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Entry version 148 (13 Nov 2019)
Sequence version 2 (13 Feb 2019)
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Protein

Rho GTPase-activating protein 21

Gene

ARHGAP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.2 Publications

Miscellaneous

Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers.
Required for In1A-dependent entry of Listeria monocytogenes into cells.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 21
Alternative name(s):
Rho GTPase-activating protein 10
Rho-type GTPase-activating protein 21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP21
Synonyms:ARHGAP10, KIAA1424
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23725 ARHGAP21

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609870 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T5U3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1000Y → A: Altered interaction with ARF1 and loss of association to membranes. 1 Publication1
Mutagenesisi1054I → A: Altered interaction with ARF1 and loss of association to membranes. 1 Publication1
Mutagenesisi1184R → A: Loss of GTPase activity and loss of function. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57584

Open Targets

More...
OpenTargetsi
ENSG00000107863

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134973559

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T5U3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745129

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003052451 – 1958Rho GTPase-activating protein 21Add BLAST1958

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphoserineBy similarity1
Modified residuei57PhosphoserineCombined sources1
Modified residuei459PhosphoserineCombined sources1
Modified residuei554Omega-N-methylarginineCombined sources1
Modified residuei575Omega-N-methylarginineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei616PhosphoserineCombined sources1
Modified residuei625PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Modified residuei747PhosphothreonineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei862PhosphoserineBy similarity1
Modified residuei881PhosphoserineCombined sources1
Modified residuei882PhosphotyrosineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei926PhosphoserineBy similarity1
Modified residuei954PhosphoserineCombined sources1
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1115PhosphoserineCombined sources1
Modified residuei1418PhosphoserineCombined sources1
Modified residuei1432PhosphoserineCombined sources1
Modified residuei1433PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei1504PhosphoserineCombined sources1
Modified residuei1516PhosphothreonineCombined sources1
Modified residuei1527PhosphoserineCombined sources1
Modified residuei1669PhosphoserineCombined sources1
Modified residuei1682PhosphothreonineBy similarity1
Modified residuei1742PhosphoserineCombined sources1
Modified residuei1917PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes.1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T5U3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5T5U3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5T5U3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T5U3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T5U3

PeptideAtlas

More...
PeptideAtlasi
Q5T5U3

PRoteomics IDEntifications database

More...
PRIDEi
Q5T5U3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64551 [Q5T5U3-1]
64552 [Q5T5U3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T5U3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T5U3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated upon cell differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107863 Expressed in 173 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5T5U3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T5U3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036610
HPA057861

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GTP-bound ARF1 and ARF6.

Interacts with CTNNA1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121636, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T5U3, 51 interactors

Molecular INTeraction database

More...
MINTi
Q5T5U3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379709

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11958
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5T5U3

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5T5U3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 159PDZPROSITE-ProRule annotationAdd BLAST110
Domaini931 – 1040PHPROSITE-ProRule annotationAdd BLAST110
Domaini1147 – 1339Rho-GAPPROSITE-ProRule annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni930 – 1097Interaction with ARF1 and ARF61 PublicationAdd BLAST168
Regioni1592 – 1861Interaction with CTNNA11 PublicationAdd BLAST270

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD1S Eukaryota
ENOG410YY7B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155406

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5T5U3

KEGG Orthology (KO)

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KOi
K20315

Identification of Orthologs from Complete Genome Data

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OMAi
DKQEPTW

Database of Orthologous Groups

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OrthoDBi
142586at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5T5U3

