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Entry version 158 (13 Nov 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Dihydrofolate reductase

Gene

dfrA12

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (D4587_00460), Dihydrofolate reductase type 8 (dhfrVIII), Dihydrofolate reductase type 9 (dhfrIX), Dihydrofolate reductase (BTQ06_28630), Dihydrofolate reductase, Dihydrofolate reductase (APZ14_00990), Dihydrofolate reductase (dfrB2), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase type A10 (dfrA10), Dihydrofolate reductase (dfrA21), Dihydrofolate reductase (C9Y95_01915), Dihydrofolate reductase (folA), Dihydrofolate reductase (C9224_00785), Dihydrofolate reductase (dfr2d), Dihydrofolate reductase (D9F05_04510), Dihydrofolate reductase (C5715_27395), Dihydrofolate reductase (DUM94_12960), Dihydrofolate reductase type 2, Dihydrofolate reductase (dfrB3), Dihydrofolate reductase type 2, Dihydrofolate reductase type 1 (dhfrI), Dihydrofolate reductase (DS143_29305), Dihydrofolate reductase (C9003_10310), Dihydrofolate reductase type 5 (dhfrV), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (DXF93_00550), Dihydrofolate reductase type 15 (dhfrXV), Dihydrofolate reductase (dfrII), Dihydrofolate reductase (D9J03_00795), Dihydrofolate reductase (EBA78_10940), Dihydrofolate reductase (D7Z87_07315), Dihydrofolate reductase (BHS87_26495), Dihydrofolate reductase (ECs0051), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA26), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (CI641_024860), Dihydrofolate reductase (dfr2d), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase type A13 (dfrA13), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase type 2, Dihydrofolate reductase (C9108_15520), Dihydrofolate reductase (CSB64_27845), Dihydrofolate reductase (C9175_03430), Dihydrofolate reductase (dfr2a), Dihydrofolate reductase type 7 (dhfrVII), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (folA_2), Dihydrofolate reductase (dfr22), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (folA), Dihydrofolate reductase (folA), Dihydrofolate reductase (dfr22), Dihydrofolate reductase (dfrA12), Dihydrofolate reductase (folA)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001936315:BJJ90_RS28890-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00077;UER00158

