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Entry version 126 (03 Jul 2019)
Sequence version 2 (23 Mar 2010)
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Protein

Nesprin-1

Gene

Syne1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nesprin-1
Alternative name(s):
Enaptin
KASH domain-containing protein 1
Short name:
KASH1
Myocyte nuclear envelope protein 1
Short name:
Myne-1
Nuclear envelope spectrin repeat protein 1
Synaptic nuclear envelope protein 1
Short name:
Syne-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Syne1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1927152 Syne1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8748CytoplasmicPROSITE-ProRule annotationAdd BLAST8748
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8749 – 8769Helical; Anchor for type IV membrane proteinPROSITE-ProRule annotationAdd BLAST21
Topological domaini8770 – 8799Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003922091 – 8799Nesprin-1Add BLAST8799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei732PhosphoserineCombined sources1
Modified residuei2268PhosphothreonineCombined sources1
Modified residuei5655PhosphoserineCombined sources1
Modified residuei8227PhosphoserineBy similarity1
Modified residuei8278PhosphothreonineCombined sources1
Modified residuei8281PhosphoserineBy similarity1
Modified residuei8284PhosphoserineCombined sources1
Modified residuei8308PhosphoserineCombined sources1
Modified residuei8363PhosphothreonineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi8776Interchain (with C-577 in SUN2); alternateBy similarity
Disulfide bondi8776Interchain (with C-759 in SUN1); alternateBy similarity
Isoform 2 (identifier: Q6ZWR6-2)
Modified residuei377PhosphoserineCombined sources1
Isoform 3 (identifier: Q6ZWR6-3)
Modified residuei377PhosphoserineCombined sources1
Isoform 4 (identifier: Q6ZWR6-4)
Modified residuei8225PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6ZWR6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6ZWR6

PeptideAtlas

More...
PeptideAtlasi
Q6ZWR6

PRoteomics IDEntifications database

More...
PRIDEi
Q6ZWR6

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6ZWR6

GlyConnect protein glycosylation platform

More...
GlyConnecti
2530

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6ZWR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6ZWR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in C2F3 and CH310T1/2 cells, brain and skeletal muscle (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000096054 Expressed in 265 organ(s), highest expression level in cerebellum lobe

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6ZWR6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6ZWR6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. The SUN2:SYNE1/KASH1 LINC complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE1/KASH1 peptides bind at the interface of adjacent SUN domains. Self-associates.

Interacts with SYNE3.

Interacts with SUN3; proposed to form a spermatogenesis-specific LINC complex with SUN3 during sperm head formation. May interact with MUSK.

Interacts with SPAG4/SUN4.

Interacts with EMD and LMNA in vitro.

Interacts with F-actin via its N-terminal domain.

Interacts with DCTN1 and DYNC1I1/2; suggesting the association with the dynein-dynactin motor complex.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE3Q6ZMZ3-12EBI-10760805,EBI-10760907From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
211015, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-60966N

