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Entry version 129 (16 Oct 2019)
Sequence version 2 (09 Jul 2014)
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Protein

ADP-ribosylation factor-like protein 6-interacting protein 4

Gene

ARL6IP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.1 Publication

Caution

It is uncertain whether Met-1 or Met-62 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 4
Short name:
ARL-6-interacting protein 4
Short name:
Aip-4
Alternative name(s):
HSP-975
HSVI-binding protein
SR-15
SRp25
Short name:
SR-25
Splicing factor SRrp37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARL6IP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18076 ARL6IP4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607668 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q66PJ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182196

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134879338

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q66PJ3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARL6IP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736329

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122701 – 421ADP-ribosylation factor-like protein 6-interacting protein 4Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei239PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q66PJ3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q66PJ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q66PJ3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q66PJ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q66PJ3

PeptideAtlas

More...
PeptideAtlasi
Q66PJ3

PRoteomics IDEntifications database

More...
PRIDEi
Q66PJ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3839
65965 [Q66PJ3-1]
65966 [Q66PJ3-2]
65967 [Q66PJ3-3]
65968 [Q66PJ3-4]
65969 [Q66PJ3-5]
65970 [Q66PJ3-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q66PJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q66PJ3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q66PJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms 3 and 7 were identified in brain, pancreas, prostate, and testis, but little or no message could be detected in other tissues.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed only in G1/S phase.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In case of Herpes simplex virus (HSVI)-binding to cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182196 Expressed in 92 organ(s), highest expression level in body of stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q66PJ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q66PJ3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052098

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARL6 (By similarity).

Interacts with ZCCHC17.

Interacts with SRSF2.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119477, 43 interactors

Protein interaction database and analysis system

More...
IntActi
Q66PJ3, 36 interactors

Molecular INTeraction database

More...
MINTi
Q66PJ3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313422

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi190 – 282Ser-richAdd BLAST93
Compositional biasi286 – 312Lys-richAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARL6IP4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYKG Eukaryota
ENOG4111ZMS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009670

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034033

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q66PJ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
WHRSAEE

Database of Orthologous Groups

More...
OrthoDBi
1047670at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350468

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019532 Nucl_RNA-splicing_assoc_SR-25

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10500 SR-25, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q66PJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK
60 70 80 90 100
TRAPQSGARS RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV
110 120 130 140 150
GAASADTGVR GCGARGPAPL LASAGGGRAR DGTWGVRTKG SGAALPSRPA
160 170 180 190 200
SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR ARGAMAHVGS RKRSRSRSRS
210 220 230 240 250
RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP SPCITERSKQ
260 270 280 290 300
KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
310 320 330 340 350
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI
360 370 380 390 400
QAMKPMTKEE WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE
410 420
INKQATRGDC LAFQMRAGLL P
Length:421
Mass (Da):44,915
Last modified:July 9, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46C75D66A5181DAC
GO
Isoform 2 (identifier: Q66PJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-245: Missing.

Show »
Length:413
Mass (Da):44,159
Checksum:iBC723AA29C3D5E59
GO
Isoform 3 (identifier: Q66PJ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-245: Missing.

Show »
Length:402
Mass (Da):43,132
Checksum:i13B57EF2169FA844
GO
Isoform 4 (identifier: Q66PJ3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-245: Missing.
     404-421: QATRGDCLAFQMRAGLLP → VGVAPLPAIRPQLCL

Show »
Length:399
Mass (Da):42,731
Checksum:i23D0D604986EE066
GO
Isoform 5 (identifier: Q66PJ3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-245: Missing.
     317-364: Missing.

Show »
Length:365
Mass (Da):38,699
Checksum:i7E2C81AE496AC2D2
GO
Isoform 6 (identifier: Q66PJ3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-276: ASPSPCITER...SSSSSSSSSS → VLLAPLLPPR...GGRRRRRGRS
     277-421: Missing.

Show »
Length:276
Mass (Da):28,528
Checksum:i6F944F7B299C9953
GO
Isoform 7 (identifier: Q66PJ3-7) [UniParc]FASTAAdd to basket
Also known as: SRrp37-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     227-237: Missing.