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dfrA12Imported
Synonyms:dfrAImported, dfrA17Imported, dhfrImported, dhfr12Imported, dhfrA12Imported, dhfrXIIImported
ORF Names:A7R67_00830Imported, AOY10_00067Imported, B9T59_28870Imported, BANRA_05550Imported, BHS81_30685Imported, BJJ90_26820Imported, BK248_28555Imported, BK292_28535Imported, BK373_28035Imported, BK383_28330Imported, BK400_25655Imported, BvCmsKSP011_01657Imported, BVL39_27785Imported, C7235_00500Imported, C7235_25370Imported, C7235_26685Imported, C9083_27435Imported, C9Y80_27165Imported, CA593_26965Imported, CEG98_16360Imported, CI694_06015Imported, CR538_27010Imported, CR538_27775Imported, CR539_26880Imported, D9C02_25135Imported, D9K48_18825Imported, D9K54_18530Imported, DL545_01045Imported, DNQ41_27240Imported, DWB25_26185Imported, EC3426_05259Imported, EIA21_26955Imported, ELV08_25350Imported, EXX06_28230Imported, EXX55_28235Imported, FQR64_25030Imported, FTV93_26310Imported, NDM1Dok01_N0147Imported, PU06_28725Imported, RCS28_PI0034Imported, RCS40_P0057Imported, RCS51_P0085Imported, RCS55_PI0020Imported, SAMEA3472043_04963Imported, SAMEA3472044_03632Imported, SAMEA3472055_02952Imported, SAMEA3472070_05347Imported, SAMEA3472080_05518Imported, SAMEA3472108_05055Imported, SAMEA3472110_05766Imported, SAMEA3472112_05959Imported, SAMEA3752372_05955Imported, SAMEA3753097_02618Imported, SAMEA3753300_05488Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid 4Imported
Plasmid IncA/CImported
Plasmid RCS28_pIImported
Plasmid RCS40_pImported
Plasmid RCS51_pImported
Plasmid RCS55_pIImported
Plasmid p14EC029bImported
Plasmid p14EC029cImported
Plasmid p14EC033fImported
Plasmid p14ec029bImported
Plasmid p14ec029cImported
Plasmid p14ec033fImported
Plasmid p1540-3Imported
Plasmid p51008369SK1_EImported
Plasmid p51008369sk1_eImported
Plasmid p5CRE51-NDM-9Imported
Plasmid p5cre51-ndm-9 sequenceImported
Plasmid pAJE0508Imported
Plasmid pBDE0502Imported
Plasmid pCERC3Imported
Plasmid pCHL5009T-94kImported
Plasmid pCR53-EC-NDM-4Imported
Plasmid pEC008-HNImported
Plasmid pEC355Imported
Plasmid pEC77-NDMImported
Plasmid pEc9Imported
Plasmid pGD31-F1928Imported
Plasmid pGUE-NDMImported
Plasmid pH17-3Imported
Plasmid pJIE101Imported
Plasmid pLD91-1-MCR1Imported
Plasmid pLEW517Imported
Plasmid pMC-NDMImported
Plasmid pNCYU-26-73-1Imported
Plasmid pNDM-1_Dok01Imported
Plasmid pNDM15-1078Imported
Plasmid pRYC301Imported
Plasmid pRYC302Imported
Plasmid pSLK172-1Imported
Plasmid pTB201Imported
Plasmid pTB202Imported
Plasmid pVI2402Imported
Plasmid pZS50Imported
Plasmid pgd31-f1928Imported
Plasmid ph17-3Imported
Plasmid pld91-1-mcr1Imported
Plasmid pslk172-1Imported
Plasmid ptb201Imported
Plasmid ptb202Imported
Plasmid unnamedImported
Plasmid unnamed broad host range plasmidImported
Plasmid unnamed4Imported
Plasmid unnamed6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 162DHFRInterPro annotationAdd BLAST156