TreeFam database of animal gene trees

More...
TreeFami
TF329345

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T5U3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMATRRTGLS EGDGDKLKAC EVSKNKDGKE QSETVSLSED ETFSWPGPKT
60 70 80 90 100
VTLKRTSQGF GFTLRHFIVY PPESAIQFSY KDEENGNRGG KQRNRLEPMD
110 120 130 140 150
TIFVKQVKEG GPAFEAGLCT GDRIIKVNGE SVIGKTYSQV IALIQNSDTT
160 170 180 190 200
LELSVMPKDE DILQVLQFTK DVTALAYSQD AYLKGNEAYS GNARNIPEPP
210 220 230 240 250
PICYPWLPSA PSAMAQPVEI SPPDSSLSKQ QTSTPVLTQP GRAYRMEIQV
260 270 280 290 300
PPSPTDVAKS NTAVCVCNES VRTVIVPSEK VVDLLSNRNN HTGPSHRTEE
310 320 330 340 350
VRYGVSEQTS LKTVSRTTSP PLSIPTTHLI HQPAGSRSLE PSGILLKSGN
360 370 380 390 400
YSGHSDGISS SRSQAVEAPS VSVNHYSPNS HQHIDWKNYK TYKEYIDNRR
410 420 430 440 450
LHIGCRTIQE RLDSLRAASQ STTDYNQVVP NRTTLQGRRR STSHDRVPQS
460 470 480 490 500
VQIRQRSVSQ ERLEDSVLMK YCPRSASQGA LTSPSVSFSN HRTRSWDYIE
510 520 530 540 550
GQDETLENVN SGTPIPDSNG EKKQTYKWSG FTEQDDRRGI CERPRQQEIH
560 570 580 590 600
KSFRGSNFTV APSVVNSDNR RMSGRGVGSV SQFKKIPPDL KTLQSNRNFQ
610 620 630 640 650
TTCGMSLPRG ISQDRSPLVK VRSNSLKAPS THVTKPSFSQ KSFVSIKDQR
660 670 680 690 700
PVNHLHQNSL LNQQTWVRTD SAPDQQVETG KSPSLSGASA KPAPQSSENA
710 720 730 740 750
GTSDLELPVS QRNQDLSLQE AETEQSDTLD NKEAVILREK PPSGRQTPQP
760 770 780 790 800
LRHQSYILAV NDQETGSDTT CWLPNDARRE VHIKRMEERK ASSTSPPGDS
810 820 830 840 850
LASIPFIDEP TSPSIDHDIA HIPASAVISA STSQVPSIAT VPPCLTTSAP
860 870 880 890 900
LIRRQLSHDH ESVGPPSLDA QPNSKTERSK SYDEGLDDYR EDAKLSFKHV
910 920 930 940 950
SSLKGIKIAD SQKSSEDSGS RKDSSSEVFS DAAKEGWLHF RPLVTDKGKR
960 970 980 990 1000
VGGSIRPWKQ MYVVLRGHSL YLYKDKREQT TPSEEEQPIS VNACLIDISY
1010 1020 1030 1040 1050
SETKRKNVFR LTTSDCECLF QAEDRDDMLA WIKTIQESSN LNEEDTGVTN
1060 1070 1080 1090 1100
RDLISRRIKE YNNLMSKAEQ LPKTPRQSLS IRQTLLGAKS EPKTQSPHSP
1110 1120 1130 1140 1150
KEESERKLLS KDDTSPPKDK GTWRKGIPSI MRKTFEKKPT ATGTFGVRLD
1160 1170 1180 1190 1200
DCPPAHTNRY IPLIVDICCK LVEERGLEYT GIYRVPGNNA AISSMQEELN
1210 1220 1230 1240 1250
KGMADIDIQD DKWRDLNVIS SLLKSFFRKL PEPLFTNDKY ADFIEANRKE
1260 1270 1280 1290 1300
DPLDRLKTLK RLIHDLPEHH YETLKFLSAH LKTVAENSEK NKMEPRNLAI
1310 1320 1330 1340 1350
VFGPTLVRTS EDNMTHMVTH MPDQYKIVET LIQHHDWFFT EEGAEEPLTT
1360 1370 1380 1390 1400
VQEESTVDSQ PVPNIDHLLT NIGRTGVSPG DVSDSATSDS TKSKGSWGSG
1410 1420 1430 1440 1450
KDQYSRELLV SSIFAAASRK RKKPKEKAQP SSSEDELDNV FFKKENVEQC
1460 1470 1480 1490 1500
HNDTKEESKK ESETLGRKQK IIIAKENSTR KDPSTTKDEK ISLGKESTPS
1510 1520 1530 1540 1550
EEPSPPHNSK HNKSPTLSCR FAILKESPRS LLAQKSSHLE ETGSDSGTLL
1560 1570 1580 1590 1600
STSSQASLAR FSMKKSTSPE TKHSEFLANV STITSDYSTT SSATYLTSLD
1610 1620 1630 1640 1650
SSRLSPEVQS VAESKGDEAD DERSELISEG RPVETDSESE FPVFPTALTS
1660 1670 1680 1690 1700
ERLFRGKLQE VTKSSRRNSE GSELSCTEGS LTSSLDSRRQ LFSSHKLIEC
1710 1720 1730 1740 1750
DTLSRKKSAR FKSDSGSLGD AKNEKEAPSL TKVFDVMKKG KSTGSLLTPT
1760 1770 1780 1790 1800
RGESEKQEPT WKTKIADRLK LRPRAPADDM FGVGNHKVNA ETAKRKSIRR
1810 1820 1830 1840 1850
RHTLGGHRDA TEISVLNFWK VHEQSGERES ELSAVNRLKP KCSAQDLSIS
1860 1870 1880 1890 1900
DWLARERLRT STSDLSRGEI GDPQTENPST REIATTDTPL SLHCNTGSSS
1910 1920 1930 1940 1950
STLASTNRPL LSIPPQSPDQ INGESFQNVS KNASSAANAQ PHKLSETPGS

KAEFHPCL
Length:1,958
Mass (Da):217,462
Last modified:February 13, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F2AC6A88F4EA9CB
GO
Isoform 3 (identifier: Q5T5U3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-175: Missing.
     1160-1175: YIPLIVDICCKLVEER → VGDTSPPDFLKSLIQF
     1176-1958: Missing.

