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Entry version 132 (16 Oct 2019)
Sequence version 2 (24 Jul 2007)
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Protein

Centrosomal protein of 162 kDa

Gene

CEP162

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.1 Publication

Miscellaneous

Promotes ectopic assembly of transition zone components at cilia tips when targeted outside distal ends of centrioles, generating extra-long cilia with strikingly swollen tips.1 Publication

Caution

Was initially thought to regulate chromosome segregation and mitotic spindle assembly (PubMed:16302001). However, it was later shown that its absence neither affect mitosis nor centriole duplication (PubMed:23644468).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5620912 Anchoring of the basal body to the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 162 kDa
Short name:
Cep162
Alternative name(s):
Protein QN1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP162
Synonyms:C6orf84, KIAA1009, QN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21107 CEP162

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610201 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TB80

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22832

Open Targets

More...
OpenTargetsi
ENSG00000135315

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134972331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5TB80

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEP162

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156630849

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002956281 – 1403Centrosomal protein of 162 kDaAdd BLAST1403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei157PhosphoserineBy similarity1
Modified residuei160PhosphoserineBy similarity1
Modified residuei474PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TB80

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TB80

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TB80

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TB80

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TB80

PeptideAtlas

More...
PeptideAtlasi
Q5TB80

PRoteomics IDEntifications database

More...
PRIDEi
Q5TB80

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64890 [Q5TB80-1]
64891 [Q5TB80-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q5TB80

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TB80

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TB80

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135315 Expressed in 193 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5TB80 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TB80 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030170
HPA030171
HPA030172
HPA030173

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CEP290 (PubMed:23644468).

Interacts with CPNE4 (By similarity).

Interacts with alpha-tubulin (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116506, 144 interactors

Database of interacting proteins

More...
DIPi
DIP-50714N

Protein interaction database and analysis system

More...
IntActi
Q5TB80, 148 interactors

Molecular INTeraction database

More...
MINTi
Q5TB80

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385215

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5TB80

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili617 – 670Sequence analysisAdd BLAST54
Coiled coili698 – 1121Sequence analysisAdd BLAST424
Coiled coili1171 – 1206Sequence analysisAdd BLAST36
Coiled coili1235 – 1386Sequence analysisAdd BLAST152

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP162 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG8C Eukaryota
ENOG410XQ44 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009631

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090261

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TB80

KEGG Orthology (KO)

More...
KOi
K16809

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRNQSFT

Database of Orthologous Groups

More...
OrthoDBi
520583at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TB80

TreeFam database of animal gene trees

More...
TreeFami
TF330884

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038774 CEP162-like

The PANTHER Classification System

More...
PANTHERi
PTHR34031 PTHR34031, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5TB80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANCSQEELD EEFEQFMKEL SDDSFENSDK TARQSKKEMK KKDTVPWWIT
60 70 80 90 100
EDDFKDDGLL GTNVSYLKTK KTSQPVMEIE EESAEKIQFL KSSGTSLLST
110 120 130 140 150
DSLETNELVV SELNHSSLGV GLDTLEEQEE KEQFFARLEK GLTSSIDYSR
160 170 180 190 200
LNKELDSNDS THFKALHSNQ ANAELTDDEH ENESKHEELA ENYSDDFEDE
210 220 230 240 250
YVGAPLTTKD EEMPSKENSK SEKISVPKQE EEKTGMLANV VLLDSLDSVA
260 270 280 290 300
EVNLDEQDKI TPKPRCLPEM TENEMTGTGV SYGQSSSDVE ALHQAYCHIA
310 320 330 340 350
HSLGDEDKQK IESNTVEDIK SSVKGHPQEN EENSKNISTM ESDLPTVEEL
360 370 380 390 400
MKPIRIDSFG ISGFDLQPVS SEKVAERKET EFFSSLPLKM NPNILSQDSQ
410 420 430 440 450
HVNLFFDKND ENVILQKTTN ESMENSCPQV TEVTATEEHV DKMYLNILRK
460 470 480 490 500
KITVNSSSLS QDDKINKTYR SQLSSEEEGA VMGKQVPYKK ARSAPPLLKR
510 520 530 540 550
KPQSGLYASV RSSGYGKPSS PLKMFSTLEK KTSEDIIKSK NLRSISTSNQ
560 570 580 590 600
PRKKEILSGT KLIKPAALDK PAHKTESCLS TRKKSENPTE TDSCIQFQTD
610 620 630 640 650
SLGYCGENKE KKLLMFKRVQ EAEDKWRGAQ ALIEQIKATF SEKEKELENK
660 670 680 690 700
LEELKKQQEK ELFKLNQDNY ILQAKLSSFE ETNKKQRWLH FGEAADPVTG
710 720 730 740 750
EKLKQIQKEI QEQETLLQGY QQENERLYNQ VKDLQEQNKK NEERMFKENQ
760 770 780 790 800
SLFSEVASLK EQMHKSRFLS QVVEDSEPTR NQNFTDLLAE LRMAQKEKDS
810 820 830 840 850
LLEDIKRLKQ DKQALEVDFE KMKKERDQAK DQIAYVTGEK LYEIKILEET
860 870 880 890 900
HKQEISRLQK RLQWYAENQE LLDKDALRLR EANEEIEKLK LEIEKLKAES
910 920 930 940 950
GNPSIRQKIR LKDKAADAKK IQDLERQVKE MEGILKRRYP NSLPALILAA
960 970 980 990 1000
SAAGDTVDKN TVEFMEKRIK KLEADLEGKD EDAKKSLRTM EQQFQKMKIQ
1010 1020 1030 1040 1050
YEQRLEQQEQ LLACKLNQHD SPRIKALEKE LDDIKEAHQI TVRNLEAEID
1060 1070 1080 1090 1100
VLKHQNAELD VKKNDKDDED FQSIEFQVEQ AHAKAKLVRL NEELAAKKRE
1110 1120 1130 1140 1150
IQDLSKTVER LQKDRRMMLS NQNSKGREEM SAKRAKKDVL HSSKGNANSF
1160 1170 1180 1190 1200
PGTLDSKLYQ PHTFTDSHVS EVLQENYRLK NELEGLISEK NELKMKSEAV
1210 1220 1230 1240 1250
MNQFENSMRR VKEDTAAHIA SLKASHQREI EKLLCQNAVE NSSSKVAELN
1260 1270 1280 1290 1300
RKIATQEVLI RHFQSQVNEL QSKQESLVVS EVREEILQKE ITKLLEELRE
1310 1320 1330 1340 1350
AKENHTPEMK HFVGLEKKIK QMEMRHAQRE QELQQIIQQT HQVVETEQNK
1360 1370 1380 1390 1400
EVEKWKRLAQ LKNRELEKFR TELDSILDVL RELHRQGVVV PVAFADEMNA

