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Entry version 145 (16 Oct 2019)
Sequence version 2 (20 Feb 2007)
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Protein

Kinesin-like protein KIF24

Gene

KIF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi313 – 320ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5620912 Anchoring of the basal body to the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF24
Synonyms:C9orf48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19916 KIF24

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613747 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T7B8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi263 – 264VD → AA: Impairs ability to suppress cilia formation. 1 Publication2
Mutagenesisi483 – 485KEC → AAA: Impairs ability to suppress cilia formation. 1 Publication3
Mutagenesisi621 – 622TS → AA: Reduces phosphorylation by NEK2 and abolishes ability to suppress cilia formation. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
347240

Open Targets

More...
OpenTargetsi
ENSG00000186638

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671589

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T7B8

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3879840

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIF24

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126215732

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782481 – 1368Kinesin-like protein KIF24Add BLAST1368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei584PhosphoserineBy similarity1
Modified residuei621Phosphothreonine; by NEK21 Publication1
Modified residuei622Phosphoserine; by NEK21 Publication1
Modified residuei646PhosphoserineCombined sources1
Modified residuei826PhosphoserineBy similarity1
Modified residuei829PhosphoserineBy similarity1
Modified residuei1012PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T7B8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T7B8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T7B8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T7B8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T7B8

PeptideAtlas

More...
PeptideAtlasi
Q5T7B8

PRoteomics IDEntifications database

More...
PRIDEi
Q5T7B8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64650 [Q5T7B8-1]
64651 [Q5T7B8-2]
64652 [Q5T7B8-3]
64653 [Q5T7B8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T7B8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T7B8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186638 Expressed in 81 organ(s), highest expression level in testis

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020643

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCP110, CEP97, TALPID3.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
131415, 11 interactors

Protein interaction database and analysis system

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IntActi
Q5T7B8, 22 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000368464

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5T7B8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 64SAMPROSITE-ProRule annotationAdd BLAST64
Domaini223 – 546Kinesin motorPROSITE-ProRule annotationAdd BLAST324

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0246 Eukaryota
COG5059 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154046

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5T7B8

KEGG Orthology (KO)

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KOi
K10393

Identification of Orthologs from Complete Genome Data

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OMAi
WTDIPPH

Database of Orthologous Groups

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OrthoDBi
418348at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T7B8

TreeFam database of animal gene trees

More...
TreeFami
TF336001

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24115 PTHR24115, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00225 Kinesin, 1 hit
PF00536 SAM_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5T7B8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND
60 70 80 90 100
RKRLFQLIKI IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF
110 120 130 140 150
DSPADNKDRN ASNDGFEMCS LSDFSANEQK STYLKVLEHM LPDDSQYHTK
160 170 180 190 200
TGILNATAGD SYVQTEISTS LFSPNYLSAI LGDCDIPIIQ RISHVSGYNY
210 220 230 240 250
GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR GEINIITVED
260 270 280 290 300
KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH
310 320 330 340 350
IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR
360 370 380 390 400
KHLFVWISFY EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV
410 420 430 440 450
ELLLEVILKG SKERSTGATG VNADSSRSHA VIQIQIKDSA KRTFGRISFI
460 470 480 490 500
DLAGSERAAD ARDSDRQTKM EGAEINQSLL ALKECIRALD QEHTHTPFRQ
510 520 530 540 550
SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA DRVKELKKGI
560 570 580 590 600
KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA
610 620 630 640 650
PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG
660 670 680 690 700
TVRSGHVAKK KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS
710 720 730 740 750
TKCKKVQTVQ PVQKQLVSRV ELSFGNAHHR AEYSQDSQRG TPARPASEAW
760 770 780 790 800
TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK LKYQPLKRSL RQYRPPEGQL
810 820 830 840 850
TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR ATKQRNTLEN
860 870 880 890 900
SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN
910 920 930 940 950
HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ
960 970 980 990 1000
ERGGGSSFDL RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ
1010 1020 1030 1040 1050
RDTVTTPLRE VSADGPIQVT STVKNGHAVP GEDPRGQLGT HAEYASGLMS
1060 1070 1080 1090 1100
PLTMSLLENP DNEGSPPSEQ LVQDGATHSL VAESTGGPVV SHTVPSGDQE
1110 1120 1130 1140 1150
AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA DKLPSREADL
1160 1170 1180 1190 1200
GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP
1210 1220 1230 1240 1250
HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN
1260 1270 1280 1290 1300
VTWLKPRPIS RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE
1310 1320 1330 1340 1350
QLDEMAELGF KEETLMSQLA SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ
1360
LYLTCHGPTA APEGTVPS
Length:1,368
Mass (Da):151,903
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE88C9E3A4C9FBFF
GO
Isoform 2 (identifier: Q5T7B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-405: Missing.

Note: No experimental confirmation available.
Show »
Length:1,234
Mass (Da):136,423
Checksum:i01797E61137372BB
GO
Isoform 3 (identifier: Q5T7B8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-1368: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):23,677
Checksum:iC3CBAB7EB7DBA678
GO
Isoform 4 (identifier: Q5T7B8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1158: SPSPIRQHPADKLPSREADLGEACQSRE → GPGEKTSYKAWLAGVWFVHRPHQVALQQ
     1159-1368: Missing.