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K18590

Database of Orthologous Groups

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OrthoDBi
1920912at2

Family and domain databases

Conserved Domains Database

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CDDi
cd00209 DHFR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.430.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22778:SF16 PTHR22778:SF16, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00186 DHFR_1, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000194 DHFR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53597 SSF53597, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q79DQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSESVRIYL VAAMGANRVI GNGPNIPWKI PGEQKIFRRL TEGKVVVMGR
60 70 80 90 100
KTFESIGKPL PNRHTLVISR QANYRATGCV VVSTLSHAIA LASELGNELY
110 120 130 140 150
VAGGAEIYTL ALPHAHGVFL SEVHQTFEGD AFFPMLNETE FELVSTETIQ
160
AVIPYTHSVY ARRNG
Length:165
Mass (Da):18,127
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD264DED1377799C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M84522 Genomic DNA Translation: AAA23681.1
AF335108 Genomic DNA Translation: AAL73193.1
DQ157751 Genomic DNA Translation: AAZ91701.1
DQ322593 Genomic DNA Translation: ABC55455.1
DQ390454 Genomic DNA Translation: ABG49196.1
EF113389 Genomic DNA Translation: ABM64219.1
EF450247 Genomic DNA Translation: ABO37110.1
EU056266 Genomic DNA Translation: ABU24278.1
EU089670 Genomic DNA Translation: ABX75132.1
FJ155842 Genomic DNA Translation: ACI05553.1
FJ381672 Genomic DNA Translation: ACJ47205.1
FJ587511 Genomic DNA Translation: ACM50313.1
FJ855131 Genomic DNA Translation: ACO92332.1
FJ950721 Genomic DNA Translation: ACS28595.1
GQ280256 Genomic DNA Translation: ACT80319.1
GQ280258 Genomic DNA Translation: ACT80325.1
GQ924762 Genomic DNA Translation: ACX70164.1
GQ924763 Genomic DNA Translation: ACX70167.1
GQ924764 Genomic DNA Translation: ACX70170.1
GQ924765 Genomic DNA Translation: ACX70173.1
GQ924766 Genomic DNA Translation: ACX70176.1
GQ924767 Genomic DNA Translation: ACX70179.1
GU001949 Genomic DNA Translation: ACY02810.1
GU120475 Genomic DNA Translation: ACY68999.1
GU120477 Genomic DNA Translation: ACY69004.1
GU731080 Genomic DNA Translation: ADE61665.1
HM043573 Genomic DNA Translation: ADH82133.1
HM106452 Genomic DNA Translation: ADI49213.1
HQ730120 Genomic DNA Translation: AEH26343.1
HQ875013 Genomic DNA Translation: AEK32469.1
HQ875012 Genomic DNA Translation: AEK32523.1
JF806493 Genomic DNA Translation: AEP16475.1
EU418922 Genomic DNA Translation: AER36591.1
JN119854 Genomic DNA Translation: AER70356.1
JN108892 Genomic DNA Translation: AEW67105.1
JN108898 Genomic DNA Translation: AEW67118.1
JN566044 Genomic DNA Translation: AEX55247.1
JN870738 Genomic DNA Translation: AFC60618.1
JQ364967 Genomic DNA Translation: AFI72849.1
JX442969 Genomic DNA Translation: AFU81211.1
KF921570 Genomic DNA Translation: AHK10477.1
KF921571 Genomic DNA Translation: AHK10486.1
KF921572 Genomic DNA Translation: AHK10495.1
KJ547717 Genomic DNA Translation: AHY82500.1
KJ679410 Genomic DNA Translation: AID65214.1
KJ192417 Genomic DNA Translation: AIM47155.1
KJ192421 Genomic DNA Translation: AIM47163.1
KJ192422 Genomic DNA Translation: AIM47166.1
KM035423 Genomic DNA Translation: AIR77225.1
KF914285 Genomic DNA Translation: AIV43450.1
KF914292 Genomic DNA Translation: AIV43464.1
KM236804 Genomic DNA Translation: AIW58905.1
