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Entry version 130 (16 Oct 2019)
Sequence version 2 (16 Jun 2009)
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Protein

All-trans retinoic acid-induced differentiation factor

Gene

ATRAID

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
All-trans retinoic acid-induced differentiation factor
Alternative name(s):
Apoptosis-related protein 3
Short name:
APR-3
p18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATRAID
Synonyms:APR3, C2orf28
ORF Names:HSPC013, UNQ214/PRO240
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24090 ATRAID

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UW56

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 199ExtracellularSequence analysisAdd BLAST169
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 229CytoplasmicSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51374

Open Targets

More...
OpenTargetsi
ENSG00000138085

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134964154

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UW56

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATRAID

Domain mapping of disease mutations (DMDM)

More...
DMDMi
239938597

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 301 PublicationAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002075231 – 229All-trans retinoic acid-induced differentiation factorAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi156 ↔ 171PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 181PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UW56

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UW56

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UW56

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UW56

PeptideAtlas

More...
PeptideAtlasi
Q6UW56

PRoteomics IDEntifications database

More...
PRIDEi
Q6UW56

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67447 [Q6UW56-1]
67448 [Q6UW56-2]
67449 [Q6UW56-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1000

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UW56

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UW56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in hematopoietic cell lines.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138085 Expressed in 225 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UW56 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UW56 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051353

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NELL1; the interaction promotes osteoblastic differentiation and mineralization.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119507, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6UW56, 6 interactors

Molecular INTeraction database

More...
MINTi
Q6UW56

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484228

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 193EGF-likePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYNU Eukaryota
ENOG4111PJW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017252

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UW56

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPQAHTA

Database of Orthologous Groups

More...
OrthoDBi
1027431at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UW56

TreeFam database of animal gene trees

More...
TreeFami
TF335766

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042350 ATRAID
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15926 PTHR15926, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UW56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPHDPGSLT TLVPWAAALL LALGVERALA LPEICTQCPG SVQNLSKVAF
60 70 80 90 100
YCKTTRELML HARCCLNQKG TILGLDLQNC SLEDPGPNFH QAHTTVIIDL
110 120 130 140 150
QANPLKGDLA NTFRGFTQLQ TLILPQHVNC PGGINAWNTI TSYIDNQICQ
160 170 180 190 200
GQKNLCNNTG DPEMCPENGS CVPDGPGLLQ CVCADGFHGY KCMRQGSFSL
210 220
LMFFGILGAT TLSVSILLWA TQRRKAKTS
Length:229
Mass (Da):24,747
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF051C5E886BCFF1
GO
Isoform 2 (identifier: Q6UW56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.
Show »
Length:171
Mass (Da):18,597
Checksum:i91A42CD2B2CB0883
GO
Isoform 3 (identifier: Q6UW56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKTSAELHEQEKPPSSPRATGPGRLGHARGRGPDALRGGAAGPGRASSGAPRERKM

Note: Produced by alternative promoter usage.
Show »
Length:284
Mass (Da):30,342
Checksum:iF7F1A5CEC82ABB39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JA62C9JA62_HUMAN
All-trans retinoic acid-induced dif...
ATRAID
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD27770 differs from that shown. Reason: Frameshift.Curated
The sequence AAD31317 differs from that shown. Reason: Frameshift.Curated
The sequence AAD31317 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH02846 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH11006 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH35850 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAX93173 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5D → G in BAF80618 (Ref. 1) Curated1
Sequence conflicti5D → G in AAD27770 (PubMed:11042152).Curated1
Sequence conflicti5D → G in AAQ89327 (PubMed:12975309).Curated1
Sequence conflicti5D → G in AAH02846 (PubMed:15489334).Curated1
Sequence conflicti5D → G in AAH11006 (PubMed:15489334).Curated1
Sequence conflicti5D → G in AAH35850 (PubMed:15489334).Curated1
Sequence conflicti33E → EP in AAK69412 (Ref. 3) Curated1
Sequence conflicti219W → S in BAF80618 (Ref. 1) Curated1
Sequence conflicti221T → A in AAK69412 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057991209A → S1 PublicationCorresponds to variant dbSNP:rs7437Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0141081 – 58Missing in isoform 2. 4 PublicationsAdd BLAST58
Alternative sequenceiVSP_0375211M → MKTSAELHEQEKPPSSPRAT GPGRLGHARGRGPDALRGGA AGPGRASSGAPRERKM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB009017 mRNA Translation: BAF80618.1
AF144055 mRNA Translation: AAD31317.2 Sequence problems.
AF275744 mRNA Translation: AAK69412.1
AF077037 mRNA Translation: AAD27770.1 Frameshift.
AY358968 mRNA Translation: AAQ89327.1
AK291894 mRNA Translation: BAF84583.1
CR600041 mRNA No translation available.
AC013403 Genomic DNA Translation: AAX93173.1 Sequence problems.
CH471053 Genomic DNA Translation: EAX00617.1
BC002846 mRNA Translation: AAH02846.2 Different initiation.
BC011006 mRNA Translation: AAH11006.3 Different initiation.
BC021237 mRNA Translation: AAH21237.1
BC035850 mRNA Translation: AAH35850.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46243.1 [Q6UW56-2]
CCDS62877.1 [Q6UW56-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001164266.1, NM_001170795.1 [Q6UW56-1]
NP_057169.2, NM_016085.4 [Q6UW56-2]
NP_542159.3, NM_080592.3 [Q6UW56-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380171; ENSP00000369518; ENSG00000138085 [Q6UW56-3]
ENST00000405489; ENSP00000384033; ENSG00000138085 [Q6UW56-2]
ENST00000606999; ENSP00000476080; ENSG00000138085 [Q6UW56-1]
ENST00000611786; ENSP00000484228; ENSG00000138085 [Q6UW56-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51374

