Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 147 (16 Oct 2019)
Sequence version 3 (03 Apr 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Collagen alpha-1(VII) chain

Gene

Col7a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2889 – 2890Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-3000157 Laminin interactions
R-MMU-5694530 Cargo concentration in the ER
R-MMU-8948216 Collagen chain trimerization

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.967

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(VII) chain
Alternative name(s):
Long-chain collagen
Short name:
LC collagen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col7a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88462 Col7a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice do not express type VII collagen in their skin; they are born with extensive cutaneous blistering and die during the first two weeks of life, possibly because of complications arising from blistering; this mouse mutant resembles the autosomal recessive inherited form of the dystrophic epidermolysis bullosa (DEB) in humans. Heterozygotes by comparison display a normal phenotype.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028295125 – 2944Collagen alpha-1(VII) chainSequence analysisAdd BLAST2920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1110N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21584-hydroxyprolineBy similarity1
Modified residuei21674-hydroxyprolineBy similarity1
Modified residuei21764-hydroxyprolineBy similarity1
Modified residuei21794-hydroxyprolineBy similarity1
Modified residuei26165-hydroxylysineBy similarity1
Modified residuei26225-hydroxylysineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2625InterchainPROSITE-ProRule annotation
Modified residuei26554-hydroxyprolineBy similarity1
Modified residuei26584-hydroxyprolineBy similarity1
Modified residuei26644-hydroxyprolineBy similarity1
Disulfide bondi2793InterchainPROSITE-ProRule annotation
Disulfide bondi2795InterchainPROSITE-ProRule annotation
Disulfide bondi2879 ↔ 2931PROSITE-ProRule annotation
Disulfide bondi2888 ↔ 2914PROSITE-ProRule annotation
Disulfide bondi2906 ↔ 2927PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q63870

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63870

PeptideAtlas

More...
PeptideAtlasi
Q63870

PRoteomics IDEntifications database

More...
PRIDEi
Q63870

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63870

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63870

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcription of COL7A1 is stimulated by TGFB1 in keratinocytes and this is possibly dependent on a putative interaction between SMADS and AP1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025650 Expressed in 191 organ(s), highest expression level in skin epidermis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q63870 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Interacts with MIA3/TANGO1; facilitating its loading into transport carriers and subsequent secretion (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-8313134,EBI-8313134

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2966 Collagen type VII trimer

Protein interaction database and analysis system

More...
IntActi
Q63870, 1 interactor

Molecular INTeraction database

More...
MINTi
Q63870

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107701

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63870

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 212VWFA 1PROSITE-ProRule annotationAdd BLAST174
Domaini235 – 330Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini331 – 417Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST87
Domaini418 – 508Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST91
Domaini511 – 598Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST88
Domaini601 – 688Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST88
Domaini689 – 776Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST88
Domaini779 – 867Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST89
Domaini870 – 957Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST88
Domaini959 – 1053Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST95
Domaini1055 – 1230VWFA 2PROSITE-ProRule annotationAdd BLAST176
Domaini2879 – 2931BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 1254Nonhelical region (NC1)Sequence analysisAdd BLAST1237
Regioni1255 – 2775Triple-helical regionSequence analysisAdd BLAST1521
Regioni1255 – 1475Interrupted collagenous regionSequence analysisAdd BLAST221
Regioni2776 – 2944Nonhelical region (NC2)Sequence analysisAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1171 – 1173Cell attachment siteSequence analysis3
Motifi2002 – 2004Cell attachment siteSequence analysis3
Motifi2063 – 2065Cell attachment siteSequence analysis3
Motifi2601 – 2603Cell attachment siteSequence analysis3
Motifi2631 – 2633Cell attachment siteSequence analysis3

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163668

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111866

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63870

KEGG Orthology (KO)