Protein interaction database and analysis system

More...
IntActi
Q6ZWR6, 8 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6ZWR6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 134Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini178 – 283Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati314 – 397Spectrin 1Add BLAST84
Repeati398 – 502Spectrin 2Add BLAST105
Repeati503 – 609Spectrin 3Add BLAST107
Repeati610 – 703Spectrin 4Add BLAST94
Repeati704 – 815Spectrin 5Add BLAST112
Repeati816 – 923Spectrin 6Add BLAST108
Repeati924 – 1024Spectrin 7Add BLAST101
Repeati1025 – 1122Spectrin 8Add BLAST98
Repeati1123 – 1246Spectrin 9Add BLAST124
Repeati1247 – 1333Spectrin 10Add BLAST87
Repeati1334 – 1442Spectrin 11Add BLAST109
Repeati1443 – 1548Spectrin 12Add BLAST106
Repeati1549 – 1651Spectrin 13Add BLAST103
Repeati1652 – 1761Spectrin 14Add BLAST110
Repeati1762 – 1877Spectrin 15Add BLAST116
Repeati1878 – 1974Spectrin 16Add BLAST97
Repeati1975 – 2079Spectrin 17Add BLAST105
Repeati2080 – 2193Spectrin 18Add BLAST114
Repeati2194 – 2301Spectrin 19Add BLAST108
Repeati2302 – 2399Spectrin 20Add BLAST98
Repeati2400 – 2511Spectrin 21Add BLAST112
Repeati2512 – 2617Spectrin 22Add BLAST106
Repeati2618 – 2729Spectrin 23Add BLAST112
Repeati2730 – 2836Spectrin 24Add BLAST107
Repeati2837 – 2960Spectrin 25Add BLAST124
Repeati2961 – 3060Spectrin 26Add BLAST100
Repeati3061 – 3169Spectrin 27Add BLAST109
Repeati3170 – 3273Spectrin 28Add BLAST104
Repeati3274 – 3385Spectrin 29Add BLAST112
Repeati3386 – 3488Spectrin 30Add BLAST103
Repeati3489 – 3591Spectrin 31Add BLAST103
Repeati3592 – 3718Spectrin 32Add BLAST127
Repeati3719 – 3812Spectrin 33Add BLAST94
Repeati3813 – 3918Spectrin 34Add BLAST106
Repeati3919 – 4026Spectrin 35Add BLAST108
Repeati4027 – 4137Spectrin 36Add BLAST111
Repeati4138 – 4233Spectrin 37Add BLAST96
Repeati4234 – 4337Spectrin 38Add BLAST104
Repeati4338 – 4449Spectrin 39Add BLAST112
Repeati4450 – 4558Spectrin 40Add BLAST109
Repeati4559 – 4667Spectrin 41Add BLAST109
Repeati4668 – 4774Spectrin 42Add BLAST107
Repeati4775 – 4880Spectrin 43Add BLAST106
Repeati4881 – 4989Spectrin 44Add BLAST109
Repeati4990 – 5097Spectrin 45Add BLAST108
Repeati5098 – 5207Spectrin 46Add BLAST110
Repeati5208 – 5316Spectrin 47Add BLAST109
Repeati5317 – 5422Spectrin 48Add BLAST106
Repeati5423 – 5520Spectrin 49Add BLAST98
Repeati5521 – 5628Spectrin 50Add BLAST108
Repeati5629 – 5745Spectrin 51Add BLAST117
Repeati5746 – 5851Spectrin 52Add BLAST106
Repeati5971 – 6080Spectrin 53Add BLAST110
Repeati6081 – 6187Spectrin 54Add BLAST107
Repeati6377 – 6488Spectrin 55Add BLAST112
Repeati6489 – 6584Spectrin 56Add BLAST96
Repeati6585 – 6694Spectrin 57Add BLAST110
Repeati6695 – 6798Spectrin 58Add BLAST104
Repeati6799 – 6905Spectrin 59Add BLAST107
Repeati6906 – 7023Spectrin 60Add BLAST118
Repeati7024 – 7131Spectrin 61Add BLAST108
Repeati7132 – 7240Spectrin 62Add BLAST109
Repeati7241 – 7353Spectrin 63Add BLAST113
Repeati7354 – 7457Spectrin 64Add BLAST104
Repeati7458 – 7561Spectrin 65Add BLAST104
Repeati7562 – 7674Spectrin 66Add BLAST113
Repeati7675 – 7786Spectrin 67Add BLAST112
Repeati7787 – 7886Spectrin 68Add BLAST100
Repeati7887 – 8000Spectrin 69Add BLAST114
Repeati8001 – 8109Spectrin 70Add BLAST109
Repeati8110 – 8221Spectrin 71Add BLAST112
Repeati8332 – 8440Spectrin 72Add BLAST109
Repeati8441 – 8550Spectrin 73Add BLAST110
Repeati8551 – 8668Spectrin 74Add BLAST118
Domaini8740 – 8799KASHPROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 289Actin-bindingAdd BLAST289

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili314 – 8666Sequence analysisAdd BLAST8353

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8665 – 8731Ser-richAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154481

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000120125

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6ZWR6

KEGG Orthology (KO)

More...
KOi
K19326

Database of Orthologous Groups

More...
OrthoDBi
47at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6ZWR6

TreeFam database of animal gene trees

More...
TreeFami
TF317709
TF337116

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR012315 KASH
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR030265 SYNE1

The PANTHER Classification System

More...
PANTHERi
PTHR14514:SF3 PTHR14514:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF10541 KASH, 1 hit
PF00435 Spectrin, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM01249 KASH, 1 hit
SM00150 SPEC, 42 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51049 KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ZWR6-1) [UniParc]FASTAAdd to basket
Also known as: Nesprin-1 Giant, Enaptin

