da):32,904
Checksum:i23B621EC61D566EA
GO
Isoform 8 (identifier: Q5T124-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:445
Mass (Da):49,445
Checksum:iBBAC87DB55A1A377
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8M6X6R8M6_HUMAN
UBX domain-containing protein 11
UBXN11
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T130Q5T130_HUMAN
UBX domain-containing protein 11
UBXN11
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RDY0X6RDY0_HUMAN
UBX domain-containing protein 11
UBXN11
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RIY5X6RIY5_HUMAN
UBX domain-containing protein 11
UBXN11
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R8K8X6R8K8_HUMAN
UBX domain-containing protein 11
UBXN11
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T118Q5T118_HUMAN
UBX domain-containing protein 11
UBXN11
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RDK7X6RDK7_HUMAN
UBX domain-containing protein 11
UBXN11
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM74202 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ15261 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19E → G in CAH56155 (Ref. 2) Curated1
Sequence conflicti103K → M in BAC05024 (PubMed:14702039).Curated1
Sequence conflicti240N → D in BAC05024 (PubMed:14702039).Curated1
Sequence conflicti320V → L in AAQ15261 (PubMed:15498874).Curated1
Sequence conflicti388S → L in AAM74202 (Ref. 2) Curated1
Sequence conflicti418N → D in BAC04307 (PubMed:17974005).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The number of repeats is polymorphic and varies from 1 to 4.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031860165E → G. Corresponds to variant dbSNP:rs6695966Ensembl.1
Natural variantiVAR_031861312L → R2 PublicationsCorresponds to variant dbSNP:rs4332350Ensembl.1
Natural variantiVAR_031862474A → V1 Publication1
Natural variantiVAR_031863486C → CPGPGPGPS1 Publication1
Natural variantiVAR_031864487 – 494Missing 2 Publications8
Natural variantiVAR_031865488 – 502Missing . Add BLAST15
Natural variantiVAR_052690509P → S2 PublicationsCorresponds to variant dbSNP:rs1134584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0247711 – 312Missing in isoform 5. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_0247721 – 75Missing in isoform 8. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_0247731 – 38Missing in isoform 4. CuratedAdd BLAST38
Alternative sequenceiVSP_02477434 – 66Missing in isoform 2 and isoform 7. 3 PublicationsAdd BLAST33
Alternative sequenceiVSP_02477567 – 186Missing in isoform 3. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_024776286 – 324SDLRN…VEEHP → ISCSSNHTFGDFEGSGDTQP PQTPPILRGSRCTPWGTPV in isoform 6 and isoform 7. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_024777325 – 520Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST196

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF521017 mRNA Translation: AAM74201.1
AF521018 mRNA Translation: AAM74202.1 Frameshift.
AF520989 mRNA Translation: AAM76060.1
CR749413 mRNA Translation: CAH18255.1
BX648412 mRNA Translation: CAH56155.1
AK093258 mRNA Translation: BAC04112.1
AK094198 mRNA Translation: BAC04307.1
AK097368 mRNA Translation: BAC05024.1
AF370425 mRNA Translation: AAQ15261.1 Frameshift.
AL451139 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07823.1
CH471059 Genomic DNA Translation: EAX07826.1
BC038106 mRNA Translation: AAH38106.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41286.1 [Q5T124-2]
CCDS41287.1 [Q5T124-3]
CCDS41288.1 [Q5T124-1]

NCBI Reference Sequences

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RefSeqi
NP_001070730.1, NM_001077262.1 [Q5T124-3]
NP_663320.2, NM_145345.2 [Q5T124-2]
NP_892120.2, NM_183008.2 [Q5T124-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000314675; ENSP00000324721; ENSG00000158062 [Q5T124-3]
ENST00000357089; ENSP00000349601; ENSG00000158062 [Q5T124-2]
ENST00000374217; ENSP00000363334; ENSG00000158062 [Q5T124-2]
ENST00000374221; ENSP00000363338; ENSG00000158062 [Q5T124-1]
ENST00000374222; ENSP00000363339; ENSG00000158062 [Q5T124-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91544

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91544

UCSC genome browser

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UCSCi
uc001blw.4 human [Q5T124-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521017 mRNA Translation: AAM74201.1
AF521018 mRNA Translation: AAM74202.1 Frameshift.
AF520989 mRNA Translation: AAM76060.1
CR749413 mRNA Translation: CAH18255.1
BX648412 mRNA Translation: CAH56155.1
AK093258 mRNA Translation: BAC04112.1
AK094198 mRNA Translation: BAC04307.1
AK097368 mRNA Translation: BAC05024.1
AF370425 mRNA Translation: AAQ15261.1 Frameshift.
AL451139 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07823.1
CH471059 Genomic DNA Translation: EAX07826.1
BC038106 mRNA Translation: AAH38106.1
CCDSiCCDS41286.1 [Q5T124-2]
CCDS41287.1 [Q5T124-3]
CCDS41288.1 [Q5T124-1]
RefSeqiNP_001070730.1, NM_001077262.1 [Q5T124-3]
NP_663320.2, NM_145345.2 [Q5T124-2]
NP_892120.2, NM_183008.2 [Q5T124-1]

3D structure databases

SMRiQ5T124
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124844, 44 interactors
IntActiQ5T124, 41 interactors
MINTiQ5T124
STRINGi9606.ENSP00000363339

PTM databases

iPTMnetiQ5T124
PhosphoSitePlusiQ5T124

Polymorphism and mutation databases

BioMutaiUBXN11
DMDMi146325810

Proteomic databases

jPOSTiQ5T124
MassIVEiQ5T124
PaxDbiQ5T124
PeptideAtlasiQ5T124
PRIDEiQ5T124
ProteomicsDBi64223 [Q5T124-1]
64224 [Q5T124-2]
64225 [Q5T124-3]
64226 [Q5T124-4]
64227 [Q5T124-5]
64228 [Q5T124-6]
64229 [Q5T124-7]
64230 [Q5T124-8]

Genome annotation databases

EnsembliENST00000314675; ENSP00000324721; ENSG00000158062 [Q5T124-3]
ENST00000357089; ENSP00000349601; ENSG00000158062 [Q5T124-2]
ENST00000374217; ENSP00000363334; ENSG00000158062 [Q5T124-2]
ENST00000374221; ENSP00000363338; ENSG00000158062 [Q5T124-1]
ENST00000374222; ENSP00000363339; ENSG00000158062 [Q5T124-1]
GeneIDi91544
KEGGihsa:91544
UCSCiuc001blw.4 human [Q5T124-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91544
DisGeNETi91544

GeneCards: human genes, protein and diseases

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GeneCardsi
UBXN11
HGNCiHGNC:30600 UBXN11
HPAiHPA028600
HPA031357
MIMi609151 gene
neXtProtiNX_Q5T124
OpenTargetsiENSG00000158062
PharmGKBiPA162408338

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00520000055567
InParanoidiQ5T124
OMAiNQVHEME
OrthoDBi690078at2759
PhylomeDBiQ5T124
TreeFamiTF329799

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UBXN11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UBXD5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91544
PharosiQ5T124

Protein Ontology

More...
PROi
PR:Q5T124

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158062 Expressed in 166 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ5T124 baseline and differential
GenevisibleiQ5T124 HS

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBX11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T124
Secondary accession number(s): D3DPK6
, Q5T117, Q5T120, Q5T125, Q5T126, Q5T129, Q5T131, Q5T133, Q63HM6, Q71RB3, Q8IY27, Q8N1L6, Q8N9M4, Q8NA18, Q8NFE3, Q8NFE4, Q8NFE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 16, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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