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Entry version 169 (13 Nov 2019)
Sequence version 2 (19 Jul 2004)
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Protein

Drebrin-like protein

Gene

Dbnl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processAdaptive immunity, Endocytosis, Immunity, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-MMU-6794361 Neurexins and neuroligins
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Drebrin-like protein
Alternative name(s):
Actin-binding protein 1
SH3 domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DbnlImported
Synonyms:Abp11 Publication, Sh3p71 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:700006 Dbnl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi340Y → F: Reduces phosphorylation. Abolishes phosphorylation; when associated with F-350. 2 Publications1
Mutagenesisi350Y → F: Reduces phosphorylation. Impairs podosome rosette formation. Abolishes phosphorylation; when associated with F-340. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797941 – 436Drebrin-like proteinAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphothreonineCombined sources1
Modified residuei160PhosphoserineBy similarity1
Modified residuei176N6-acetyllysineBy similarity1
Modified residuei277PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei283PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei296N6-acetyllysineBy similarity1
Modified residuei299PhosphothreonineBy similarity1
Modified residuei340Phosphotyrosine2 Publications1
Modified residuei350Phosphotyrosine2 Publications1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei367 – 368Cleavage; by caspase-3By similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q62418

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q62418

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62418

PeptideAtlas

More...
PeptideAtlasi
Q62418

PRoteomics IDEntifications database

More...
PRIDEi
Q62418

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62418

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62418

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q62418

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in hippocampus neurons and in the Purkinje cell layer in cerebellum (at protein level). Predominantly expressed in brain, thymus and spleen. Also found in testis, heart and lung. Little or no expression detected in ovary or muscle.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the embryo, expression is high during early development but drops during later development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020476 Expressed in 282 organ(s), highest expression level in lens of camera-type eye

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62418 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHANK3, SYN1 and PRAM1 (By similarity).

Interacts with SHANK2.

Interacts with FGD1, DNM1 and MAP4K1.

Interacts with ANKRD54.

Interacts with COBL.

Interacts with WASL and WIPF1.

By similarity8 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
199059, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-39835N

Protein interaction database and analysis system

More...
IntActi
Q62418, 7 interactors

Molecular INTeraction database

More...
MINTi
Q62418

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62418

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 133ADF-HPROSITE-ProRule annotationAdd BLAST132
Domaini377 – 436SH3PROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili179 – 233Sequence analysisAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABP1 family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3655 Eukaryota
ENOG410XRVX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156732

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62418

KEGG Orthology (KO)

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KOi
K20520

Identification of Orthologs from Complete Genome Data

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OMAi
GYEGQTN

Database of Orthologous Groups

More...
OrthoDBi
885776at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62418

TreeFam database of animal gene trees

More...
TreeFami
TF318935

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11960 SH3_Abp1_eu, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029923 Dbnl
IPR035717 Drebrin-like_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR10829:SF12 PTHR10829:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00102 ADF, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51263 ADF_H, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q62418-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVNLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL
60 70 80 90 100
EELVEELNSG KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACANH
110 120 130 140 150
VSTMANFLKG AHVTINARAE EDVEPECIME KVAKASGANY SFHKESTSFQ
160 170 180 190 200
DVGPQAPVGS VYQKTNAISE IKRVGKDNFW AKAEKEEENR RLEEKRRAEE
210 220 230 240 250
ERQRLEEERR ERELQEAARR EQRYQEQHRS AGAPSPSSRT GEPEQEAVSR
260 270 280 290 300
TRQEWESAGQ QAPHPREIFK QKERAMSTTS VTSSQPGKLR SPFLQKQLTQ
310 320 330 340 350
PETSYGREPT APVSRPAAGV CEEPAPSTLS SAQTEEEPTY EVPPEQDTLY
360 370 380 390 400
EEPPLVQQQG AGSEHIDNYM QSQGFSGQGL CARALYDYQA ADDTEISFDP
410 420 430
ENLITGIEVI DEGWWRGYGP DGHFGMFPAN YVELIE
Length:436
Mass (Da):48,700
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85AEF9781C698A3F
GO
Isoform 21 Publication (identifier: Q62418-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-238: Missing.

Show »
Length:433
Mass (Da):48,428
Checksum:i602D3862C446FA4D
GO
Isoform 3Curated (identifier: Q62418-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-238: Missing.

