Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (13 Nov 2019)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

ELAV-like protein 4

Gene

Elavl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:15764704, PubMed:16554442, PubMed:17035636, PubMed:20064466, PubMed:22387028, PubMed:23383270, PubMed:26305964, PubMed:28111162). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:15764704, PubMed:23383270, PubMed:26305964, PubMed:28111162). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (By similarity). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (PubMed:26305964). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:20064466). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:15764704, PubMed:16554442, PubMed:18218628, PubMed:23383270, PubMed:24599466, PubMed:25692578, PubMed:26305964, PubMed:28111162). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (PubMed:15764704). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (PubMed:26305964). Binds and stabilizes MSI1 mRNA in neural stem cells (PubMed:16554442). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (PubMed:24599466). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:28111162). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:23383270, PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (PubMed:28111162). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (PubMed:20064466). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (PubMed:22387028). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (PubMed:22387028). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (PubMed:17035636).By similarity11 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ELAV-like protein 4
Alternative name(s):
Hu-antigen D
Short name:
HuD
Paraneoplastic encephalomyelitis antigen HuD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Elavl4
Synonyms:Hud
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107427 Elavl4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Transiently impaired neurite extensions of several cranial nerves, including glossopharyngeal nerve, hypoglossal nerve, trigeminal nerve and acousticofacial nerves in the midembryonic nervous system at 10.5 dpc, however no developmental delays of the nervous system in later-stage embryos at 14 dpc are obvious (PubMed:15764704). By postnatal weeks 4 to 8, 70-80% of the mice exhibit an abnormal clasping reflex of the hind limbs upon being suspended by the tail (PubMed:15764704). Decreased motor coordination, as impaired performance on an accelerating rotarod is observed (PubMed:15764704). Embryonic neural stem cells exhibit enhanced cell renewal capacity and decreased ability to differentiate into neurons (PubMed:15764704). Failure of neural progenitor cells to leave the cell cycle, resulting in increased apoptosis and in reduced production of postmitotic neurons (PubMed:15764704). Increased number of slowly dividing cells in the subventricular zone (PubMed:15764704). High insulin levels in pancreatic beta cells (PubMed:22387028). At 28 dpc, a decreased number of lower layer neocortical neurons is observed and lower layer neocortical neurons and CA3 hippocampal neurons exhibit a decreased dendritic complexity with fewer basal and apical branchpoints, fewer branch endings and shorter basal dendrites (PubMed:24599466). Basal branching deficiency in neocortical lower layer neurons and in hippocampal CA3 neurons persists into adulthood at 90 dpc (PubMed:24599466). Increased time spent in low-energy-expending activities and less in the high-energy activity of locomotion, indicating an anxiety response (PubMed:24599466). Decreased performance in finding a hidden platform in a water bath (Morris water maze test), suggesting difficulty in learning, lack of avoidance of the open arm in a elevated plus maze test, suggesting an aberrant response to anxiety-producing environments, and higher susceptibility to auditory-induced seizures (PubMed:24599466). RNAi-mediated knockdown in the neocortex at 13.5 dpc results in reduced neurite outgrowth (PubMed:24599466). RNAi-mediated knockdown in neural stem/progenitor cells in the adult subventricular zone impairs early neuronal differentiation (PubMed:26305964).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 215Missing : Reduced association with polysomes and reduced stimulation of translation. 1 PublicationAdd BLAST215
Mutagenesisi149T → A: Decreased dendritic localization and decreased translation of reporter mRNA, when associated with Ala-165. 1 Publication1
Mutagenesisi165T → A: Decreased dendritic localization and decreased translation of reporter mRNA, when associated with Ala-149. 1 Publication1
Mutagenesisi277R → A: No impact on interaction with EIF4A. 1 Publication1
Mutagenesisi278F → A: Disrupts interaction with EIF4A and fails to stimulate translation. 1 Publication1
Mutagenesisi279S → A: No impact on interaction with EIF4A. 1 Publication1
Mutagenesisi280P → A: No impact on interaction with EIF4A. 1 Publication1
Mutagenesisi303 – 385Missing : Loss of association with polysomes and loss of translation stimulation. 1 PublicationAdd BLAST83

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000815841 – 385ELAV-like protein 4Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei248Omega-N-methylated arginine; by CARM1By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (By similarity). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity). Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61701

