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UniProtKB - Q6PIU2 (NCEH1_HUMAN)

Entry version 138 (16 Oct 2019)
Sequence version 3 (12 Dec 2006)
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Protein

Neutral cholesterol ester hydrolase 1

Gene

NCEH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei191PROSITE-ProRule annotation1
Active sitei348PROSITE-ProRule annotation1
Active sitei378PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.13 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8964038 LDL clearance

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-NCEH1 Arylacetamide_deacetylase

MEROPS protease database

More...MEROPSi		S09.992

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000634

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutral cholesterol ester hydrolase 1 (EC:3.1.1.-)
Short name:
NCEH
Alternative name(s):
Arylacetamide deacetylase-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCEH1
Synonyms:AADACL1, KIAA1363
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29260 NCEH1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613234 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6PIU2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4CytoplasmicSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini26 – 408LumenalSequence analysisAdd BLAST383

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57552

Open Targets

More...OpenTargetsi		ENSG00000144959

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165697847

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6PIU2

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5048

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NCEH1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74737782

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002659391 – 408Neutral cholesterol ester hydrolase 1Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6PIU2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PIU2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6PIU2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6PIU2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PIU2

PeptideAtlas

More...PeptideAtlasi		Q6PIU2

PRoteomics IDEntifications database

More...PRIDEi		Q6PIU2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27511
67177 [Q6PIU2-1]
67178 [Q6PIU2-2]
67179 [Q6PIU2-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1563

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PIU2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PIU2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6PIU2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144959 Expressed in 191 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6PIU2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PIU2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA026888

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		121608, 51 interactors

Protein interaction database and analysis system

More...IntActi		Q6PIU2, 45 interactors

Molecular INTeraction database

More...MINTi		Q6PIU2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000442464

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q6PIU2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi113 – 115Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1515 Eukaryota
COG0657 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156699

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PIU2

KEGG Orthology (KO)

More...KOi		K14349

Database of Orthologous Groups

More...OrthoDBi		1263520at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6PIU2

TreeFam database of animal gene trees

More...TreeFami		TF314978

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
IPR033140 Lipase_GDXG_put_SER_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07859 Abhydrolase_3, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037251 Arylacetamide_deacetylase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01174 LIPASE_GDXG_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PIU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSSCVLLTA LVALAAYYVY IPLPGSVSDP WKLMLLDATF RGAQQVSNLI 
        60         70         80         90        100
HYLGLSHHLL ALNFIIVSFG KKSAWSSAQV KVTDTDFDGV EVRVFEGPPK 
       110        120        130        140        150
PEEPLKRSVV YIHGGGWALA SAKIRYYDEL CTAMAEELNA VIVSIEYRLV 
       160        170        180        190        200
PKVYFPEQIH DVVRATKYFL KPEVLQKYMV DPGRICISGD SAGGNLAAAL 
       210        220        230        240        250
GQQFTQDASL KNKLKLQALI YPVLQALDFN TPSYQQNVNT PILPRYVMVK 
       260        270        280        290        300
YWVDYFKGNY DFVQAMIVNN HTSLDVEEAA AVRARLNWTS LLPASFTKNY 
       310        320        330        340        350
KPVVQTTGNA RIVQELPQLL DARSAPLIAD QAVLQLLPKT YILTCEHDVL 
       360        370        380        390        400
RDDGIMYAKR LESAGVEVTL DHFEDGFHGC MIFTSWPTNF SVGIRTRNSY 

IKWLDQNL
Length:408
Mass (Da):45,808
Last modified:December 12, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5754850BE9805B5
GO
Isoform 2 (identifier: Q6PIU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-123: K → SASWSPSDE

Show »
Length:416
Mass (Da):46,627
Checksum:iA315923F59D660E7
GO
Isoform 3 (identifier: Q6PIU2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:275
Mass (Da):31,168
Checksum:i1D5212243D62F48B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTJ9A0A0A0MTJ9_HUMAN
Neutral cholesterol ester hydrolase...
NCEH1
448Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2G3A0A0R4J2G3_HUMAN
Arylacetamide deacetylase-like 1
NCEH1 AADACL1, hCG_20251
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C046H7C046_HUMAN
Neutral cholesterol ester hydrolase...
NCEH1
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE33F8WE33_HUMAN
Neutral cholesterol ester hydrolase...
NCEH1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH28734 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH47588 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AC007919 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AC069237 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA92601 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAH13028 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAH14142 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAH14802 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16A → T in BAA92601 (PubMed:10718198).Curated1
Sequence conflicti58H → R in BAH13028 (PubMed:14702039).Curated1
Sequence conflicti72K → R in BAH14802 (PubMed:14702039).Curated1
Sequence conflicti79Q → K in AAH47588 (PubMed:15489334).Curated1
Sequence conflicti254D → G in BAH14142 (PubMed:14702039).Curated1
Sequence conflicti329A → S in BAH14142 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04709919V → F. Corresponds to variant dbSNP:rs35316420Ensembl.1
Natural variantiVAR_04710071K → Q. Corresponds to variant dbSNP:rs2302815Ensembl.1
Natural variantiVAR_047101343L → M1 PublicationCorresponds to variant dbSNP:rs17857335Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0375181 – 133Missing in isoform 3. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_037519123K → SASWSPSDE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB037784 mRNA Translation: BAA92601.1 Different initiation.
AK294811 mRNA Translation: BAH11890.1
AK295641 mRNA Translation: BAH12137.1
AK299422 mRNA Translation: BAH13028.1 Different initiation.
AK304253 mRNA Translation: BAH14142.1 Different initiation.
AK316431 mRNA Translation: BAH14802.1 Different initiation.
AC007919 Genomic DNA No translation available.
AC069237 Genomic DNA No translation available.
BC028734 mRNA Translation: AAH28734.2 Different initiation.
BC047588 mRNA Translation: AAH47588.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33893.1 [Q6PIU2-1]
CCDS54681.1 [Q6PIU2-3]
CCDS54682.1 [Q6PIU2-2]

