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Entry version 106 (08 May 2019)
Sequence version 2 (17 Oct 2006)
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Protein

LHFPL tetraspan subfamily member 2 protein

Gene

LHFPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in female and male fertility. Involved in distal reproductive tract development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFertilization

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LHFPL tetraspan subfamily member 2 proteinImported
Alternative name(s):
Lipoma HMGIC fusion partner-like 2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LHFPL2Imported
Synonyms:KIAA0206
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6588 LHFPL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609718 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6ZUX7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10184

Open Targets

More...
OpenTargetsi
ENSG00000145685

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30360

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LHFPL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242618

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002447631 – 228LHFPL tetraspan subfamily member 2 proteinAdd BLAST228

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6ZUX7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZUX7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6ZUX7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZUX7

PeptideAtlas

More...
PeptideAtlasi
Q6ZUX7

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZUX7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68376

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZUX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZUX7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6ZUX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues and cell lines examined except brain and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145685 Expressed in 227 organ(s), highest expression level in layer of synovial tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZUX7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZUX7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042402

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115482, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q6ZUX7, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369702

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4026 Eukaryota
ENOG410XSUB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182669

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285972

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZUX7

Identification of Orthologs from Complete Genome Data

More...
OMAi
YPGEWKA

Database of Orthologous Groups

More...
OrthoDBi
1431349at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZUX7

TreeFam database of animal gene trees

More...
TreeFami
TF321143

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019372 LHFPL

The PANTHER Classification System

More...
PANTHERi
PTHR12489 PTHR12489, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6ZUX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHVIVTCRS MLWTLLSIVV AFAELIAFMS ADWLIGKARS RGGVEPAGPG
60 70 80 90 100
GGSPEPYHPT LGIYARCIRN PGVQHFQRDT LCGPYAESFG EIASGFWQAT
110 120 130 140 150
AIFLAVGIFI LCMVALVSVF TMCVQSIMKK SIFNVCGLLQ GIAGLFLILG
160 170 180 190 200
LILYPAGWGC QKAIDYCGHY ASAYKPGDCS LGWAFYTAIG GTVLTFICAV
210 220
FSAQAEIATS SDKVQEEIEE GKNLICLL
Length:228
Mass (Da):24,486
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8FD766FFD9D0D31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35I → T in BAC86089 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026913102I → V. Corresponds to variant dbSNP:rs2303654Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK125227 mRNA Translation: BAC86089.1
AY309920 mRNA Translation: AAP74733.1
CH471084 Genomic DNA Translation: EAW95818.1
BC136335 mRNA Translation: AAI36336.1
BC136336 mRNA Translation: AAI36337.1
D86961 mRNA Translation: BAA13197.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4042.1

NCBI Reference Sequences

More...
RefSeqi
NP_005770.1, NM_005779.2
XP_006714578.1, XM_006714515.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380345; ENSP00000369702; ENSG00000145685
ENST00000515007; ENSP00000425906; ENSG00000145685

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10184

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10184

UCSC genome browser

More...
UCSCi
uc003kfo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125227 mRNA Translation: BAC86089.1
AY309920 mRNA Translation: AAP74733.1
CH471084 Genomic DNA Translation: EAW95818.1
BC136335 mRNA Translation: AAI36336.1
BC136336 mRNA Translation: AAI36337.1
D86961 mRNA Translation: BAA13197.1
CCDSiCCDS4042.1
RefSeqiNP_005770.1, NM_005779.2
XP_006714578.1, XM_006714515.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115482, 11 interactors
IntActiQ6ZUX7, 8 interactors
STRINGi9606.ENSP00000369702

PTM databases

iPTMnetiQ6ZUX7
PhosphoSitePlusiQ6ZUX7
SwissPalmiQ6ZUX7

Polymorphism and mutation databases

BioMutaiLHFPL2
DMDMi116242618

Proteomic databases

EPDiQ6ZUX7
jPOSTiQ6ZUX7
MaxQBiQ6ZUX7
PaxDbiQ6ZUX7
PeptideAtlasiQ6ZUX7
PRIDEiQ6ZUX7
ProteomicsDBi68376

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380345; ENSP00000369702; ENSG00000145685
ENST00000515007; ENSP00000425906; ENSG00000145685
GeneIDi10184
KEGGihsa:10184
UCSCiuc003kfo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10184
DisGeNETi10184

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LHFPL2
HGNCiHGNC:6588 LHFPL2
HPAiHPA042402
MIMi609718 gene
neXtProtiNX_Q6ZUX7
OpenTargetsiENSG00000145685
PharmGKBiPA30360

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4026 Eukaryota
ENOG410XSUB LUCA
GeneTreeiENSGT00950000182669
HOGENOMiHOG000285972
InParanoidiQ6ZUX7
OMAiYPGEWKA
OrthoDBi1431349at2759
PhylomeDBiQ6ZUX7
TreeFamiTF321143

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LHFPL2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LHFPL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10184

Protein Ontology

More...
PROi
PR:Q6ZUX7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145685 Expressed in 227 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiQ6ZUX7 baseline and differential
GenevisibleiQ6ZUX7 HS

Family and domain databases

InterProiView protein in InterPro
IPR019372 LHFPL
PANTHERiPTHR12489 PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLHPL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZUX7
Secondary accession number(s): B2RMQ6, Q7Z5P0, Q92605
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: May 8, 2019
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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