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSRASSRS HRDITNVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV
60 70 80 90 100
DDLFEDMKDG IKLLALLEVL SGQKLPCEQG HRVKRIHAVA NIGTALKFLE
110 120 130 140 150
GRKIKLVNIN ATDIADGRPS IVLGLMWTII LYFQIEELTS NLPQLQSLSS
160 170 180 190 200
SASSVDSMVS TETASPPSKR KVAAKIQGNA KKTLLKWVQH TAGKQMGIEV
210 220 230 240 250
KDFGKSWRTG LAFHSVIHAI QPELVDLEKV KTRSNRENLE DAFTIAETQL
260 270 280 290 300
GIPRLLDPED VDVDKPDEKS IMTYVAQFLT QYPDIHGAGC DGQEDDVVFV
310 320 330 340 350
GFTNNIALLL GFQRDDRLIL KETKVWIEQF ERDFTRAQMT ESSLQDKYQA
360 370 380 390 400
FKHFRVQYEM KRKQVEHIIQ PLQRDGKLTL DQALVKQCWE RVSSRLFDWH
410 420 430 440 450
IQLDKSLPAP LGTIGAWLYR AEVALREEIT IQQVHEETAN TIQRKLEQHK
460 470 480 490 500
DLLQNTDAHK RAFHEIYQTR SVNGIPMPPD QLEDMAERFH FVSSTSELHL
510 520 530 540 550
MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVELLL QSYISFIENS
560 570 580 590 600
KFFEQYEVTY QILKQTADIY VKAEGSVEEA ENVMKFMSEA TAQWRNLSVE
610 620 630 640 650
VRSVRSMLEE VISNWDRYGD TVASLQAWLE DAEKMLSQSE HAKKDFFRNL
660 670 680 690 700
PHWIQQHTAM NDAGNFLIET CDEIVSRDLK QQLLLLNGRW RELFMEVKQY
710 720 730 740 750
ARADEMDRMK KEYIDVTTTL FGFATEAHRK LSEPLEVSFI NVKLLIQDLE
760 770 780 790 800
DLEKRVPVMD AQYKMIAKKA HLFAKESPQE EANEMLTTMS KLKEQLSKVK
810 820 830 840 850
ECCSPLLYEA QQLTVPLEEL ETQITSFYDS LGKINEILSV LEQEAQSSTL
860 870 880 890 900
FKQKHQELLA SQENCKKSLT LIEKGSQSVQ KLVTSSQARK PWDHTKLQKQ
910 920 930 940 950
IADVHHAFQS MIKKTGDWKK HVEANSRLMK KFEESRAELE KVLRVAQEGL
960 970 980 990 1000
EEKGDPEELL RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA
1010 1020 1030 1040 1050
VRKLHKQWKD LQGEAPYHLL HLKIAVEKDR FSAAVEECRA ELEQETKLAP
1060 1070 1080 1090 1100
QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL IEELCGKLPV QDPVRDTCGA
1110 1120 1130 1140 1150
CHTALKELKA SIDNTYTMLV DDPDKWKDYT SRFSEFSSWV SAKKACLKKI
1160 1170 1180 1190 1200
KDEPIDTGNH DEVKHMVDEI RNDITKKGES LSWLKSRLKY LIDISSENEA
1210 1220 1230 1240 1250
QKRGDELAEL SSSFKALVAL LSEVEKLLSN FGECVQYKEI VKSSLEGLIS
1260 1270 1280 1290 1300
GPQESKEEAE MILDSKNLLE AQQLLLHHQQ KTKMISAKKR DLQEQMEQAQ
1310 1320 1330 1340 1350
QGGQAGPGQE ELRKLESTLT GLEQSRERQE RRIQVSLRKW ERFETNKETV
1360 1370 1380 1390 1400
VRYLFQTGSS HERFLSFSSL ESLSSELEQT KEFSKRTESI ATQAENLVKE
1410 1420 1430 1440 1450
AAELPLGPRN KRVLQRQAKS IKEQVTTLED TLEEDIKTME MVKSKWDHFG
1460 1470 1480 1490 1500
SNFETLSIWI LEKENELSSL EASASAADVQ ISQIKVTIQE IESKIDSIVG
1510 1520 1530 1540 1550
LEEEAQSFAQ FVTTGESARI KAKLTQIRRY WEELQEHARG LEGTILGHLS
1560 1570 1580 1590 1600
QQQKFEENLR KIRQSVSEFA ERLADPIKIC SSAAETYKVL QEHMDLCQAV
1610 1620 1630 1640 1650
ESLSSTVTMF SASAQKAVNR ESCTQEAAAL QQQYEEILHK AKEMQTALED
1660 1670 1680 1690 1700
LLARWQRLEK GLSPFLTWLE RCEAIASSPE KDISADRGKV ESELQLIQAL
1710 1720 1730 1740 1750
QNEVVSQASL YSNLLQLKEA LFSVASKEDV AVMKLQLEQL DERWGDLPQI
1760 1770 1780 1790 1800
ISKRMHFLQS VLAEHKQFDE LLFSFSVWIK QFLGELQRTS EINLRDHQVA
