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Entry version 138 (16 Oct 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Interleukin-23 receptor

Gene

IL23R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020933 Interleukin-23 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5VWK5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5VWK5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-23 receptor
Short name:
IL-23 receptor
Short name:
IL-23R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL23R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19100 IL23R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607562 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VWK5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 355ExtracellularSequence analysisAdd BLAST332
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 629CytoplasmicSequence analysisAdd BLAST253

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Inflammatory bowel disease 17 (IBD17)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
149233

MalaCards human disease database

More...
MalaCardsi
IL23R
MIMi612261 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000162594

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
117 Behcet disease
206 NON RARE IN EUROPE: Crohn disease
771 NON RARE IN EUROPE: Ulcerative colitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134935109

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VWK5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL23R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033431

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000026866224 – 629Interleukin-23 receptorAdd BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagine; partial1 Publication1
Glycosylationi47N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi81N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi180N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi232N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi262N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi273N-linked (GlcNAc...) asparagine; partial1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to IL23.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VWK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VWK5

PeptideAtlas

More...
PeptideAtlasi
Q5VWK5

PRoteomics IDEntifications database

More...
PRIDEi
Q5VWK5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65533 [Q5VWK5-1]
65534 [Q5VWK5-2]
65535 [Q5VWK5-3]
65536 [Q5VWK5-4]
65537 [Q5VWK5-5]
65538 [Q5VWK5-6]
65539 [Q5VWK5-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VWK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VWK5

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q5VWK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162594 Expressed in 32 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5VWK5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5VWK5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056427

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor.

Interacts with JAK2 and in presence of IL23 with STAT3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127199, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-383 Interleukin-23-receptor complex

Protein interaction database and analysis system

More...
IntActi
Q5VWK5, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1629
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5VWK5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini127 – 217Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini219 – 318Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHH9 Eukaryota
ENOG410YRR7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064198

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VWK5

KEGG Orthology (KO)

More...
KOi
K05065

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTIQWDV

Database of Orthologous Groups

More...
OrthoDBi
144839at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VWK5

TreeFam database of animal gene trees

More...
TreeFami
TF335930

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VWK5-1) [UniParc]FASTAAdd to basket
Also known as: IL-23R1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI
60 70 80 90 100
YCQAAIKNCQ PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY
110 120 130 140 150
CTAECPKHFQ ETLICGKDIS SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK
160 170 180 190 200
LTYIDTKYVV HVKSLETEEE QQYLTSSYIN ISTDSLQGGK KYLVWVQAAN
210 220 230 240 250
ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII YWDSQTTIEK
260 270 280 290 300
VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG
310 320 330 340 350
KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN
360 370 380 390 400
RGDIGLLLGM IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI
410 420 430 440 450
PNMKNSNVVK MLQENSELMN NNSSEQVLYV DPMITEIKEI FIPEHKPTDY
460 470 480 490 500
KKENTGPLET RDYPQNSLFD NTTVVYIPDL NTGYKPQISN FLPEGSHLSN
510 520 530 540 550
NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL SNTIFLGELS
560 570 580 590 600
LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI
610 620
VNEELPSINT YFPQNILESH FNRISLLEK
Length:629
Mass (Da):71,722
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC63C89E81AABF05
GO
Isoform 2 (identifier: Q5VWK5-2) [UniParc]FASTAAdd to basket
Also known as: IL-23R2-F2

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 4. No experimental confirmation available.
Show »
Length:375
Mass (Da):42,822
Checksum:iF6436B1432AD56A9
GO
Isoform 3 (identifier: Q5VWK5-3) [UniParc]FASTAAdd to basket
Also known as: IL-23R3-F1

The sequence of this isoform differs from the canonical sequence as follows:
     349-356: DNRGDIGL → GLKEGSYC
     357-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 5. No experimental confirmation available.
Show »
Length:356
Mass (Da):40,859
Checksum:iD9A98F0E8F380490
GO
Isoform 4 (identifier: Q5VWK5-4) [UniParc]FASTAAdd to basket
Also known as: IL-23R2-F1

