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Entry version 106 (18 Sep 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Uncharacterized protein C20orf194

Gene

C20orf194

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as an effector for ARL3.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C20orf194
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17721 C20orf194

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614146 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5TEA3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25943

Open Targets

More...
OpenTargetsi
ENSG00000088854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905007

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C20orf194

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74746271

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002360421 – 1177Uncharacterized protein C20orf194Add BLAST1177

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5TEA3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5TEA3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5TEA3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5TEA3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5TEA3

PeptideAtlas

More...
PeptideAtlasi
Q5TEA3

PRoteomics IDEntifications database

More...
PRIDEi
Q5TEA3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65039

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5TEA3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5TEA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088854 Expressed in 210 organ(s), highest expression level in quadriceps femoris

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5TEA3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052103
HPA067418

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARL3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117440, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-61818N

Protein interaction database and analysis system

More...
IntActi
Q5TEA3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000252032

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFVP Eukaryota
ENOG410XS7X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003692

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231572

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5TEA3

Identification of Orthologs from Complete Genome Data

More...
OMAi
HMVVQCV

Database of Orthologous Groups

More...
OrthoDBi
226711at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5TEA3

TreeFam database of animal gene trees

More...
TreeFami
TF329802

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040342 C20orf194-like

The PANTHER Classification System

More...
PANTHERi
PTHR33664 PTHR33664, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5TEA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVYPPRRQG LPRARSPGGS SRGSPSVSCS RLRQVQSILT QSSKSRPDGI
60 70 80 90 100
LCILGIDSRY NEGCRELANY LLFGLYNQNT SDFEKTGFSE EVLDDVIILI
110 120 130 140 150
KSDSVHLYCN PVNFRYLLPY VAHWRNLHFH CMTENEYEDE EAAEEFKITS
160 170 180 190 200
FVDMVRDCSR IGIPYSSQGH LQIFDMFVVE KWPIVQAFAL EGIGGDGFFT
210 220 230 240 250
MKYELQDVSL NLWNVYSKMD PMSLESLLSD DLVAFEHQWT SFFANFDTEI
260 270 280 290 300
PFLLELSESQ AGEPFRSYFS HGMISSHITE NSPNRQPFVL FGNHSTRENL
310 320 330 340 350
NAGNFNFPSE GHLVRSTGPG GSFAKHMVAQ CVSPKGPLAC SRTYFFGATH
360 370 380 390 400
VPYLGGDSKL PKKTEQIRLL SQIYAAVIEA VLAGIACYAK TSSLTKAKEV
410 420 430 440 450
AEQTLGSGLD SFELIPFKAA LRSKMTFHIH AVNNQGRIVP LDSEDSLSFV
460 470 480 490 500
KTACMAVYDI PDLLGGNGCL GSVVFSESFL TSQILVKEKD GTVTTETSSV
510 520 530 540 550
VLTAAVPRFC SWLVEDNEVK LSEKTQQAVR GDESFLGTYL TGGEGAYLYS
560 570 580 590 600
SNLQSWPEEG NVHFFSSGLL FSHCRHRSII ISKDHMNSIS FYDGDSTSTV
610 620 630 640 650
AALLIDFKSS LLPHLPVHFH GSSNFLMIAL FPKSKIYQAF YSEVFSLWKQ
660 670 680 690 700
QDNSGISLKV IQEDGLSVEQ KRLHSSAQKL FSALSQPAGE KRSSLKLLSA
710 720 730 740 750
KLPELDWFLQ HFAISSISQE PVMRTHLPVL LQQAEINTTH RIESDKVIIS
760 770 780 790 800
IVTGLPGCHA SELCAFLVTL HKECGRWMVY RQIMDSSECF HAAHFQRYLS
810 820 830 840 850
SALEAQQNRS ARQSAYIRKK TRLLVVLQGY TDVIDVVQAL QTHPDSNVKA
860 870 880 890 900
SFTIGAITAC VEPMSCYMEH RFLFPKCLDQ CSQGLVSNVV FTSHTTEQRH
910 920 930 940 950
PLLVQLQSLI RAANPAAAFI LAENGIVTRN EDIELILSEN SFSSPEMLRS
960 970 980 990 1000
RYLMYPGWYE GKLNAGSVYP LMVQICVWFG RPLEKTRFVA KCKAIQSSIK
1010 1020 1030 1040 1050
PSPFSGNIYH ILGKVKFSDS ERTMEVCYNT LANSLSIMPV LEGPTPPPDS
1060 1070 1080 1090 1100
KSVSQDSSGQ QECYLVFIGC SLKEDSIKDW LRQSAKQKPQ RKALKTRGML
1110 1120 1130 1140 1150
TQQEIRSIHV KRHLEPLPAG YFYNGTQFVN FFGDKTDFHP LMDQFMNDYV
1160 1170
EEANREIEKY NQELEQQEYH DLFELKP
Length:1,177
Mass (Da):132,287
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CDC79CC97B6DB1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti345F → L in CAB53697 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05963786T → M. Corresponds to variant dbSNP:rs8124486Ensembl.1
Natural variantiVAR_065913265F → L1 PublicationCorresponds to variant dbSNP:rs149767043Ensembl.1
Natural variantiVAR_050923481T → P. Corresponds to variant dbSNP:rs16988463Ensembl.1
Natural variantiVAR_050924577R → G1 PublicationCorresponds to variant dbSNP:rs2422864Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL117334 Genomic DNA No translation available.
AL109976 Genomic DNA No translation available.
AL110249 mRNA Translation: CAB53697.1
BC064352 mRNA Translation: AAH64352.1
BC080528 mRNA Translation: AAH80528.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42851.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T14777