PeptideAtlas

More...
PeptideAtlasi
Q61701

PRoteomics IDEntifications database

More...
PRIDEi
Q61701

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61701

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61701

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, including the hippocampus, and in pancreatic beta cells (at protein level) (PubMed:22387028, PubMed:18493953, PubMed:15764704, PubMed:24599466). Expressed in pyramidal neurons of the hippocampal CA3 and CA1 region and in the hilus but not in dentate granule cells (at protein level) (PubMed:15519747). Expressed in the dorsal root ganglion and the spinal cord (at protein level) (PubMed:17035636, PubMed:28111162). Expressed in neural stem and progenitor cells (at protein level) (PubMed:16554442). Expressed in radial glia-like cells and in transient amplifying cells in the subventricular zone (SVZ), and in immature neurons both in the SVZ and the rostral migratory stream as well as in mature neurons in the olfactory bulb (at protein level) (PubMed:26305964). Expressed in testis and in the brain, including the hippocampus, the neocortex and the cerebellum (PubMed:8535975, PubMed:11573004, PubMed:24857657). Expressed in lower- but not upper-layer primary neurons of the mature neocortex, in the hippocampal regions CA1-3 and the dentate gyrus (PubMed:24599466, PubMed:9096138). Expressed in the mitral and granule cells of the olfactory bulb, cerebral cortex, entorhinal cortex, thalamus, medial habenula, amygdala, granule cells of the cerebellum, pons, olivary nucleus, dorsal and ventral spinal cord and in dorsal root ganglia (PubMed:9096138). Expressed in motor neurons (PubMed:21389246). Isoform 4: Expressed in the brain (PubMed:9096138, PubMed:22895702). Isoform 5: Expressed in the brain (PubMed:9096138). Isoform 6: Expressed in the brain (PubMed:22895702). Isoform 7: Expressed in the brain (PubMed:22895702). Isoform 8: Expressed in the brain (PubMed:22895702). Isoform 9: Expressed in the brain (PubMed:22895702). Isoform 10: Expressed in the brain (PubMed:22895702). Isoform 11: Expressed in the brain (PubMed:22895702).15 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 14 dpc, expressed in the intermediate zone of the cortex (PubMed:9096138). At 15 dpc, high expression in the neocortex, with decreased expression at postnatal day 7 and in adulthood (PubMed:24599466). At 16 dpc and at birth, expressed in the retina, thalamus, hypothalamus, midbrain, pons, dorsal and ventral spinal cord, and the dorsal root ganglia (PubMed:9096138). At birth, expressed in the nasal epithelium, olfactory bulb, trigeminal ganglia, cerebral cortex, the pyramidal cells of the hippocampus and the sympathetic ganglia (PubMed:9096138). Widely expressed in the cerebellum at postnatal day 9 (PubMed:9096138). Isoform 4: Highly expressed in the brain at 10 dpc to 14 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 5: Highly expressed in the brain at 10 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 6: Expressed in the brain at 14 dpc (PubMed:22895702). Isoform 7: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 8: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 9: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 10: Expressed in the brain at 14 dpc, including the amygdala, hippocampus and cerebral cortex, and strong expression in the olfactory bulb and retina (PubMed:22895702). Isoform 11: Expressed in the brain at 14 dpc (PubMed:9096138).3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by glucose and by insulin (PubMed:22387028). Up-regulated after memory training in radial arm maze experiments (PubMed:11573004). Up-regulated after sciatic nerve injury (PubMed:28111162). Up-regulated during adult neuronal stem cell differentiation (PubMed:26305964).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028546 Expressed in 222 organ(s), highest expression level in dorsal root ganglion

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q61701 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q61701 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (PubMed:15086518). Associates with the EIF4F cap-binding complex, composed of EIF4G, EIF4A, EIF4E and PABP (PubMed:20064466). Within the EIF4F cap-binding complex, interacts with EIF4A (PubMed:20064466).

Interacts with SMN (via Tudor domain) in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules (By similarity).

Interacts with MAP1 light chain LC1 (via C-terminus); the interaction contributes to the association of ELAVL4 with microtubules (PubMed:21288476).

Interacts with MAP1 light chain LC2 (PubMed:21288476).

By similarity3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200486, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q61701, 4 interactors

Molecular INTeraction database

More...
MINTi
Q61701

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000102207

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q61701

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 129RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini137 – 217RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini302 – 380RRM 3PROSITE-ProRule annotationAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RRM 3 domain is required for binding to poly(A) RNA, for the association with polysomes and with the EIF4F cap-binding complex and for the stimulation of translation (PubMed:20064466). The RRM 1 and RRM 2 domains may contribute to polysome association and stimulation of translation (PubMed:20064466).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0145 Eukaryota
ENOG410XP7S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157399

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231162

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61701

KEGG Orthology (KO)

More...
KOi
K13208

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIDSCKL

Database of Orthologous Groups

More...
OrthoDBi
614259at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q61701