The sequence of this isoform differs from the canonical sequence as follows:
     165-174: LETEEEQQYL → DTFCSRHFQG
     175-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 2. No experimental confirmation available.
Show »
Length:174
Mass (Da):20,068
Checksum:i2F45099F46F673A5
GO
Isoform 5 (identifier: Q5VWK5-5) [UniParc]FASTAAdd to basket
Also known as: IL-23R3-F3

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.
     366-383: MLSILSLIGIFNRSFRTG → MEFWANSCFHLYRAPYFW

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 3. No experimental confirmation available.
Show »
Length:264
Mass (Da):30,278
Checksum:i1695194600E3DABF
GO
Isoform 6 (identifier: Q5VWK5-6) [UniParc]FASTAAdd to basket
Also known as: IL-23R6

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-266: RYKATTNQTWN → MILRPYQPCGT

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):42,587
Checksum:iFCB35A2F849DA5F7
GO
Isoform 7 (identifier: Q5VWK5-7) [UniParc]FASTAAdd to basket
Also known as: IL-23R5

The sequence of this isoform differs from the canonical sequence as follows:
     1-402: Missing.

Note: No experimental confirmation available.
Show »
Length:227
Mass (Da):25,551
Checksum:i43A70A48046FA1F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GV19A0A1B0GV19_HUMAN
Interleukin-23 receptor
IL23R
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFJ7A0A0D9SFJ7_HUMAN
Interleukin-23 receptor
IL23R
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16829 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46M → T in AAY18346 (PubMed:16372191).Curated1
Sequence conflicti133C → R in AAY18348 (PubMed:16372191).Curated1
Sequence conflicti302R → G in AAY18348 (PubMed:16372191).Curated1
Sequence conflicti475V → A in AAY18347 (PubMed:16372191).Curated1
Sequence conflicti481N → D in AAY18347 (PubMed:16372191).Curated1
Sequence conflicti581S → R in AAY18349 (PubMed:16372191).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0297523Q → H1 PublicationCorresponds to variant dbSNP:rs1884444Ensembl.1
Natural variantiVAR_047955175T → N. Corresponds to variant dbSNP:rs11465797Ensembl.1
Natural variantiVAR_029753310L → P5 PublicationsCorresponds to variant dbSNP:rs7530511Ensembl.1
Natural variantiVAR_029754381R → Q Polymorphism; associated with reduced disease susceptibility; has a protective effect against Crohn disease and psoriasis. 4 PublicationsCorresponds to variant dbSNP:rs11209026EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0219901 – 402Missing in isoform 7. 1 PublicationAdd BLAST402
Alternative sequenceiVSP_0219911 – 365Missing in isoform 5. 1 PublicationAdd BLAST365
Alternative sequenceiVSP_0219921 – 255Missing in isoform 6. 1 PublicationAdd BLAST255
Alternative sequenceiVSP_0219931 – 254Missing in isoform 2. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_021994165 – 174LETEEEQQYL → DTFCSRHFQG in isoform 4. 1 Publication10
Alternative sequenceiVSP_021995175 – 629Missing in isoform 4. 1 PublicationAdd BLAST455
Alternative sequenceiVSP_021996256 – 266RYKATTNQTWN → MILRPYQPCGT in isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_021997349 – 356DNRGDIGL → GLKEGSYC in isoform 3. 1 Publication8
Alternative sequenceiVSP_021998357 – 629Missing in isoform 3. 1 PublicationAdd BLAST273
Alternative sequenceiVSP_021999366 – 383MLSIL…SFRTG → MEFWANSCFHLYRAPYFW in isoform 5. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF461422 mRNA Translation: AAM44229.1
AY937250 mRNA Translation: AAY18345.1
AY937251 mRNA Translation: AAY18346.1
AY937252 mRNA Translation: AAY18347.1
AY937253 mRNA Translation: AAY18348.1
AY937254 mRNA Translation: AAY18349.1
AY937255 mRNA Translation: AAY18350.1
AL109843 Genomic DNA No translation available.
AL389925 Genomic DNA No translation available.
BC016829 mRNA Translation: AAH16829.1 Different initiation.
BC040720 mRNA Translation: AAH40720.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS637.1 [Q5VWK5-1]