Show »
Length:226
Mass (Da):25,349
Checksum:iC41994822C524656
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYV5F5GYV5_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7X4F5H7X4_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCT1F8WCT1_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEP2F8WEP2_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZV4H7BZV4_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG62A0A0C4DG62_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTG7A0A0A0MTG7_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH18A0A0C4DH18_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP4
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Isoform 6 : The sequence AAF76892 differs from that shown. Reason: Frameshift.Curated
The sequence AAF76892 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH01958 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH15569 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH15909 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH94839 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ACF07995 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA94744 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160S → P in AAH94839 (PubMed:15489334).Curated1
Sequence conflicti233A → V in AAF76892 (PubMed:11884129).Curated1

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at position 286.1 Publication
Partially edited. In the brain, edited at about 68%.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059583149P → A. Corresponds to variant dbSNP:rs12825243Ensembl.1
Natural variantiVAR_058333286K → R in RNA edited version. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545811 – 184Missing in isoform 7. 1 PublicationAdd BLAST184
Alternative sequenceiVSP_029780227 – 245Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_054582227 – 237Missing in isoform 7. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_029781238 – 276ASPSP…SSSSS → VLLAPLLPPRPPPLPPVMAG RSGGSTRTRGGRRRRRGRS in isoform 6. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_029782238 – 245Missing in isoform 2 and isoform 5. 3 Publications8
Alternative sequenceiVSP_029783277 – 421Missing in isoform 6. 1 PublicationAdd BLAST145
Alternative sequenceiVSP_029784317 – 364Missing in isoform 5. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_029785404 – 421QATRG…AGLLP → VGVAPLPAIRPQLCL in isoform 4. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU624490 mRNA Translation: ACF07995.1 Different initiation.
EU624491 mRNA Translation: ACF07996.1
AC026362 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98376.1
CH471054 Genomic DNA Translation: EAW98374.1
BC001958 mRNA Translation: AAH01958.1 Different initiation.
BC015569 mRNA Translation: AAH15569.1 Different initiation.
BC015909 mRNA Translation: AAH15909.2 Different initiation.
BC094839 mRNA Translation: AAH94839.1 Different initiation.
AF267748 mRNA Translation: AAF76892.1 Sequence problems.
AB035384 mRNA Translation: BAA94744.1 Different initiation.
DQ099385 mRNA Translation: AAZ13761.1
EF036485 mRNA Translation: ABO65071.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31923.2 [Q66PJ3-1]
CCDS41856.2 [Q66PJ3-4]
CCDS45004.2 [Q66PJ3-2]
CCDS53843.2 [Q66PJ3-3]
CCDS61273.1 [Q66PJ3-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7220

NCBI Reference Sequences

More...
RefSeqi
NP_001002251.2, NM_001002251.2 [Q66PJ3-2]
NP_001002252.2, NM_001002252.2 [Q66PJ3-4]
NP_001265307.1, NM_001278378.1 [Q66PJ3-5]
NP_001265308.1, NM_001278379.1
NP_001265309.1, NM_001278380.1 [Q66PJ3-7]
NP_057722.3, NM_016638.3 [Q66PJ3-3]
NP_061164.3, NM_018694.3 [Q66PJ3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315580; ENSP00000313422; ENSG00000182196 [Q66PJ3-1]
ENST00000392435; ENSP00000376230; ENSG00000182196 [Q66PJ3-4]
ENST00000453766; ENSP00000414847; ENSG00000182196 [Q66PJ3-2]
ENST00000454885; ENSP00000396723; ENSG00000182196 [Q66PJ3-7]
ENST00000543566; ENSP00000442718; ENSG00000182196 [Q66PJ3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51329

