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Entry version 145 (05 Jun 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Syntaxin-binding protein 5

Gene

STXBP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5T5C0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-binding protein 5
Alternative name(s):
Lethal(2) giant larvae protein homolog 3
Tomosyn-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STXBP5
Synonyms:LLGL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19665 STXBP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604586 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T5C0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
134957

Open Targets

More...
OpenTargetsi
ENSG00000164506

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134954258

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STXBP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762236

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000512441 – 1151Syntaxin-binding protein 5Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei692PhosphoserineCombined sources1
Modified residuei723Phosphoserine; by PKABy similarity1
Modified residuei759PhosphoserineCombined sources1
Modified residuei762PhosphothreonineCombined sources1
Modified residuei782PhosphoserineBy similarity1
Modified residuei784PhosphothreonineBy similarity1
Modified residuei785PhosphoserineCombined sources1
Modified residuei900PhosphoserineBy similarity1
Modified residuei902PhosphoserineBy similarity1
Modified residuei1039PhosphothreonineCombined sources1
Modified residuei1058PhosphoserineBy similarity1
Modified residuei1131PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T5C0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T5C0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T5C0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T5C0

PeptideAtlas

More...
PeptideAtlasi
Q5T5C0

PRoteomics IDEntifications database

More...
PRIDEi
Q5T5C0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64509
64510 [Q5T5C0-2]
64511 [Q5T5C0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T5C0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T5C0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164506 Expressed in 188 organ(s), highest expression level in anterior cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5T5C0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T5C0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB079016
HPA039991
HPA049727

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126417, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T5C0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321826

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati61 – 94WD 1Add BLAST34
Repeati101 – 140WD 2Add BLAST40
Repeati145 – 181WD 3Add BLAST37
Repeati200 – 234WD 4Add BLAST35
Repeati240 – 272WD 5Add BLAST33
Repeati294 – 336WD 6Add BLAST43
Repeati344 – 378WD 7Add BLAST35
Repeati400 – 477WD 8Add BLAST78
Repeati505 – 619WD 9Add BLAST115
Repeati633 – 695WD 10Add BLAST63
Repeati794 – 851WD 11Add BLAST58
Repeati860 – 934WD 12Add BLAST75
Repeati939 – 983WD 13Add BLAST45
Repeati997 – 1020WD 14Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1086 – 1146v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 27Poly-Gln6
Compositional biasi584 – 590Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INFH Eukaryota
ENOG410XTER LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182906

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000110929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T5C0

KEGG Orthology (KO)

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KOi
K08518

Identification of Orthologs from Complete Genome Data

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OMAi
LGQAMYL

Database of Orthologous Groups

More...
OrthoDBi
84844at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T5C0

TreeFam database of animal gene trees

More...
TreeFami
TF314585

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR001388 Synaptobrevin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit
PF00400 WD40, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00962 LETHAL2GIANT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50892 V_SNARE, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T5C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK
60 70 80 90 100
TVRHGFPYQP SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA
110 120 130 140 150
VIQLQFLINE GALVSALADD TLHLWNLRQK RPAILHSLKF CRERVTFCHL
160 170 180 190 200
PFQSKWLYVG TERGNIHIVN VESFTLSGYV IMWNKAIELS SKSHPGPVVH
210 220 230 240 250
ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI HSVAWHHEGK
260 270 280 290 300
QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF
310 320 330 340 350
KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL
360 370 380 390 400
CETPYPNDFQ EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT
410 420 430 440 450
CCEYFADCPV DLIPALYSVG ARQKRQGYSK KEWPINGGNW GLGAQSYPEI
460 470 480 490 500
IITGHADGSV KFWDASAITL QVLYKLKTSK VFEKSRNKDD RPNTDIVDED
510 520 530 540 550
PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI PMLEVRLLYE
560 570 580 590 600
INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL
610 620 630 640 650
KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN
660 670 680 690 700
GIAMVDYLQK AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS
710 720 730 740 750
EGTVVPEDRC KSPTSGSSSP HNSDDEQKMN NFIEKVKTKS RKFSKMVAND
760 770 780 790 800
IAKMSRKLSL PTDLKPDLDV KDNSFSRSRS SSVTSIDKES REAISALHFC
810 820 830 840 850
ETFTRKTDSS PSPCLWVGTT LGTVLVIALN LPPGGEQRLL QPVIVSPSGT
860 870 880 890 900
ILRLKGAILR MAFLDTTGCL IPPAYEPWRE HNVPEEKDEK EKLKKRRPVS
910 920 930 940 950
VSPSSSQEIS ENQYAVICSE KQAKVISLPT QNCAYKQNIT ETSFVLRGDI
960 970 980 990 1000
VALSNSICLA CFCANGHIMT FSLPSLRPLL DVYYLPLTNM RIARTFCFTN
1010 1020 1030 1040 1050
NGQALYLVSP TEIQRLTYSQ ETCENLQEML GELFTPVETP EAPNRGFFKG
1060 1070 1080 1090 1100
LFGGGAQSLD REELFGESSS GKASRSLAQH IPGPGGIEGV KGAASGVVGE
1110 1120 1130 1140 1150
LARARLALDE RGQKLGDLEE RTAAMLSSAE SFSKHAHEIM LKYKDKKWYQ

F
Length:1,151
Mass (Da):127,573
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i247083A17DEA4811
GO
Isoform 2 (identifier: Q5T5C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-751: Missing.