More...
KOi
K16628

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEPPQKV

Database of Orthologous Groups

More...
OrthoDBi
67372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63870

TreeFam database of animal gene trees

More...
TreeFami
TF351645

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 9 hits
cd00109 KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits
3.40.50.410, 2 hits
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 20 hits
PF00041 fn3, 7 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 9 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF53300 SSF53300, 2 hits
SSF57362 SSF57362, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 9 hits
PS50234 VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q63870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLRLLVAAL CAAEILMGAP EVWAQPRDRV TCTRLYAADI VFLLDGSSSI
60 70 80 90 100
GRSNFREVRG FLEGLVLPFS GAASAQGVRF ATVQYSDDPQ TEFGLDTLGS
110 120 130 140 150
GSDTIRAIRE LSYKGGNTRT GAALHHVSDR VFLPRLTRPG VPKVCILITD
160 170 180 190 200
GKSQDLVDTA AQKLKGQGVK LFAVGIKNAD PEELKRVASQ PTSDFFFFVN
210 220 230 240 250
DFSILRTLLP LISRRVCTTA GGVPVTLPSD DTPSGPRDLV LSEPSSQSLR
260 270 280 290 300
VQWTAASGPV TGYKVQYTPL TGLGQPLPSE RQEVNIPAGE TSTRLQGLRP
310 320 330 340 350
LTDYQVTVVA LYANSIGEAV SGTARTTAKE GLELSLQNIT SHSLLVAWRR
360 370 380 390 400
VPGANGYRVT WRDLSGGPTQ QQDLSPGQGS VFLDHLEPGT DYEVTVSALF
410 420 430 440 450
GHSVGPAASL TARTASSVEQ TLHPIILSPT SILLSWNLVP EARGYRLEWR
460 470 480 490 500
RESGLETPQK VELPPDVTRH QLDGLQPGTE YRLTLYTLLE GREVATPATV
510 520 530 540 550
VPTGLEQLVS PVMNLQAIEL PGQRVRVSWN PVPGATEYRF TVRTTQGVER
560 570 580 590 600
TLLLPGSQTT FDLDDVRAGL SYTVRVSARV GAQEGDASIL TIHRDPEAPL
610 620 630 640 650
VVPGLRVVAS DATRIRVAWG LVPGASGFRI SWRTGSGPES SRTLTPDSTV
660 670 680 690 700
TDILGLQPST SYQVAVSALR GREEGPPVVI VARTDPLGPV RRVHLTQAGS
710 720 730 740 750
SSVSITWTGV PGATGYRVSW HSGHGPEKSL LVSGDATVAE IDGLEPDTEY
760 770 780 790 800
IVRVRTHVAG VDGAPASVVV RTAPEPVGSV SKLQILNASS DVLRVTWVGV
810 820 830 840 850
PGATSYKLAW GRSEGGPMKH RILPGNKESA EIRDLEGGVS YSVRVTALVG
860 870 880 890 900
DREGAPVSIV ITTPPATPAL LETLQVVQSG EHSLRLRWEP VPGAPGFRLH
910 920 930 940 950
WQPEGGQEQS LTLGPESNSY NLVGLEPATK YQVWLTVLGQ TGEGPPRKVT
960 970 980 990 1000
AYTEPSHIPS TELRVVDTSI DSVTLTWTPV SGASSYILSW RPLRGTGQEV
1010 1020 1030 1040 1050
PRAPQTLPGT SSSHRVTGLE PGISYVFSLT PIQSGVRGSE ISVTQTPACS
1060 1070 1080 1090 1100
HGPVDVVFLL HATRDNAHNA EAVRRVLERL VSALGPLGPQ AAQVGLLTYS
1110 1120 1130 1140 1150
HRPSPLFPLN SSHDLGIILR KIRDIPYVDP SGNNLGTAVT TAHRYLLASN
1160 1170 1180 1190 1200
APGRRQQVPG VMVLLVDEPL RGDILSPIRE AQTSGLKVMA LSLVGADPEQ
1210 1220 1230 1240 1250
LRRLAPGTDP IQNFFAVDNG PGLDRAVSDL AVALCQAAVT IEPQTGPCAV
1260 1270 1280 1290 1300
HCPKGQKGEP GVTGLQGQAG PPGPPGLPGR TGAPGPQGPP GSTQAKGERG
1310 1320 1330 1340 1350
FPGPEGPPGS PGLPGVPGSP GIKGSTGRPG PRGEQGERGP QGPKGEPGEP
1360 1370 1380 1390 1400
GQITGGGGPG FPGKKGDPGP SGPPGSRGPV GDPGPRGPPG LPGISVKGDK
1410 1420 1430 1440 1450
GDRGERGPPG PGIGASEQGD PGLPGLPGSP GPQGPAGRPG EKGEKGDCED