NCBI Reference Sequences

More...
RefSeqi
NP_001009984.1, NM_001009984.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252032; ENSP00000252032; ENSG00000088854

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25943

UCSC genome browser

More...
UCSCi
uc002wii.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117334 Genomic DNA No translation available.
AL109976 Genomic DNA No translation available.
AL110249 mRNA Translation: CAB53697.1
BC064352 mRNA Translation: AAH64352.1
BC080528 mRNA Translation: AAH80528.1
CCDSiCCDS42851.1
PIRiT14777
RefSeqiNP_001009984.1, NM_001009984.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117440, 2 interactors
DIPiDIP-61818N
IntActiQ5TEA3, 2 interactors
STRINGi9606.ENSP00000252032

PTM databases

iPTMnetiQ5TEA3
PhosphoSitePlusiQ5TEA3

Polymorphism and mutation databases

BioMutaiC20orf194
DMDMi74746271

Proteomic databases

EPDiQ5TEA3
jPOSTiQ5TEA3
MassIVEiQ5TEA3
MaxQBiQ5TEA3
PaxDbiQ5TEA3
PeptideAtlasiQ5TEA3
PRIDEiQ5TEA3
ProteomicsDBi65039

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252032; ENSP00000252032; ENSG00000088854
GeneIDi25943
KEGGihsa:25943
UCSCiuc002wii.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25943
DisGeNETi25943

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C20orf194
HGNCiHGNC:17721 C20orf194
HPAiHPA052103
HPA067418
MIMi614146 gene
neXtProtiNX_Q5TEA3
OpenTargetsiENSG00000088854
PharmGKBiPA134905007

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFVP Eukaryota
ENOG410XS7X LUCA
GeneTreeiENSGT00390000003692
HOGENOMiHOG000231572
InParanoidiQ5TEA3
OMAiHMVVQCV
OrthoDBi226711at2759
PhylomeDBiQ5TEA3
TreeFamiTF329802

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C20orf194 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25943

Pharos

More...
Pharosi
Q5TEA3

Protein Ontology

More...
PROi
PR:Q5TEA3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088854 Expressed in 210 organ(s), highest expression level in quadriceps femoris
GenevisibleiQ5TEA3 HS

Family and domain databases

InterProiView protein in InterPro
IPR040342 C20orf194-like
PANTHERiPTHR33664 PTHR33664, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCT194_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5TEA3
Secondary accession number(s): Q66K86, Q6P2R9, Q9UFX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: September 18, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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