NCBI Reference Sequences

More...RefSeqi		NP_001139748.1, NM_001146276.1 [Q6PIU2-2]
NP_001139749.1, NM_001146277.1 [Q6PIU2-3]
NP_001139750.1, NM_001146278.1 [Q6PIU2-3]
NP_065843.3, NM_020792.4 [Q6PIU2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000475381; ENSP00000418571; ENSG00000144959 [Q6PIU2-1]
ENST00000543711; ENSP00000443227; ENSG00000144959 [Q6PIU2-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57552

UCSC genome browser

More...UCSCi		uc003fig.4 human [Q6PIU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037784 mRNA Translation: BAA92601.1 Different initiation.
AK294811 mRNA Translation: BAH11890.1
AK295641 mRNA Translation: BAH12137.1
AK299422 mRNA Translation: BAH13028.1 Different initiation.
AK304253 mRNA Translation: BAH14142.1 Different initiation.
AK316431 mRNA Translation: BAH14802.1 Different initiation.
AC007919 Genomic DNA No translation available.
AC069237 Genomic DNA No translation available.
BC028734 mRNA Translation: AAH28734.2 Different initiation.
BC047588 mRNA Translation: AAH47588.2 Different initiation.
CCDSiCCDS33893.1 [Q6PIU2-1]
CCDS54681.1 [Q6PIU2-3]
CCDS54682.1 [Q6PIU2-2]
RefSeqiNP_001139748.1, NM_001146276.1 [Q6PIU2-2]
NP_001139749.1, NM_001146277.1 [Q6PIU2-3]
NP_001139750.1, NM_001146278.1 [Q6PIU2-3]
NP_065843.3, NM_020792.4 [Q6PIU2-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi121608, 51 interactors
IntActiQ6PIU2, 45 interactors
MINTiQ6PIU2
STRINGi9606.ENSP00000442464

Chemistry databases

BindingDBiQ6PIU2
ChEMBLiCHEMBL5048
SwissLipidsiSLP:000000634

Protein family/group databases

ESTHERihuman-NCEH1 Arylacetamide_deacetylase
MEROPSiS09.992

PTM databases

GlyConnecti1563
iPTMnetiQ6PIU2
PhosphoSitePlusiQ6PIU2
SwissPalmiQ6PIU2

Polymorphism and mutation databases

BioMutaiNCEH1
DMDMi74737782

Proteomic databases

EPDiQ6PIU2
jPOSTiQ6PIU2
MassIVEiQ6PIU2
MaxQBiQ6PIU2
PaxDbiQ6PIU2
PeptideAtlasiQ6PIU2
PRIDEiQ6PIU2
ProteomicsDBi27511
67177 [Q6PIU2-1]
67178 [Q6PIU2-2]
67179 [Q6PIU2-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		57552

Genome annotation databases

EnsembliENST00000475381; ENSP00000418571; ENSG00000144959 [Q6PIU2-1]
ENST00000543711; ENSP00000443227; ENSG00000144959 [Q6PIU2-3]
GeneIDi57552
KEGGihsa:57552
UCSCiuc003fig.4 human [Q6PIU2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57552
DisGeNETi57552

GeneCards: human genes, protein and diseases

More...GeneCardsi		NCEH1
HGNCiHGNC:29260 NCEH1
HPAiHPA026888
MIMi613234 gene
neXtProtiNX_Q6PIU2
OpenTargetsiENSG00000144959
PharmGKBiPA165697847

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00940000156699
InParanoidiQ6PIU2
KOiK14349
OrthoDBi1263520at2759
PhylomeDBiQ6PIU2
TreeFamiTF314978

Enzyme and pathway databases

BRENDAi3.1.1.13 2681
ReactomeiR-HSA-8964038 LDL clearance

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NCEH1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NCEH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57552
PharosiQ6PIU2

Protein Ontology

More...PROi		PR:Q6PIU2

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144959 Expressed in 191 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ6PIU2 baseline and differential
GenevisibleiQ6PIU2 HS

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
IPR033140 Lipase_GDXG_put_SER_AS
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PIRSFiPIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01174 LIPASE_GDXG_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCEH1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PIU2
Secondary accession number(s): B7Z2K4
, B7Z3A1, B7Z5U2, B7Z906, B7ZAW6, F5H7K4, Q86WZ1, Q9P2I4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: October 16, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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