TreeFam database of animal gene trees

More...
TreeFami
TF313377

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12650 RRM1_Hu, 1 hit
cd12656 RRM3_HuD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034918 HuD_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00961 HUDSXLRNA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01661 ELAV_HUD_SF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 10 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61701-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGAATDDSK
60 70 80 90 100
TNLIVNYLPQ NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI
110 120 130 140 150
DPKDAEKAIN TLNGLRLQTK TIKVSYARPS SASIRDANLY VSGLPKTMTQ
160 170 180 190 200
KELEQLFSQY GRIITSRILV DQVTGVSRGV GFIRFDKRIE AEEAIKGLNG
210 220 230 240 250
QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG PLHHQAQRFR
260 270 280 290 300
LDNLLNMAYG VKRLMSGPVP PSACPPRFSP ITIDGMTSLV GMNIPGHTGT
310 320 330 340 350
GWCIFVYNLS PDSDESVLWQ LFGPFGAVNN VKVIRDFNTN KCKGFGFVTM
360 370 380
TNYDEAAMAI ASLNGYRLGD RVLQVSFKTN KAHKS
Length:385
Mass (Da):42,368
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EA9CDAB7E9BC683
GO
Isoform 2 (identifier: Q61701-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     251-277: Missing.

Show »
Length:358
Mass (Da):39,489
Checksum:iBE2984EA2BBCD038
GO
Isoform 3 (identifier: Q61701-4) [UniParc]FASTAAdd to basket
Also known as: sv11 Publication, E1b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEWNGLK → MV

Note: Produced by alternative initiation.1 Publication
Show »
Length:380
Mass (Da):41,740
Checksum:i3C1200B6629237B3
GO
Isoform 4 (identifier: Q61701-5) [UniParc]FASTAAdd to basket
Also known as: sv21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEWNGLK → MV
     264-277: Missing.

Note: Produced by alternative splicing of isoform 4.
Show »
Length:366
Mass (Da):40,349
Checksum:iDBF05DBE58CF9937
GO
Isoform 5 (identifier: Q61701-6) [UniParc]FASTAAdd to basket
Also known as: E1a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEWNGLKM → MRLQNQ
     251-277: Missing.

Note: Produced by alternative initiation.1 Publication
Show »
Length:356
Mass (Da):39,269
Checksum:iCEBCE5A9619C6F28
GO
Isoform 6 (identifier: Q61701-7) [UniParc]FASTAAdd to basket
Also known as: E1a11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEWNGLKM → MEQ
     264-277: Missing.

Note: Produced by alternative initiation.1 Publication
Show »
Length:366
Mass (Da):40,376
Checksum:iF22C176D8E20C60D
GO
Isoform 7 (identifier: Q61701-8) [UniParc]FASTAAdd to basket
Also known as: E1a21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEWNGLKM → MFEISRTLNAALLNNE
     85-385: Missing.

Note: Produced by alternative initiation.1 Publication
Show »
Length:92
Mass (Da):10,025
Checksum:iC3F7DDD97952C428
GO
Isoform 8 (identifier: Q61701-9) [UniParc]FASTAAdd to basket
Also known as: E1a31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MEWNGLK → MGLLLLREIVINESRNCSF
     264-277: Missing.

Note: Produced by alternative initiation.1 Publication
Show »
Length:383
Mass (Da):42,308
Checksum:i4EE69A79CDE179DD
GO
Isoform 9 (identifier: Q61701-10) [UniParc]FASTAAdd to basket
Also known as: E1c1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     264-277: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:371
Mass (Da):40,978
Checksum:i05EC044545F5C059
GO
Isoform 10 (identifier: Q61701-11) [UniParc]FASTAAdd to basket
Also known as: E1c11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEWNGLKM → MPNALLFQCLCSR

Note: Produced by alternative initiation.1 Publication
Show »
Length:390
Mass (Da):42,856
Checksum:i5D85C94DB403D934
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A9R4A2A9R4_MOUSE
ELAV-like protein 4
Elavl4
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A9R5A2A9R5_MOUSE
ELAV-like protein 4
Elavl4
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0602911 – 8MEWNGLKM → MPNALLFQCLCSR in isoform 10. 8
Alternative sequenceiVSP_0602841 – 8MEWNGLKM → MRLQNQ in isoform 5. 1 Publication8
Alternative sequenceiVSP_0602851 – 8MEWNGLKM → MEQ in isoform 6. 1 Publication8
Alternative sequenceiVSP_0602861 – 8MEWNGLKM → MFEISRTLNAALLNNE in isoform 7. 1 Publication8
Alternative sequenceiVSP_0602871 – 7MEWNGLK → MV in isoform 3 and isoform 4. 1 Publication7
Alternative sequenceiVSP_0602881 – 7MEWNGLK → MGLLLLREIVINESRNCSF in isoform 8. 1 Publication7
Alternative sequenceiVSP_06028985 – 385Missing in isoform 7. Add BLAST301
Alternative sequenceiVSP_005792251 – 277Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_060290264 – 277Missing in isoform 4, isoform 6, isoform 8 and isoform 9. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D31953 mRNA Translation: BAA06723.1
AF041341 mRNA Translation: AAC40080.1
BC052451 mRNA Translation: AAH52451.2
AK079088 mRNA Translation: BAC37532.1
AL627425 Genomic DNA No translation available.
AL627206 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18470.1 [Q61701-4]
CCDS18471.1 [Q61701-1]
CCDS51261.1 [Q61701-10]
CCDS51262.1 [Q61701-6]
CCDS84777.1 [Q61701-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2298