Note: No experimental confirmation available.
Show »
Length:1,165
Mass (Da):129,375
Checksum:i0716CD8AFDD7AAED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WW76A0A087WW76_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV73A0A1B0GV73_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTZ9A0A1B0GTZ9_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESW5E7ESW5_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A452Q6Z5A0A452Q6Z5_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
1,407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5T2H0Y5T2_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y468H0Y468_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JSD8Q5JSD8_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW11A0A1B0GW11_HUMAN
Rho GTPase-activating protein 21
ARHGAP21
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM22955 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti306S → N in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti901S → P in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti1783V → A in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti1950S → T in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti1950S → T in CAD39153 (PubMed:17974005).Curated1
Sequence conflicti1950S → T in AAH22931 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035187713N → S2 PublicationsCorresponds to variant dbSNP:rs3748222Ensembl.1
Natural variantiVAR_0351881594T → A. Corresponds to variant dbSNP:rs1133897Ensembl.1
Natural variantiVAR_0351891611V → A. Corresponds to variant dbSNP:rs1143051Ensembl.1
Natural variantiVAR_0351901629E → K. Corresponds to variant dbSNP:rs1143057Ensembl.1
Natural variantiVAR_0351911727A → T. Corresponds to variant dbSNP:rs1143075Ensembl.1
Natural variantiVAR_0351921950S → N. Corresponds to variant dbSNP:rs1127893Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028298166 – 175Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_0283001160 – 1175YIPLI…LVEER → VGDTSPPDFLKSLIQF in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0283011176 – 1958Missing in isoform 3. 1 PublicationAdd BLAST783

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF480466 mRNA Translation: AAM22955.1 Different initiation.
AL355979 Genomic DNA No translation available.
AL392104 Genomic DNA No translation available.
AB037845 mRNA Translation: BAA92662.2
BX537570 mRNA Translation: CAD97787.1
AL834495 mRNA Translation: CAD39153.1
BC022931 mRNA Translation: AAH22931.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7144.2 [Q5T5U3-1]

Protein sequence database of the Protein Information Resource

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PIRi
A59438

NCBI Reference Sequences

More...
RefSeqi
NP_065875.3, NM_020824.3 [Q5T5U3-1]
XP_005252599.1, XM_005252542.3
XP_016871948.1, XM_017016459.1 [Q5T5U3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376410; ENSP00000365592; ENSG00000107863 [Q5T5U3-3]
ENST00000396432; ENSP00000379709; ENSG00000107863 [Q5T5U3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57584

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57584

UCSC genome browser

More...
UCSCi
uc001isb.2 human [Q5T5U3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480466 mRNA Translation: AAM22955.1 Different initiation.
AL355979 Genomic DNA No translation available.
AL392104 Genomic DNA No translation available.
AB037845 mRNA Translation: BAA92662.2
BX537570 mRNA Translation: CAD97787.1
AL834495 mRNA Translation: CAD39153.1
BC022931 mRNA Translation: AAH22931.1
CCDSiCCDS7144.2 [Q5T5U3-1]
PIRiA59438
RefSeqiNP_065875.3, NM_020824.3 [Q5T5U3-1]
XP_005252599.1, XM_005252542.3
XP_016871948.1, XM_017016459.1 [Q5T5U3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DHJNMR-A931-1042[»]
2J59X-ray2.10M/N/O/P/Q/R930-1097[»]
2YUYNMR-A47-159[»]
SMRiQ5T5U3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121636, 48 interactors
IntActiQ5T5U3, 51 interactors
MINTiQ5T5U3
STRINGi9606.ENSP00000379709

PTM databases

iPTMnetiQ5T5U3
PhosphoSitePlusiQ5T5U3

Polymorphism and mutation databases

BioMutaiARHGAP21
DMDMi74745129

Proteomic databases

EPDiQ5T5U3
jPOSTiQ5T5U3
MassIVEiQ5T5U3
MaxQBiQ5T5U3
PaxDbiQ5T5U3
PeptideAtlasiQ5T5U3
PRIDEiQ5T5U3
ProteomicsDBi64551 [Q5T5U3-1]
64552 [Q5T5U3-3]

Genome annotation databases

EnsembliENST00000376410; ENSP00000365592; ENSG00000107863 [Q5T5U3-3]
ENST00000396432; ENSP00000379709; ENSG00000107863 [Q5T5U3-1]
GeneIDi57584
KEGGihsa:57584
UCSCiuc001isb.2 human [Q5T5U3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57584
DisGeNETi57584

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP21
HGNCiHGNC:23725 ARHGAP21
HPAiHPA036610
HPA057861
MIMi609870 gene
neXtProtiNX_Q5T5U3
OpenTargetsiENSG00000107863
PharmGKBiPA134973559

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KD1S Eukaryota
ENOG410YY7B LUCA
GeneTreeiENSGT00940000155406
InParanoidiQ5T5U3
KOiK20315
OMAiDKQEPTW
OrthoDBi142586at2759
PhylomeDBiQ5T5U3
TreeFamiTF329345

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGAP21 human
EvolutionaryTraceiQ5T5U3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57584
PharosiQ5T5U3

Protein Ontology

More...
PROi
PR:Q5T5U3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107863 Expressed in 173 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ5T5U3 baseline and differential
GenevisibleiQ5T5U3 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG21_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T5U3
Secondary accession number(s): Q0VF98
, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 13, 2019
Last modified: November 13, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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