1810 1820 1830 1840 1850
LTRHKDHAAE IEKKRGEITH LQGHLSQLRS LGRAQDLHPL QSKVDDCFQL
1860 1870 1880 1890 1900
FEEASQVVER RKLALAQLAE FLQSHACMST LLYQLRQTVE ATKSMSKKQS
1910 1920 1930 1940 1950
DSLKTDLHSA IQDVKTLESS AISLDGTLTK AQCHLKSASP EERTSCRATT
1960 1970 1980 1990 2000
DQLSLEVERI QNLLGTKQSE ADALVALKEA FREQKEELLR SIEDIEERMD
2010 2020 2030 2040 2050
RERLKVPTRQ ALQHRLRVFN QLEDELNSHE HELCWLKDKA KQIAQKDVAF
2060 2070 2080 2090 2100
APEVDREING LEATWDDTRR QIHENQGQCC GLIDLVREYQ SLKSTVCNVL
2110 2120 2130 2140 2150
EDASNVVVMR ATIKDQGDLK WAFSKHETSR NEMNSKQKEL DSFTSKGKHL
2160 2170 2180 2190 2200
LSELKKIHSG DFSLVKTDME STLDKWLDVS ERIEENMDML RVSLSIWDDV
2210 2220 2230 2240 2250
LSRKDEIEGW SNSSLPKLAE NISNLNNSLR AEELLKELES EVKIKALKLE
2260 2270 2280 2290 2300
DLHSKINNLK ELTKNPETPT ELQFIEADLR QKLEHAKEIT EEARGTLKDF
2310 2320 2330 2340 2350
TAQRTQVERF VKDITAWLIN VEESLTRCAQ TETCEGLKKA KDIRKELQSQ
2360 2370 2380 2390 2400
QNSITSTQEE LNSLCRKHHS VELESLGRAM TGLIKKHEAT SQLCSQTQAR
2410 2420 2430 2440 2450
IQDSLEKHFS GSMKEFQEWF LGAKAAARES SNLTGDSQIL EARLHNLQGV
2460 2470 2480 2490 2500
LDSLSDGQSK LDVVTQEGQT LYAHLPKQIV SSIQEQITKA NEEFQAFLKQ
2510 2520 2530 2540 2550
CLKEKQALQD CVSELGSFED QHRKLNLWIH EMEERLKTEN LGESKHHISE
2560 2570 2580 2590 2600
KKNEVRKVEM FLGELLAARE SLDKLSQRGQ LLSEESHSAG KGGCRSTQLL
2610 2620 2630 2640 2650
TSYQSLLRVT KEKLRSCQLA LKEHEALEEA TQSMWARVKD VQDRLACAES
2660 2670 2680 2690 2700
TLGNKETLEG RLSQIQDILL MKGEGEVKLN LAIGKGDQAL RSSNKEGQQA
2710 2720 2730 2740 2750
IQDQLEMLKK AWAEAMNSAV HAQSTLESVI DQWNDYLEKK SQLEQWMESV
2760 2770 2780 2790 2800
DQRLEHPLQL QPGLKEKFSL LDHFQSIVSE AEDHTGALQQ LAAKSRELYQ
2810 2820 2830 2840 2850
KTQDESFKEA GQEELRTQFQ DIMTVAKEKM RTVEDLVKDH LMYLDAVQEF
2860 2870 2880 2890 2900
ADWLHSAKEE LHRWSDTSGD PSATQKKLLK IKELIDSREI GAGRLSRVES
2910 2920 2930 2940 2950
LAPAVKQNTA ASGCELLNSE MQALRADWRQ WEDCLFQTQS SLESLVSEMA
2960 2970 2980 2990 3000
LSEQEFFGQV TQLEQALEQF CTLLKTWAQQ LTLLEGKNSD EEILECWHKG
3010 3020 3030 3040 3050
REILDALQKA EPMTEDLKSQ LNELCRFSRD LSPYSEKVSG LIKEYNCLCL
3060 3070 3080 3090 3100
QASKGCQNKE QILQERFQKA SRGFQQWLVN AKITTAKCFD LPQNLSEVSS
3110 3120 3130 3140 3150
SLQKIQEFLS ESENGQHKLN TMLFKGELLS SLLTEEKAQA VQAKVLTAKE
3160 3170 3180 3190 3200
EWKSFHANLH QKESALENLK IQMKDFEVSA ELVQNWLSKT ERLVQESSNR
3210 3220 3230 3240 3250
LYDLPAKRRE QQKLQSVLEE IQCYEPQLHR LKEKARQLWE GQAASKSFVH
3260 3270 3280 3290 3300
RVSQLSSQYL ALSNVTKEKV SRLDRIIAEH NRFSQGVKEL QDWMSDAVHM
3310 3320 3330 3340 3350
LDSYCLPTSD KSVLDSRMLK LEALLSVRQE KEIQMKMVVT RGEYVLQSTS
3360 3370 3380 3390 3400
LEGSAAVQQQ LQAVKDMWES LLSAAIRCKS QLEGALSKWT SYQDDVRQFS
3410 3420 3430 3440 3450
SWMDSVEVSL TESEKQHTEL REKITALGKA KLLNEEVLSH SSLLETIEVK
3460 3470 3480 3490 3500
RAAMTEHYVT QLELQDLQER HQALKEKAKE AVTKLEKLVR LHQEYQRDLK
3510 3520 3530 3540 3550
AFESWLEQEQ EKLDRCSVHE GDTNAHETML RDLQELQVRC AEGQALLNSV
3560 3570 3580 3590 3600
LHTREDVIPS GLPQAEDRVL ESLRQDWQVY QHRLAEARMQ LNNVVNKLRL
3610 3620 3630 3640 3650
