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Entry version 111 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

GTPase activating protein 1

Gene

GAP1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (By similarity). Stimulates the GTPase/ATPase activities of YCHF1, and regulates its subcellular localization (PubMed:19086295, PubMed:20876569, PubMed:23550829). Binds phospholipids in a Ca2+-independent manner (PubMed:20876569). Promotes tolerance towards salinity stress by limiting the accumulation of reactive oxygen species (ROS) (PubMed:19086295, PubMed:23550829). Promotes resistance to bacterial pathogens, such as Xanthomonas oryzae pv. oryzae and Pseudomonas syringae pv. tomato strain DC3000 (PubMed:19086295). Binding to YCHF1 is required for its role in stimulating defense responses and the ability to alleviate salt stress (PubMed:26286751).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi22Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi23Calcium 1By similarity1
Metal bindingi23Calcium 2By similarity1
Metal bindingi28Calcium 2By similarity1
Metal bindingi74Calcium 1By similarity1
Metal bindingi74Calcium 2By similarity1
Metal bindingi75Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi76Calcium 1By similarity1
Metal bindingi76Calcium 2By similarity1
Metal bindingi81Calcium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processAbscisic acid signaling pathway, Plant defense
LigandCalcium, Lipid-binding, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTPase activating protein 11 Publication
Short name:
OsGAP11 Publication
Alternative name(s):
G-protein binding protein 11 Publication
Short name:
OsGPBP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAP11 Publication
Synonyms:GPBP11 Publication
Ordered Locus Names:Os02g0327000Imported, LOC_Os02g22130Curated
ORF Names:OsJ_06508Imported, OSJNBb0042G06.10Imported, P0476C12.36Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5L → A: Abolishes binding to YCHF1, but no effect on phospholipid binding; when associated with A-8; A-58 and A-60. 1 Publication1
Mutagenesisi8L → A: Abolishes binding to YCHF1, but no effect on phospholipid binding; when associated with A-5; A-58 and A-60. 1 Publication1
Mutagenesisi23D → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-28. 1 Publication1
Mutagenesisi28D → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-23. 1 Publication1
Mutagenesisi37K → A: Abolishes binding to YCHF1, and partial loss of phospholipid binding; when associated with A-39; A-41 and A-43. 1 Publication1
Mutagenesisi39K → A: Abolishes binding to YCHF1, and partial loss of phospholipid binding; when associated with A-37; A-41 and A-43. 1 Publication1
Mutagenesisi41K → A: Abolishes binding to YCHF1, and partial loss of phospholipid binding; when associated with A-37; A-39 and A-43. 1 Publication1
Mutagenesisi43R → A: Abolishes binding to YCHF1, and partial loss of phospholipid binding; when associated with A-37; A-39 and A-41. 1 Publication1
Mutagenesisi58T → A: Abolishes binding to YCHF1, but no effect on phospholipid binding; when associated with A-5; A-8 and A-60. 1 Publication1
Mutagenesisi60S → A: Abolishes binding to YCHF1, but no effect on phospholipid binding; when associated with A-8; A-8 and A-58. 1 Publication1
Mutagenesisi117R → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-119; A-123 and A-124. 1 Publication1
Mutagenesisi119N → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-117; A-123 and A-124. 1 Publication1
Mutagenesisi123E → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-117; A-119 and A-124. 1 Publication1
Mutagenesisi124E → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-117; A-119 and A-123. 1 Publication1
Mutagenesisi141R → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-143; A-146 and A-149. 1 Publication1
Mutagenesisi143R → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-141; A-146 and A-149. 1 Publication1
Mutagenesisi146E → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-141; A-143 and A-149. 1 Publication1
Mutagenesisi149E → A: Abolishes phospholipid binding, but no effect on binding to YCHF1; when associated with A-141; A-143 and A-146. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004333091 – 165GTPase activating protein 1Add BLAST165

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6YWF1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By wounding.1 Publication

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6YWF1 OS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to PYR/PYL/RCAR abscisic acid intracellular receptors in an ABA-independent manner, both at the plasma membrane and in the nucleus (By similarity).

Interacts with YchF1 (PubMed:19086295, PubMed:23550829, PubMed:20876569).

By similarity3 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS02T0327000-01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6YWF1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 87C2PROSITE-ProRule annotationAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plant CAR protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1030 Eukaryota
COG5038 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6YWF1

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMYNQKL

Database of Orthologous Groups

More...
OrthoDBi
1360428at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6YWF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGHLVGLVK VRVVRGVNLA VRDLRSSDPY VIVRMGKQKL KTRVIKKTTN
60 70 80 90 100
PEWNDELTLS IEDPAVPVRL EVYDKDTFID DAMGNAELDI RPLVEVVKMK
110 120 130 140 150
IEGVADNTVV KKVVPNRQNC LAEESTIYIS EGKVKQDVVL RLRDVECGEI
160
ELQLQWVDIP GSKGV
Length:165
Mass (Da):18,548
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FC73789C7A67D74
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF584506 mRNA Translation: ABU62827.1
AP004789 Genomic DNA Translation: BAD15699.1
AP005778 Genomic DNA Translation: BAD16390.1
AP008208 Genomic DNA Translation: BAF08623.1
AP014958 Genomic DNA Translation: BAS78417.1
CM000139 Genomic DNA Translation: EAZ22831.1
AK073631 mRNA Translation: BAG93560.1
AK104165 mRNA Translation: BAG96469.1

NCBI Reference Sequences

More...
RefSeqi
XP_015627601.1, XM_015772115.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Os02t0327000-01; Os02t0327000-01; Os02g0327000
Os02t0327000-02; Os02t0327000-02; Os02g0327000

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4329192

Gramene; a comparative resource for plants

More...
Gramenei
Os02t0327000-01; Os02t0327000-01; Os02g0327000
Os02t0327000-02; Os02t0327000-02; Os02g0327000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4329192

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF584506 mRNA Translation: ABU62827.1
AP004789 Genomic DNA Translation: BAD15699.1
AP005778 Genomic DNA Translation: BAD16390.1
AP008208 Genomic DNA Translation: BAF08623.1
AP014958 Genomic DNA Translation: BAS78417.1
CM000139 Genomic DNA Translation: EAZ22831.1
AK073631 mRNA Translation: BAG93560.1
AK104165 mRNA Translation: BAG96469.1
RefSeqiXP_015627601.1, XM_015772115.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RJ9X-ray1.63A1-165[»]
SMRiQ6YWF1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi4530.OS02T0327000-01

Proteomic databases

PaxDbiQ6YWF1

Genome annotation databases

EnsemblPlantsiOs02t0327000-01; Os02t0327000-01; Os02g0327000
Os02t0327000-02; Os02t0327000-02; Os02g0327000
GeneIDi4329192
GrameneiOs02t0327000-01; Os02t0327000-01; Os02g0327000
Os02t0327000-02; Os02t0327000-02; Os02g0327000
KEGGiosa:4329192

Phylogenomic databases

eggNOGiKOG1030 Eukaryota
COG5038 LUCA
InParanoidiQ6YWF1
OMAiKMYNQKL
OrthoDBi1360428at2759

Gene expression databases

GenevisibleiQ6YWF1 OS

Family and domain databases

InterProiView protein in InterPro
IPR000008 C2_dom
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGAP1_ORYSJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6YWF1
Secondary accession number(s): A0A0N7KF73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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