KM403389 Genomic DNA Translation: AIW82230.1
KP010147 Genomic DNA Translation: AJN91210.1
KP826711 Genomic DNA Translation: AKN35322.1
KP796139 Genomic DNA Translation: AKT95180.1
KP789948 Genomic DNA Translation: AKU38036.1
KR827684 Genomic DNA Translation: AKZ61008.1
KP965723 Genomic DNA Translation: ALD19894.1
KR610433 Genomic DNA Translation: ALJ84042.1
KT692982 Genomic DNA Translation: ALL73824.1
CP012902 Genomic DNA Translation: ALV81584.1
CP017632 Genomic DNA Translation: APT05551.1
CP021177 Genomic DNA Translation: ARR36645.1
KY887590 Genomic DNA Translation: ASF79902.1
CP024153 Genomic DNA Translation: AUJ98772.1
CP024143 Genomic DNA Translation: AUK03942.1
CP024144 Genomic DNA Translation: AUK04090.1
CP019054 Genomic DNA Translation: AUL71842.1
CP029242 Genomic DNA Translation: AWJ97276.1
CP029243 Genomic DNA Translation: AWK01912.1
CP029244 Genomic DNA Translation: AWK02110.1
CP021196 Genomic DNA Translation: AWR84867.1
CP029978 Genomic DNA Translation: AWV13848.1
CP031653 Genomic DNA Translation: AXP24787.1
CP032938 Genomic DNA Translation: AYM25134.1
CP031295 Genomic DNA Translation: AZR91814.1
AB154407 Genomic DNA Translation: BAD22691.1
AP012208 Genomic DNA Translation: BAK69640.1
AB898038 Genomic DNA Translation: BAO27820.1
Z21672 Genomic DNA Translation: CAA79767.1
AM040708 Genomic DNA Translation: CAJ13564.1
AM932675 Genomic DNA Translation: CAP69690.1
FM244708 Genomic DNA Translation: CAR92034.1
FR875297 Genomic DNA Translation: CCC21002.1
FR875303 Genomic DNA Translation: CCC21013.1
HG003695 Other DNA Translation: CDF66138.1
BFZV01000032 Genomic DNA Translation: GDJ76379.1
JUDN01000239 Genomic DNA Translation: KHJ09428.1
LZCC01000581 Genomic DNA Translation: OFE04620.1
MOFD01000161 Genomic DNA Translation: OJK67276.1
MOGU01000112 Genomic DNA Translation: OJM82924.1
MOJX01000143 Genomic DNA Translation: OJQ93476.1
MOKI01000142 Genomic DNA Translation: OJR43017.1
MOKZ01000057 Genomic DNA Translation: OJS86682.1
NAHY01000816 Genomic DNA Translation: ORJ59148.1
NQBT01000060 Genomic DNA Translation: OYI54827.1
NIYQ01000118 Genomic DNA Translation: PAY71734.1
CP042587 Genomic DNA Translation: QED54952.1
CP042616 Genomic DNA Translation: QED76179.1
RQUH01000116 Genomic DNA Translation: RRB80782.1
RIZO01000083 Genomic DNA Translation: RXP29486.1
RIZT01000075 Genomic DNA Translation: RXP42978.1
SHID01000103 Genomic DNA Translation: RZX30154.1
SHKA01000106 Genomic DNA Translation: RZZ91443.1
LT985227 Genomic DNA Translation: SPD96421.1
LT985241 Genomic DNA Translation: SPD98169.1
LT985252 Genomic DNA Translation: SPD99066.1
LT985387 Genomic DNA Translation: SPE75939.1
UCTY01000025 Genomic DNA Translation: SQJ64050.1
UCTW01000020 Genomic DNA Translation: SQJ67204.1
UCVC01000018 Genomic DNA Translation: SQL22529.1
UCVG01000032 Genomic DNA Translation: SQL54290.1
UCWC01000027 Genomic DNA Translation: SQM48927.1
UCXQ01000107 Genomic DNA Translation: SQO15881.1
UCZF01000092 Genomic DNA Translation: SQP95964.1
UCZZ01000016 Genomic DNA Translation: SQR03825.1
UINN01000085 Genomic DNA Translation: SVF53885.1
UINI01000111 Genomic DNA Translation: SVF54863.1
UINH01000101 Genomic DNA Translation: SVF54902.1
LS992188 Genomic DNA Translation: SYX53200.1
RZDD01000136 Genomic DNA Translation: TFP29504.1
RRKL01000138 Genomic DNA Translation: TJK87617.1
RRDB01000217 Genomic DNA Translation: TJU23472.1
UWXJ01000003 Genomic DNA Translation: VCZ28719.1