MEQKFQQADE WLKRMEEKIN FRSECQSSRS DKEIQLLQLK KWHEDLSAHR
3660 3670 3680 3690 3700
DEVEEVGTRA QGILDETHIS SRMGCQATQL TSRYQALLLQ VLEQIKFFEE
3710 3720 3730 3740 3750
ELQCLEETES SLSSYSDWYG STHKNFKNVA TKIDKVDESM MGKKLKTLEV
3760 3770 3780 3790 3800
LLKDMEKGHS LLKSAREKGE RAMKFLAEHE AEALRKEIHT YMEQLKNLTS
3810 3820 3830 3840 3850
TVRKECMSLE KGLHLAKEFS DKYKVLAQWM AEYQEILCTP EEPKMELYEK
3860 3870 3880 3890 3900
KAQLSKYKSL QQMVLSHEPS VTSVQEKSEA LLELVQDQSL KDKIQKLQSD
3910 3920 3930 3940 3950
FQDLCSRAKE RVFSLEAKVK DHEDYNTELQ EVEKWLLQMS GRLVAPDLLE
3960 3970 3980 3990 4000
MSSLETITQQ LAHHKAMMEE IAGFEDRLDN LKAKGDTLIG QCPEHLQAKQ
4010 4020 4030 4040 4050
KQTVQAHLQG TKDSYSAICS TAQRVYRSLE YELQKHVSSQ DTLQQCQAWI
4060 4070 4080 4090 4100
SAVQPDLKPS PQPPLSRAEA VKQVKHFRAL QEQARTYLDL LCSMCDLSNS
4110 4120 4130 4140 4150
SVKNTAKDIQ QTEQLIEQRL VQAQNLTQGW EEIKSLKAEL WIYLQDADQQ
4160 4170 4180 4190 4200
LQNMKRRHTE LEINIAQNMV MQVKDFIKQL QCKQVSVSTI VEKVDKLTKN
4210 4220 4230 4240 4250
QESPEHKEIT HLNDQWQDLC LQSDKLCAQR EQDLQRTSSY HDHMRVVEAF
4260 4270 4280 4290 4300
LEKFTTEWDS LARSNAESTA IHLEALKKLA LALQEEMYAI DDLKDCKQKL
4310 4320 4330 4340 4350
IEQLGLDDRE LVREQTSHLE QRWFQLQDLV KRKIQVSVTN LEELNVIQSR
4360 4370 4380 4390 4400
FQELMEWAEE QQPNIVEALK QSPPPGMAQH LLMDHLAICS ELEAKQVLLK
4410 4420 4430 4440 4450
SLMKDADRVM ADLGLNERKV IQKALSEAQK HVSCLSDLVG QRRKYLNKAL
4460 4470 4480 4490 4500
SEKTQFLMAV FQATSQIQQH ERKIVFREYI CLLPDDVSKQ VKTCKTAQAS
4510 4520 4530 4540 4550
LKTYQNEVTG LCAQGRELMK GITKQEQEEV LGKLQELQTV YDTVLQKCSH
4560 4570 4580 4590 4600
RLQELEKSLV SRKHFKEDFD KACHWLKQAD IVTFPEINLM NEKTELHAQL
4610 4620 4630 4640 4650
DKYQSILEQS PEYENLLLTL QTTGQAMLPS LNEVDHSYLS EKLSALPQQF
4660 4670 4680 4690 4700
NVIVALAKDK FYKTQEAILA RKEYTSLIEL TTQSLGDLED QFLKMRKMPS
4710 4720 4730 4740 4750
DLIVEESVSL QQSCSALLGE VVALGEAVNE LNQKKESFRS TGQPWQPEKM
4760 4770 4780 4790 4800
LQLATLYHRL KRQAEQRVSF LEDTTSVYKE HAQMCRQLES QLEVVKREQA
4810 4820 4830 4840 4850
KVNEETLPAE EKLKVYHSLA GSLQDSGILL KRVATHLEDL SPHLDPTAYE
4860 4870 4880 4890 4900
KAKSQVQSWQ EELKQMTSDV GELVTECESR MVQSIDFQTE MSRSLDWLRR
4910 4920 4930 4940 4950
VKAELSGPVC LDLSLQDIQE EIRKIQIHQE EVLSSLRIMS ALSHKEQEKF
4960 4970 4980 4990 5000
TKAKELISAD LEHTLAELQE LDGDVQEALR TRQATLTEIY SRCQRYYQVF
5010 5020 5030 5040 5050
QAANDWLDDA QEMLQLAGNG LDVESAEENL RSHMEFFKTE GQFHSNMEEL
5060 5070 5080 5090 5100
RGLVARLDPL IKATGKEELA QKMASLEKRS QGIIQESHTQ RDLLQRCMVQ
5110 5120 5130 5140 5150
WQEYQKAREG VIELMNDAEK KLSEFAVLKT SSIHEAEEKL SKHKALVSVV
5160 5170 5180 5190 5200
DSFHEKIVAL EEKASQLEQT GNDTSKATLS RSMTTVWQRW TRLRAVAQDQ
5210 5220 5230 5240 5250
EKILEDAVDE WKRLSAKVKE TTEVINQLQG RLPGSSTEKA SKAELMTLLE
5260 5270 5280 5290 5300
SHDTYLMDLE SQQLTLGVLQ QRALSMLQDR AFPGTEEEVP ILRAITALQD
5310 5320 5330 5340 5350
QCLNMQEKVK NHGKLVKQEL QEREAVETRI NSVKSWVQET KDYLGNPTIE
5360 5370 5380 5390 5400
IDTQLEELKR LLAEATSHQE SIEKIAEEQK NKYLGLYTVL PSEISLQLAE
5410 5420 5430 5440 5450
