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Entry version 115 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Guanine nucleotide exchange factor

Gene

arhgef12

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Guanine nucleotide exchange factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arhgef12Imported
Synonyms:LargImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-865525 arhgef12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 138PDZInterPro annotationAdd BLAST65
Domaini771 – 961DHInterPro annotationAdd BLAST191
Domaini1003 – 1116PHInterPro annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59
Regioni248 – 328DisorderedSequence analysisAdd BLAST81
Regioni556 – 653DisorderedSequence analysisAdd BLAST98
Regioni670 – 694DisorderedSequence analysisAdd BLAST25
Regioni1117 – 1187DisorderedSequence analysisAdd BLAST71
Regioni1353 – 1380DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili202 – 222Sequence analysisAdd BLAST21
Coiled coili819 – 839Sequence analysisAdd BLAST21
Coiled coili1222 – 1249Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 59PolyampholyteSequence analysisAdd BLAST48
Compositional biasi250 – 295PolarSequence analysisAdd BLAST46
Compositional biasi296 – 315PolyampholyteSequence analysisAdd BLAST20
Compositional biasi556 – 584PolyampholyteSequence analysisAdd BLAST29
Compositional biasi616 – 653PolarSequence analysisAdd BLAST38
Compositional biasi1117 – 1132PolarSequence analysisAdd BLAST16
Compositional biasi1140 – 1168PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1358 – 1376PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K07532

Database of Orthologous Groups

More...
OrthoDBi
319635at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
IPR015212 RGS-like_dom
IPR036305 RGS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820 PDZ_6, 1 hit
PF17838 PH_16, 1 hit
PF09128 RGS-like, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6XS95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTQSAASD RFHSRKPTRH GSILYRESST DKKQKVERSV SSSHDFDATE
60 70 80 90 100
SVSRKAKSTW DESRQETYGL VQRCVVIQRD ENGFGLTVSG DNPVFVQSVK
110 120 130 140 150
EDGAAMRAGV QTGDRIIKVN GTLVTHSNHL EVVKLIKSGS YVALTVQGRP
160 170 180 190 200
LGSPTIPLTD SEADNFVPIM PPHSPVPQGH GKGITSPILM EEENNIVHTQ
210 220 230 240 250
KLDILMKMLQ KEQDQLHQFQ EEFHTTPSQR LSKEIQDSKK HIAQLQDGLS
260 270 280 290 300
KARGLSQGSE SLQISELDAD SSDILGQTDC SSGDGSRPNS DIVDSPRSGQ
310 320 330 340 350
RDKSFLEESL EKSEIQDTDS QSSMGSPSIR FTHNIIGAED DDFDAEPEQS
360 370 380 390 400
PQINGQCSCF QNMDLLKSHP AHLAVFIHHV VSQFDPAALL CYLHADLYQQ
410 420 430 440 450
TNSKETRRVF MEFNQFFLER AANLKVPVPD DVALELEKRR PELIPEELHR
460 470 480 490 500
QYIQTVQERL SEDVKKNLED FKQKRSMGLT LAEGELSKLD TERFRDRNTI
510 520 530 540 550
DKERACAEQI VQKIEEILFT SQTPEDEKSN TIQYVILTYM KHLGVKVKEP
560 570 580 590 600
RSLEQKRGRI GFLPKIKQSM KKDREGEEKV KRRGFPSILA PQRKPSRQDS
610 620 630 640 650
NAIGKAMELQ RQRHPKHLST SSSSSPEPAD GSRLRTSGGS IEGSDTPFSP
660 670 680 690 700
SSNLGAAYTF QEVGREVEGV SRCGGENMSS VDTLDGGTRT SGPIFDFPSP
710 720 730 740 750
SLDHLHEEIG EADRLTDLGT PKLLRKLDSV ALSDIQSEDE HHEIDQEEHP
760 770 780 790 800
PNWQQLVSKD TLQKLKPHEI KQQEVINELF CTERAHVQKL SVLDQVFHQR
810 820 830 840 850
VIRENLLTPA ETRNIFSNLE EILQLHGALN EQMKAVKKRY ETSVVEEIGD
860 870 880 890 900
YVLNWFSGAE EEKLKQAVAT FCSNQPFALE MIKSRQKKDL KFLAFVQDAE
910 920 930 940 950
SNPLCKRLQL KDIIPTEMQR LTKYPLLLDN IARYSDQEDE KEKVNKAANH
960 970 980 990 1000
CRNILDYVNQ AVKEAENKQR LEDYQRRLDL SCLKPGEYPM IDELRNLDLT
1010 1020 1030 1040 1050
KRKLIHEGPL TWKVNKDKSI DLYSLLLEDI LVLLQRQDDK FNSEMRKQDL
1060 1070 1080 1090 1100
AATSESKHIF SPVIKLNTVL VRQVATDNKA FFVISMSENG AQIYELMANS
1110 1120 1130 1140 1150
VSEKNGWQDL ITSMAATSKT ENSQPAQLQQ TDPDLDSEEE HEDQLKLSND
1160 1170 1180 1190 1200
KEDERLLHRH RTDKDTESLV QPKSFSPSPT HGSILPHHAG ILKDQNQQDF
1210 1220 1230 1240 1250
RCSTSPSSCH PSTEHHLAVH ALRNLGLLKQ LLEQQLKFLQ KEEEENFQRF
1260 1270 1280 1290 1300
CSHKTKEQNL TRVSSLNKQN RGSRESDLNK DLHALHRAID KGSEHGNTGP
1310 1320 1330 1340 1350
DCVAEILEES GEQFFDAQEP HSDIYVDGSR REKHIEEAQF RSSENYLILD
1360 1370 1380 1390 1400
GYENVPESST DDDLSASHYS NQGDPNDSLH GEERLAFNAL EPASSSEAFD
1410 1420 1430 1440 1450
QMLHYIETIE SDLQQLKGLE DHYITYRNRV ALSGVLEEDP DKAMLPTDKG
Length:1,450
Mass (Da):164,238
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i018A0613CD0968F8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY211396 mRNA Translation: AAP43996.1

NCBI Reference Sequences

More...
RefSeqi
NP_001082763.1, NM_001089294.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
398710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:398710

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY211396 mRNA Translation: AAP43996.1
RefSeqiNP_001082763.1, NM_001089294.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi398710
KEGGixla:398710

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
398710
XenbaseiXB-GENE-865525 arhgef12

Phylogenomic databases

KOiK07532
OrthoDBi319635at2759

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
IPR015212 RGS-like_dom
IPR036305 RGS_sf
PfamiView protein in Pfam
PF17820 PDZ_6, 1 hit
PF17838 PH_16, 1 hit
PF09128 RGS-like, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6XS95_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XS95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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