NCBI Reference Sequences

More...
RefSeqi
WP_001083725.1, NZ_VRXY01000040.1
YP_001096357.1, NC_009132.1
YP_006939953.1, NC_018994.1
YP_006953616.1, NC_019082.1
YP_006953867.1, NC_019089.1
YP_009066448.1, NC_025106.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ANM85714; ANM85714; A8V37_24730
CTZ12492; CTZ12492; ERS139269_04799
KHJ09428; KHJ09428; PU06_28725
KIG95300; KIG95300; PU21_26375
KIQ43468; KIQ43468; IY32_27010
ODH19759; ODH19759; A6804_25290
ODH26528; ODH26528; A6803_24235

Database of genes from NCBI RefSeq genomes

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GeneIDi
13876921
13906554
13906804
20471930
40104635
4924682

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:CAA79767

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|562.7588.peg.5182

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84522 Genomic DNA Translation: AAA23681.1
AF335108 Genomic DNA Translation: AAL73193.1
DQ157751 Genomic DNA Translation: AAZ91701.1
DQ322593 Genomic DNA Translation: ABC55455.1
DQ390454 Genomic DNA Translation: ABG49196.1
EF113389 Genomic DNA Translation: ABM64219.1
EF450247 Genomic DNA Translation: ABO37110.1
EU056266 Genomic DNA Translation: ABU24278.1
EU089670 Genomic DNA Translation: ABX75132.1
FJ155842 Genomic DNA Translation: ACI05553.1
FJ381672 Genomic DNA Translation: ACJ47205.1
FJ587511 Genomic DNA Translation: ACM50313.1
FJ855131 Genomic DNA Translation: ACO92332.1
FJ950721 Genomic DNA Translation: ACS28595.1
GQ280256 Genomic DNA Translation: ACT80319.1
GQ280258 Genomic DNA Translation: ACT80325.1
GQ924762 Genomic DNA Translation: ACX70164.1
GQ924763 Genomic DNA Translation: ACX70167.1
GQ924764 Genomic DNA Translation: ACX70170.1
GQ924765 Genomic DNA Translation: ACX70173.1
GQ924766 Genomic DNA Translation: ACX70176.1
GQ924767 Genomic DNA Translation: ACX70179.1
GU001949 Genomic DNA Translation: ACY02810.1
GU120475 Genomic DNA Translation: ACY68999.1
GU120477 Genomic DNA Translation: ACY69004.1
GU731080 Genomic DNA Translation: ADE61665.1
HM043573 Genomic DNA Translation: ADH82133.1
HM106452 Genomic DNA Translation: ADI49213.1
HQ730120 Genomic DNA Translation: AEH26343.1
HQ875013 Genomic DNA Translation: AEK32469.1
HQ875012 Genomic DNA Translation: AEK32523.1
JF806493 Genomic DNA Translation: AEP16475.1
EU418922 Genomic DNA Translation: AER36591.1
JN119854 Genomic DNA Translation: AER70356.1
JN108892 Genomic DNA Translation: AEW67105.1
JN108898 Genomic DNA Translation: AEW67118.1
JN566044 Genomic DNA Translation: AEX55247.1
JN870738 Genomic DNA Translation: AFC60618.1
JQ364967 Genomic DNA Translation: AFI72849.1
JX442969 Genomic DNA Translation: AFU81211.1
KF921570 Genomic DNA Translation: AHK10477.1
KF921571 Genomic DNA Translation: AHK10486.1
KF921572 Genomic DNA Translation: AHK10495.1
KJ547717 Genomic DNA Translation: AHY82500.1
KJ679410 Genomic DNA Translation: AID65214.1
KJ192417 Genomic DNA Translation: AIM47155.1
KJ192421 Genomic DNA Translation: AIM47163.1
KJ192422 Genomic DNA Translation: AIM47166.1
KM035423 Genomic DNA Translation: AIR77225.1
KF914285 Genomic DNA Translation: AIV43450.1
KF914292 Genomic DNA Translation: AIV43464.1
KM236804 Genomic DNA Translation: AIW58905.1
KM403389 Genomic DNA Translation: AIW82230.1
KP010147 Genomic DNA Translation: AJN91210.1
KP826711 Genomic DNA Translation: AKN35322.1
KP796139 Genomic DNA Translation: AKT95180.1
KP789948 Genomic DNA Translation: AKU38036.1
KR827684 Genomic DNA Translation: AKZ61008.1
KP965723 Genomic DNA Translation: ALD19894.1
KR610433 Genomic DNA Translation: ALJ84042.1
KT692982 Genomic DNA Translation: ALL73824.1
CP012902 Genomic DNA Translation: ALV81584.1
CP017632 Genomic DNA Translation: APT05551.1
CP021177 Genomic DNA Translation: ARR36645.1
KY887590 Genomic DNA Translation: ASF79902.1
CP024153 Genomic DNA Translation: AUJ98772.1
CP024143 Genomic DNA Translation: AUK03942.1