VALDLKIHDQ IQEKVQEIEE GKAMSQEFSC KIQKVTKDLT TILTKLKAKT
5460 5470 5480 5490 5500
DDLVHAKAEH KMLGEELDGC NSKLMELDAA IQTFSERHSQ LGQPLAKKIG
5510 5520 5530 5540 5550
KLTELHQQTI RQAENRLSKL NQALSHMEEY NEMLETVRKW IEKAKVLVHG
5560 5570 5580 5590 5600
NIAWNSASQL QEQYILHQTL LEESGEIDSD LEAMAEKVQH LANVYCTGKL
5610 5620 5630 5640 5650
SQQVTQFGRE MEELRQAIRV RLRNLQDAAK DMKKFEGELR NLQVALEQAQ
5660 5670 5680 5690 5700
TILTSPEVGR RSLKEQLCHR QHLLSEMESL KPKMQAVQLC QSALRIPEDV
5710 5720 5730 5740 5750
VASLPLCHAA LRLQEEASQL QHTAIQQCNI MQAKKHSLIF PPKEAVVQYE
5760 5770 5780 5790 5800
QYKQEMKHLQ QLIEEAHREI EDKPVATSNI QELQAQISLH EELAQKIKGY
5810 5820 5830 5840 5850
QEQIDSLNSK CKMLTMKAKH ATMLLTVTEV EGLAEGTEDL DRELHPTPSA
5860 5870 5880 5890 5900
HPSVVMMTAG RCHTLLSPVT EESGEEGTNS EISSPPACRS PSPVANTEAA
5910 5920 5930 5940 5950
VNQDIAYYQA LSAEGLQTDA ARIPPSAAVS QELYEPGLEP SATAKLGDLQ
5960 5970 5980 5990 6000
RSWETLKNVI SEKQRTLYEV LERQQKYQDS LQSISTKMEA MEMKLGESLE
6010 6020 6030 6040 6050
PSRSPESQMA EHQALMDEVQ MLQDEINGLQ VSLAEELVAE SQESDPAEQL
6060 6070 6080 6090 6100
ALQSTLTVLA ERMSTIRMKA AGKRQLLEEK LSDQLEEQRQ EQALQRYRCE
6110 6120 6130 6140 6150
ADELDHWLLN TKATLDVALG TSQEPMDMDA QLVDCQNMLV EIEQKVVALS
6160 6170 6180 6190 6200
QLSVHNENLL LEGKAHTKEE AEQLAVKLRL LKGSLGELQR ALHDRQLDMQ
6210 6220 6230 6240 6250
GVTQEKEEND VDFTDTQSPG VQEWLAQART TRTHQRQSSL QQQKEFEQEL
6260 6270 6280 6290 6300
AEQKSLLRSV ASRGEEILTQ HSTAEGSGGL GEKPDVLSQE LGIAEDQMRV
6310 6320 6330 6340 6350
KWESLHQEFS AKQKLLQNIL EQEQEQVLYS SPNRLLSGVL PFRGEAQTQD
6360 6370 6380 6390 6400
KTSVTSLLDG LSQAFGEASS QSGGTDRQSI HLEQKLYDGV SATSTWLNDV
6410 6420 6430 6440 6450
EERLFVATAP LPEETEACLF NQEALAKDIK EMSEEMDKNK NLFSQAFPED
6460 6470 6480 6490 6500
SDNRDVIEDT LGCLLGRLSL LDSVVDQRCH QMKERLQQIL RFQNDLKVLF
6510 6520 6530 6540 6550
TSLADSKYII LQKLANVFEQ PIVEQMQAIQ QAEEGLRDLE GGISELKRWA
6560 6570 6580 6590 6600
DKLQVEQSAV QELSKLQDMY DELLMTVSSR RSSLHQNLAL KSQYDKALQD
6610 6620 6630 6640 6650
LVDLLDTGQE KMTGDQKIIV CSKEEIQQLL GKHKEYFQGL ESHMILTEIL
6660 6670 6680 6690 6700
FRKIVGFAAV KETQFHTDCM AQASAVLKQA HKRGVELEYI LEMWSHLDEN
6710 6720 6730 6740 6750
RQELSRQLEV IENSIPSVGL VEESEDRLVE RTNLYQHLKS SLNEYQPKLY
6760 6770 6780 6790 6800
QALDDGKRLL MSVSCSELES QLNQLGEHWL SNTNKVSKEL HRLETILKHW
6810 6820 6830 6840 6850
TRYQSEAAAL NHWLQCAKDR LAFWTQQSVT VPQELEMVRD HLSAFLEFSK
6860 6870 6880 6890 6900
EVDAKSALKS SVTSTGNQLL RLKKVDTAAL RAELSRMDSQ WTDLLTGIPV
6910 6920 6930 6940 6950
VQEKLHQLQM DKLPSRHAIS EVMSWISLME SVILKDEEDI RNAIGYKAIH
6960 6970 6980 6990 7000
EYLQKYKGFK IDLNCKQLTA DFVNQSVLQI SSQDVESKRS DKTDFAEQLG
7010 7020 7030 7040 7050
AMNKSWQLLQ GRVGEKIQML EGLLESWSEY ENSVQSLKAW FANQERKLKE
7060 7070 7080 7090 7100
QHLLGDRNSV ENALKDCQEL EDLIKAKEKE VEKIEQNGLA LIQNKREEVS
7110 7120 7130 7140 7150
GSVMSTLQEL RQTWISLDRT VEQLKIQLTS ALGQWSNHKA ACDEINGHLM
7160 7170 7180 7190 7200
EARYSLSRFR LLTGSSEAVQ VQVDNLQNLH DELEKQEGGL QKFGSITNQL
7210 7220 7230 7240 7250