1460 1470 1480 1490 1500
GGPGLPGQPG PPGEPGLRGA PGMTGPKGDR GLTGTPGEPG VKGERGHPGP
1510 1520 1530 1540 1550
VGPQGLPGAA GHPGVEGPEG PPGPTGRRGE KGEPGRPGDP AVGPGGAGAK
1560 1570 1580 1590 1600
GEKGEAGLPG PRGASGSKGE QGAPGLALPG DPGPKGDPGD RGPIGLTGRA
1610 1620 1630 1640 1650
GPTGDSGPPG EKGEPGRPGS PGPVGPRGRD GEAGEKGDEG IPGEPGLPGK
1660 1670 1680 1690 1700
AGERGLRGAP GPRGPVGEKG DQGDPGEDGR NGSPGSSGPK GDRGEPGPPG
1710 1720 1730 1740 1750
PPGRLVDAGI ESRDKGEPGQ EGPRGPKGDP GPPGVSGERG IDGLRGPPGP
1760 1770 1780 1790 1800
QGDPGVRGPA GDKGDRGPPG LDGRSGLDGK PGAPGPPGLH GASGKAGDPG
1810 1820 1830 1840 1850
RDGLPGLRGE HGPPGPPGPP GVPGKAGDDG KPGLNGKNGD PGDPGEDGRK
1860 1870 1880 1890 1900
GEKGDSGAPG REGPDGPKGE RGAPGNPGLQ GPPGLPGQVG PPGQGFPGVP
1910 1920 1930 1940 1950
GITGPKGDRG ETGSKGEQGL PGERGLRGEP GSLPNAERLL ETAGIKVSAL
1960 1970 1980 1990 2000
REIVDTWDES SGSFLPVPER RPGPKGDPGD RGPPGKEGLI GFPGERGLKG
2010 2020 2030 2040 2050
ERGDPGPQGP PGLALGERGP PGPPGLAGEP GKPGIPGLPG RAGGSGEAGR
2060 2070 2080 2090 2100
PGERGERGEK GERGDQGRDG LPGLPGPPGP PGPKVAIEEP GPGLAREQGP
2110 2120 2130 2140 2150
PGLKGAKGEP GSDGDPGPKG DRGVPGIKGD VGEPGKRGHD GNPGLPGERG
2160 2170 2180 2190 2200
VAGPEGKPGL QGPRGTPGPV GSHGDPGPPG APGLAGPAGP QGPSGLKGEP
2210 2220 2230 2240 2250
GETGPPGRGL PGPVGAVGLP GPPGPSGLVG PQGSPGLPGQ VGETGKPGPP
2260 2270 2280 2290 2300
GRDGSSGKDG DRGSPGVPGS PGLPGPVGPK GEPGPVGAPG QVVVGPPGAK
2310 2320 2330 2340 2350
GEKGAPGDLA GALLGEPGAK GDRGLPGPRG EKGEAGRAGG PGDPGEDGQK
2360 2370 2380 2390 2400
GAPGLKGLKG EPGIGVQGPP GPSGPPGMKG DLGPPGAPGA PGVVGFPGQT
2410 2420 2430 2440 2450
GPRGETGQPG PVGERGLAGP PGREGAPGPL GPPGPPGSAG APGASGLKGD
2460 2470 2480 2490 2500
KGDPGAGLPG PRGERGEPGV RGEDGHPGQE GPRGLVGPPG SRGEQGEKGA
2510 2520 2530 2540 2550
AGAAGLKGDK GDSAVIEGPP GPRGAKGDMG ERGPRGIDGD KGPRGESGNP
2560 2570 2580 2590 2600
GDKGSKGEPG DKGSAGSIGV RGLTGPKGEP GAAGIPGEPG APGKDGIPGF
2610 2620 2630 2640 2650
RGDKGDIGFM GPRGLKGEKG IKGTCGRDGE RGDKGEAGFP GRPGLAGKKG
2660 2670 2680 2690 2700
DMGEPGLPGQ SGAPGKEGLI GPKGDRGFDG QSGPKGDQGE KGERGPPGVG
2710 2720 2730 2740 2750
GFPGPRGNDG SSGPPGPPGG VGPKGPEGLQ GQKGERGPPG ESVVGAPGAP
2760 2770 2780 2790 2800
GTPGERGEQG RPGPAGPRGE KGEAALTEDD IRDFVRQEMS QHCACQGQFI
2810 2820 2830 2840 2850
ASGSRPLPGY AADTAGSQLH HVPVLRVSHV EEEGQVPPED DDDFSEYSVY
2860 2870 2880 2890 2900
SVEDYQEPEV PWDGEAEIKG WDQRGSDLCS LPLDEGSCTA YTLRWYHRAV
2910 2920 2930 2940
PGGTACHPFV YGGCGGNANR FGTREACERR CPPQGVHSQK TGAA
Length:2,944
Mass (Da):295,232
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13D01CA7ED36C958
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti659S → G in AAB66593 (PubMed:8752674).Curated1
Sequence conflicti1927R → A in AAB66593 (PubMed:8752674).Curated1
Sequence conflicti1927R → A in AAB27492 (PubMed:8325648).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32107 mRNA Translation: AAB66593.1
AC174646 Genomic DNA No translation available.
S63654 mRNA Translation: AAB27492.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40770.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45748

