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Entry version 101 (11 Dec 2019)
Sequence version 1 (19 Jul 2004)
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Protein

FACT complex subunit SPT16

Gene

SPT16

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).By similarity

Caution

Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FACT complex subunit SPT16
Alternative name(s):
Facilitates chromatin transcription complex subunit SPT16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPT16
Ordered Locus Names:CAGL0C03047g
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284593 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002428 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome C

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0127194 CAGL0C03047g

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CAGL0C03047g

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002451821 – 1027FACT complex subunit SPT16Add BLAST1027

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6FWT4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5478.XP_445310.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6FWT4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili8 – 28Sequence analysisAdd BLAST21
Coiled coili82 – 102Sequence analysisAdd BLAST21
Coiled coili208 – 233Sequence analysisAdd BLAST26
Coiled coili484 – 507Sequence analysisAdd BLAST24
Coiled coili637 – 658Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi955 – 1013Glu-rich (acidic)Add BLAST59

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M24 family. SPT16 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1189 Eukaryota
COG5406 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000209079

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6FWT4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCDHELL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.40.350.10, 1 hit
3.90.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR013719 DUF1747
IPR029148 FACT-Spt16_Nlobe
IPR013953 FACT_Spt16
IPR000994 Pept_M24
IPR011993 PH-like_dom_sf
IPR040258 Spt16

The PANTHER Classification System

More...
PANTHERi
PTHR13980 PTHR13980, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14826 FACT-Spt16_Nlob, 1 hit
PF00557 Peptidase_M24, 1 hit
PF08512 Rtt106, 1 hit
PF08644 SPT16, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01285 FACT-Spt16_Nlob, 1 hit
SM01287 Rtt106, 1 hit
SM01286 SPT16, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55920 SSF55920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6FWT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELNIDAEA FKARVELLHG KYREFENEPN SMVFALGSSN PENPYQKTTA
60 70 80 90 100
LHYWLMGYEF PATLIVFTPG KVVIITSGPK AKHLEKVVEL FKNNNNGVEL
110 120 130 140 150
EIWQRNNKDV EHSQKLFKDI IELINTAGKT VGIPEKDVYE GKFMKEWKPI
160 170 180 190 200
WDAAIKEHEF KLVDISAGLS STWEVKDDKE KAYISIASKC SDRFMNLLSD
210 220 230 240 250
EMVRAVDDEL KITNSKLSDK IENKIDDLKF LKKITNDLSA MCPPNHKFTL
260 270 280 290 300
DLLDWTYSPI IQSGNKFDLR VSAHSNNDQL HGNGCILASC GIRYNNYCSN
310 320 330 340 350
TTRTFLIDPS EEMVNNYVFL LDLQKHIIEN ELKAGRTGKE VYESVVEFIK
360 370 380 390 400
KVRPELAGNF TKNIGSLIGL EFRDSFFVLN SKNDKRKIQV GDCFNISFGF
410 420 430 440 450
NALKDMKTNT NYALQLADTV ILNEDGPKIL TEYTKSKSQV SFYFNNDEVE
460 470 480 490 500
KEKKPAASTK IPTNLDGNSK ILRSKLRGDA RGESQDAQKE QIRKENQRKL
510 520 530 540 550
HEKLQKEGLL RFTAEDATTE GSETRQYFKK YESYVRESQI PNNVRDLRIH
560 570 580 590 600
VDWRSQTIIV PIYGRPVPFH INSYKNGSKN EEGEYTYLRL NFHSPGSAGG
610 620 630 640 650
ISKNVVELPY DDSPDNQFMR SITLRSKDGD RMSETFKQIT DLKKESTKRE
660 670 680 690 700
QERKALADVV QQDKLIENKT GRTKRLDQIF VRPSPDTKRV PSTVFIHENG
710 720 730 740 750
IRYQSPLRTD SRIDILFSNI KNLIFQSCKG ELIVIIHIHL KNPIMMGKKK
760 770 780 790 800
IQDVQFYREA SDVSVDETGT GRRNQNKFRK YGDEDELEQE QEERRKRAML
810 820 830 840 850
DKEFKYFADA IAEASNGLVS VESTFRDLGF QGVPNRSAVF CMPTTDCLVQ
860 870 880 890 900
LIEPPFLVVN LEEIEVAILE RVQFGLKNFD LVFVYKDFKK PVTHINTIPI
910 920 930 940 950
ESLDFLKQWL TDMDIPYAIS TINLKWSTIM QSLQEDPHQF FLDGGWSFLN
960 970 980 990 1000
ANSDEEGSDE SEEEISEYEA SEEEPEDESA YSDEDDYSED ISDGSYSGAD
1010 1020
SEEEEGEDWD ELEKKAAKAD RTAGLRD
Length:1,027
Mass (Da):117,896
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FFCB8772A0ACED5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR380949 Genomic DNA Translation: CAG58216.1

NCBI Reference Sequences

More...
RefSeqi
XP_445310.1, XM_445310.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG58216; CAG58216; CAGL0C03047g

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2886759

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgr:CAGL0C03047g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380949 Genomic DNA Translation: CAG58216.1
RefSeqiXP_445310.1, XM_445310.1

3D structure databases

SMRiQ6FWT4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5478.XP_445310.1

Proteomic databases

PRIDEiQ6FWT4

Genome annotation databases

EnsemblFungiiCAG58216; CAG58216; CAGL0C03047g
GeneIDi2886759
KEGGicgr:CAGL0C03047g

Organism-specific databases

CGDiCAL0127194 CAGL0C03047g
EuPathDBiFungiDB:CAGL0C03047g

Phylogenomic databases

eggNOGiKOG1189 Eukaryota
COG5406 LUCA
HOGENOMiHOG000209079
InParanoidiQ6FWT4
OMAiPCDHELL

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.40.350.10, 1 hit
3.90.230.10, 1 hit
InterProiView protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR013719 DUF1747
IPR029148 FACT-Spt16_Nlobe
IPR013953 FACT_Spt16
IPR000994 Pept_M24
IPR011993 PH-like_dom_sf
IPR040258 Spt16
PANTHERiPTHR13980 PTHR13980, 1 hit
PfamiView protein in Pfam
PF14826 FACT-Spt16_Nlob, 1 hit
PF00557 Peptidase_M24, 1 hit
PF08512 Rtt106, 1 hit
PF08644 SPT16, 1 hit
SMARTiView protein in SMART
SM01285 FACT-Spt16_Nlob, 1 hit
SM01287 Rtt106, 1 hit
SM01286 SPT16, 1 hit
SUPFAMiSSF55920 SSF55920, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPT16_CANGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6FWT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 19, 2004
Last modified: December 11, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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