Show »
Length:432
Mass (Da):48,341
Checksum:i4A36D3B6E59C707F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30L → F in BAE40714 (PubMed:16141072).Curated1
Sequence conflicti101V → D in BAE31953 (PubMed:16141072).Curated1
Sequence conflicti135A → V in BAE30108 (PubMed:16141072).Curated1
Sequence conflicti135A → V in BAE31033 (PubMed:16141072).Curated1
Sequence conflicti327S → C in BAE22028 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050789235 – 238Missing in isoform 3. 2 Publications4
Alternative sequenceiVSP_050790236 – 238Missing in isoform 2. 3 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U58884 mRNA Translation: AAC52640.1
AY098595 mRNA Translation: AAM28340.1
AK046073 mRNA Translation: BAC32592.1
AK053796 mRNA Translation: BAC35528.1
AK078082 mRNA Translation: BAC37118.1
AK134136 mRNA Translation: BAE22028.1
AK134487 mRNA Translation: BAE22160.1
AK140752 mRNA Translation: BAE24466.1
AK142818 mRNA Translation: BAE25201.1
AK146920 mRNA Translation: BAE27532.1
AK151096 mRNA Translation: BAE30108.1
AK152204 mRNA Translation: BAE31033.1
AK153389 mRNA Translation: BAE31953.1
AK159984 mRNA Translation: BAE35535.1
AK168898 mRNA Translation: BAE40714.1
AK172471 mRNA Translation: BAE43024.1
AL627069 Genomic DNA No translation available.
BC046430 mRNA Translation: AAH46430.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24403.1 [Q62418-2]
CCDS48746.1 [Q62418-1]
CCDS48747.1 [Q62418-3]

NCBI Reference Sequences

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RefSeqi
NP_001139780.1, NM_001146308.1 [Q62418-1]
NP_001139781.1, NM_001146309.1 [Q62418-3]
NP_038838.1, NM_013810.3 [Q62418-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020769; ENSMUSP00000020769; ENSMUSG00000020476 [Q62418-1]
ENSMUST00000102928; ENSMUSP00000099992; ENSMUSG00000020476 [Q62418-2]
ENSMUST00000109845; ENSMUSP00000105471; ENSMUSG00000020476 [Q62418-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
13169

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:13169

UCSC genome browser

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UCSCi
uc007hxb.2 mouse [Q62418-2]
uc007hxc.2 mouse [Q62418-3]
uc007hxd.2 mouse [Q62418-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58884 mRNA Translation: AAC52640.1
AY098595 mRNA Translation: AAM28340.1
AK046073 mRNA Translation: BAC32592.1
AK053796 mRNA Translation: BAC35528.1
AK078082 mRNA Translation: BAC37118.1
AK134136 mRNA Translation: BAE22028.1
AK134487 mRNA Translation: BAE22160.1
AK140752 mRNA Translation: BAE24466.1
AK142818 mRNA Translation: BAE25201.1
AK146920 mRNA Translation: BAE27532.1
AK151096 mRNA Translation: BAE30108.1
AK152204 mRNA Translation: BAE31033.1
AK153389 mRNA Translation: BAE31953.1
AK159984 mRNA Translation: BAE35535.1
AK168898 mRNA Translation: BAE40714.1
AK172471 mRNA Translation: BAE43024.1
AL627069 Genomic DNA No translation available.
BC046430 mRNA Translation: AAH46430.1
CCDSiCCDS24403.1 [Q62418-2]
CCDS48746.1 [Q62418-1]
CCDS48747.1 [Q62418-3]
RefSeqiNP_001139780.1, NM_001146308.1 [Q62418-1]
NP_001139781.1, NM_001146309.1 [Q62418-3]
NP_038838.1, NM_013810.3 [Q62418-2]

3D structure databases

SMRiQ62418
ModBaseiSearch...

Protein-protein interaction databases

BioGridi199059, 5 interactors
DIPiDIP-39835N
IntActiQ62418, 7 interactors
MINTiQ62418
STRINGi10090.ENSMUSP00000020769

PTM databases

iPTMnetiQ62418
PhosphoSitePlusiQ62418
SwissPalmiQ62418

Proteomic databases

EPDiQ62418
jPOSTiQ62418
PaxDbiQ62418
PeptideAtlasiQ62418
PRIDEiQ62418

Genome annotation databases

EnsembliENSMUST00000020769; ENSMUSP00000020769; ENSMUSG00000020476 [Q62418-1]
ENSMUST00000102928; ENSMUSP00000099992; ENSMUSG00000020476 [Q62418-2]
ENSMUST00000109845; ENSMUSP00000105471; ENSMUSG00000020476 [Q62418-3]
GeneIDi13169
KEGGimmu:13169
UCSCiuc007hxb.2 mouse [Q62418-2]
uc007hxc.2 mouse [Q62418-3]
uc007hxd.2 mouse [Q62418-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
28988
MGIiMGI:700006 Dbnl

Phylogenomic databases

eggNOGiKOG3655 Eukaryota
ENOG410XRVX LUCA
GeneTreeiENSGT00940000156732
InParanoidiQ62418
KOiK20520
OMAiGYEGQTN
OrthoDBi885776at2759
PhylomeDBiQ62418
TreeFamiTF318935

Enzyme and pathway databases

ReactomeiR-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-MMU-6794361 Neurexins and neuroligins
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dbnl mouse

Protein Ontology

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PROi
PR:Q62418

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000020476 Expressed in 282 organ(s), highest expression level in lens of camera-type eye
GenevisibleiQ62418 MM

Family and domain databases

CDDicd11960 SH3_Abp1_eu, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029923 Dbnl
IPR035717 Drebrin-like_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10829:SF12 PTHR10829:SF12, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDBNL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62418
Secondary accession number(s): Q3TG34
, Q3U5X3, Q3U8I5, Q3UZ33, Q5NCI5, Q5NCI6, Q5NCI7, Q80WP1, Q8BH56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 19, 2004
Last modified: November 13, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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