CP024144 Genomic DNA Translation: AUK04090.1
CP019054 Genomic DNA Translation: AUL71842.1
CP029242 Genomic DNA Translation: AWJ97276.1
CP029243 Genomic DNA Translation: AWK01912.1
CP029244 Genomic DNA Translation: AWK02110.1
CP021196 Genomic DNA Translation: AWR84867.1
CP029978 Genomic DNA Translation: AWV13848.1
CP031653 Genomic DNA Translation: AXP24787.1
CP032938 Genomic DNA Translation: AYM25134.1
CP031295 Genomic DNA Translation: AZR91814.1
AB154407 Genomic DNA Translation: BAD22691.1
AP012208 Genomic DNA Translation: BAK69640.1
AB898038 Genomic DNA Translation: BAO27820.1
Z21672 Genomic DNA Translation: CAA79767.1
AM040708 Genomic DNA Translation: CAJ13564.1
AM932675 Genomic DNA Translation: CAP69690.1
FM244708 Genomic DNA Translation: CAR92034.1
FR875297 Genomic DNA Translation: CCC21002.1
FR875303 Genomic DNA Translation: CCC21013.1
HG003695 Other DNA Translation: CDF66138.1
BFZV01000032 Genomic DNA Translation: GDJ76379.1
JUDN01000239 Genomic DNA Translation: KHJ09428.1
LZCC01000581 Genomic DNA Translation: OFE04620.1
MOFD01000161 Genomic DNA Translation: OJK67276.1
MOGU01000112 Genomic DNA Translation: OJM82924.1
MOJX01000143 Genomic DNA Translation: OJQ93476.1
MOKI01000142 Genomic DNA Translation: OJR43017.1
MOKZ01000057 Genomic DNA Translation: OJS86682.1
NAHY01000816 Genomic DNA Translation: ORJ59148.1
NQBT01000060 Genomic DNA Translation: OYI54827.1
NIYQ01000118 Genomic DNA Translation: PAY71734.1
CP042587 Genomic DNA Translation: QED54952.1
CP042616 Genomic DNA Translation: QED76179.1
RQUH01000116 Genomic DNA Translation: RRB80782.1
RIZO01000083 Genomic DNA Translation: RXP29486.1
RIZT01000075 Genomic DNA Translation: RXP42978.1
SHID01000103 Genomic DNA Translation: RZX30154.1
SHKA01000106 Genomic DNA Translation: RZZ91443.1
LT985227 Genomic DNA Translation: SPD96421.1
LT985241 Genomic DNA Translation: SPD98169.1
LT985252 Genomic DNA Translation: SPD99066.1
LT985387 Genomic DNA Translation: SPE75939.1
UCTY01000025 Genomic DNA Translation: SQJ64050.1
UCTW01000020 Genomic DNA Translation: SQJ67204.1
UCVC01000018 Genomic DNA Translation: SQL22529.1
UCVG01000032 Genomic DNA Translation: SQL54290.1
UCWC01000027 Genomic DNA Translation: SQM48927.1
UCXQ01000107 Genomic DNA Translation: SQO15881.1
UCZF01000092 Genomic DNA Translation: SQP95964.1
UCZZ01000016 Genomic DNA Translation: SQR03825.1
UINN01000085 Genomic DNA Translation: SVF53885.1
UINI01000111 Genomic DNA Translation: SVF54863.1
UINH01000101 Genomic DNA Translation: SVF54902.1
LS992188 Genomic DNA Translation: SYX53200.1
RZDD01000136 Genomic DNA Translation: TFP29504.1
RRKL01000138 Genomic DNA Translation: TJK87617.1
RRDB01000217 Genomic DNA Translation: TJU23472.1
UWXJ01000003 Genomic DNA Translation: VCZ28719.1
RefSeqiWP_001083725.1, NZ_VRXY01000040.1
YP_001096357.1, NC_009132.1
YP_006939953.1, NC_018994.1
YP_006953616.1, NC_019082.1
YP_006953867.1, NC_019089.1
YP_009066448.1, NC_025106.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Genome annotation databases

EnsemblBacteriaiANM85714; ANM85714; A8V37_24730
CTZ12492; CTZ12492; ERS139269_04799
KHJ09428; KHJ09428; PU06_28725
KIG95300; KIG95300; PU21_26375
KIQ43468; KIQ43468; IY32_27010
ODH19759; ODH19759; A6804_25290
ODH26528; ODH26528; A6803_24235
GeneIDi13876921
13906554
13906804
20471930
40104635
4924682
KEGGiag:CAA79767
PATRICifig|562.7588.peg.5182

Phylogenomic databases

KOiK18590
OrthoDBi1920912at2

Enzyme and pathway databases

UniPathwayiUPA00077;UER00158
BioCyciGCF_001936315:BJJ90_RS28890-MONOMER

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ79DQ2_ECOLX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q79DQ2
Secondary accession number(s): A0A236GMM9, A0A384LNE8, C7ENE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 13, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported
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