NCBI Reference Sequences

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RefSeqi
NP_653302.2, NM_144701.2 [Q5VWK5-1]
XP_005270573.1, XM_005270516.2 [Q5VWK5-2]
XP_011539092.1, XM_011540790.2 [Q5VWK5-1]
XP_011539093.1, XM_011540791.2 [Q5VWK5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347310; ENSP00000321345; ENSG00000162594 [Q5VWK5-1]
ENST00000395227; ENSP00000378652; ENSG00000162594 [Q5VWK5-7]
ENST00000425614; ENSP00000387640; ENSG00000162594 [Q5VWK5-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
149233

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:149233

UCSC genome browser

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UCSCi
uc001ddo.4 human [Q5VWK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461422 mRNA Translation: AAM44229.1
AY937250 mRNA Translation: AAY18345.1
AY937251 mRNA Translation: AAY18346.1
AY937252 mRNA Translation: AAY18347.1
AY937253 mRNA Translation: AAY18348.1
AY937254 mRNA Translation: AAY18349.1
AY937255 mRNA Translation: AAY18350.1
AL109843 Genomic DNA No translation available.
AL389925 Genomic DNA No translation available.
BC016829 mRNA Translation: AAH16829.1 Different initiation.
BC040720 mRNA Translation: AAH40720.1
CCDSiCCDS637.1 [Q5VWK5-1]
RefSeqiNP_653302.2, NM_144701.2 [Q5VWK5-1]
XP_005270573.1, XM_005270516.2 [Q5VWK5-2]
XP_011539092.1, XM_011540790.2 [Q5VWK5-1]
XP_011539093.1, XM_011540791.2 [Q5VWK5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MZVX-ray2.80C1-317[»]
SMRiQ5VWK5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127199, 3 interactors
ComplexPortaliCPX-383 Interleukin-23-receptor complex
IntActiQ5VWK5, 6 interactors
STRINGi9606.ENSP00000321345

PTM databases

iPTMnetiQ5VWK5
PhosphoSitePlusiQ5VWK5
UniCarbKBiQ5VWK5

Polymorphism and mutation databases

BioMutaiIL23R
DMDMi311033431

Proteomic databases

MassIVEiQ5VWK5
PaxDbiQ5VWK5
PeptideAtlasiQ5VWK5
PRIDEiQ5VWK5
ProteomicsDBi65533 [Q5VWK5-1]
65534 [Q5VWK5-2]
65535 [Q5VWK5-3]
65536 [Q5VWK5-4]
65537 [Q5VWK5-5]
65538 [Q5VWK5-6]
65539 [Q5VWK5-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
149233

Genome annotation databases

EnsembliENST00000347310; ENSP00000321345; ENSG00000162594 [Q5VWK5-1]
ENST00000395227; ENSP00000378652; ENSG00000162594 [Q5VWK5-7]
ENST00000425614; ENSP00000387640; ENSG00000162594 [Q5VWK5-6]
GeneIDi149233
KEGGihsa:149233
UCSCiuc001ddo.4 human [Q5VWK5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
149233
DisGeNETi149233

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL23R
HGNCiHGNC:19100 IL23R
HPAiHPA056427
MalaCardsiIL23R
MIMi607562 gene
612261 phenotype
neXtProtiNX_Q5VWK5
OpenTargetsiENSG00000162594
Orphaneti117 Behcet disease
206 NON RARE IN EUROPE: Crohn disease
771 NON RARE IN EUROPE: Ulcerative colitis
PharmGKBiPA134935109

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHH9 Eukaryota
ENOG410YRR7 LUCA
GeneTreeiENSGT00530000064198
InParanoidiQ5VWK5
KOiK05065
OMAiVTIQWDV
OrthoDBi144839at2759
PhylomeDBiQ5VWK5
TreeFamiTF335930

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020933 Interleukin-23 signaling
SignaLinkiQ5VWK5
SIGNORiQ5VWK5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL23R human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin-23_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
149233
PharosiQ5VWK5

Protein Ontology

More...
PROi
PR:Q5VWK5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162594 Expressed in 32 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ5VWK5 baseline and differential
GenevisibleiQ5VWK5 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL23R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VWK5
Secondary accession number(s): C9JGX4
, Q4VGP1, Q4VGP2, Q4VGP3, Q4VGP4, Q4VGP5, Q4VGP6, Q5VWK7, Q8IW84, Q8NFQ9, Q96AS1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 2, 2010
Last modified: October 16, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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