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Entry version 124 (13 Nov 2019)
Sequence version 2 (23 Oct 2007)
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Protein

Protein virilizer homolog

Gene

VIRMA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein virilizer homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VIRMAImported
Synonyms:KIAA14291 Publication
ORF Names:MSTP054
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24500 VIRMA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616447 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q69YN4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25962

Open Targets

More...
OpenTargetsi
ENSG00000164944

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671611

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q69YN4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VIRMA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160221326

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003086052 – 1812Protein virilizer homologAdd BLAST1811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei133PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei184PhosphothreonineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei914PhosphotyrosineCombined sources1
Modified residuei1579PhosphoserineCombined sources1
Modified residuei1708PhosphothreonineCombined sources1
Modified residuei1723Omega-N-methylarginineCombined sources1
Modified residuei1741Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei1741Omega-N-methylarginine; alternateBy similarity1
Modified residuei1773Asymmetric dimethylarginineCombined sources1
Modified residuei1775Asymmetric dimethylarginineCombined sources1
Modified residuei1793Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q69YN4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q69YN4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q69YN4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q69YN4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q69YN4

PeptideAtlas

More...
PeptideAtlasi
Q69YN4

PRoteomics IDEntifications database

More...
PRIDEi
Q69YN4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66164 [Q69YN4-1]
66165 [Q69YN4-2]
66166 [Q69YN4-3]
66167 [Q69YN4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q69YN4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q69YN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164944 Expressed in 201 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q69YN4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q69YN4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031530

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29507755). The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:24981863, PubMed:29507755).

Interacts with WTAP (PubMed:24100041). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).

Interacts with NUDT21 and CPSF6 (PubMed:29507755).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117452, 2884 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1605 WMM N6-adenosine-methyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q69YN4

Protein interaction database and analysis system

More...
IntActi
Q69YN4, 34 interactors

Molecular INTeraction database

More...
MINTi
Q69YN4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297591

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q69YN4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi139 – 202Pro-richAdd BLAST64
Compositional biasi208 – 314Glu-richAdd BLAST107
Compositional biasi943 – 946Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vir family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4822 Eukaryota
ENOG410XSTI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002833

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q69YN4

KEGG Orthology (KO)

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KOi
K22910

Identification of Orthologs from Complete Genome Data

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OMAi
ETSPHAF

Database of Orthologous Groups

More...
OrthoDBi
210051at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q69YN4

TreeFam database of animal gene trees

More...
TreeFami
TF323505

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR031801 VIR_N
IPR026736 Virilizer