Show »
Length:1,115
Mass (Da):123,492
Checksum:i2F1874662D9B30F6
GO
Isoform 3 (identifier: Q5T5C0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-768: Missing.

Show »
Length:1,098
Mass (Da):121,597
Checksum:iB8EAE43977084610
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JRH0Q5JRH0_HUMAN
Syntaxin-binding protein 5
STXBP5
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3B794Q3B794_HUMAN
STXBP5 protein
STXBP5
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y332H0Y332_HUMAN
Syntaxin-binding protein 5
STXBP5
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03475 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035235436N → S. Corresponds to variant dbSNP:rs1039084Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016204716 – 768Missing in isoform 3. CuratedAdd BLAST53
Alternative sequenceiVSP_016205716 – 751Missing in isoform 2. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL356415 Genomic DNA No translation available.
AL355365 Genomic DNA No translation available.
AL590709 Genomic DNA No translation available.
BC113382 mRNA Translation: AAI13383.1
AK055484 mRNA Translation: BAB70930.1
AK090549 mRNA Translation: BAC03475.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47499.1 [Q5T5C0-1]
CCDS5211.1 [Q5T5C0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001121187.1, NM_001127715.2 [Q5T5C0-1]
NP_640337.3, NM_139244.4 [Q5T5C0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321680; ENSP00000321826; ENSG00000164506 [Q5T5C0-1]
ENST00000367480; ENSP00000356450; ENSG00000164506 [Q5T5C0-3]
ENST00000367481; ENSP00000356451; ENSG00000164506 [Q5T5C0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
134957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:134957

UCSC genome browser

More...
UCSCi
uc003qlz.4 human [Q5T5C0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356415 Genomic DNA No translation available.
AL355365 Genomic DNA No translation available.
AL590709 Genomic DNA No translation available.
BC113382 mRNA Translation: AAI13383.1
AK055484 mRNA Translation: BAB70930.1
AK090549 mRNA Translation: BAC03475.1 Different initiation.
CCDSiCCDS47499.1 [Q5T5C0-1]
CCDS5211.1 [Q5T5C0-2]
RefSeqiNP_001121187.1, NM_001127715.2 [Q5T5C0-1]
NP_640337.3, NM_139244.4 [Q5T5C0-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126417, 13 interactors
IntActiQ5T5C0, 2 interactors
STRINGi9606.ENSP00000321826

PTM databases

iPTMnetiQ5T5C0
PhosphoSitePlusiQ5T5C0

Polymorphism and mutation databases

BioMutaiSTXBP5
DMDMi74762236

Proteomic databases

EPDiQ5T5C0
jPOSTiQ5T5C0
MaxQBiQ5T5C0
PaxDbiQ5T5C0
PeptideAtlasiQ5T5C0
PRIDEiQ5T5C0
ProteomicsDBi64509
64510 [Q5T5C0-2]
64511 [Q5T5C0-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321680; ENSP00000321826; ENSG00000164506 [Q5T5C0-1]
ENST00000367480; ENSP00000356450; ENSG00000164506 [Q5T5C0-3]
ENST00000367481; ENSP00000356451; ENSG00000164506 [Q5T5C0-2]
GeneIDi134957
KEGGihsa:134957
UCSCiuc003qlz.4 human [Q5T5C0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
134957
DisGeNETi134957

GeneCards: human genes, protein and diseases

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GeneCardsi
STXBP5

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0019766
HGNCiHGNC:19665 STXBP5
HPAiCAB079016
HPA039991
HPA049727
MIMi604586 gene
neXtProtiNX_Q5T5C0
OpenTargetsiENSG00000164506
PharmGKBiPA134954258

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410INFH Eukaryota
ENOG410XTER LUCA
GeneTreeiENSGT00950000182906
HOGENOMiHOG000110929
InParanoidiQ5T5C0
KOiK08518
OMAiLGQAMYL
OrthoDBi84844at2759
PhylomeDBiQ5T5C0
TreeFamiTF314585

Enzyme and pathway databases

SignaLinkiQ5T5C0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STXBP5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STXBP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
134957

Protein Ontology

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PROi
PR:Q5T5C0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164506 Expressed in 188 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasiQ5T5C0 baseline and differential
GenevisibleiQ5T5C0 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR001388 Synaptobrevin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit
PF00400 WD40, 1 hit
PRINTSiPR00962 LETHAL2GIANT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50892 V_SNARE, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTXB5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T5C0
Secondary accession number(s): Q14DF3
, Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: June 5, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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