NCBI Reference Sequences

More...
RefSeqi
NP_001033787.1, NM_001038698.1 [Q61701-4]
NP_001334107.1, NM_001347178.1 [Q61701-5]
NP_034618.2, NM_010488.4 [Q61701-1]
XP_006502862.1, XM_006502799.3 [Q61701-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000102722; ENSMUSP00000099783; ENSMUSG00000028546 [Q61701-10]
ENSMUST00000102723; ENSMUSP00000099784; ENSMUSG00000028546 [Q61701-4]
ENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546 [Q61701-1]
ENSMUST00000106598; ENSMUSP00000102208; ENSMUSG00000028546 [Q61701-5]
ENSMUST00000106600; ENSMUSP00000102210; ENSMUSG00000028546 [Q61701-9]
ENSMUST00000106601; ENSMUSP00000102212; ENSMUSG00000028546 [Q61701-7]
ENSMUST00000106603; ENSMUSP00000102214; ENSMUSG00000028546 [Q61701-6]
ENSMUST00000142722; ENSMUSP00000121828; ENSMUSG00000028546 [Q61701-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
15572

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15572

UCSC genome browser

More...
UCSCi
uc008ucw.1 mouse [Q61701-1]
uc008ucx.1 mouse

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31953 mRNA Translation: BAA06723.1
AF041341 mRNA Translation: AAC40080.1
BC052451 mRNA Translation: AAH52451.2
AK079088 mRNA Translation: BAC37532.1
AL627425 Genomic DNA No translation available.
AL627206 Genomic DNA No translation available.
CCDSiCCDS18470.1 [Q61701-4]
CCDS18471.1 [Q61701-1]
CCDS51261.1 [Q61701-10]
CCDS51262.1 [Q61701-6]
CCDS84777.1 [Q61701-5]
PIRiJC2298
RefSeqiNP_001033787.1, NM_001038698.1 [Q61701-4]
NP_001334107.1, NM_001347178.1 [Q61701-5]
NP_034618.2, NM_010488.4 [Q61701-1]
XP_006502862.1, XM_006502799.3 [Q61701-9]

3D structure databases

SMRiQ61701
ModBaseiSearch...

Protein-protein interaction databases

BioGridi200486, 5 interactors
IntActiQ61701, 4 interactors
MINTiQ61701
STRINGi10090.ENSMUSP00000102207

PTM databases

iPTMnetiQ61701
PhosphoSitePlusiQ61701

Proteomic databases

PaxDbiQ61701
PeptideAtlasiQ61701
PRIDEiQ61701

Genome annotation databases

EnsembliENSMUST00000102722; ENSMUSP00000099783; ENSMUSG00000028546 [Q61701-10]
ENSMUST00000102723; ENSMUSP00000099784; ENSMUSG00000028546 [Q61701-4]
ENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546 [Q61701-1]
ENSMUST00000106598; ENSMUSP00000102208; ENSMUSG00000028546 [Q61701-5]
ENSMUST00000106600; ENSMUSP00000102210; ENSMUSG00000028546 [Q61701-9]
ENSMUST00000106601; ENSMUSP00000102212; ENSMUSG00000028546 [Q61701-7]
ENSMUST00000106603; ENSMUSP00000102214; ENSMUSG00000028546 [Q61701-6]
ENSMUST00000142722; ENSMUSP00000121828; ENSMUSG00000028546 [Q61701-8]
GeneIDi15572
KEGGimmu:15572
UCSCiuc008ucw.1 mouse [Q61701-1]
uc008ucx.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1996
MGIiMGI:107427 Elavl4

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00940000157399
HOGENOMiHOG000231162
InParanoidiQ61701
KOiK13208
OMAiEIDSCKL
OrthoDBi614259at2759
PhylomeDBiQ61701
TreeFamiTF313377

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Elavl4 mouse

Protein Ontology

More...
PROi
PR:Q61701

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028546 Expressed in 222 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiQ61701 baseline and differential
GenevisibleiQ61701 MM

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12656 RRM3_HuD, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034918 HuD_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELAV4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61701
Secondary accession number(s): A2A9R6
, A2A9R7, A2A9R8, A2A9S0, A2A9S1, A2A9S2, A2A9S3, O55010, Q6PHZ3, Q8BVA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 13, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again