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UniProtKB - Q6P4Z2 (CO2A1_XENTR)

Entry version 80 (03 Jul 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Collagen alpha-1(II) chain

Gene

col2a1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1306CalciumBy similarity1
Metal bindingi1308CalciumBy similarity1
Metal bindingi1309Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1311Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1314CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-XTR-1442490 Collagen degradation
R-XTR-1474244 Extracellular matrix organization
R-XTR-1650814 Collagen biosynthesis and modifying enzymes
R-XTR-186797 Signaling by PDGF
R-XTR-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-XTR-2022090 Assembly of collagen fibrils and other multimeric structures
R-XTR-216083 Integrin cell surface interactions
R-XTR-3000171 Non-integrin membrane-ECM interactions
R-XTR-3000178 ECM proteoglycans
R-XTR-419037 NCAM1 interactions
R-XTR-8874081 MET activates PTK2 signaling
R-XTR-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(II) chainBy similarity
Alternative name(s):
Alpha-1 type II collagenBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:col2a1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-6258353 col2a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000028618127 – 186N-terminal propeptideBy similarityAdd BLAST160
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000286182187 – 1246Collagen alpha-1(II) chainAdd BLAST1060
PropeptideiPRO_00002861831247 – 1492C-terminal propeptideBy similarityAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6644-hydroxyprolineBy similarity1
Modified residuei6734-hydroxyprolineBy similarity1
Modified residuei6753-hydroxyprolineBy similarity1
Modified residuei6764-hydroxyprolineBy similarity1
Modified residuei6794-hydroxyprolineBy similarity1
Modified residuei9123-hydroxyprolineBy similarity1
Modified residuei9134-hydroxyprolineBy similarity1
Modified residuei9194-hydroxyprolineBy similarity1
Modified residuei9254-hydroxyprolineBy similarity1
Modified residuei11493-hydroxyprolineBy similarity1
Modified residuei11864-hydroxyprolineBy similarity1
Modified residuei11913-hydroxyprolineBy similarity1
Modified residuei11924-hydroxyprolineBy similarity1
Modified residuei12063-hydroxyprolineBy similarity1
Modified residuei12074-hydroxyprolineBy similarity1
Modified residuei12104-hydroxyprolineBy similarity1
Modified residuei12123-hydroxyprolineBy similarity1
Modified residuei12134-hydroxyprolineBy similarity1
Modified residuei12164-hydroxyprolineBy similarity1
Modified residuei12183-hydroxyprolineBy similarity1
Modified residuei12194-hydroxyprolineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1288 ↔ 1320PROSITE-ProRule annotation
Disulfide bondi1294Interchain (with C-1311)PROSITE-ProRule annotation
Disulfide bondi1311Interchain (with C-1294)PROSITE-ProRule annotation
Disulfide bondi1328 ↔ 1490PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1393N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1398 ↔ 1443PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains mostly 4-hydroxyproline. Prolines at the third position of the tripeptide repeating unit (G-X-P) are 4-hydroxylated in some or all of the chains.By similarity
Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.By similarity
Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains.By similarity
O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei186 – 187Cleavage; by procollagen N-endopeptidaseBy similarity2
Sitei1246 – 1247Cleavage; by procollagen C-endopeptidaseBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P4Z2

PRoteomics IDEntifications database

More...PRIDEi		Q6P4Z2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimers of alpha 1(II) chains.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		8364.ENSXETP00000043834

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P4Z2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 94VWFCPROSITE-ProRule annotationAdd BLAST59
Domaini1258 – 1492Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 1219Triple-helical regionAdd BLAST1014
Regioni1220 – 1246Nonhelical region (C-terminal)Add BLAST27

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3544 Eukaryota
ENOG410XNMM LUCA

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P4Z2

KEGG Orthology (KO)