LKECHPPVAE TLSSTLQEVN MRWNNLLEEI AEQLHSSKAL LQLWQRYKDY
7260 7270 7280 7290 7300
SKQCASAIQR QEEQTSVLLK AATNKDIADD EVTKWIQDCN DLLKGLETVK
7310 7320 7330 7340 7350
DSLFILRELG EQLGQQVDVS AAAAIQCEQL CFSQRLGALE QALCKQQAVL
7360 7370 7380 7390 7400
QAGVVDYETF AKSLEALEVW MVEAEGILQG QDPTHSSDLS TIQERMEELK
7410 7420 7430 7440 7450
GQMLKFSSLA PDLDRLNELG YRLPLNDKEI KRMQNLNRHW SLTSSQTTER
7460 7470 7480 7490 7500
FSKLQSFLLQ HQTFLEKCET WMEFLVQTEH KLAVEISGNY QHLLEQQRAH
7510 7520 7530 7540 7550
ELFQAEMFSR QQILHSIIVD GQNLLEQGQV DDREEFSLKL TLLSNQWQGV
7560 7570 7580 7590 7600
IRRAQQRRGI IDSQIRQWQR YREMAEKLRK WLAEVSHLPL SGLGNIPVPL
7610 7620 7630 7640 7650
QQVRMLFDEV QFKEKVFLRQ QGSYILTVEA GKQLLLSADS GAEAALQAEL
7660 7670 7680 7690 7700
TDIQEKWKAA SMHLEEQKKK LAFLLKDWEK CERGIANSLE KLRMFKKRLS
7710 7720 7730 7740 7750
QPLPDHHEEL HAEQMRCKEL ENAVGRWTDD LTELMLVRDA LAVYLSAEDI
7760 7770 7780 7790 7800
SMLKERVELL QRQWEELCHQ VSLRRQQVSE RLNEWAVFSE KNKELCEWLT
7810 7820 7830 7840 7850
QMESKVSQNG DILIEEMIEK LKKDYQEEIA VAQENKIQLQ EMGERLAKAS
7860 7870 7880 7890 7900
HESKASEIQY KLSRVKDRWQ HLLDLMAARV KKLKETLVAV QQLDKNMGSL
7910 7920 7930 7940 7950
RTWLAHMESE LAKPIVYDSC NSEEIQRKLN EQQELQRDIE KHSTGVASVL
7960 7970 7980 7990 8000
NLCEVLLHDC DACATDAECD SIQQATRNLD RRWRNICAMS MERRLKIEET
8010 8020 8030 8040 8050
WRLWQKFLDD YSRFEDWLEV SERTAAFPSS SGVLYTVAKE ELKKFEAFQR
8060 8070 8080 8090 8100
QVHESLTQLE LINKQYRRLA RENRTDSACS LRQMVHGGNQ RWDDLQKRVT
8110 8120 8130 8140 8150
SILRRLKHFI SQREEFETAR DSILVWLTEM DLQLTNIEHF SECDVQAKIK
8160 8170 8180 8190 8200
QLKAFQQEIS LNHNKIEQII AQGEQLIEKS EPLDAAVIEE ELDELRRYCQ
8210 8220 8230 8240 8250
EVFGRVERYH KKLIRLPVRL PDDHDLSDRE LDLEDSTALS DLRWQDPSAD
8260 8270 8280 8290 8300
GMPSPQPSSN PSLSLPQPLR SERSGRDTPA SVDSIPLEWD HDYDLSRDLE
8310 8320 8330 8340 8350
SASRTLPSED EEGEEDKEFY LRGAVGLSGD PSSLESQMRQ LDKALDDSRF
8360 8370 8380 8390 8400
QIQQTANILR SKTPTGPDLD TSYKGYMKLL GECSGSIDSV RRLEHKLAEE
8410 8420 8430 8440 8450
ESFPGFVNLN STETQTAGVI DRWELLQAQA MSKELRMKQN LQKWQQFNSD
8460 8470 8480 8490 8500
LNNIWAWLGE TEEELDRLQH LALSTDIHTI ESHIKKLKEL QKAVDHRKAI
8510 8520 8530 8540 8550
ILSINLCSSE FTQADSKESH DLQDRLSQMN GRWDRVCSLL EDWRGLLQDA
8560 8570 8580 8590 8600
LMQCQEFHEM SHALLLMLEN IDRRKNEIVP IDSTLDPETL QDHHKQLMQI
8610 8620 8630 8640 8650
KQELLKSQLR VASLQDMSRQ LLVNAEGSDC LEAKEKVHVI GNRLKLLLKE
8660 8670 8680 8690 8700
VSHHIKDLEK LLDMSSSQQD LSSWSSADEL DTSGSVSPTS GRSTPNRQKS
8710 8720 8730 8740 8750
PRGKCSLSQP GPSVSSPKSR STRDGSDSSR SDPRPERVGR AFLFRILRAA
8760 8770 8780 8790
LPFQLLLLLL IGLTCLVPMS EKDYSCALSN NFARSFHPML RYTNGPPPL
Length:8,799
Mass (Da):1,009,926
Last modified:March 23, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A457DC081969CF0
GO
Isoform 2 (identifier: Q6ZWR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7828: Missing.
     7829-7878: IAVAQENKIQ...WQHLLDLMAA → MVVAEDLHGPRMAEDSSVDADLPDCDCDVS
     8218-8219: Missing.
     8328-8328: S → SDVVIPENPEAYVKLTENAIRNTS