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51374

UCSC genome browser

More...
UCSCi
uc002rjf.5 human [Q6UW56-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009017 mRNA Translation: BAF80618.1
AF144055 mRNA Translation: AAD31317.2 Sequence problems.
AF275744 mRNA Translation: AAK69412.1
AF077037 mRNA Translation: AAD27770.1 Frameshift.
AY358968 mRNA Translation: AAQ89327.1
AK291894 mRNA Translation: BAF84583.1
CR600041 mRNA No translation available.
AC013403 Genomic DNA Translation: AAX93173.1 Sequence problems.
CH471053 Genomic DNA Translation: EAX00617.1
BC002846 mRNA Translation: AAH02846.2 Different initiation.
BC011006 mRNA Translation: AAH11006.3 Different initiation.
BC021237 mRNA Translation: AAH21237.1
BC035850 mRNA Translation: AAH35850.1 Different initiation.
CCDSiCCDS46243.1 [Q6UW56-2]
CCDS62877.1 [Q6UW56-1]
RefSeqiNP_001164266.1, NM_001170795.1 [Q6UW56-1]
NP_057169.2, NM_016085.4 [Q6UW56-2]
NP_542159.3, NM_080592.3 [Q6UW56-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119507, 4 interactors
IntActiQ6UW56, 6 interactors
MINTiQ6UW56
STRINGi9606.ENSP00000484228

PTM databases

GlyConnecti1000
iPTMnetiQ6UW56
PhosphoSitePlusiQ6UW56

Polymorphism and mutation databases

BioMutaiATRAID
DMDMi239938597

Proteomic databases

jPOSTiQ6UW56
MassIVEiQ6UW56
MaxQBiQ6UW56
PaxDbiQ6UW56
PeptideAtlasiQ6UW56
PRIDEiQ6UW56
ProteomicsDBi67447 [Q6UW56-1]
67448 [Q6UW56-2]
67449 [Q6UW56-3]

Genome annotation databases

EnsembliENST00000380171; ENSP00000369518; ENSG00000138085 [Q6UW56-3]
ENST00000405489; ENSP00000384033; ENSG00000138085 [Q6UW56-2]
ENST00000606999; ENSP00000476080; ENSG00000138085 [Q6UW56-1]
ENST00000611786; ENSP00000484228; ENSG00000138085 [Q6UW56-3]
GeneIDi51374
KEGGihsa:51374
UCSCiuc002rjf.5 human [Q6UW56-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51374
DisGeNETi51374

GeneCards: human genes, protein and diseases

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GeneCardsi
ATRAID
HGNCiHGNC:24090 ATRAID
HPAiHPA051353
neXtProtiNX_Q6UW56
OpenTargetsiENSG00000138085
PharmGKBiPA134964154

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IYNU Eukaryota
ENOG4111PJW LUCA
GeneTreeiENSGT00390000017252
InParanoidiQ6UW56
OMAiFPQAHTA
OrthoDBi1027431at2759
PhylomeDBiQ6UW56
TreeFamiTF335766

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATRAID human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C2orf28

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51374
PharosiQ6UW56

Protein Ontology

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PROi
PR:Q6UW56

Gene expression databases

BgeeiENSG00000138085 Expressed in 225 organ(s), highest expression level in testis
ExpressionAtlasiQ6UW56 baseline and differential
GenevisibleiQ6UW56 HS

Family and domain databases

InterProiView protein in InterPro
IPR042350 ATRAID
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PANTHERiPTHR15926 PTHR15926, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARAID_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UW56
Secondary accession number(s): A8C1S2
, A8K779, Q96FF6, Q96RT2, Q9Y2R7, Q9Y5L7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 16, 2009
Last modified: October 16, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
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