UCSC genome browser

More...
UCSCi
uc001uec.5 human [Q66PJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU624490 mRNA Translation: ACF07995.1 Different initiation.
EU624491 mRNA Translation: ACF07996.1
AC026362 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98376.1
CH471054 Genomic DNA Translation: EAW98374.1
BC001958 mRNA Translation: AAH01958.1 Different initiation.
BC015569 mRNA Translation: AAH15569.1 Different initiation.
BC015909 mRNA Translation: AAH15909.2 Different initiation.
BC094839 mRNA Translation: AAH94839.1 Different initiation.
AF267748 mRNA Translation: AAF76892.1 Sequence problems.
AB035384 mRNA Translation: BAA94744.1 Different initiation.
DQ099385 mRNA Translation: AAZ13761.1
EF036485 mRNA Translation: ABO65071.1
CCDSiCCDS31923.2 [Q66PJ3-1]
CCDS41856.2 [Q66PJ3-4]
CCDS45004.2 [Q66PJ3-2]
CCDS53843.2 [Q66PJ3-3]
CCDS61273.1 [Q66PJ3-7]
PIRiJC7220
RefSeqiNP_001002251.2, NM_001002251.2 [Q66PJ3-2]
NP_001002252.2, NM_001002252.2 [Q66PJ3-4]
NP_001265307.1, NM_001278378.1 [Q66PJ3-5]
NP_001265308.1, NM_001278379.1
NP_001265309.1, NM_001278380.1 [Q66PJ3-7]
NP_057722.3, NM_016638.3 [Q66PJ3-3]
NP_061164.3, NM_018694.3 [Q66PJ3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119477, 43 interactors
IntActiQ66PJ3, 36 interactors
MINTiQ66PJ3
STRINGi9606.ENSP00000313422

PTM databases

iPTMnetiQ66PJ3
PhosphoSitePlusiQ66PJ3
SwissPalmiQ66PJ3

Polymorphism and mutation databases

BioMutaiARL6IP4
DMDMi74736329

Proteomic databases

EPDiQ66PJ3
jPOSTiQ66PJ3
MassIVEiQ66PJ3
MaxQBiQ66PJ3
PaxDbiQ66PJ3
PeptideAtlasiQ66PJ3
PRIDEiQ66PJ3
ProteomicsDBi3839
65965 [Q66PJ3-1]
65966 [Q66PJ3-2]
65967 [Q66PJ3-3]
65968 [Q66PJ3-4]
65969 [Q66PJ3-5]
65970 [Q66PJ3-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51329

Genome annotation databases

EnsembliENST00000315580; ENSP00000313422; ENSG00000182196 [Q66PJ3-1]
ENST00000392435; ENSP00000376230; ENSG00000182196 [Q66PJ3-4]
ENST00000453766; ENSP00000414847; ENSG00000182196 [Q66PJ3-2]
ENST00000454885; ENSP00000396723; ENSG00000182196 [Q66PJ3-7]
ENST00000543566; ENSP00000442718; ENSG00000182196 [Q66PJ3-3]
GeneIDi51329
KEGGihsa:51329
UCSCiuc001uec.5 human [Q66PJ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51329

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARL6IP4
HGNCiHGNC:18076 ARL6IP4
HPAiHPA052098
MIMi607668 gene
neXtProtiNX_Q66PJ3
OpenTargetsiENSG00000182196
PharmGKBiPA134879338

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYKG Eukaryota
ENOG4111ZMS LUCA
GeneTreeiENSGT00390000009670
HOGENOMiHOG000034033
InParanoidiQ66PJ3
OMAiWHRSAEE
OrthoDBi1047670at2759
TreeFamiTF350468

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARL6IP4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARL6IP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51329
PharosiQ66PJ3

Protein Ontology

More...
PROi
PR:Q66PJ3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182196 Expressed in 92 organ(s), highest expression level in body of stomach
ExpressionAtlasiQ66PJ3 baseline and differential
GenevisibleiQ66PJ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR019532 Nucl_RNA-splicing_assoc_SR-25
PfamiView protein in Pfam
PF10500 SR-25, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAR6P4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66PJ3
Secondary accession number(s): A4UCR8
, B3V0L0, B3V0L1, Q4F966, Q504R8, Q96BI2, Q9NR05, Q9P2R9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 9, 2014
Last modified: October 16, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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