PEY
Note: No experimental confirmation available.
Length:1,403
Mass (Da):161,943
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93638BE4BC3A4B29
GO
Isoform 2 (identifier: Q5TB80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:1,327
Mass (Da):153,060
Checksum:i6F094643A2DE802B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V2J0F6V2J0_HUMAN
Centrosomal protein of 162 kDa
CEP162
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76853 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti168S → I in BAA76853 (PubMed:10231032).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033301266C → S. Corresponds to variant dbSNP:rs17790493Ensembl.1
Natural variantiVAR_033302272E → Q. Corresponds to variant dbSNP:rs16874323Ensembl.1
Natural variantiVAR_051293342S → C. Corresponds to variant dbSNP:rs17790493Ensembl.1
Natural variantiVAR_051294348E → Q. Corresponds to variant dbSNP:rs16874323Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0269531 – 76Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023226 mRNA Translation: BAA76853.2 Different initiation.
AL138742 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34494.2 [Q5TB80-1]
CCDS69149.1 [Q5TB80-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273135.1, NM_001286206.1 [Q5TB80-2]
NP_055710.2, NM_014895.3 [Q5TB80-1]
XP_006715443.1, XM_006715380.2 [Q5TB80-2]
XP_016865973.1, XM_017010484.1 [Q5TB80-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257766; ENSP00000257766; ENSG00000135315 [Q5TB80-2]
ENST00000403245; ENSP00000385215; ENSG00000135315 [Q5TB80-1]
ENST00000617909; ENSP00000481760; ENSG00000135315 [Q5TB80-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22832

UCSC genome browser

More...
UCSCi
uc003pkj.6 human [Q5TB80-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023226 mRNA Translation: BAA76853.2 Different initiation.
AL138742 Genomic DNA No translation available.
CCDSiCCDS34494.2 [Q5TB80-1]
CCDS69149.1 [Q5TB80-2]
RefSeqiNP_001273135.1, NM_001286206.1 [Q5TB80-2]
NP_055710.2, NM_014895.3 [Q5TB80-1]
XP_006715443.1, XM_006715380.2 [Q5TB80-2]
XP_016865973.1, XM_017010484.1 [Q5TB80-2]

3D structure databases

SMRiQ5TB80
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116506, 144 interactors
DIPiDIP-50714N
IntActiQ5TB80, 148 interactors
MINTiQ5TB80
STRINGi9606.ENSP00000385215

PTM databases

CarbonylDBiQ5TB80
iPTMnetiQ5TB80
PhosphoSitePlusiQ5TB80

Polymorphism and mutation databases

BioMutaiCEP162
DMDMi156630849

Proteomic databases

EPDiQ5TB80
jPOSTiQ5TB80
MassIVEiQ5TB80
MaxQBiQ5TB80
PaxDbiQ5TB80
PeptideAtlasiQ5TB80
PRIDEiQ5TB80
ProteomicsDBi64890 [Q5TB80-1]
64891 [Q5TB80-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
22832

Genome annotation databases

EnsembliENST00000257766; ENSP00000257766; ENSG00000135315 [Q5TB80-2]
ENST00000403245; ENSP00000385215; ENSG00000135315 [Q5TB80-1]
ENST00000617909; ENSP00000481760; ENSG00000135315 [Q5TB80-2]
GeneIDi22832
KEGGihsa:22832
UCSCiuc003pkj.6 human [Q5TB80-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22832
DisGeNETi22832

GeneCards: human genes, protein and diseases

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GeneCardsi
CEP162
HGNCiHGNC:21107 CEP162
HPAiHPA030170
HPA030171
HPA030172
HPA030173
MIMi610201 gene
neXtProtiNX_Q5TB80
OpenTargetsiENSG00000135315
PharmGKBiPA134972331

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IG8C Eukaryota
ENOG410XQ44 LUCA
GeneTreeiENSGT00390000009631
HOGENOMiHOG000090261
InParanoidiQ5TB80
KOiK16809
OMAiTRNQSFT
OrthoDBi520583at2759
PhylomeDBiQ5TB80
TreeFamiTF330884

Enzyme and pathway databases

ReactomeiR-HSA-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CEP162 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22832
PharosiQ5TB80

Protein Ontology

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PROi
PR:Q5TB80

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000135315 Expressed in 193 organ(s), highest expression level in testis
ExpressionAtlasiQ5TB80 baseline and differential
GenevisibleiQ5TB80 HS

Family and domain databases

InterProiView protein in InterPro
IPR038774 CEP162-like
PANTHERiPTHR34031 PTHR34031, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE162_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TB80
Secondary accession number(s): A6PVL7
, A6PVL8, Q6P475, Q9Y2L2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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