Note: No experimental confirmation available.
Show »
Length:1,158
Mass (Da):128,840
Checksum:iBF300F8909F152D9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI10504 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86074 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86329 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03072050D → E. Corresponds to variant dbSNP:rs16935508Ensembl.1
Natural variantiVAR_061284109R → G. Corresponds to variant dbSNP:rs41274845Ensembl.1
Natural variantiVAR_030721140M → V. Corresponds to variant dbSNP:rs10972048Ensembl.1
Natural variantiVAR_049706218W → L. Corresponds to variant dbSNP:rs17350674Ensembl.1
Natural variantiVAR_061285837S → F2 PublicationsCorresponds to variant dbSNP:rs41274041Ensembl.1
Natural variantiVAR_0497071077T → K. Corresponds to variant dbSNP:rs34101674Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023211209 – 1368Missing in isoform 3. 1 PublicationAdd BLAST1160
Alternative sequenceiVSP_023210272 – 405Missing in isoform 2. CuratedAdd BLAST134
Alternative sequenceiVSP_0232121131 – 1158SPSPI…CQSRE → GPGEKTSYKAWLAGVWFVHR PHQVALQQ in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0232131159 – 1368Missing in isoform 4. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL353662 Genomic DNA No translation available.
AK001795 mRNA No translation available.
AK125180 mRNA Translation: BAC86074.1 Different initiation.
AK125872 mRNA Translation: BAC86329.1 Different initiation.
BC048311 mRNA Translation: AAH48311.1
BC110502 mRNA Translation: AAI10503.2
BC110503 mRNA Translation: AAI10504.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6551.2 [Q5T7B8-1]

NCBI Reference Sequences

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RefSeqi
NP_919289.2, NM_194313.2 [Q5T7B8-1]
XP_011516165.1, XM_011517863.2 [Q5T7B8-1]
XP_016870186.1, XM_017014697.1 [Q5T7B8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000379174; ENSP00000368472; ENSG00000186638 [Q5T7B8-2]
ENST00000402558; ENSP00000384433; ENSG00000186638 [Q5T7B8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
347240

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:347240

UCSC genome browser

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UCSCi
uc003zua.5 human [Q5T7B8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353662 Genomic DNA No translation available.
AK001795 mRNA No translation available.
AK125180 mRNA Translation: BAC86074.1 Different initiation.
AK125872 mRNA Translation: BAC86329.1 Different initiation.
BC048311 mRNA Translation: AAH48311.1
BC110502 mRNA Translation: AAI10503.2
BC110503 mRNA Translation: AAI10504.1 Different initiation.
CCDSiCCDS6551.2 [Q5T7B8-1]
RefSeqiNP_919289.2, NM_194313.2 [Q5T7B8-1]
XP_011516165.1, XM_011517863.2 [Q5T7B8-1]
XP_016870186.1, XM_017014697.1 [Q5T7B8-1]

3D structure databases

SMRiQ5T7B8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131415, 11 interactors
IntActiQ5T7B8, 22 interactors
STRINGi9606.ENSP00000368464

Chemistry databases

ChEMBLiCHEMBL3879840

PTM databases

iPTMnetiQ5T7B8
PhosphoSitePlusiQ5T7B8

Polymorphism and mutation databases

BioMutaiKIF24
DMDMi126215732

Proteomic databases

EPDiQ5T7B8
jPOSTiQ5T7B8
MassIVEiQ5T7B8
MaxQBiQ5T7B8
PaxDbiQ5T7B8
PeptideAtlasiQ5T7B8
PRIDEiQ5T7B8
ProteomicsDBi64650 [Q5T7B8-1]
64651 [Q5T7B8-2]
64652 [Q5T7B8-3]
64653 [Q5T7B8-4]

Genome annotation databases

EnsembliENST00000379174; ENSP00000368472; ENSG00000186638 [Q5T7B8-2]
ENST00000402558; ENSP00000384433; ENSG00000186638 [Q5T7B8-1]
GeneIDi347240
KEGGihsa:347240
UCSCiuc003zua.5 human [Q5T7B8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
347240
DisGeNETi347240

GeneCards: human genes, protein and diseases

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GeneCardsi
KIF24
HGNCiHGNC:19916 KIF24
HPAiHPA020643
MIMi613747 gene
neXtProtiNX_Q5T7B8
OpenTargetsiENSG00000186638
PharmGKBiPA142671589

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000154046
InParanoidiQ5T7B8
KOiK10393
OMAiWTDIPPH
OrthoDBi418348at2759
PhylomeDBiQ5T7B8
TreeFamiTF336001

Enzyme and pathway databases

ReactomeiR-HSA-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIF24 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIF24

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
347240
PharosiQ5T7B8

Protein Ontology

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PROi
PR:Q5T7B8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186638 Expressed in 81 organ(s), highest expression level in testis

Family and domain databases

Gene3Di1.10.150.50, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF24_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T7B8
Secondary accession number(s): Q2TB93
, Q5T7B5, Q5T7B7, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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