NCBI Reference Sequences

More...
RefSeqi
NP_031764.2, NM_007738.3
XP_006511998.1, XM_006511935.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000026740; ENSMUSP00000026740; ENSMUSG00000025650
ENSMUST00000112070; ENSMUSP00000107701; ENSMUSG00000025650

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12836

UCSC genome browser

More...
UCSCi
uc009rrh.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32107 mRNA Translation: AAB66593.1
AC174646 Genomic DNA No translation available.
S63654 mRNA Translation: AAB27492.1
CCDSiCCDS40770.1
PIRiA45748
RefSeqiNP_031764.2, NM_007738.3
XP_006511998.1, XM_006511935.3

3D structure databases

SMRiQ63870
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2966 Collagen type VII trimer
IntActiQ63870, 1 interactor
MINTiQ63870
STRINGi10090.ENSMUSP00000107701

Protein family/group databases

MEROPSiI02.967

PTM databases

iPTMnetiQ63870
PhosphoSitePlusiQ63870

Proteomic databases

MaxQBiQ63870
PaxDbiQ63870
PeptideAtlasiQ63870
PRIDEiQ63870

Genome annotation databases

EnsembliENSMUST00000026740; ENSMUSP00000026740; ENSMUSG00000025650
ENSMUST00000112070; ENSMUSP00000107701; ENSMUSG00000025650
GeneIDi12836
KEGGimmu:12836
UCSCiuc009rrh.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1294
MGIiMGI:88462 Col7a1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000163668
HOGENOMiHOG000111866
InParanoidiQ63870
KOiK16628
OMAiLEPPQKV
OrthoDBi67372at2759
PhylomeDBiQ63870
TreeFamiTF351645

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-3000157 Laminin interactions
R-MMU-5694530 Cargo concentration in the ER
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Col7a1 mouse

Protein Ontology

More...
PROi
PR:Q63870

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025650 Expressed in 191 organ(s), highest expression level in skin epidermis
GenevisibleiQ63870 MM

Family and domain databases

CDDicd00063 FN3, 9 hits
cd00109 KU, 1 hit
Gene3Di2.60.40.10, 9 hits
3.40.50.410, 2 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 20 hits
PF00041 fn3, 7 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 2 hits
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SM00327 VWA, 1 hit
SUPFAMiSSF49265 SSF49265, 5 hits
SSF53300 SSF53300, 2 hits
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 9 hits
PS50234 VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO7A1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63870
Secondary accession number(s): Q78EC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 16, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again