The PANTHER Classification System

More...
PANTHERi
PTHR23185 PTHR23185, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15912 VIR_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q69YN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVDSAMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH
60 70 80 90 100
SSLPDNRAYG ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF
110 120 130 140 150
RPNSKVNTDG LVLRGWYNCL TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ
160 170 180 190 200
PQPSLKRNPK HADGEKEDQF NGSPPRPQPR GPRTPPGPPP PDDDEDDPVP
210 220 230 240 250
LPVSGDKEED APHREDYFEP ISPDRNSVPQ EGQYSDEGEV EEEQQEEGEE
260 270 280 290 300
DEDDVDVEEE EDEDEDDRRT VDSIPEEEEE DEEEEGEEDE EGEGDDGYEQ
310 320 330 340 350
ISSDEDGIAD LERETFKYPN FDVEYTAEDL ASVPPMTYDP YDRELVPLLY
360 370 380 390 400
FSCPYKTTFE IEISRMKDQG PDKENSGAIE ASVKLTELLD LYREDRGAKW
410 420 430 440 450
VTALEEIPSL IIKGLSYLQL KNTKQDSLGQ LVDWTMQALN LQVALRQPIA
460 470 480 490 500
LNVRQLKAGT KLVSSLAECG AQGVTGLLQA GVISGLFELL FADHVSSSLK
510 520 530 540 550
LNAFKALDSV ISMTEGMEAF LRGRQNEKSG YQKLLELILL DQTVRVVTAG
560 570 580 590 600
SAILQKCHFY EVLSEIKRLG DHLAEKTSSL PNHSEPDHDT DAGLERTNPE
610 620 630 640 650
YENEVEASMD MDLLESSNIS EGEIERLINL LEEVFHLMET APHTMIQQPV
660 670 680 690 700
KSFPTMARIT GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPVTSAHPGV
710 720 730 740 750
LQATKDVLKF LAQSQKGLLF FMSEYEATNL LIRALCHFYD QDEEEGLQSD
760 770 780 790 800
GVIDDAFALW LQDSTQTLQC ITELFSHFQR CTASEETDHS DLLGTLHNLY
810 820 830 840 850
LITFNPVGRS AVGHVFSLEK NLQSLITLME YYSKEALGDS KSKKSVAYNY
860 870 880 890 900
ACILILVVVQ SSSDVQMLEQ HAASLLKLCK ADENNAKLQE LGKWLEPLKN
910 920 930 940 950
LRFEINCIPN LIEYVKQNID NLMTPEGVGL TTALRVLCNV ACPPPPVEGQ
960 970 980 990 1000
QKDLKWNLAV IQLFSAEGMD TFIRVLQKLN SILTQPWRLH VNMGTTLHRV
1010 1020 1030 1040 1050
TTISMARCTL TLLKTMLTEL LRGGSFEFKD MRVPSALVTL HMLLCSIPLS
1060 1070 1080 1090 1100
GRLDSDEQKI QNDIIDILLT FTQGVNEKLT ISEETLANNT WSLMLKEVLS
1110 1120 1130 1140 1150
SILKVPEGFF SGLILLSELL PLPLPMQTTQ VIEPHDISVA LNTRKLWSMH
1160 1170 1180 1190 1200
LHVQAKLLQE IVRSFSGTTC QPIQHMLRRI CVQLCDLASP TALLIMRTVL
1210 1220 1230 1240 1250
DLIVEDLQST SEDKEKQYTS QTTRLLALLD ALASHKACKL AILHLINGTI
1260 1270 1280 1290 1300
KGDERYAEIF QDLLALVRSP GDSVIRQQCV EYVTSILQSL CDQDIALILP
1310 1320 1330 1340 1350
SSSEGSISEL EQLSNSLPNK ELMTSICDCL LATLANSESS YNCLLTCVRT
1360 1370 1380 1390 1400
MMFLAEHDYG LFHLKSSLRK NSSALHSLLK RVVSTFSKDT GELASSFLEF
1410 1420 1430 1440 1450
MRQILNSDTI GCCGDDNGLM EVEGAHTSRT MSINAAELKQ LLQSKEESPE
1460 1470 1480 1490 1500
NLFLELEKLV LEHSKDDDNL DSLLDSVVGL KQMLESSGDP LPLSDQDVEP
1510 1520 1530 1540 1550
VLSAPESLQN LFNNRTAYVL ADVMDDQLKS MWFTPFQAEE IDTDLDLVKV
1560 1570 1580 1590 1600
DLIELSEKCC SDFDLHSELE RSFLSEPSSP GRTKTTKGFK LGKHKHETFI
1610 1620 1630 1640 1650
TSSGKSEYIE PAKRAHVVPP PRGRGRGGFG QGIRPHDIFR QRKQNTSRPP
1660 1670 1680 1690 1700
SMHVDDFVAA ESKEVVPQDG IPPPKRPLKV SQKISSRGGF SGNRGGRGAF
1710 1720 1730 1740 1750
HSQNRFFTPP ASKGNYSRRE GTRGSSWSAQ NTPRGNYNES RGGQSNFNRG
1760 1770 1780 1790 1800
PLPPLRPLSS TGYRPSPRDR ASRGRGGLGP SWASANSGSG GSRGKFVSGG
1810
SGRGRHVRSF TR
Length:1,812
Mass (Da):202,025
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFF7F006B5EF5B75
GO
Isoform 2 (identifier: Q69YN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1366-1377: SSLRKNSSALHS → RDAVEMIMVSWK
     1378-1812: Missing.

Show »
Length:1,377
Mass (Da):154,472
Checksum:iB32781D9044FD415
GO
Isoform 3 (identifier: Q69YN4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1684-1812: ISSRGGFSGN...RGRHVRSFTR → EQEAPVGVLR...HFTRTIKIRH

Show »
Length:1,797
Mass (Da):201,057
Checksum:i785EC7223BA62A6C
GO
Isoform 4 (identifier: Q69YN4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1147: IEPHDISVALNTRKLW → SLPYNMHLINDCSNTF
     1148-1812: Missing.

Show »
Length:1,147
Mass (Da):128,734
Checksum:iD5CA3651E44FBF31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC41H0YC41_HUMAN
Protein virilizer homolog
VIRMA
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB68H0YB68_HUMAN
Protein virilizer homolog
VIRMA
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBN5H0YBN5_HUMAN
Protein virilizer homolog
VIRMA
730Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91316 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14301 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB55922 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti97S → P in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti185Missing in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti524R → G in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti574A → P in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti664Missing in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti1183Q → E in CAB55922 (PubMed:17974005).Curated1
Sequence conflicti1434N → D in BAB14301 (PubMed:14702039).Curated1
Sequence conflicti1563F → I in CAH10773 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036845753I → V. Corresponds to variant dbSNP:rs7814840Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0290171132 – 1147IEPHD…TRKLW → SLPYNMHLINDCSNTF in isoform 4. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_0290181148 – 1812Missing in isoform 4. 2 PublicationsAdd BLAST665
Alternative sequenceiVSP_0290191366 – 1377SSLRK…SALHS → RDAVEMIMVSWK in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0290201378 – 1812Missing in isoform 2. 1 PublicationAdd BLAST435
Alternative sequenceiVSP_0290211684 – 1812ISSRG…RSFTR → EQEAPVGVLRILLEEITMKV VEARAILTEALFHHYDPLVL QVTAQVLGTVLLEVVGDLDL PGLVQIAAVEAQEESLLVEA VVEVVMYAPLHDKNPFGNIL TVYEHFTRTIKIRH in isoform 3. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL117434 mRNA Translation: CAB55922.1 Different initiation.
AL832487 mRNA Translation: CAH10773.1
CR627454 mRNA Translation: CAH10535.1
BC003701 mRNA Translation: AAH03701.2
BC053875 mRNA No translation available.
BC069239 mRNA Translation: AAH69239.1
BC112288 mRNA Translation: AAI12289.1
BC113380 mRNA Translation: AAI13381.1
AF116724 mRNA Translation: AAO15300.1
AB037850 mRNA Translation: BAA92667.1
AK000668 mRNA Translation: BAA91316.1 Different initiation.
AK022906 mRNA Translation: BAB14301.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34923.1 [Q69YN4-1]
CCDS47894.1 [Q69YN4-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17232