More...KOi		K19719

Database of Orthologous Groups

More...OrthoDBi		337699at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 6 hits
PF00093 VWC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P4Z2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSFVDSRTL VLFAATQVIL LAVVRCQDEE DVLATGSCVQ HGQRYSDKDV 
        60         70         80         90        100
WKPEPCQICV CDTGNVLCDE IICEDPKDCP NAEIPFGECC PICPTEQSST 
       110        120        130        140        150
SSGQGVLKGQ KGEPGDIKDV VGPKGPPGPQ GPSGEQGPRG DRGDKGEKGA 
       160        170        180        190        200
PGPRGRDGEP GTPGNPGPVG PPGPPGPPGL GGNFAAQMTG GFDEKAGGAQ 
       210        220        230        240        250
MGVMQGPMGP MGPRGPPGPT GAPGPQGFQG NPGEPGEPGA GGPMGPRGPP 
       260        270        280        290        300
GPAGKPGDDG EAGKPGKSGE RGPPGPQGAR GFPGTPGLPG VKGHRGYPGL 
       310        320        330        340        350
DGSKGEAGAA GAKGEGGATG EAGSPGPMGP RGLPGERGRP GASGAAGARG 
       360        370        380        390        400
NDGLPGPAGP PGPVGPAGAP GFPGAPGSKG EAGPTGARGP EGAQGPRGES 
       410        420        430        440        450
GTPGSPGPAG ASGNPGTDGI PGAKGSSGAP GIAGAPGFPG PRGPPGPQGA 
       460        470        480        490        500
TGPLGPKGQT GDPGVAGFKG EHGPKGEIGS AGPQGAPGPA GEEGKRGARG 
       510        520        530        540        550
EPGAAGPLGP PGERGAPGNR GFPGQDGLAG PKGAPGERGV PGLGGPKGAN 
       560        570        580        590        600
GDPGRPGEPG LPGARGLTGR PGDAGPQGKV GPSGASGEDG RPGPPGPQGA 
       610        620        630        640        650
RGQPGVMGFP GPKGANGEPG KAGEKGLLGA PGLRGLPGKD GETGAQGPNG 
       660        670        680        690        700
PAGPAGERGE QGPPGPSGFQ GLPGPPGSPG EGGKPGDQGV PGEAGAPGLV 
       710        720        730        740        750
GPRGERGFPG ERGSSGPQGL QGPRGLPGTP GTDGPKGATG PSGPNGAQGP 
       760        770        780        790        800
PGLQGMPGER GAAGISGPKG DRGDTGEKGP EGAPGKDGSR GLTGPIGPPG 
       810        820        830        840        850
PSGPNGEKGE SGPSGPAGIV GARGAPGDRG ETGPPGPAGF AGPPGADGQA 
       860        870        880        890        900
GLKGDQGESG QKGDAGAPGP QGPSGAPGPQ GPTGVNGPKG ARGAQGPPGA 
       910        920        930        940        950
TGFPGAAGRV GPPGPNGNPG PSGAPGSAGK EGPKGARGDA GPTGRAGDPG 
       960        970        980        990       1000
LQGPAGVPGE KGESGEDGPS GPDGPPGPQG LSGQRGIVGL PGQRGERGFP 
      1010       1020       1030       1040       1050
GLPGPSGEPG KQGGPGSAGD RGPPGPVGPP GLTGPAGEPG REGNAGSDGP 
      1060       1070       1080       1090       1100
PGRDGATGIK GDRGETGPLG APGAPGAPGA PGPVGPTGKQ GDRGESGPQG 
      1110       1120       1130       1140       1150
PLGPSGPAGA RGLPGPQGPR GDKGEAGEAG ERGQKGHRGF TGLQGLPGPP 
      1160       1170       1180       1190       1200
GTAGDQGASG PAGPGGPRGP PGPVGPSGKD GSNGLPGPIG PPGPRGRGGE 
      1210       1220       1230       1240       1250
TGPAGPPGQP GPPGPPGPPG PGIDMSAFAG LSQPEKGPDP MRYMRADQAS 
      1260       1270       1280       1290       1300
SSVPQRDVDV EATLKSLNNQ IESIRSPDGT KKNPARTCRD LKLCHPEWKS 
      1310       1320       1330       1340       1350
GDYWIDPNQG CTVDAIKVFC NMETGETCVY PNPSKIPKKN WWSAKGKEKK 
      1360       1370       1380       1390       1400
HIWFGETING GFQFSYGDDS SAPNTANIQM TFLRLLSTDA TQNITYHCKN 
      1410       1420       1430       1440       1450
SIAFMDEASG NLKKAVLLQG SNDVEIRAEG NSRFTYNALE DGCKKHTGKW 
      1460       1470       1480       1490 
SKTVIEYRTQ KTSRLPIVDI APMDIGGADQ EFGVDIGPVC FL
Length:1,492
Mass (Da):142,696
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB7AF42B94210EB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WIP1F6WIP1_XENTR
Collagen alpha-1(II) chain
col2a1
1,494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B315F7B315_XENTR
Collagen alpha-1(II) chain
col2a1
1,492Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC063191 mRNA Translation: AAH63191.1

NCBI Reference Sequences

More...RefSeqi		NP_989220.1, NM_203889.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		394828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xtr:394828

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063191 mRNA Translation: AAH63191.1
RefSeqiNP_989220.1, NM_203889.1

3D structure databases

SMRiQ6P4Z2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043834

Proteomic databases

PaxDbiQ6P4Z2
PRIDEiQ6P4Z2

Genome annotation databases

GeneIDi394828
KEGGixtr:394828

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1280
XenbaseiXB-GENE-6258353 col2a1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
InParanoidiQ6P4Z2
KOiK19719
OrthoDBi337699at2759

Enzyme and pathway databases

ReactomeiR-XTR-1442490 Collagen degradation
R-XTR-1474244 Extracellular matrix organization
R-XTR-1650814 Collagen biosynthesis and modifying enzymes
R-XTR-186797 Signaling by PDGF
R-XTR-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-XTR-2022090 Assembly of collagen fibrils and other multimeric structures
R-XTR-216083 Integrin cell surface interactions
R-XTR-3000171 Non-integrin membrane-ECM interactions
R-XTR-3000178 ECM proteoglycans
R-XTR-419037 NCAM1 interactions
R-XTR-8874081 MET activates PTK2 signaling
R-XTR-8948216 Collagen chain trimerization

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 6 hits
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO2A1_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P4Z2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: July 3, 2019
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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