Show »
Length:972
Mass (Da):111,334
Checksum:i6ED3F1A381AACC9A
GO
Isoform 3 (identifier: Q6ZWR6-3) [UniParc]FASTAAdd to basket
Also known as: Syne-1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-7828: Missing.
     7829-7878: IAVAQENKIQ...WQHLLDLMAA → MVVAEDLHGPRMAEDSSVDADLPDCDCDVS
     8218-8219: Missing.

Show »
Length:949
Mass (Da):108,779
Checksum:i40ABE338F614825E
GO
Isoform 4 (identifier: Q6ZWR6-4) [UniParc]FASTAAdd to basket
Also known as: Syne-1B

The sequence of this isoform differs from the canonical sequence as follows:
     8218-8219: Missing.

Note: Incomplete sequence.Combined sources
Show »
Length:8,797
Mass (Da):1,009,670
Checksum:i08970A024A161721
GO
Isoform 5 (identifier: Q6ZWR6-5) [UniParc]FASTAAdd to basket
Also known as: Enaptin-165

The sequence of this isoform differs from the canonical sequence as follows:
     103-103: K → KSMYRGSP
     297-313: Missing.
     1435-1441: DIKTMEM → EYVLHHF
     1442-8799: Missing.

Show »
Length:1,431
Mass (Da):165,244
Checksum:i0D4C7DA8ADAE612F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1STC6A0A1L1STC6_MOUSE
Nesprin-1
Syne1
8,799Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SRV6A0A1L1SRV6_MOUSE
Nesprin-1
Syne1
1,288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6ZWR5Q6ZWR5_MOUSE
Nesprin-1
Syne1
615Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG24393 differs from that shown. Reason: Frameshift at positions 6810, 7656 and 7658.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1086G → W in AAN03487 (PubMed:15093733).Curated1
Sequence conflicti1150I → T in AAN03487 (PubMed:15093733).Curated1
Sequence conflicti7187E → G in AAG24393 (PubMed:10878022).Curated1
Sequence conflicti7876M → I in AAG24393 (PubMed:10878022).Curated1
Sequence conflicti8266P → L in AAG24392 (PubMed:10878022).Curated1
Sequence conflicti8266P → L in AAG24393 (PubMed:10878022).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0387911 – 7828Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST7828
Alternative sequenceiVSP_038792103K → KSMYRGSP in isoform 5. 1 Publication1
Alternative sequenceiVSP_038793297 – 313Missing in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0387941435 – 1441DIKTMEM → EYVLHHF in isoform 5. 1 Publication7
Alternative sequenceiVSP_0387951442 – 8799Missing in isoform 5. 1 PublicationAdd BLAST7358
Alternative sequenceiVSP_0387967829 – 7878IAVAQ…DLMAA → MVVAEDLHGPRMAEDSSVDA DLPDCDCDVS in isoform 2 and isoform 3. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_0387978218 – 8219Missing in isoform 2, isoform 3 and isoform 4. 2 Publications2
Alternative sequenceiVSP_0387988328S → SDVVIPENPEAYVKLTENAI RNTS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF281869 mRNA Translation: AAG24392.1
AF281870 mRNA Translation: AAG24393.1 Frameshift.
AF535143 mRNA Translation: AAN03487.1
AK036828 mRNA Translation: BAC29595.1
AC156392 Genomic DNA No translation available.
AC156393 Genomic DNA No translation available.
AC157020 Genomic DNA No translation available.
AC159748 Genomic DNA No translation available.
AC161829 Genomic DNA No translation available.
AC162381 Genomic DNA No translation available.
AC162385 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS56679.1 [Q6ZWR6-3]
CCDS56680.1 [Q6ZWR6-5]

NCBI Reference Sequences

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RefSeqi
NP_001073154.1, NM_001079686.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000041639; ENSMUSP00000039440; ENSMUSG00000096054 [Q6ZWR6-5]
ENSMUST00000095899; ENSMUSP00000093587; ENSMUSG00000096054 [Q6ZWR6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64009

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:64009

UCSC genome browser

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UCSCi
uc007egn.1 mouse [Q6ZWR6-5]
uc007egt.2 mouse [Q6ZWR6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281869 mRNA Translation: AAG24392.1
AF281870 mRNA Translation: AAG24393.1 Frameshift.
AF535143 mRNA Translation: AAN03487.1
AK036828 mRNA Translation: BAC29595.1
AC156392 Genomic DNA No translation available.
AC156393 Genomic DNA No translation available.
AC157020 Genomic DNA No translation available.
AC159748 Genomic DNA No translation available.
AC161829 Genomic DNA No translation available.
AC162381 Genomic DNA No translation available.
AC162385 Genomic DNA No translation available.
CCDSiCCDS56679.1 [Q6ZWR6-3]
CCDS56680.1 [Q6ZWR6-5]
RefSeqiNP_001073154.1, NM_001079686.1

3D structure databases

SMRiQ6ZWR6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi211015, 6 interactors
DIPiDIP-60966N
IntActiQ6ZWR6, 8 interactors
STRINGi10090.ENSMUSP00000039440

PTM databases

CarbonylDBiQ6ZWR6
GlyConnecti2530
iPTMnetiQ6ZWR6
PhosphoSitePlusiQ6ZWR6

Proteomic databases

jPOSTiQ6ZWR6
PaxDbiQ6ZWR6
PeptideAtlasiQ6ZWR6
PRIDEiQ6ZWR6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041639; ENSMUSP00000039440; ENSMUSG00000096054 [Q6ZWR6-5]
ENSMUST00000095899; ENSMUSP00000093587; ENSMUSG00000096054 [Q6ZWR6-3]
GeneIDi64009
KEGGimmu:64009
UCSCiuc007egn.1 mouse [Q6ZWR6-5]
uc007egt.2 mouse [Q6ZWR6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23345
MGIiMGI:1927152 Syne1

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000154481
HOGENOMiHOG000120125
InParanoidiQ6ZWR6
KOiK19326
OrthoDBi47at2759
PhylomeDBiQ6ZWR6
TreeFamiTF317709
TF337116

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Syne1 mouse

Protein Ontology

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PROi
PR:Q6ZWR6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000096054 Expressed in 265 organ(s), highest expression level in cerebellum lobe
ExpressionAtlasiQ6ZWR6 baseline and differential
GenevisibleiQ6ZWR6 MM

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR012315 KASH
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR030265 SYNE1
PANTHERiPTHR14514:SF3 PTHR14514:SF3, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF10541 KASH, 1 hit
PF00435 Spectrin, 11 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM01249 KASH, 1 hit
SM00150 SPEC, 42 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51049 KASH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYNE1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6ZWR6
Secondary accession number(s): Q8K3T7, Q9ERT7, Q9ERT8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: July 3, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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