NCBI Reference Sequences

More...
RefSeqi
NP_056311.2, NM_015496.4 [Q69YN4-1]
NP_892121.1, NM_183009.2 [Q69YN4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297591; ENSP00000297591; ENSG00000164944 [Q69YN4-1]
ENST00000421249; ENSP00000398390; ENSG00000164944 [Q69YN4-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25962

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25962

UCSC genome browser

More...
UCSCi
uc003ygo.3 human [Q69YN4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117434 mRNA Translation: CAB55922.1 Different initiation.
AL832487 mRNA Translation: CAH10773.1
CR627454 mRNA Translation: CAH10535.1
BC003701 mRNA Translation: AAH03701.2
BC053875 mRNA No translation available.
BC069239 mRNA Translation: AAH69239.1
BC112288 mRNA Translation: AAI12289.1
BC113380 mRNA Translation: AAI13381.1
AF116724 mRNA Translation: AAO15300.1
AB037850 mRNA Translation: BAA92667.1
AK000668 mRNA Translation: BAA91316.1 Different initiation.
AK022906 mRNA Translation: BAB14301.1 Different initiation.
CCDSiCCDS34923.1 [Q69YN4-1]
CCDS47894.1 [Q69YN4-4]
PIRiT17232
RefSeqiNP_056311.2, NM_015496.4 [Q69YN4-1]
NP_892121.1, NM_183009.2 [Q69YN4-4]

3D structure databases

SMRiQ69YN4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117452, 2884 interactors
ComplexPortaliCPX-1605 WMM N6-adenosine-methyltransferase complex
CORUMiQ69YN4
IntActiQ69YN4, 34 interactors
MINTiQ69YN4
STRINGi9606.ENSP00000297591

PTM databases

iPTMnetiQ69YN4
PhosphoSitePlusiQ69YN4

Polymorphism and mutation databases

BioMutaiVIRMA
DMDMi160221326

Proteomic databases

EPDiQ69YN4
jPOSTiQ69YN4
MassIVEiQ69YN4
MaxQBiQ69YN4
PaxDbiQ69YN4
PeptideAtlasiQ69YN4
PRIDEiQ69YN4
ProteomicsDBi66164 [Q69YN4-1]
66165 [Q69YN4-2]
66166 [Q69YN4-3]
66167 [Q69YN4-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25962

Genome annotation databases

EnsembliENST00000297591; ENSP00000297591; ENSG00000164944 [Q69YN4-1]
ENST00000421249; ENSP00000398390; ENSG00000164944 [Q69YN4-4]
GeneIDi25962
KEGGihsa:25962
UCSCiuc003ygo.3 human [Q69YN4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25962
DisGeNETi25962

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VIRMA
HGNCiHGNC:24500 VIRMA
HPAiHPA031530
MIMi616447 gene
neXtProtiNX_Q69YN4
OpenTargetsiENSG00000164944
PharmGKBiPA142671611

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4822 Eukaryota
ENOG410XSTI LUCA
GeneTreeiENSGT00390000002833
InParanoidiQ69YN4
KOiK22910
OMAiETSPHAF
OrthoDBi210051at2759
PhylomeDBiQ69YN4
TreeFamiTF323505

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA1429 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25962
PharosiQ69YN4

Protein Ontology

More...
PROi
PR:Q69YN4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164944 Expressed in 201 organ(s), highest expression level in testis
ExpressionAtlasiQ69YN4 baseline and differential
GenevisibleiQ69YN4 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR031801 VIR_N
IPR026736 Virilizer
PANTHERiPTHR23185 PTHR23185, 1 hit
PfamiView protein in Pfam
PF15912 VIR_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q69YN4
Secondary accession number(s): Q2M1N0
, Q6AHX9, Q6NT78, Q7Z6C7, Q8IXH4, Q9BTH4, Q9H9C9, Q9NWR3, Q9P2B8, Q9UFW1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 13, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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